Abstract:
:Our group already demonstrated that europium hydroxide nanorods (EHNs) show none or mild toxicity in C57BL/6 mice even at high dose and exhibited excellent pro-angiogenic activity towards in vitro and in vivo models. In the present study, we evaluated the in vivo cytogenetic toxicity of intraperitoneally administered EHNs (12.5-250 mg/kg/b.w.) in male and female Swiss albino mice by analyzing chromosomal aberrations (CAs), mitotic index (MI), micronucleus (MN) from bone marrow and peripheral blood. Furthermore, we performed the cytogenetic toxicity study of EHNs towards Chinese hamster ovary (CHO) cells, in order to compare with the in vivo results. The results of CA assay of mice treated with EHNs (12.5-125 mg/kg/b.w.) showed no significant change in the formation of aberrant metaphases compared to the control group. Also, there was no significant difference in the number of dividing cells between the control group and EHNs-treated groups observed by MI study, suggesting the non-cytotoxicity of EHNs. Additionally, FACS study revealed that EHNs do not arrest cells at any phase of cell cycle in the mouse model. Furthermore, MN test of both bone marrow and peripheral blood showed no significant differences in the induction of MNs when compared with the control group. In vitro results from CHO cells also support our in vivo observations. Considering the role of angiogenesis by EHNs and the absence of its genotoxicity in mouse model, we strongly believe the future application of EHNs in treating various diseases, where angiogenesis plays an important role such as cardiovascular diseases, ischemic diseases and wound healing.
journal_name
Nanotoxicologyjournal_title
Nanotoxicologyauthors
Bollu VS,Nethi SK,Dasari RK,Rao SS,Misra S,Patra CRdoi
10.3109/17435390.2015.1073398subject
Has Abstractpub_date
2016-01-01 00:00:00pages
413-25issue
4eissn
1743-5390issn
1743-5404journal_volume
10pub_type
杂志文章相关文献
Nanotoxicology文献大全abstract::Foodborne nanoparticles (NPs) refer to the nanostructures generated during food processing, rather than the man-made nano-structural additives that are added to improve the property of food. In this research, discovery of fluorescent NPs in roasted pork was reported at different temperature of 180, 230, and 280 °C. Th...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.1080/17435390.2019.1652943
更新日期:2019-12-01 00:00:00
abstract::Copper oxide nanoparticles (CuO NPs) have severe nano-toxic effects on organisms. Limited data is available on influence of CuO NPs on plant cells. Here, the molecular mechanisms involved in the toxicity of CuO NPs are studied. Exposure to CuO NPs significantly increased copper content in roots (0.062-0.325 mg/g FW), ...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.1080/17435390.2019.1678693
更新日期:2020-02-01 00:00:00
abstract::We evaluated and compared the pulmonary clearance kinetics and extrapulmonary translocations of seven titanium dioxide (TiO2) nano- and submicron particles with different characteristics, including size, shape and surface coating. Varying doses of TiO2 nano- and submicron particles dispersed in 0.2% disodium phosphate...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2015.1015644
更新日期:2015-01-01 00:00:00
abstract::The objective of this study was to evaluate the distribution of silver nanoparticles (NPs) in pregnant mice and their developing embryos. Silver NPs (average diameter 50 nm) were intravenously injected into pregnant CD-1 mice on gestation days (GDs) 7, 8, and 9 at dose levels of 0, 35, or 66 μg Ag/mouse. Mice were eut...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2011.626539
更新日期:2012-12-01 00:00:00
abstract::Copper nanoparticles (Cu NPs) have various uses, including as additives in polymers/plastics, lubricants for metallic coating, and biomedical applications. We investigated the role of transforming growth factor (TGF)-β1 signaling in hepatic damage caused by Cu NPs and explored the effects of a 28-day repeated oral adm...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.1080/17435390.2018.1472313
更新日期:2018-08-01 00:00:00
abstract::No detailed information on in vivo biokinetics of CeO2 nanoparticles (NPs) following chronic low-dose inhalation is available. The CeO2 burden for lung, lung-associated lymph nodes, and major non-pulmonary organs, blood, and feces, was determined in a chronic whole-body inhalation study in female Wistar rats undertake...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.1080/17435390.2020.1736355
更新日期:2020-05-01 00:00:00
abstract::Administration of poly-dispersed acid-functionalized single-walled carbon nanotubes (AF-SWCNTs, 10 µg intravenously on alternate days) induced a sustained anemia in mice. Using a modified double in vivo biotinylation (DIB) technique, blood counts of reticulocytes and erythrocytes of different age groups were simultane...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2014.998307
更新日期:2015-01-01 00:00:00
abstract::Titanium-dioxide nanoparticles (TiO2-NPs) are increasingly released in agricultural soils through, e.g. biosolids, irrigation or nanoagrochemicals. Soils are submitted to a wide range of concentrations of TiO2-NPs depending on the type of exposure. However, most studies have assessed the effects of unrealistically hig...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.1080/17435390.2017.1290845
更新日期:2017-03-01 00:00:00
abstract::The printer is one of the most common office equipment. Recently, it was reported that toner formulations for printing equipment constitute nano-enabled products (NEPs) and contain engineered nanomaterials (ENMs) that become airborne during printing. To date, insufficient research has been performed to understand the ...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2014.976603
更新日期:2015-01-01 00:00:00
abstract::Abstract Nickel, zinc, and copper oxide nanoparticles (NiONP, ZnONP, and CuONP) and their aqueous extracts (AEs) were applied to A549 lung epithelial cells to determine the cytotoxicity, IL-8 production, and activation of transcription factors. Nanoparticles (NPs) and their AEs were also instilled into rat lungs to ...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2011.552810
更新日期:2012-02-01 00:00:00
abstract::Foodborne nanoparticles (NPs) have drawn great attention due to human health concerns. This study reports the detection of the presence of fluorescent NPs, about 5 nm, in two of the most popular beverages, Coca-Cola (Coke) and Pepsi-Cola (Pepsi). The NPs contain H, C and O, three elements with a tunable emission and w...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.1080/17435390.2017.1418443
更新日期:2018-02-01 00:00:00
abstract::Despite the wide use of silver nanoparticles (nano Ag), its toxicity still remains poorly understood. In this report, nano Ag induced an increase in platelet aggregation and procoagulant activation which are the key contributors to thrombotic diseases. In freshly isolated human platelets, nano Ag induced platelet aggr...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2010.506250
更新日期:2011-06-01 00:00:00
abstract::Accumulating evidence indicates that carbon nanotubes (CNTs) are biopersistent and can cause lung damage. With similar fibrous morphology and mode of exposure to asbestos, a known human carcinogen, growing concern has arisen for elevated risk of CNT-induced lung carcinogenesis; however, relatively little is known abou...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2013.801089
更新日期:2014-08-01 00:00:00
abstract::The influence of size, surface charge and surface functionality of poly(amido amine) dendrimers and silica nanoparticles (SNPs) on their toxicity was studied in immunocompetent mice. After systematic characterization of nanoparticles, they were administered to CD-1 (caesarean derived-1) mice to evaluate acute toxicity...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2011.604442
更新日期:2012-11-01 00:00:00
abstract::Understanding the relationship between adverse exposure events and specific material properties will facilitate predictive classification of carbon nanotubes (CNTs) according to their mechanisms of action, and a safe-by-design approach for the next generation of CNTs. Mass-spectrometry-based proteomics is a reliable t...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.1080/17435390.2018.1465141
更新日期:2018-08-01 00:00:00
abstract::Engineered nanoparticles are increasingly used in medical applications and day-to-day consumer products, leading to concerns about the potential environmental and human health impacts. Silver nanoparticles are particularly prevalent because of their use as anti-bacterial agents in many commonly available products. Nan...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2013.866284
更新日期:2014-08-01 00:00:00
abstract::In our previous studies of nanocalcium carbonate, in which we performed physicochemical analysis, genotoxicity, acute single-dose and repeated-dose 14-day oral toxicity testings in Sprague-Dawley (SD) rats, nanocalcium carbonate did not show a difference in toxicity compared to vehicle control. Here, we provide the fi...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2014.958587
更新日期:2015-01-01 00:00:00
abstract::Metal oxide nanoparticles are highly reactive from the biological point of view and, for this reason, it exists important reservations in regard human health impact. We used Drosophila as a promising in vivo model to diagnose the biological effects of copper oxide nanoparticles (CuO-NPs). Due to the potential role of ...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2015.1121413
更新日期:2016-08-01 00:00:00
abstract::Nanoparticle (NP) uptake across the gut is poorly understood. In vitro gut sac preparations and isolated perfused intestines were used to investigate the absorption mechanism(s). Exposure of whole gut sacs to 1 mg/l TiO₂ NPs for 4 h caused total Ti metal concentrations to increase in the intestine, with 80% or more of...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2012.735268
更新日期:2013-12-01 00:00:00
abstract::The increasing presence of ZnO nanoparticles (NPs) in consumer products may be having a dramatic impact in aquatic environments. The evaluation of ZnO NP toxicity represents a great challenge. This study aimed at evaluating the cytotoxic effect of micro- and nanosized ZnO in a fish and a mammalian hepatoma cell line. ...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2012.676098
更新日期:2013-08-01 00:00:00
abstract::The spread of antibiotic resistance genes (ARGs) has become a global environmental issue; it has been found that nanoparticles (NPs) can promote the transfer of ARGs between bacteria. However, it remains unclear whether NPs can affect this kind of conjugation in Streptomyces, which mainly conjugate with other bacteria...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.1080/17435390.2019.1669731
更新日期:2019-12-01 00:00:00
abstract::Here, we present evidence on complete transformation of ZnO and CuO nanoparticles, which are among the most heavily studied metal oxide particles, during 24 h in vitro toxicological testing with human T-lymphocytes. Synchrotron radiation-based X-ray absorption near edge structure (XANES) spectroscopy results revealed ...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.1080/17435390.2017.1282049
更新日期:2017-03-01 00:00:00
abstract::Engineered nanoparticles are increasingly discharged into the environment. After discharge, these nanoparticles can interact with co-existing organic contaminants, resulting in a phenomena referred to as 'joint toxicity'. This study evaluated joint toxicities of TiO2 nanoparticles (TiO2NPs) with four different (atrazi...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.1080/17435390.2017.1398358
更新日期:2017-01-01 00:00:00
abstract::In the present study, ZnS and ZnO quantum dots (QDs) were synthesized via an all-aqueous process with polyethylene glycol (PEG) chains on their surface, and their toxicity as well as biodistribution were evaluated. No haemolysis occurred at a high concentration of 1600 µg/mL in vitro haemolytic assay, which demonstrat...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2012.760014
更新日期:2014-02-01 00:00:00
abstract::The number of engineered nanomaterials (ENMs) being exploited commercially is growing rapidly, due to the novel properties they exhibit. Clearly, it is important to understand and minimize any risks to health or the environment posed by the presence of ENMs. Data-driven models that decode the relationships between the...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2016.1161857
更新日期:2016-09-01 00:00:00
abstract::Since nanomaterials are a heterogeneous group of substances used in various applications, risk assessment needs to be done on a case-by-case basis. Here the authors assess the risk (hazard and exposure) of a glass cleaner with synthetic amorphous silicon dioxide (SAS) nanoparticles during production and consumer use (...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2012.689881
更新日期:2013-08-01 00:00:00
abstract::Nanowires (NWs) have unique electrical and optical properties of value for many applications including lighting, sensing, and energy harnessing. Consumer products containing NWs increase the risk of NWs being released in the environment, especially into aquatic ecosystems through sewage systems. Daphnia magna is a com...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.1080/17435390.2016.1189615
更新日期:2016-10-01 00:00:00
abstract::To address the impact of cadmium sulphide nanoparticles (CdSNPs) of two different sizes (8 and 50 nm), Danio rerio zebrafish were dietary exposed to very low doses: 100 or 40 ng CdSNPs/day/g body weight for 36 or 60 days, respectively. The results obtained using RAPD-PCR genotoxicity test showed genomic alteration sin...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.3109/17435390.2013.822116
更新日期:2014-09-01 00:00:00
abstract::Nanoscale titanium dioxide (TiO2) is manufactured in wide scale, with a range of applications in consumer products. Significant toxicity of TiO2 nanoparticles has, however, been recognized, suggesting considerable risk to human health. To evaluate fully their toxicity, assessment of the epigenetic action of these nano...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.1080/17435390.2020.1723730
更新日期:2020-05-01 00:00:00
abstract::Passion fruit-like nano-architectures (NAs) are all-in-one platforms of increasing interest for the translation of metal nanoparticles into clinics. NAs are nature-inspired disassembling inorganic theranostics, which jointly combine most of the appealing behaviors of noble metal nanoparticles with their potential orga...
journal_title:Nanotoxicology
pub_type: 杂志文章
doi:10.1080/17435390.2018.1498551
更新日期:2018-10-01 00:00:00