Spectroscopic, radiochemical, and theoretical studies of the Ga3+-N-2-hydroxyethyl piperazine-N'-2-ethanesulfonic acid (HEPES buffer) system: evidence for the formation of Ga3+ - HEPES complexes in (68) Ga labeling reactions.

abstract：:An experimental setup consisting of a hollow fiber module (HFM) was developed for the in vitro study of contrast agent (CA) permeability. Controllable flow and known fiber characteristics allowed permeability studies under well-defined conditions with CAs of different molecular weight (MW). In the MRI experiments perf...

journal_title：Contrast media & molecular imaging

authors： Heilmann M,Vautier J,Robert P,Volk A

更新日期：2009-03-01 00:00:00

abstract：PURPOSE:Microbubble contrast agents are currently implemented in a variety of both clinical and preclinical ultrasound imaging studies. The therapeutic and diagnostic capabilities of these contrast agents are limited by their short in-vivo lifetimes, and research to lengthen their circulation times is on going. In this...

journal_title：Contrast media & molecular imaging

authors： Mullin L,Gessner R,Kwan J,Kaya M,Borden MA,Dayton PA

更新日期：2011-05-01 00:00:00

abstract：Objective:The purpose of this study was to demonstrate the feasibility of using hyperpolarized carbon-13 (13C) metabolic imaging with [1-13C]-labeled pyruvate for evaluating real-time in vivo metabolism of orthotopic diffuse intrinsic pontine glioma (DIPG) xenografts. Materials and Methods:3D 13C magnetic resonance sp...

journal_title：Contrast media & molecular imaging

authors： Autry AW,Hashizume R,James CD,Larson PEZ,Vigneron DB,Park I

更新日期：2018-07-30 00:00:00

abstract：:Quantum dot micelles (pQDs) with a paramagnetic coating are promising nanoparticles for bimodal molecular imaging. Their bright fluorescence allows for optical detection, while their Gd payload enables visualization with contrast-enhanced MRI. A popular approach in molecular MRI is the targeting of abundantly expresse...

journal_title：Contrast media & molecular imaging

authors： Starmans LW,Kok MB,Sanders HM,Zhao Y,Donegá Cde M,Meijerink A,Mulder WJ,Grüll H,Strijkers GJ,Nicolay K

更新日期：2011-03-01 00:00:00

abstract：:The combination of the size-dependent properties of nanomaterials with radioisotopes is emerging as a novel tool for molecular imaging. There are numerous examples already showing how the controlled synthesis of nanoparticles and the incorporation of a radioisotope in the nanostructure offer new features beyond the si...

journal_title：Contrast media & molecular imaging

authors： Pellico J,Llop J,Fernández-Barahona I,Bhavesh R,Ruiz-Cabello J,Herranz F

更新日期：2017-11-21 00:00:00

abstract：:The gonadotropin-releasing hormone (GnRH) receptor is overexpressed in the majority of tumors of the human reproductive system. The purpose of this study was to develop an 18F-labeled peptide for tumor GnRH receptor imaging. In this study, the GnRH (pGlu1-His2-Trp3-Ser4-Tyr5-Gly6-Leu7-Arg8-Pro9-Gly10-NH2) peptide anal...

journal_title：Contrast media & molecular imaging

authors： Huang S,Li H,Han Y,Fu L,Ren Y,Zhang Y,Li Y,Sun P,Wang M,Wu H,Wang Q,Hu K

更新日期：2019-03-07 00:00:00

abstract：:Developing agents with 'seek, treat and see' capability is critical for personalized molecular medicine. Those agents will specifically target the disease markers for diagnosis and apply the biologically effective dose for treatment. Retinoids regulate a multitude of biological processes. In addition, retinoic acid ca...

journal_title：Contrast media & molecular imaging

authors： Wang W,Qiu X,Zhang F,Sun J,Cameron AG,Wendt JA,Mawad ME,Ke S

更新日期：2011-07-01 00:00:00

abstract：:D-α-Tocopheryl polyethylene glycol 1000 succinate (TPGS) is a Food and Drug Administration (FDA) approved biomaterial that can form nanosized micelles in aqueous solution. TPGS micelles stand as an interesting system to perform drug delivery as they can carry lipophilic drugs and overcome P glycoprotein efflux as well...

journal_title：Contrast media & molecular imaging

authors： Tesan FC,Nicoud MB,Nuñez M,Medina VA,Chiappetta DA,Salgueiro MJ

更新日期：2019-04-23 00:00:00

abstract：:Targeted magnetic resonance contrast agents (e.g. iron oxide nanoparticles) have the potential to become highly selective imaging tools. In this context, quantification of the coupled amount of protein is essential for the design of antibody- or antibody fragment-conjugated nanoparticles. Nevertheless, the presence of...

journal_title：Contrast media & molecular imaging

authors： Rimkus G,Bremer-Streck S,Grüttner C,Kaiser WA,Hilger I

更新日期：2011-05-01 00:00:00

abstract：:The transplantation of pancreatic islets containing β-cells, which produce insulin, is an alternative approach to the treatment of type 1 diabetes mellitus. The non-invasive visualization of transplanted islets can be performed using MRI; however, this requires labeling of the islets with a suitable contrast agent pri...

journal_title：Contrast media & molecular imaging

authors： Herynek V,Berková Z,Dovolilová E,Jirák D,Kříž J,Girman P,Saudek F,Hájek M

更新日期：2011-07-01 00:00:00

abstract：:Barium sulfate and lead oxide contrast media are frequently used for cadaver-based angiography studies. These contrast media have not previously been compared to determine which is optimal for the visualisation and measurement of blood vessels. In this study, the lower limb vessels of 16 embalmed Wistar rats, and four...

journal_title：Contrast media & molecular imaging

authors： Kingston MJ,Perriman DM,Neeman T,Smith PN,Webb AL

更新日期：2016-07-01 00:00:00

abstract：:The purpose of this study was to determine if parameters derived from diffusion-weighted (DW-) and dynamic contrast-enhanced (DCE-) magnetic resonance imaging (MRI) can help to assess early response to peptide receptor radionuclide therapy (PRRT) with 90Y-DOTATOC in neuroendocrine hepatic metastases (NET-HM). Twenty p...

journal_title：Contrast media & molecular imaging

authors： Weikert T,Maas OC,Haas T,Klarhöfer M,Bremerich J,Forrer F,Sauter AW,Sommer G

更新日期：2019-11-11 00:00:00

abstract：:Stem cells, cancer cells and immune cells were labeled by co-incubation with a new ultra-small iron oxide nanoparticle called Molday ION Rhodamine-B (MIRB). Iron staining, fluorescence imaging, transmission electron microscopy and flow cytometry were used to assess cell viability, function and labeling efficiency. Thi...

journal_title：Contrast media & molecular imaging

authors： McFadden C,Mallett CL,Foster PJ

更新日期：2011-11-01 00:00:00

abstract：Objective:To provide a clinically relevant overview of the analytical interference by contrast agents (CA) in laboratory blood test measurements. Materials and Methods:The effects of five CAs, gadobutrol, gadoterate meglumine, gadoxetate disodium, iodixanol, and iomeprol, were studied on the 29 most frequently perform...

journal_title：Contrast media & molecular imaging

authors： Otnes S,Fogh-Andersen N,Rømsing J,Thomsen HS

更新日期：2017-04-10 00:00:00

abstract：:In the pursuit of understanding the pathological alterations that underlie ischaemic injuries, such as vascular remodelling and reorganisation, there is a need for recognising the capabilities and limitations of in vivo imaging techniques. Thus, this review presents contemporary published research of imaging modalitie...

journal_title：Contrast media & molecular imaging

authors： Gandhi R,Tsoumpas C

更新日期：2019-02-03 00:00:00

abstract：:Optical fluorescence imaging has been developed as an aid to intraoperative diagnosis to improve surgical and endoscopic procedures. Compared with other intraoperative imaging methods, it is lower in cost, has a high safety margin, is portable and easy to use. γ-glutamyl hydroxymethyl rhodamine green (gGlu-HMRG) is a ...

journal_title：Contrast media & molecular imaging

authors： Harada T,Nakamura Y,Sato K,Nagaya T,Choyke PL,Seto Y,Kobayashi H

更新日期：2016-11-01 00:00:00

abstract：:The development of molecular probes and novel imaging modalities, allowing better resolution and specificity, is associated with an increased potential for molecular imaging of atherosclerotic plaques especially in basic and pre-clinical research applications. In that context, a photoacoustic molecular probe based on ...

journal_title：Contrast media & molecular imaging

authors： Rouleau L,Berti R,Ng VW,Matteau-Pelletier C,Lam T,Saboural P,Kakkar AK,Lesage F,Rhéaume E,Tardif JC

更新日期：2013-01-01 00:00:00

abstract：:An observational study was set up to assess the feasibility of [18F]FPRGD2 PET/CT for imaging patients with multiple myeloma (MM) and to compare its detection rate with low dose CT alone and combined [18F]NaF/[18F]FDG PET/CT images. Four patients (2 newly diagnosed patients and 2 with relapsed MM) were included and un...

journal_title：Contrast media & molecular imaging

authors： Withofs N,Cousin F,De Prijck B,Bonnet C,Hustinx R,Gambhir SS,Beguin Y,Caers J

更新日期：2017-07-27 00:00:00

abstract：:Photoacoustic imaging is an emerging imaging modality for noninvasive detection of tissue structural and functional anomalies. Multifunctional microbubbles (MBs) and nanobubbles (NBs) are contrast agents integrating multiple disease-targeting, imaging and therapeutic functions. Multifunctional MBs and NBs represent an...

journal_title：Contrast media & molecular imaging

authors： Xu RX

更新日期：2011-09-01 00:00:00

abstract：:We evaluated the difference in the status of dopamine transporters (DATs) depending on Parkinsonism, cerebellar, and autonomic features using F-18 FP-CIT positron emission tomography (PET) in multiple system atrophy with cerebellar ataxia (MSA-C). We also assessed whether the DAT PET could be useful in the management ...

journal_title：Contrast media & molecular imaging

authors： Jeong YJ,Cheon SM,Kang DY,Kim JW

更新日期：2017-11-29 00:00:00

abstract：:Recent advances in artificial intelligence (AI) and deep learning (DL) have impacted many scientific fields including biomedical maging. Magnetic resonance imaging (MRI) is a well-established method in breast imaging with several indications including screening, staging, and therapy monitoring. The rapid development a...

journal_title：Contrast media & molecular imaging

authors： Meyer-Bäse A,Morra L,Meyer-Bäse U,Pinker K

更新日期：2020-08-28 00:00:00

abstract：:Overexpression of the chemokine-4 receptor (CXCR4) in brain tumors is associated with high cancer cell invasiveness. Recently, we reported the preclinical evaluation of 99mTc-CXCR4-L (cyclo-D-Tyr-D-[NMe]Orn[EDDA-99mTc-6-hydrazinylnicotinyl]-Arg-NaI-Gly) as a SPECT radioligand capable of specifically detecting the CXCR...

journal_title：Contrast media & molecular imaging

authors： Vallejo-Armenta P,Santos-Cuevas C,Soto-Andonaegui J,Villanueva-Pérez RM,González-Díaz JI,García-Pérez FO,Arrellano-Zarate A,Luna-Gutiérrez M,Azorín-Vega E,Ocampo-García B,Ferro-Flores G

更新日期：2020-04-27 00:00:00

abstract：:Glioblastoma multiforme is the most aggressive form of brain tumor. Early and accurate diagnosis of glioma and its borders is an important step for its successful treatment. One of the promising targets for selective visualization of glioma and its margins is connexin 43 (Cx43), which is highly expressed in reactive a...

journal_title：Contrast media & molecular imaging

authors： Abakumova T,Abakumov M,Shein S,Chelushkin P,Bychkov D,Mukhin V,Yusubalieva G,Grinenko N,Kabanov A,Nukolova N,Chekhonin V

更新日期：2016-01-01 00:00:00

abstract：:Various studies have shown that various cell types can be labeled with iron oxide particles and visualized by magnetic resonance imaging (MRI). However, reported protocols for cell labeling show a large variation in terms of labeling dose and incubation time. It is therefore not clear how different labeling protocols ...

journal_title：Contrast media & molecular imaging

authors： van Tiel ST,Wielopolski PA,Houston GC,Krestin GP,Bernsen MR

更新日期：2010-09-01 00:00:00

abstract：:Melanoma is the most dangerous form of skin cancer and its incidence is rising each year. Because the current methods of diagnosis based on the visual aspect of the tumor show limitations, several new techniques are emerging to help in this diagnosis, amongst which are magnetic resonance imaging (MRI) and electron par...

journal_title：Contrast media & molecular imaging

authors： Godechal Q,Mignion L,Karroum O,Magat J,Danhier P,Morandini R,Ghanem GE,Leveque P,Gallez B

更新日期：2014-03-01 00:00:00

abstract：:Magnetic fluid hyperthermia (MFH) with chemically synthesized nanoparticles is currently used in clinical trials as it destroys tumor cells with an extremely localized deposition of thermal energy. In this paper, we investigated an MFH protocol based on magnetic nanoparticles naturally produced by magnetotactic bacter...

journal_title：Contrast media & molecular imaging

authors： Mannucci S,Tambalo S,Conti G,Ghin L,Milanese A,Carboncino A,Nicolato E,Marinozzi MR,Benati D,Bassi R,Marzola P,Sbarbati A

更新日期：2018-07-11 00:00:00

abstract：Objective:To synthesize 68Ga-Glu-urea-Lys(Ahx)-HBED-CC (68Ga-PSMA-11) with a synthesis module and investigate PET-CT imaging to monitor PSMA expression during prostate cancer (PCa) progression and tumor growth in mice bearing subcutaneous PCa xenografts. Method:The radiochemical purity and stability of  68Ga-PSMA-11 w...

journal_title：Contrast media & molecular imaging

authors： Wang Y,Shao G,Wu J,Cui C,Zang S,Qiu F,Jia R,Wang Z,Wang F

更新日期：2018-04-26 00:00:00

abstract：:A new high-throughput MRI method for screening chemical exchange saturation transfer (CEST) agents is demonstrated, allowing simultaneous testing of multiple samples with minimal attention to sample configuration and shimming of the main magnetic field (B(0)). This approach, which is applicable to diamagnetic, paramag...

journal_title：Contrast media & molecular imaging

authors： Liu G,Gilad AA,Bulte JW,van Zijl PC,McMahon MT

更新日期：2010-05-01 00:00:00

abstract：:Spectral molecular imaging is a new X-ray-based imaging technology providing highly specific 3D imaging at high spatial resolution that has the potential to measure disease activity and response to treatment noninvasively. The ability to identify and quantify components of tissue and biomarkers of disease activity der...

journal_title：Contrast media & molecular imaging

authors： Anderson NG,Butler AP

更新日期：2014-01-01 00:00:00

abstract：:Monodisperse mesoporous silica (mSiO(2) ) coated superparamagnetic iron oxide (Fe(3) O(4) @mSiO(2) ) nanoparticles (NPs) have been developed as a potential magnetic resonance imaging (MRI) T(2) contrast agent. To evaluate the effect of surface coating on MRI contrast efficiency, we examined the proton relaxivities of ...

journal_title：Contrast media & molecular imaging

authors： Ye F,Laurent S,Fornara A,Astolfi L,Qin J,Roch A,Martini A,Toprak MS,Muller RN,Muhammed M

更新日期：2012-09-01 00:00:00