Nascent peptides that block protein synthesis in bacteria.

abstract：:Melanomas occur mainly in sunlight-exposed skin. Xeroderma pigmentosum (XP) patients have 1,000-fold higher incidence of melanoma, suggesting that sunlight-induced "bulky" photoproducts are responsible for melanomagenesis. Sunlight induces a high level of reactive oxygen species in melanocytes (MCs); oxidative DNA dam...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang HT,Choi B,Tang MS

更新日期：2010-07-06 00:00:00

abstract：:While the general structure of immunoglobulin chains has remained relatively unchanged throughout evolution, the organization of the genes encoding these molecules differs substantially. To understand how the rearranging immunoglobulin system arose, it is necessary to examine living representatives of the most early v...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hohman VS,Schuchman DB,Schluter SF,Marchalonis JJ

更新日期：1993-11-01 00:00:00

abstract：:Cytochrome C is a mitochondrial protein that induces apoptosis when released into the cytosol or when added to cell-free extracts. Here we show that cells that overexpress the Bcl-2-related protein Bcl-xL fail to accumulate cytosolic cytochrome C or undergo apoptosis in response to genotoxic stress. Coimmunoprecipitat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kharbanda S,Pandey P,Schofield L,Israels S,Roncinske R,Yoshida K,Bharti A,Yuan ZM,Saxena S,Weichselbaum R,Nalin C,Kufe D

更新日期：1997-06-24 00:00:00

abstract：:Temporal dynamics of urban warming have been extensively studied at the diurnal scale, but the impact of background climate on the observed seasonality of surface urban heat islands (SUHIs) remains largely unexplored. On seasonal time scales, the intensity of urban-rural surface temperature differences ([Formula: see ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Manoli G,Fatichi S,Bou-Zeid E,Katul GG

更新日期：2020-03-31 00:00:00

abstract：:The RuvC protein of Escherichia coli catalyzes the resolution of recombination intermediates during genetic recombination and the recombinational repair of damaged DNA. Resolution involves specific recognition of the Holliday structure to form a complex that exhibits twofold symmetry with the DNA in an open configurat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bennett RJ,West SC

更新日期：1996-10-29 00:00:00

abstract：:Ancient DNA (aDNA) analysis provides a powerful means of investigating human migration, social organization, and a plethora of other crucial questions about humanity's past. Recently, specialists have suggested that the ideal research design involving aDNA would include multiple independent lines of evidence. In this ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bongers JL,Nakatsuka N,O'Shea C,Harper TK,Tantaleán H,Stanish C,Fehren-Schmitz L

更新日期：2020-08-04 00:00:00

abstract：:The x-ray crystal structure of an oligomeric miniprotein has been determined to a 1.2-A resolution by means of multiwavelength anomalous diffraction phasing with selenomethionine analogs that retain the biophysical characteristics of the native peptide. Peptide 1, comprising alpha and beta secondary structure elements...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ali MH,Peisach E,Allen KN,Imperiali B

更新日期：2004-08-17 00:00:00

abstract：:During development, organisms acquire three-dimensional (3D) shapes with important physiological consequences. While basic mechanisms underlying morphogenesis are known in eukaryotes, it is often difficult to manipulate them in vivo. To circumvent this issue, here we present a study of developing Vibrio cholerae biofi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fei C,Mao S,Yan J,Alert R,Stone HA,Bassler BL,Wingreen NS,Košmrlj A

更新日期：2020-04-07 00:00:00

abstract：:Type I (IFN-alpha/beta) and type III (IFN-lambdas) IFNs are important components of the host antiviral response. Although type III IFNs possess intrinsic antiviral activity similar to that of type I IFNs, they signal through a specific unique receptor complex, and their functional importance for antiviral resistance i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huang J,Smirnov SV,Lewis-Antes A,Balan M,Li W,Tang S,Silke GV,Pütz MM,Smith GL,Kotenko SV

更新日期：2007-06-05 00:00:00

abstract：:Transforming growth factor alpha (TGF-alpha) is generated by cleavage of a membrane-anchored precursor protein, proTGF-alpha. ProTGF-alpha is cleaved at a slow rate and accumulates on the cell surface, thereby mediating cell-cell adhesion and mitogenic stimulation. We show here that cleavage of membrane proTGF-alpha b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pandiella A,Massagué J

更新日期：1991-03-01 00:00:00

abstract：:Nerve growth factor has been quantified by both bioassay and radial immunodiffusion in mouse saliva elicited by several secretagogues. The concentrations by bioassay of nerve growth factor in both epinephrine- and norepinephrine-induced saliva (3400 and 900 mug/ml, respectively) are higher than reported in any other s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wallace LJ,Partlow LM

更新日期：1976-11-01 00:00:00

abstract：:Synthesis of the iron-storage protein ferritin is thought to be regulated at the translational level by the cytosolic content of chelatable iron. This response to iron is regulated by the iron-modulated binding to ferritin mRNAs of a repressor protein, the iron regulatory element-binding protein. From measurements mad...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eisenstein RS,Garcia-Mayol D,Pettingell W,Munro HN

更新日期：1991-02-01 00:00:00

abstract：:Crop species experienced strong selective pressure directed at genes controlling traits of agronomic importance during their domestication and subsequent episodes of selective breeding. Consequently, these genes are expected to exhibit the signature of selection. We screened 501 maize genes for the signature of select...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vigouroux Y,McMullen M,Hittinger CT,Houchins K,Schulz L,Kresovich S,Matsuoka Y,Doebley J

更新日期：2002-07-23 00:00:00

abstract：:Most of the cell-surface molecules involved in T-cell immune responses are N-linked glycoproteins. We have investigated the effects of inhibitors of glycoprotein processing on specific T-cell functions, with the dual aims of examining the functional role of carbohydrate and of testing the usefulness of such compounds ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wall KA,Pierce JD,Elbein AD

更新日期：1988-08-01 00:00:00

abstract：:Plasmodium parasites must complete development in the mosquito vector for transmission to occur. The mosquito innate immune response is remarkably efficient in limiting parasite numbers. Previous work has identified a LPS-induced TNFα transcription factor (LITAF)-like transcription factor, LITAF-like 3 (LL3), which si...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Smith RC,Barillas-Mury C,Jacobs-Lorena M

更新日期：2015-06-30 00:00:00

abstract：:Myosin-binding protein C (MyBP-C) is a thick filament protein playing an essential role in muscle contraction, and MyBP-C mutations cause heart and skeletal muscle disease in millions worldwide. Despite its discovery 40 y ago, the mechanism of MyBP-C function remains unknown. In vitro studies suggest that MyBP-C could...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Luther PK,Winkler H,Taylor K,Zoghbi ME,Craig R,Padrón R,Squire JM,Liu J

更新日期：2011-07-12 00:00:00

abstract：:In vitro assembly of tobacco mosaic virus (TMV) from its constituent RNA and protein occurs in two steps: formation of the initial complex by interaction of the 5'-end of TMV-RNA with 20S protein aggregate, and growth of the helical rod by sequential addition of protein subunits.Such a process was also observed in the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ono T,Inoue H,Okada Y

更新日期：1972-12-01 00:00:00

abstract：:The actin cytoskeleton is a critical regulator of cytoplasmic architecture and mechanics, essential in a myriad of physiological processes. Here we demonstrate a liquid phase of actin filaments in the presence of the physiological cross-linker, filamin. Filamin condenses short actin filaments into spindle-shaped dropl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weirich KL,Banerjee S,Dasbiswas K,Witten TA,Vaikuntanathan S,Gardel ML

更新日期：2017-02-28 00:00:00

abstract：:Increased understanding of the precise molecular mechanisms involved in cell survival and cell death signaling pathways offers the promise of harnessing these molecules to eliminate cancer cells without damaging normal cells. Tyrosine kinase oncoproteins promote the genesis of leukemias through both increased cell pro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kurokawa M,Ito T,Yang CS,Zhao C,Macintyre AN,Rizzieri DA,Rathmell JC,Deininger MW,Reya T,Kornbluth S

更新日期：2013-02-05 00:00:00

abstract：:Although x-ray crystallography is the most widely used method for macromolecular structure determination, it does not provide dynamical information, and either experimental tricks or complementary experiments must be used to overcome the inherently static nature of crystallographic structures. Here we used specific x-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Colletier JP,Bourgeois D,Sanson B,Fournier D,Sussman JL,Silman I,Weik M

更新日期：2008-08-19 00:00:00

abstract：:The naked mole-rat (Heterocephalus glaber) is a subterranean eusocial rodent with a markedly long lifespan and resistance to tumorigenesis. Multiple data implicate modulation of protein translation in longevity. Here we report that 28S ribosomal RNA (rRNA) of the naked mole-rat is processed into two smaller fragments ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Azpurua J,Ke Z,Chen IX,Zhang Q,Ermolenko DN,Zhang ZD,Gorbunova V,Seluanov A

更新日期：2013-10-22 00:00:00

abstract：:A cloned Bacillus subtilis gene (sprE) expressed only during the stationary growth phase is shown to encode the subtilisin E protease, an enzyme associated with sporulation. We have determined the DNA sequence of the sprE promoter region and the promoter-proximal half of the structural gene. The sprE gene codes for a ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wong SL,Price CW,Goldfarb DS,Doi RH

更新日期：1984-02-01 00:00:00

abstract：:In vivo phage display identifies peptides that selectively home to the vasculature of individual organs, tissues, and tumors. Here we report the identification of a cyclic nonapeptide, CPGPEGAGC, which homes to normal breast tissue with a 100-fold selectivity over nontargeted phage. The homing of the phage is inhibite...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Essler M,Ruoslahti E

更新日期：2002-02-19 00:00:00

abstract：:We investigated patterns of genetic diversity of Plasmodium falciparum associated with its two main African vectors: Anopheles gambiae and Anopheles funestus. We dissected 10,296 wild-caught mosquitoes from three tropical sites, two in Cameroon (Simbock and Tibati, separated by 320 km) and one in Kenya (Rota, >2,000 k...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Annan Z,Durand P,Ayala FJ,Arnathau C,Awono-Ambene P,Simard F,Razakandrainibe FG,Koella JC,Fontenille D,Renaud F

更新日期：2007-05-08 00:00:00

abstract：:The specific nucleocytoplasmic compartmentalization of proteins has been examined for some major soluble acidic nuclear proteins in oocytes of different amphibia. Proteins synthesized and radioactively labeled by translation in vitro, by using mRNA from ovaries of the frog Xenopus laevis, were injected into the cytopl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dabauvalle MC,Franke WW

更新日期：1982-09-01 00:00:00

abstract：:In this article we report an experiment that examines how demand-side bidding can discipline generators in a market for electric power. First we develop a treatment without demand-side bidding; two large firms are allocated baseload and intermediate cost generators such that either firm might unilaterally withhold the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rassenti SJ,Smith VL,Wilson BJ

更新日期：2003-03-04 00:00:00

abstract：:Tritiated photoaffinity analogs of the natural lepidopteran juvenile hormones, JH I and II [epoxy[3H]bishomofarnesyl diazoacetate ([3H]EBDA) and epoxy[3H]homofarnesyl diazoacetate ([3H]EHDA)], and of the JH analog methoprene [[3H]methoprene diazoketone ([3H]MDK)] were synthesized and used to identify specific JH bindi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Palli SR,Osir EO,Eng W,Boehm MF,Edwards M,Kulcsar P,Ujvary I,Hiruma K,Prestwich GD,Riddiford LM

更新日期：1990-01-01 00:00:00

abstract：:An unusual cAMP signaling system mediates many of the events that prepare spermatozoa to meet the egg. Its components include the atypical, bicarbonate-stimulated, sperm adenylyl cyclase and a cAMP-dependent protein kinase (PKA) with the unique catalytic subunit termed Calpha(2) or C(s). We generated mice that lack Ca...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nolan MA,Babcock DF,Wennemuth G,Brown W,Burton KA,McKnight GS

更新日期：2004-09-14 00:00:00

abstract：:Serotonin (5-HT) plays a key role in early brain development, and manipulation of 5-HT levels during this period can have lasting neurobiological and behavioral consequences. It is unclear how perinatal exposure to drugs, such as selective serotonin reuptake inhibitors (SSRIs), impacts cortical neural network function...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Simpson KL,Weaver KJ,de Villers-Sidani E,Lu JY,Cai Z,Pang Y,Rodriguez-Porcel F,Paul IA,Merzenich M,Lin RC

更新日期：2011-11-08 00:00:00

abstract：:Aliphatic hydrocarbons such as fatty alcohols and petroleum-derived alkanes have numerous applications in the chemical industry. In recent years, the renewable synthesis of aliphatic hydrocarbons has been made possible by engineering microbes to overaccumulate fatty acids. However, to generate end products with the de...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Akhtar MK,Turner NJ,Jones PR

更新日期：2013-01-02 00:00:00