Abstract:
CONTEXT:Free radical associated damages play a major role in causation of cancer in tobacco habituates. The free radicals released by tobacco bring about alterations in antioxidant levels in humans and these free radical associated damages are reflected through antioxidant enzyme activities in blood. AIMS:To evaluate the effects of tobacco consumption on the erythrocyte Antioxidant enzymes-Superoxide dismutase (SOD) and Glutathione Peroxidase (GPx) as they act as first line of defense antioxidants. MATERIALS AND METHODS:A case control study comprising of 4 study groups of healthy controls (n = 27), smokers (n = 27), tobacco chewers (n = 30) and combination habit (n = 22) were included. Erythrocyte SOD and GPx enzyme activities were measured by spectrophotometry. The results were statistically analyzed using one way-Anova and Mann Whitney test. RESULTS:The data analysis revealed an alteration in mean SOD levels as it was decreased in cases compared to control group where as mean GPx was seen to be increased in cases compared to controls. When SOD and GPx were compared for the frequency and duration of habit, GPx showed a significant decrease in chewers with increase in frequency and duration of habit. CONCLUSIONS:The present study gave us an insight about the relationship between antioxidant enzyme activity, oxidative stress and tobacco. The altered antioxidant enzyme levels observed in this study will act as a predictor for pre potentially malignant lesions. Therefore an early intervention of tobacco habit and its related oxidative stress would prevent the development of tobacco induced lesions.
journal_name
J Cancer Res Therjournal_title
Journal of cancer research and therapeuticsauthors
Naga Sirisha CV,Manohar RMdoi
10.4103/0973-1482.113352subject
Has Abstractpub_date
2013-04-01 00:00:00pages
210-4issue
2eissn
0973-1482issn
1998-4138pii
JCanResTher_2013_9_2_210_113352journal_volume
9pub_type
杂志文章abstract:PURPOSE:A few prospective studies demonstrated that bilirubin levels were inversely associated with the risk of lung cancer. However, the retrospective study about the relationship between bilirubin levels and lung cancer in China was not available. So, we want to know whether there has a difference in serum bilirubin ...
journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
doi:10.4103/0973-1482.168179
更新日期:2015-10-01 00:00:00
abstract::Lymphoproliferative malignancies can involve both nodal- and extra-nodal tissues. The most common extranodal site involved is the gastrointestinal (GI) tract, and it is secondary to the widespread primary nodal disease. However, about 33% of non-Hodgkin's lymphoma primarily arise from tissues other than lymph nodes, s...
journal_title:Journal of cancer research and therapeutics
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abstract:PURPOSE:To investigate feasibility and safety of GliaSite brachytherapy for treatment of central nervous system (CNS) tumors following neurosurgical resection. We report mature results of long-term follow-up, outcomes and toxicity. MATERIALS AND METHODS:In the period from 2004 to 2007, 10 consecutive adult patients wi...
journal_title:Journal of cancer research and therapeutics
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abstract::Renal cell carcinoma is the most frequent kidney neoplasm, with a high tendency to metastasize. The occurrence of renal carcinoma metastasis to the head and neck region is extremely rare. Here we present one such case where the tongue metastasis was the initial presenting feature of disease. ...
journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
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更新日期:2013-01-01 00:00:00
abstract::Most neuroendocrine tumors of the gastrointestinal tract are traditionally termed "carcinoid tumors." More than 90% of all gastrointestinal carcinoids are located in the appendix, small intestine, rectum, and mesenteric carcinoids are rare. Even when invasive, most carcinoids are relatively indolent and display minima...
journal_title:Journal of cancer research and therapeutics
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更新日期:2015-07-01 00:00:00
abstract::Intra-nodal palisaded myofibroblastoma (IPM) is a rare benign lymph node mesenchymal tumor. It presents as a slow growing, painless nodular mass confined mostly to the inguinal area. Histologically, it shows palisading spindle cells, hemorrhages, hemosiderin laden macrophages, and amianthoid fibers, almost totally rep...
journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
doi:10.4103/0973-1482.113395
更新日期:2013-04-01 00:00:00
abstract:INTRODUCTION:Intracranial meningiomas are the second most common tumor of the CNS. The high-grade tumors are atypical and malignant meningioma comprising 5-7% and 1-3% of all meningiomas. The high-grade meningioma have an aggressive histopathological and clinical behavior. MATERIALS AND METHODS:We retrospectively revi...
journal_title:Journal of cancer research and therapeutics
pub_type: 临床试验,杂志文章
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更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:Oral cancer (OC) mortality is very high in Sudan, particularly among men due to the habit of Toombak use (tobacco specific nitrose amine (TSN)) rich tobacco. AIMS:Our aim was to determine whether OC is gender-specific due to increased Toombak use among males as suggested a risk for subsequent development of...
journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
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abstract::We report a case of a 63-year-old lady presenting with pain in the right hypochondrium, jaundice, anorexia, and firm tender hepatomegaly with remarkably high serum alkaline phosphatase. Abdominal ultrasonography revealed a hypoechoic solid space-occupying lesion in right lobe of liver which was cytologically diagnosed...
journal_title:Journal of cancer research and therapeutics
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更新日期:2014-01-01 00:00:00
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journal_title:Journal of cancer research and therapeutics
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journal_title:Journal of cancer research and therapeutics
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更新日期:2016-01-01 00:00:00
abstract:Background:Natural orifice transluminal endoscopic surgery (NOTES) is a minimal invasive treatment. However, tissue dissection under endoscopy is still challenging due to the flexibility of endoscopy body and there is still no effective method for establishing a tunnel towards the targeted area. We previously showed th...
journal_title:Journal of cancer research and therapeutics
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更新日期:2019-01-01 00:00:00
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journal_title:Journal of cancer research and therapeutics
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更新日期:2018-06-01 00:00:00
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journal_title:Journal of cancer research and therapeutics
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journal_title:Journal of cancer research and therapeutics
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doi:10.4103/jcrt.JCRT_1277_16
更新日期:2019-01-01 00:00:00
abstract::Primary pulmonary epithelioid angiosarcoma is an extremely rare malignancy. Herein, we report the case of an elderly Chinese patient with primary pulmonary epithelioid angiosarcoma. The 72-year-old man presented with a 1-month history of persistent hemoptysis and left chest pain and weight loss of 3 kg. A chest comput...
journal_title:Journal of cancer research and therapeutics
pub_type: 信件,评审
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更新日期:2018-06-01 00:00:00
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journal_title:Journal of cancer research and therapeutics
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journal_title:Journal of cancer research and therapeutics
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journal_title:Journal of cancer research and therapeutics
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journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
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更新日期:2018-06-01 00:00:00
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journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
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更新日期:2008-01-01 00:00:00
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journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
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更新日期:2016-01-01 00:00:00
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journal_title:Journal of cancer research and therapeutics
pub_type: 杂志文章
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更新日期:2019-01-01 00:00:00
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journal_title:Journal of cancer research and therapeutics
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journal_title:Journal of cancer research and therapeutics
pub_type: 信件,评审
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