The Bordetella pertussis type III secretion system tip complex protein Bsp22 is not a protective antigen and fails to elicit serum antibody responses during infection of humans and mice.

abstract：:Genetically based natural resistance to brucellosis in cattle provides for novel strategies to control zoonotic diseases. Bovine NRAMP1, the homologue of a murine gene (Bcg), has been identified as a major candidate for controlling the in vivo resistant phenotype. We developed an in vitro model for expression of resis...

journal_title：Infection and immunity

authors： Barthel R,Feng J,Piedrahita JA,McMurray DN,Templeton JW,Adams LG

更新日期：2001-05-01 00:00:00

abstract：:The pattern of invasion of human hair in vitro by the dermatophyte Microsporum gypseum was studied by transmission and scanning electron microscopy. Mycelia that invaded the hair cortex through the edge of cuticles showed a flattened "frond" growth in contrast to the filamentous form seen on ordinary laboratory media....

journal_title：Infection and immunity

authors： Kanbe T,Tanaka K

更新日期：1982-11-01 00:00:00

abstract：:Vibrio vulnificus causes rapidly progressing septicemia with an extremely high mortality rate (≥50%), even with aggressive antibiotic treatment. The bacteria secrete multifunctional autoprocessing repeats-in-toxin (MARTX) toxins, which are involved in the pathogenesis of Gram-negative Vibrio species. Recently, we repo...

journal_title：Infection and immunity

authors： Lee TH,Cha SS,Lee CS,Rhee JH,Chung KM

更新日期：2014-11-01 00:00:00

abstract：:An impressive change in the epidemiology and severity of invasive group A streptococcal infections occurred in the 1980s, and the incidence of streptococcal toxic shock syndrome cases continues to rise. The reason for the resurgence of severe invasive cases remains a mystery-has there been a change in the pathogen or ...

journal_title：Infection and immunity

authors： Basma H,Norrby-Teglund A,Guedez Y,McGeer A,Low DE,El-Ahmedy O,Schwartz B,Kotb M

更新日期：1999-04-01 00:00:00

abstract：:Most Campylobacter jejuni strains are sensitive and most Campylobacter fetus strains are resistant to the bactericidal activity in normal human serum. We purified lipopolysaccharides from Campylobacter strains to determine whether their composition and structure relate to serum susceptibility. The lipopolysaccharide o...

journal_title：Infection and immunity

authors： Perez Perez GI,Blaser MJ

更新日期：1985-02-01 00:00:00

abstract：:The literature on chronic mucocutaneous candidiasis contains multiple reports which suggest that loss of cell-mediated immunity in this disease may be related in part to the presence of an inhibitory factor(s) present in patient plasma. One such inhibitory factor has been suggested to be mannan polysaccharide released...

journal_title：Infection and immunity

authors： Nelson RD,Herron MJ,McCormack RT,Gehrz RC

更新日期：1984-03-01 00:00:00

abstract：:The 9.5-kilobase plasmid of Yersinia pestis determines plasminogen activator, coagulase, pesticin, and pesticin immunity activities. We have mapped and cloned the loci encoding these activities and demonstrated that both plasminogen activator and coagulase were determined by the same gene, designated pla. The primary ...

journal_title：Infection and immunity

authors： Sodeinde OA,Goguen JD

更新日期：1988-10-01 00:00:00

abstract：:Phagosome acidification is an important component of the microbicidal response by infected eukaryotic cells. Thus, intracellular pathogens that reside within phagosomes must either block phagosome acidification or be able to survive at low pH. In this work, we studied the effect of phagosomal acidification on the surv...

journal_title：Infection and immunity

authors： Steele-Mortimer O,St-Louis M,Olivier M,Finlay BB

更新日期：2000-09-01 00:00:00

abstract：:Virus population dynamics in the lungs, trachea, and nasopharynx of Swiss-ICR mice were studied after respiratory challenge with mouse-adapted preparations of strain A2/Aichi/2/68 influenza virus. Markedly higher doses of virus were required to produce infection with nasopharyngeal challenge than with bronchoalveolar ...

journal_title：Infection and immunity

authors： Larson EW,Dominik JW,Rowberg AH,Higbee GA

更新日期：1976-02-01 00:00:00

abstract：:Relapsing fever is a rapidly progressive and severe septic disease caused by certain Borrelia spirochetes. The disease is divided into two forms, i.e., epidemic relapsing fever, caused by Borrelia recurrentis and transmitted by lice, and the endemic form, caused by several Borrelia species, such as B. duttonii, and tr...

journal_title：Infection and immunity

authors： Meri T,Cutler SJ,Blom AM,Meri S,Jokiranta TS

更新日期：2006-07-01 00:00:00

abstract：:Hybridomas secreting monoclonal antibodies (MABs) specific for Clostridium perfringens type A enterotoxin were produced by fusion of P3X63Ag8.653 myeloma cells with spleen cells from BALB/c mice immunized with purified enterotoxin. Wells containing hybridomas secreting immunoglobulin G (IgG) antibodies against enterot...

journal_title：Infection and immunity

authors： Wnek AP,Strouse RJ,McClane BA

更新日期：1985-11-01 00:00:00

abstract：:Francisella tularensis is a facultative intracellular bacterial pathogen and the causative agent of tularemia. After infection of macrophages, the organism escapes from its phagosome and replicates to high density in the cytosol, but the bacterial factors required for these aspects of virulence are incompletely define...

journal_title：Infection and immunity

authors： Long ME,Lindemann SR,Rasmussen JA,Jones BD,Allen LA

更新日期：2013-03-01 00:00:00

abstract：:Thrombospondin-related anonymous protein (TRAP) of the malaria parasite Plasmodium falciparum shares two sequence motifs with other proteins which possess adhesive properties. Recently, findings indicate that TRAP is an antigen which contributes to antisporozoite immunity. We have cloned and expressed the TRAP coding ...

journal_title：Infection and immunity

authors： Scarselli E,Tolle R,Koita O,Diallo M,Müller HM,Früh K,Doumbo O,Crisanti A,Bujard H

更新日期：1993-08-01 00:00:00

abstract：:We previously showed that the Uganda Palo Alto line of Plasmodium falciparum propagated in Saimiri monkeys and the line maintained in culture in human erythrocytes for many years in our laboratory are genetically unrelated (T. Fandeur, S. Bonnefoy, and O. Mercereau-Puijalon, Mol. Biochem. Parasitol. 47:167, 1991). Whe...

journal_title：Infection and immunity

authors： Fandeur T,Gysin J,Mercereau-Puijalon O

更新日期：1992-04-01 00:00:00

abstract：:In order to determine the carrier nature of lipopolysaccharide from Brucella abortus (LPS-BA) in evoking humoral responses, normal and immunodeficient mice were immunized with trinitrophenyl (TNP)-conjugated LPS-BA (TNP-LPS-BA) and the responses were compared with those to known T-dependent and T-independent antigens....

journal_title：Infection and immunity

authors： Betts M,Beining P,Brunswick M,Inman J,Angus RD,Hoffman T,Golding B

更新日期：1993-05-01 00:00:00

abstract：:The interactions between Capnocytophaga ochracea ATCC 33596 and Streptococcus sanguis H1, Actinomyces naeslundii PK984, or Actinomyces israelii PK16 are dependent on specific recognitions between heat-sensitive adhesins on C. ochracea and heat-stable structures (probably carbohydrate-containing receptors) on the surfa...

journal_title：Infection and immunity

authors： Weiss EI,London J,Kolenbrander PE,Kagermeier AS,Andersen RN

更新日期：1987-05-01 00:00:00

abstract：:Intestinal mucus is postulated to play a role in preventing colonization of the gastrointestinal tract by microbial pathogens. To evaluate the ability of both crude mucus and purified mucin, a glycoprotein of goblet cell origin, to inhibit mucosal adherence of enteric pathogens, we examined whether mucus and mucin der...

journal_title：Infection and immunity

authors： Drumm B,Roberton AM,Sherman PM

更新日期：1988-09-01 00:00:00

abstract：:The Toll-like receptor 2 (TLR2)/TLR1 receptor complex responds to amyloid fibrils, a common component of biofilm material produced by members of the phyla Firmicutes, Bacteroidetes, and Proteobacteria. To determine whether this TLR2/TLR1 ligand stimulates inflammatory responses when bacteria enter intestinal tissue, w...

journal_title：Infection and immunity

authors： Nishimori JH,Newman TN,Oppong GO,Rapsinski GJ,Yen JH,Biesecker SG,Wilson RP,Butler BP,Winter MG,Tsolis RM,Ganea D,Tükel Ç

更新日期：2012-12-01 00:00:00

abstract：:The serum antibody response to proteins encoded by the virulence-associated plasmid of Shigella flexneri was determined in monkeys challenged with virulent S. flexneri serotype 2a. With water-extractable antigen in an enzyme-linked immunosorbent assay, a significant increase in antibody titer against proteins from a p...

journal_title：Infection and immunity

authors： Oaks EV,Hale TL,Formal SB

更新日期：1986-07-01 00:00:00

abstract：:Merozoite surface protein 2 (MSP2) is an abundant glycosylphosphatidylinositol (GPI)-anchored protein of Plasmodium falciparum, which is a potential component of a malaria vaccine. As all forms of MSP2 can be categorized into two allelic families, a vaccine containing two representative forms of MSP2 may overcome the ...

journal_title：Infection and immunity

authors： Adda CG,MacRaild CA,Reiling L,Wycherley K,Boyle MJ,Kienzle V,Masendycz P,Foley M,Beeson JG,Norton RS,Anders RF

更新日期：2012-12-01 00:00:00

abstract：:Pseudomonas aeruginosa is one of the most frequently encountered bacterial pathogens in patients with chronic pulmonary infections, including cystic fibrosis and diffuse panbronchiolitis. Bronchus-associated lymphoid tissue (BALT), noted frequently in patients with cystic fibrosis and diffuse panbronchiolitis, is cons...

journal_title：Infection and immunity

authors： Iwata M,Sato A

更新日期：1991-04-01 00:00:00

abstract：:Exoantigens of Plasmodium vivax-parasitized erythrocytes stimulated macrophages to secrete tumor necrosis factor, and antisera raised against the exoantigens inhibited this secretion. The antisera also inhibited the activity of Plasmodium falciparum and Plasmodium yoelii exoantigens, and conversely, antisera against t...

journal_title：Infection and immunity

authors： Bate CA,Taverne J,Karunaweera ND,Mendis KN,Kwiatkowski D,Playfair JH

更新日期：1992-03-01 00:00:00

abstract：:Using a PCR-based strategy and degenerate oligonucleotides, we isolated a Legionella pneumophila gene that showed high sequence similarity to members of the fliI gene family. An insertion mutation that disrupted the fliI open reading frame was recombined onto the L. pneumophila chromosome and analyzed for its effects ...

journal_title：Infection and immunity

authors： Merriam JJ,Mathur R,Maxfield-Boumil R,Isberg RR

更新日期：1997-06-01 00:00:00

abstract：:Aerobic microorganisms were isolated and identified from 9 of 10 malignant tissues aseptically obtained from surgical patients. The organisms isolated are species commonly associated with the flora of the human body. When these cancer-associated organisms were grown in Trypticase soy broth (BBL Microbiology Systems), ...

journal_title：Infection and immunity

authors： Backus BT,Affronti LF

更新日期：1981-06-01 00:00:00

abstract：:The unpredictable nature of bioterrorism and the absence of real-time detection systems have highlighted the need for an efficient postexposure therapy for Bacillus anthracis infection. One approach is passive immunization through the administration of antibodies that mitigate the biological action of anthrax toxin. W...

journal_title：Infection and immunity

authors： Albrecht MT,Li H,Williamson ED,LeButt CS,Flick-Smith HC,Quinn CP,Westra H,Galloway D,Mateczun A,Goldman S,Groen H,Baillie LW

更新日期：2007-11-01 00:00:00

abstract：:Natural antibodies are those immunoglobulin molecules found in mammalian serum that arise in the absence of exposure to environmental pathogens and may comprise an early host defense against invading pathogens. The spirochete Borrelia burgdorferi first encounters natural antibodies when its arthropod vector, Ixodes sc...

journal_title：Infection and immunity

authors： Belperron AA,Bockenstedt LK

更新日期：2001-10-01 00:00:00

abstract：:Yersinia enterocolitica serotype 9 contained an antigenic component giving a reaction of total identity with Brucella native hapten and polysaccharide B. This component was present in a phenol-water extract (fraction 5; M. Redfearn, Ph.D. Thesis, University of Wisconsin, Madison, 1960) along with the smooth lipopolysa...

journal_title：Infection and immunity

authors： Fernandez-Lago L,Moriyon I,Toyos J,Diaz R

更新日期：1982-11-01 00:00:00

abstract：:A lectin with strong hemagglutinating activity toward erythrocytes of several animal species was isolated from an 18-h culture supernatant of a diarrheagenic strain, V2, of non-O1 Vibrio cholerae. The hemagglutinin (HA) was purified free of lipopolysaccharide by salt fractionation followed by gel filtration, hydrophob...

journal_title：Infection and immunity

authors： Banerjee KK,Ghosh AN,Dutta-Roy K,Pal SC,Ghose AC

更新日期：1990-11-01 00:00:00

abstract：:Membrane and soluble fractions of Mycoplasma pneumoniae, M. pulmonis, and M. laidlawii B were prepared by hypotonic lysis of whole cells. The membranes of M. pneumoniae and M. laidlawii B contained, as percentage of dry weight: 34 to 37% protein, 59 to 61% lipid, 3 to 4% carbohydrate as hexose, and 0.2% ribonucleic ac...

journal_title：Infection and immunity

authors： Pollack JD,Somerson NL,Senterfit LB

更新日期：1970-09-01 00:00:00

abstract：:Resistance to cutaneous syphilitic reinfection in strain 2 and strain 13 guinea pigs developed gradually 3 to 7 months after primary infection and reached maximum levels at 6 to 7 months after the induction of primary cutaneous disease. Associated with this acquired resistance was the occurrence of Arthus reactions an...

journal_title：Infection and immunity

authors： Pavia CS,Niederbuhl CJ

更新日期：1985-10-01 00:00:00