alpha-Adrenergic regulation of secretion of mouse saliva rich in nerve growth factor.

abstract：:Cells from the spleens and thymuses of BALB/c mice whose Moloney sarcoma virus (MSV)-induced, primary sarcomas have regressed 2-3 months earlier ("MSV regressors") or are in the process of regressing can, when adoptively transferred to syngeneic mice given MSV at the age of 20 days, prevent the natural regression of t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hellström I,Hellström KE,Bernstein ID

更新日期：1979-10-01 00:00:00

abstract：:Active opioid binding proteins were solubilized from rat brain membranes in high yield with sodium deoxycholate in the presence of NaCl. Purification of opioid binding proteins was accomplished by opioid antagonist affinity chromatography. Chromatography using the delta-opioid antagonist N,N-diallyl-Tyr-D-Leu-Gly-Tyr-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Loukas S,Mercouris M,Panetsos F,Zioudrou C

更新日期：1994-05-10 00:00:00

abstract：:The Fbw7 (F-box/WD repeat-containing protein 7) ubiquitin ligase targets multiple oncoproteins for degradation and is commonly mutated in cancers. Like other pleiotropic tumor suppressors, Fbw7's complex biology has impeded our understanding of how Fbw7 mutations promote tumorigenesis and hindered the development of t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Davis RJ,Gönen M,Margineantu DH,Handeli S,Swanger J,Hoellerbauer P,Paddison PJ,Gu H,Raftery D,Grim JE,Hockenbery DM,Margolin AA,Clurman BE

更新日期：2018-05-22 00:00:00

abstract：:Viperin is an interferon (IFN)-inducible multifunctional protein. Recent evidence from high-throughput analyses indicates that most IFN-inducible proteins, including viperin, are intrinsically expressed in specific tissues; however, the respective intrinsic functions are unknown. Here we show that the intrinsic expres...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eom J,Kim JJ,Yoon SG,Jeong H,Son S,Lee JB,Yoo J,Seo HJ,Cho Y,Kim KS,Choi KM,Kim IY,Lee HY,Nam KT,Cresswell P,Seong JK,Seo JY

更新日期：2019-08-27 00:00:00

abstract：:Human pluripotent stem cells have the potential to provide comprehensive model systems for the earliest stages of human ontogenesis. To serve in this capacity, these cells must undergo a targeted, stepwise differentiation process that follows a normal developmental timeline. Here we demonstrate the ability of both hum...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Meyer JS,Shearer RL,Capowski EE,Wright LS,Wallace KA,McMillan EL,Zhang SC,Gamm DM

更新日期：2009-09-29 00:00:00

abstract：:The phosphorylation of diacylglycerol (DG), a reaction catalyzed by DG kinase, may be critical in the termination of effector-induced signals mediated by protein kinase C. Synapsin I is a principal target of intracellular protein kinases and is thought to be involved in the release of neurotransmitter from axon termin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kahn DW,Besterman JM

更新日期：1991-07-15 00:00:00

abstract：:Visual development is thought to be completed at an early age. We suggest that the maturation of the visual brain is not homogeneous: functions with greater need for early availability, such as visuomotor control, mature earlier, and the development of other visual functions may extend well into childhood. We found si...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kovács I,Kozma P,Fehér A,Benedek G

更新日期：1999-10-12 00:00:00

abstract：:Restenosis, a process characterized in part by excessive smooth muscle cell (SMC) proliferation in areas of vascular injury, occurs in up to 50% of patients undergoing balloon angioplasty. In an effort to develop a treatment strategy for restenosis, we constructed a replication-deficient recombinant adenovirus (AdMLP....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Guzman RJ,Hirschowitz EA,Brody SL,Crystal RG,Epstein SE,Finkel T

更新日期：1994-10-25 00:00:00

abstract：:Metal detoxification is essential for bacteria's survival in adverse environments and their pathogenesis in hosts. Understanding the underlying mechanisms is crucial for devising antibacterial treatments. In the Gram-negative bacterium Escherichia coli, membrane-bound sensor CusS and its response regulator CusR togeth...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fu B,Sengupta K,Genova LA,Santiago AG,Jung W,Krzemiński Ł,Chakraborty UK,Zhang W,Chen P

更新日期：2020-06-16 00:00:00

abstract：:High ambient ozone (O3) concentrations are a widespread and persistent problem globally. Although studies have documented the role of forests in removing O3 and one of its precursors, nitrogen dioxide (NO2), the cost effectiveness of using peri-urban reforestation for O3 abatement purposes has not been examined. We de...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kroeger T,Escobedo FJ,Hernandez JL,Varela S,Delphin S,Fisher JR,Waldron J

更新日期：2014-10-07 00:00:00

abstract：:The recent discovery of superconductivity with relatively high transition temperature (Tc) in the layered iron-based quaternary oxypnictides La[O(1-x)F(x)] FeAs by Kamihara et al. [Kamihara Y, Watanabe T, Hirano M, Hosono H (2008) Iron-based layered superconductor La[O1-xFx] FeAs (x = 0.05-0.12) with Tc = 26 K. J Am C...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hsu FC,Luo JY,Yeh KW,Chen TK,Huang TW,Wu PM,Lee YC,Huang YL,Chu YY,Yan DC,Wu MK

更新日期：2008-09-23 00:00:00

abstract：:Autophagy is responsible for nonspecific, bulk degradation of cytoplasmic components. Recent work has revealed also that there is specific, autophagic degradation of polyubiquitinated protein aggregates, whose buildup occurs during neurodegenerative disease. Here, we report that simple mono-ubiquitination of normally ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim PK,Hailey DW,Mullen RT,Lippincott-Schwartz J

更新日期：2008-12-30 00:00:00

abstract：:Construction of deletion derivative plasmids and cloning of restriction fragments from plasmids containing the Salmonella typhimurium origin of replication (ori) were used to locate the functional origin to within a DNA fragment of 296 base pairs between the genes uncB and asn. The nucleotide sequence of the S. typhim...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zyskind JW,Smith DW

更新日期：1980-05-01 00:00:00

abstract：:The POT1 (protection of telomeres 1) protein binds the ssDNA overhangs at the ends of chromosomes in diverse eukaryotes. POT1 is essential for chromosome end-protection, as best demonstrated in fission yeast. In human cells, hPOT1 is also involved in telomere-length regulation. We now show that telomeric oligonucleoti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zaug AJ,Podell ER,Cech TR

更新日期：2005-08-02 00:00:00

abstract：:Vertebrate embryogenesis and organogenesis are driven by cell biological processes, ranging from mitosis and migration to changes in cell size and polarity, but their control and causal relationships are not fully defined. Here, we use the developing limb skeleton to better define the relationships between mitosis and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li Y,Junge JA,Arnesano C,Gross GG,Miner JH,Moats R,Roberts RW,Arnold DB,Fraser SE

更新日期：2018-11-13 00:00:00

abstract：:Siphoviridae is the most abundant viral family on earth which infects bacteria as well as archaea. All known siphophages infecting gram+ Lactococcus lactis possess a baseplate at the tip of their tail involved in host recognition and attachment. Here, we report analysis of the p2 phage baseplate structure by X-ray cry...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sciara G,Bebeacua C,Bron P,Tremblay D,Ortiz-Lombardia M,Lichière J,van Heel M,Campanacci V,Moineau S,Cambillau C

更新日期：2010-04-13 00:00:00

abstract：:Predicting the timing of upcoming events is critical for successful interaction in a dynamic world, and is recognized as a key computation for attentional orienting. Temporal predictions can be formed when recent events define a rhythmic structure, as well as in aperiodic streams or even in isolation, when a specified...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Breska A,Ivry RB

更新日期：2018-11-27 00:00:00

abstract：:Apolipoprotein L-1 (APOL1), the trypanolytic factor of human serum, can lyse several African trypanosome species including Trypanosoma brucei brucei, but not the human-infective pathogens T. brucei rhodesiense and T. brucei gambiense, which are resistant to lysis by human serum. Lysis follows the uptake of APOL1 into ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thomson R,Finkelstein A

更新日期：2015-03-03 00:00:00

abstract：:A reaction cycle for electron-transportdriven proton pumps is proposed. It includes two distinct conformational states of the pump protein in which the primary electron acceptor has different reduction potentials. This has as an unavoidable consequence that the steady-state rate equation for the catalytic reaction dri...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brzezinski P,Malmström BG

更新日期：1986-06-01 00:00:00

abstract：:Although the unifying hallmark of prion diseases is CNS neurodegeneration caused by conformational corruption of host prion protein (PrP) to its infective counterpart, contagious transmission of chronic wasting disease (CWD) results from shedding of prions produced at high titers in the periphery of diseased cervids. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bian J,Christiansen JR,Moreno JA,Kane SJ,Khaychuk V,Gallegos J,Kim S,Telling GC

更新日期：2019-06-18 00:00:00

abstract：:A highly effective vaccine would be a valuable weapon in the drive toward malaria elimination. No such vaccine currently exists, and only a handful of the hundreds of potential candidates in the parasite genome have been evaluated. In this study, we systematically evaluated 29 antigens likely to be involved in erythro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bustamante LY,Powell GT,Lin YC,Macklin MD,Cross N,Kemp A,Cawkill P,Sanderson T,Crosnier C,Muller-Sienerth N,Doumbo OK,Traore B,Crompton PD,Cicuta P,Tran TM,Wright GJ,Rayner JC

更新日期：2017-11-07 00:00:00

abstract：:A TL+ leukemia of a (B6 X A)F1 hybrid mouse (H-2b/H-2a) was previously subjected to immunoselection against H-2a by passage in (B6 X A.SW)F1 mice (H-2b/H-2s). A variant leukemia line was obtained that serologically lacked not only the H-2a phenotype but also the TL phenotype determined by the linked cis Tlaa allele of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shen FW,Chaganti RS,Doucette LA,Litman GW,Steinmetz M,Hood L,Boyse EA

更新日期：1984-10-01 00:00:00

abstract：:Total chemical synthesis was used to prepare the mirror image (D-protein) form of the angiogenic protein vascular endothelial growth factor (VEGF-A). Phage display against D-VEGF-A was used to screen designed libraries based on a unique small protein scaffold in order to identify a high affinity ligand. Chemically syn...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mandal K,Uppalapati M,Ault-Riché D,Kenney J,Lowitz J,Sidhu SS,Kent SB

更新日期：2012-09-11 00:00:00

abstract：:Loss of miR-15/16 is the most common genetic lesion in chronic lymphocytic leukemia (CLL), promoting overexpression of BCL2, which factors in leukemia pathogenesis. Indeed, an inhibitor of Bcl2, venetoclcax, is highly active in the treatment of patients with CLL. However, single-agent venetoclcax fails to eradicate mi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rassenti LZ,Balatti V,Ghia EM,Palamarchuk A,Tomasello L,Fadda P,Pekarsky Y,Widhopf GF 2nd,Kipps TJ,Croce CM

更新日期：2017-10-03 00:00:00

abstract：:In Saccharomyces cerevisiae cells harboring a GAL1 promoter-linked beta-galactosidase gene, the simultaneous expression of Escherichia coli DNA topoisomerase I and inactivation of yeast DNA topoisomerases I and II reduces the cellular level of beta-galactosidase to an undetectable level. Analysis of intracellular mRNA...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gartenberg MR,Wang JC

更新日期：1992-12-01 00:00:00

abstract：:Aspartic acid in the second transmembrane domain is a highly conserved amino acid among the G protein-coupled receptors and is functionally important for agonist binding and G-protein coupling in beta 2-adrenergic and luteinizing hormone receptors. To determine whether this aspartic acid is also involved in the functi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bihoreau C,Monnot C,Davies E,Teutsch B,Bernstein KE,Corvol P,Clauser E

更新日期：1993-06-01 00:00:00

abstract：:Thrombospondin, a 450-kDa multinodular glycoprotein with lectin-type activity, is found in human platelets, endothelial cells, fibroblasts, smooth muscle cells, monocytes, and granular pneumocytes. Thrombospondin interacts with heparin, fibrinogen, fibronectin, collagen, histidine-rich glycoprotein, and plasminogen. R...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Asch AS,Leung LL,Shapiro J,Nachman RL

更新日期：1986-05-01 00:00:00

abstract：:Microtubule-targeting agents (MTAs) are widely used for treatment of cancer and other diseases, and a detailed understanding of the mechanism of their action is important for the development of improved microtubule-directed therapies. Although there is a large body of data on the interactions of different MTAs with pu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mohan R,Katrukha EA,Doodhi H,Smal I,Meijering E,Kapitein LC,Steinmetz MO,Akhmanova A

更新日期：2013-05-28 00:00:00

abstract：:Like many physiological ligands, several viruses and toxins enter mammalian cells through receptor-mediated endocytosis. Once internalized, the nucleic acids of several viruses and the toxic subunit of diphtheria toxin gain access to the cytosol of the host cell through an acidic intracellular compartment. In this rep...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Merion M,Schlesinger P,Brooks RM,Moehring JM,Moehring TJ,Sly WS

更新日期：1983-09-01 00:00:00

abstract：:Self-assembled monolayer-protected nanoparticles are promising candidates for applications, such as sensing and drug delivery, in which the molecular ligands' interactions with the surrounding environment play a crucial role. We recently showed that, when gold nanoparticles are coated with a binary mixture of immiscib...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Centrone A,Penzo E,Sharma M,Myerson JW,Jackson AM,Marzari N,Stellacci F

更新日期：2008-07-22 00:00:00