Lipopolysaccharide from Brucella abortus behaves as a T-cell-independent type 1 carrier in murine antigen-specific antibody responses.

abstract：:Cell walls from Streptococcus mutans were prepared by conventional technique and subjected to a series of extraction procedures involving classical protein solvents. The extracted walls contained several non-peptidoglycan amino acids and were also amenable to radiolabeling with [125I]sodium iodide and chloramine T. Th...

journal_title：Infection and immunity

authors： Nesbitt WE,Staat RH,Rosan B,Taylor KG,Doyle RJ

更新日期：1980-04-01 00:00:00

abstract：:Streptococcus pneumoniae is the most frequent microbe causing middle ear infection. The pathophysiology of pneumococcal otitis media has been characterized by measurement of local inflammatory mediators such as inflammatory cells, lysozyme, oxidative metabolic products, and inflammatory cytokines. The role of cytokine...

journal_title：Infection and immunity

authors： Sato K,Liebeler CL,Quartey MK,Le CT,Giebink GS

更新日期：1999-04-01 00:00:00

abstract：:A better knowledge on how immune responses are initiated in mucosal tissues would facilitate the design of new mucosal vaccines, as well as improve our understanding on host defense against infection. We investigated the mechanisms of adjuvanticity of the Mycoplasma-derived macrophage-activating 2-kDa lipopeptide (MAL...

journal_title：Infection and immunity

authors： Rharbaoui F,Westendorf A,Link C,Felk S,Buer J,Gunzer M,Guzmán CA

更新日期：2004-12-01 00:00:00

abstract：:Proteins from human polymorphonuclear leukocyte granules were extracted with 0.2 M acetate, pH 4.0, and fractionated by Sephadex G-100 column chromatography. The fractions demonstrated selective bactericidal action against a deep rough cell wall mutant of Escherichia coli O111:B4 with rough lipopolysacharide and cell ...

journal_title：Infection and immunity

authors： Modrzakowski MC,Cooney MH,Martin LE,Spitznagel JK

更新日期：1979-03-01 00:00:00

abstract：:Borrelia burgdorferi synthesizes a variety of differentially regulated outer surface lipoproteins in the tick vector and in vertebrate hosts. Among these is OspD, a protein that is highly induced in vitro by conditions that mimic the tick environment. Using genetically engineered strains in which ospD is deleted, we d...

journal_title：Infection and immunity

authors： Stewart PE,Bestor A,Cullen JN,Rosa PA

更新日期：2008-05-01 00:00:00

abstract：:Humoral immune responses in experimental African trypanosomiasis were assessed in rabbits infected with Trypanosoma rhodesiense. Immune complexes as measured by a Clq binding assay or a Clq solid-phase assay were detected by day 10 and increased progressively through day 28. Immune complexes analyzed by double diffusi...

journal_title：Infection and immunity

authors： Lindsley HB,Janecek LL,Gilman-Sachs AM,Hassanein KM

更新日期：1981-08-01 00:00:00

abstract：:Intestinal epithelial activation of nuclear factor kappa B (NF-κB) exerts both detrimental and beneficial functions in response to various luminal insults, including ones associated with mucosa-associated pathogens. Gastrointestinal infection with enteropathogenic Escherichia coli (EPEC) causes severe injuries in epit...

journal_title：Infection and immunity

authors： Choi HJ,Kim J,Do KH,Park SH,Moon Y

更新日期：2013-06-01 00:00:00

abstract：:Otitis media developed in 67% of chinchillas inoculated intranasally with type 7 Streptococcus pneumoniae and influenza A virus. Only 4% of chinchillas inoculated with influenza alone and 21% of chinchillas inoculated with S. pneumoniae alone developed otitis media. Among the chinchillas that developed otitis media af...

journal_title：Infection and immunity

authors： Giebink GS,Berzins IK,Marker SC,Schiffman G

更新日期：1980-11-01 00:00:00

abstract：:Leishmania-infected macrophages are potential antigen-presenting cells for CD4+ T lymphocytes, which recognize parasite antigens bound to major histocompatibility complex class II molecules (Ia). However, the intracellular sites where Ia and antigens may interact are far from clear, since parasites grow within the mod...

journal_title：Infection and immunity

authors： Antoine JC,Jouanne C,Lang T,Prina E,de Chastellier C,Frehel C

更新日期：1991-03-01 00:00:00

abstract：:Vibrio cholerae is a monoflagellated gram-negative bacterium that causes the severe diarrheal disease cholera. In contrast to Salmonella enterica serovar Typhimurium infection, which is accompanied by both acute diarrhea and high-level inflammation, V. cholerae infection is largely noninflammatory in human hosts. Bact...

journal_title：Infection and immunity

authors： Yoon SS,Mekalanos JJ

更新日期：2008-03-01 00:00:00

abstract：:Ninety-six Aeromonas hydrophila isolates were tested for cytotoxin and hemolysin production. Sixty-six (69%) of the isolates were both cytotoxic and hemolytic, whereas the rest produced neither cytotoxin nor hemolysin. No evidence of a separate cytotonic activity could be found in any of the isolates. Cytotoxin activi...

journal_title：Infection and immunity

authors： Cumberbatch N,Gurwith MJ,Langston C,Sack RB,Brunton JL

更新日期：1979-03-01 00:00:00

abstract：:Cryptococcus neoformans is a facultative intracellular opportunistic pathogen and the leading cause of fungal meningitis in humans. In the absence of a protective cellular immune response, the inhalation of C. neoformans cells or spores results in pulmonary infection. C. neoformans cells produce a polysaccharide capsu...

journal_title：Infection and immunity

authors： Geunes-Boyer S,Oliver TN,Janbon G,Lodge JK,Heitman J,Perfect JR,Wright JR

更新日期：2009-07-01 00:00:00

abstract：:Defensins are antibiotic peptides expressed in human and animal myeloid and epithelial cells. Due to the limited availability of natural peptides, the properties of human epithelial defensins have not been studied. We assayed the microbicidal activity of recombinant human intestinal defensin 5 (rHD-5) in the presence ...

journal_title：Infection and immunity

authors： Porter EM,van Dam E,Valore EV,Ganz T

更新日期：1997-06-01 00:00:00

abstract：:We reexamined the binding specificity of the Shiga-like toxin variant associated with porcine edema disease, SLT2e, which is reported to be more cytotoxic for Vero cells than for HeLa cells, by using receptor-deficient cells and a liposomal insertion system for purified glycolipids. We found that SLT2e preferentially ...

journal_title：Infection and immunity

authors： Keusch GT,Jacewicz M,Acheson DW,Donohue-Rolfe A,Kane AV,McCluer RH

更新日期：1995-03-01 00:00:00

abstract：:Various pathogenic bacteria with the capacity to live within eukaryotic cells activate an apoptotic program in infected host cells. Induction of apoptosis by Listeria monocytogenes in murine dendritic cells and hepatocytes has been described. Here we address the questions of whether and how the pathogen kills macropha...

journal_title：Infection and immunity

authors： Barsig J,Kaufmann SH

更新日期：1997-10-01 00:00:00

abstract：:Cell-mediated immunity is critical in host resistance against the pathogenic fungus Histoplasma capsulatum. To explore the role of L3T4+ T cells in protection of mice against H. capsulatum infection, we examined the effect of in vivo treatment with anti-L3T4 monoclonal antibody (MAb) GK1.5 on the course of murine diss...

journal_title：Infection and immunity

authors： Gomez AM,Bullock WE,Taylor CL,Deepe GS Jr

更新日期：1988-07-01 00:00:00

abstract：:TB10.4 is a newly identified antigen of Mycobacterium tuberculosis recognized by human and murine T cells upon mycobacterial infection. Here, we show that immunization with Mycobacterium bovis BCG induces a strong, genetically controlled, Th1 immune response against TB10.4 in mice. BALB/c and C57BL/6 strains behave as...

journal_title：Infection and immunity

authors： Hervas-Stubbs S,Majlessi L,Simsova M,Morova J,Rojas MJ,Nouzé C,Brodin P,Sebo P,Leclerc C

更新日期：2006-06-01 00:00:00

abstract：:The infection of HeLa 229 cells in monolayer culture with trachoma (B/TW-5/OT) and lymphogranuloma venereum (LGV) (L2/434/Bu) organism was studied in terms of two parameters: radioactivity counts of cell-associated tritium labeled organisms at the initial stage of inoculation for measurement of attachment, and inclusi...

journal_title：Infection and immunity

authors： Kuo CC,Grayston T

更新日期：1976-04-01 00:00:00

abstract：:Group A streptococcal pyrogenic exotoxin (SPE) type C, produced by strain T18P grown in the presence of 32P, was separated from culture supernatant fluids by using alcohol precipitation. The resulting toxin (EtOH-1) contained 3 X 10(6) to 5 X 10(6) cpm of 32P per milligram of protein. The radiolabel migrated with SPE ...

journal_title：Infection and immunity

authors： Schlievert PM,Bettin KM,Watson DW

更新日期：1979-11-01 00:00:00

abstract：:Candida albicans serotype A (C. albicans A) possesses a specific antigen, designated antigen 6, which resides in mannans on the cell surface. To determine the role of the mannan moiety of the C. albicans cell wall in adherence to buccal epithelial cells, we used antigen 6-deficient mutants which had been isolated by s...

journal_title：Infection and immunity

authors： Miyakawa Y,Kuribayashi T,Kagaya K,Suzuki M,Nakase T,Fukazawa Y

更新日期：1992-06-01 00:00:00

abstract：:A receptor moiety and blood group substance recognized by the O75X adhesin was studied. Well-defined erythrocytes representing different blood group systems and bacterial derivatives carrying plasmid pBJN406 encoding the adhesin were used in a direct hemagglutination assay. We showed that Dr blood group antigen, a com...

journal_title：Infection and immunity

authors： Nowicki B,Moulds J,Hull R,Hull S

更新日期：1988-05-01 00:00:00

abstract：:Malaria infection treatment vaccine (ITV) is a promising strategy to induce homologous and heterologous protective immunity against the blood stage of the parasite. However, the underlying mechanism of protection remains largely unknown. Here, we found that a malaria-specific antibody (Ab) could mediate the protective...

journal_title：Infection and immunity

authors： Liu T,Lu X,Zhao C,Fu X,Zhao T,Xu W

更新日期：2015-05-01 00:00:00

abstract：:Streptococcus pneumoniae is a major cause of illness and death in children in developing countries. In these children, zinc deficiency is associated with an increased risk of acute respiratory tract infections, which can be reduced by daily zinc administration. Severe infections decrease zinc levels in plasma and may ...

journal_title：Infection and immunity

authors： Strand TA,Hollingshead SK,Julshamn K,Briles DE,Blomberg B,Sommerfelt H

更新日期：2003-04-01 00:00:00

abstract：:Lipopolysaccharide (LPS) from three human and four monkey isolates of Campylobacter jejuni was extracted in high yields that revealed ladder-like structures in polyacrylamide gels by direct silver staining. These observations demonstrate that C. jejuni possesses LPS with O-chain repeating units typical of the family E...

journal_title：Infection and immunity

authors： Blake DC Jr,Russell RG

更新日期：1993-12-01 00:00:00

abstract：:Antigens were extracted from a virulent isolate of Pasteurella multocida (serotype 3, 12, 15:D) with potassium thiocyanate, and a vaccine was prepared. Pasteurella-free rabbits were vaccinated intranasally and intraconjuctivally twice with a 2-week interval and challenged intranasally with the homologous P. multocida ...

journal_title：Infection and immunity

authors： Ringler DH,Peter GK,Chrisp CE,Keren DF

更新日期：1985-09-01 00:00:00

abstract：:We studied the oligosaccharides (OS) of outer membrane lipooligosaccharides (LOS) of Neisseria gonorrhoeae and Neisseria meningitidis. OS from the LOS of an individual neisserial strain always eluted from Sephadex G-50S as multiple peaks; the polyacrylamide gel elution profiles were nearly identical to the polyacrylam...

journal_title：Infection and immunity

authors： Griffiss JM,O'Brien JP,Yamasaki R,Williams GD,Rice PA,Schneider H

更新日期：1987-08-01 00:00:00

abstract：:During the systemic phase of murine infection with Salmonella enterica serovar Typhimurium, bacterial virulence is correlated with the ability to grow and survive within host macrophages. Salmonella pathogenicity island 2 (SPI-2), encoding a type three secretion system, has emerged as an important contributor to Salmo...

journal_title：Infection and immunity

authors： Linehan SA,Rytkönen A,Yu XJ,Liu M,Holden DW

更新日期：2005-07-01 00:00:00

abstract：:Virulent Streptococcus suis serotype 2 strains are invasive extracellular bacteria causing septicemia and meningitis in piglets and humans. One objective of this study was to elucidate the function of complement in innate immune defense against S. suis. Experimental infection of wild-type (WT) and C3(-/-) mice demonst...

journal_title：Infection and immunity

authors： Seitz M,Beineke A,Singpiel A,Willenborg J,Dutow P,Goethe R,Valentin-Weigand P,Klos A,Baums CG

更新日期：2014-06-01 00:00:00

abstract：:A total of 224 strains were serogrouped by coagglutination (COA) and serotyped by protein I enzyme-linked immunosorbent assay (ELISA). Of these strains, 61 were from patients with disseminated gonococcal infection, 21 were from patients with pelvic inflammatory disease, and 115 were from patients with uncomplicated go...

journal_title：Infection and immunity

authors： Sandstrom EG,Knapp JS,Buchanan TB

更新日期：1982-01-01 00:00:00

abstract：:Although it has been known for some time that Salmonella typhimurium is able to survive and even replicate in the normally bactericidal environment of the macrophage phagosome, the mechanisms by which this organism accomplishes this feat remain obscure. In this study, a murine macrophage cell line and confocal immunof...

journal_title：Infection and immunity

authors： Rathman M,Barker LP,Falkow S

更新日期：1997-04-01 00:00:00