Abstract：
:Recently published studies suggest a weak positive correlation between increased dietary acrylamide intake and the increased risk of endometrial and ovarian cancer. However, risk assessment of acrylamide remains difficult because the carcinogenic mechanisms are still unknown and in particular the molecular effects of low level acrylamide exposure as seen by dietary intake are not well understood. Therefore, we analyzed in ovarian and endometrial cancer cell lines as well as in primary hepatocytes the expression of genes involved in cancer development and xenobiotic metabolism after high and low dose exposure (1-0.001mM) of acrylamide and its metabolite glycidamide. In conclusion our in vitro results demonstrate that exposure to high doses of glycidamide/acrylamide - exceeding the dietary exposure of the general population by far - can induce genes with growth promoting potential like the oncogene cMYC and genes involved in the MAPK pathway. However, low-dose exposure seems to activate primarily genes involved in the elimination of the toxicant.
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
Ehlers A,Lenze D,Broll H,Zagon J,Hummel M,Lampen Adoi
10.1016/j.toxlet.2012.12.017subject
Has Abstractpub_date
2013-02-27 00:00:00pages
111-20issue
2eissn
0378-4274issn
1879-3169pii
S0378-4274(12)01455-5journal_volume
217pub_type
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