Abstract:
:Rats given calcium disodium ethylenediaminetetraacetic acid (CaNa2EDTA), diethylenetriaminepentaacetic acid (DTPA), dimercaprol, p-aminosalicylic acid (PAS), or d-penicillamine (penicillamine) i.p. for 7 successive days showed a significant decrease in the activity of hepatic microsomal benzphetamine N-demethylase. There was no appreciable change in the microsomal cytochrome P-450 concentration. In vitro incubation of the chelating drugs with liver microsomes isolated from rats pre-treated with phenobarbital caused no significant loss of the hemoprotein. The decreased rate of benzphetamine metabolism in microsomal preparations from rats, pretreated with the chelating drugs, may be attributed partly to hepatic depletion of essential trace elements by the chelating drugs.
journal_name
Toxicol Lettjournal_title
Toxicology lettersauthors
Dalvi RR,McGowan C,Ademoyero Adoi
10.1016/0378-4274(80)90097-1subject
Has Abstractpub_date
1980-06-01 00:00:00pages
25-8issue
1eissn
0378-4274issn
1879-3169pii
0378-4274(80)90097-1journal_volume
6pub_type
杂志文章abstract::Aminoglycosides have detrimental effects on the hair cells of the inner ear, yet these agents indisputably are one of the cornerstones in antibiotic therapy. Hence, there is a demand for strategies to prevent aminoglycoside-induced ototoxicity, which are not available today. In vitro data suggests that the pleiotropic...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2018.04.007
更新日期:2018-07-01 00:00:00
abstract::Rates of alkaline hydrolysis of 18 natural or semisynthetic pyrrolizidine alkaloids, all retronecine diesters, have been compared. Steric hindrance around the ester groups was the major factor inhibiting hydrolysis. Relative rates of hydrolysis by esterases in a rat liver homogenate were also dependent on steric hindr...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(82)90017-0
更新日期:1982-11-01 00:00:00
abstract::Intraperitoneal (i.p.) and intravenous (i.v.) injection of 44Ti in a chloride solution into mice produced no detectable translocation in body fluids. There was no obvious interorgan exchange up to 16 days after injection. The whole body biological retention half-lives had a mean of 642 days for both routes, another in...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(80)90177-0
更新日期:1980-07-01 00:00:00
abstract::The risk of lung and urinary bladder cancers was reported to be increased in individuals who carried high risk genotypes in either cytochrome P450 (CYP)1A1, CYP2E1 or glutathione S-transferase (GST)M1, and the combined genotype of both CYP1A1 and GSTM1 enzymes have an enhanced tendency of risk to lung cancer more sign...
journal_title:Toxicology letters
pub_type: 杂志文章,评审
doi:10.1016/s0378-4274(98)00303-8
更新日期:1998-12-28 00:00:00
abstract::Cadmium is a carcinogenic metal known to increase the expression of several protooncogenes in a variety of cells. although the underlying mechanisms are unknown. Renal mesangial cells are smooth muscle cells in which Ca2+ signaling pathways regulate the induction of c-fos through both cAMP-dependent and mitogen-activa...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/s0378-4274(98)00015-0
更新日期:1998-03-16 00:00:00
abstract::Deoxynivalenol (DON) is a type B trichothecene mycotoxin that exerts multiple toxic effects on plants, animals and humans. Several reports have shown that DON leads to G2/M cell cycle arrest. However, its molecular mechanism is still unclear. In this study, we showed that DON induced strong G2/M cell cycle arrest in H...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2018.09.012
更新日期:2018-12-15 00:00:00
abstract::Modulation of the cytochrome P450 (CYP) monooxygenase system by cadmium was investigated in male, adult DBA/2J mice treated with a single dose (16 micromol/kg body weight, i.p.) of cadmium chloride (CdCl2). Total CYP content of liver and kidney microsomes decreased maximally (56% and 85%, respectively) 24 and 18 h, re...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2003.10.029
更新日期:2004-03-21 00:00:00
abstract::New psychoactive substances (NPS) are an emerging topic amongst abused compounds. New varieties appear constantly on the market, without any knowledge about their toxicodynamic and/or -kinetic properties and knowledge of their metabolism is crucial for the development of analytical methods employed for their detection...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2019.01.010
更新日期:2019-05-01 00:00:00
abstract::Considering of novel biochemical modulation by some foods and beverages, we have performed screening for green tea components that have enhancing effects on doxorubicin (DOX) induced antitumor activity. Components, such as caffeine, theanine, (-)-epigallocatechin gallate (EGCG) and flavonoids have inhibitory effects o...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/s0378-4274(99)00290-8
更新日期:2000-04-03 00:00:00
abstract::The repeated use of the nerve agent sarin against civilians in Syria in 2013 emphasizes the continuing threat by chemical warfare agents. Multiple studies demonstrated a limited efficacy of standard atropine-oxime treatment in nerve agent poisoning and called for the development of alternative and more effective treat...
journal_title:Toxicology letters
pub_type: 杂志文章,评审
doi:10.1016/j.toxlet.2015.07.012
更新日期:2016-02-26 00:00:00
abstract::To test the toxicity of some substances, known to affect the nervous system i.e. organic solvents, heavy metals and DDT, their ability to cause cell detachment of cultured mouse neuroblastoma cells was investigated. A TD25 value was obtained by graphic estimation of the concentration needed to cause 25% of the total c...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(81)90024-2
更新日期:1981-10-01 00:00:00
abstract::The hedgehog (HH) signaling pathway plays an important role in lung development, but its significance in silicosis is unclear. We showed that in human coal pneumoconiosis autopsy specimens, Sonic Hedgehog (SHH) and the Glioma-associated oncogene homolog transcription factors family (GLI) 1 proteins were up-regulated, ...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2019.05.023
更新日期:2019-10-01 00:00:00
abstract::A partially purified toxin fraction and lantadene A were obtained from Lantana camara L. leaves by batch extraction, column chromatography and fractional crystallization. Toxicity was tested in guinea pigs. The total number of chemical entities in the partially purified toxin preparation was 7, the 2 major ones being ...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(87)90153-6
更新日期:1987-07-01 00:00:00
abstract::Trichothecenes are mycotoxins which produce lethal toxicosis in humans and animals, yet no adequate therapeutic regimen has been developed. This study provides evidence that the selective platelet activating factor (PAF) antagonist, BN 52021 (5-15 mg/kg i.v.) can prolong the survival of conscious rats exposed to a hig...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(87)90008-7
更新日期:1987-10-01 00:00:00
abstract::The phototoxic potentials of quinolone derivatives and the possibility of free radical contribution to their phototoxicity were investigated by measuring increments in ear thickness. Balb/c mice, fasted overnight, were orally administered ofloxacin (OFLX), lomefloxacin (LMFX), enoxacin (ENX), ciprofloxacin (CPFX) and ...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(91)90176-7
更新日期:1991-10-01 00:00:00
abstract::Dysglycemia and central nervous system (CNS) complications are the known adverse effects of fluoroquinolone antibiotics. Ciprofloxacin and levofloxacin are among the most prescribed antibiotics. In this study we demonstrate that ciprofloxacin and levofloxacin disturb glucose transport into HepG2 cells and such inhibit...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2008.10.017
更新日期:2009-01-30 00:00:00
abstract::Doxorubicin (DOX) is a chemotherapeutic agent of which the medical use is limited due to cardiotoxicity. While acute cardiotoxicity is reversible, chronic cardiotoxicity is persistent or progressive, dose-dependent and irreversible. While DOX mechanisms of action are not fully understood yet, 3 toxicity processes are ...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2018.05.029
更新日期:2018-09-15 00:00:00
abstract::Tubule segments from defined stages of the mouse seminiferous epithelium were incubated for 4, 8 and 24 h in the presence of different concentrations of mono-2-ethylhexyl phthalate (MEHP), adriamycin, and N-ethyl-N-nitrosourea (ENU) to study the effects of these chemicals on germ cell apoptosis and DNA synthesis. Apop...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/s0378-4274(03)00170-x
更新日期:2003-07-20 00:00:00
abstract::The effect of dietary vomitoxin on the serum IgA and IgG responses to two model intestinal antigens, casein and cholera toxin (CT), were assessed in 4 experimental groups: (1) mice fed casein-based diet, (2) mice fed casein-based diet containing 25 ppm vomitoxin, (3) mice fed casein-based diet and immunized with CT, a...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(90)90254-j
更新日期:1990-01-01 00:00:00
abstract::Kahweol, the coffee-specific diterpene, has been reported to have anti-carcinogenic properties. Animal data support such a chemopreventive effect of coffee. However, the precise underlying protective mechanisms are poorly understood. In this study, the apoptotic effect of kahweol in human lung adenocarcinoma A549 cell...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2009.01.022
更新日期:2009-05-22 00:00:00
abstract::Mechanisms of zinc (Zn) toxicity are incompletely understood and data regarding potential endocrine alterations in Zn toxicity are scarce. To examine mechanisms of Zn toxicity, day-old chicks were pair-fed diets containing 5280 ppm (Hz) or 73 ppm (CON) Zn. Impaired postnatal growth, independent of feed consumption, an...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(91)90205-k
更新日期:1991-08-01 00:00:00
abstract::Nitropyrene (1-NP) is classified as Group 2B carcinogen and is one of the main components of diesel exhaust particles (DEP), which are generated from incomplete combustion of automobile engines to cause human cancer or inflammatory diseases. Although many reports on the mutagenesis or carcinogenesis of 1-NP have been ...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2008.10.028
更新日期:2009-01-30 00:00:00
abstract::Nickel is a metal widely employed in dental alloys, and due to peculiar properties of certain nickel-based materials, it cannot be substituted with other metals in some applications. The release of nickel ions from dental alloys placed into long-term contact with mouth soft tissues is alarming because of the toxic, im...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2005.05.019
更新日期:2005-12-15 00:00:00
abstract::The disposition of methanol and its putative toxic metabolite formate has been studied in humans, non-human primates, and rodents after exposure to high, neurotoxic doses. The rate at which rodents detoxify formate is more rapid than that of primates. Formate, an endogenous biological substrate, is detoxified by metab...
journal_title:Toxicology letters
pub_type: 杂志文章,评审
doi:10.1016/0378-4274(95)03515-x
更新日期:1995-12-01 00:00:00
abstract::Polarographic measurements of the rates of oxygen consumption by isolated rat liver mitochondria respiring on pyruvate/malate in metabolic state 4 revealed that additions of micromolar amounts of chalepin, a naturally occurring furocoumarin resulted in significant decreases in respiratory rates. At 16 microM chalepin,...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(83)90151-0
更新日期:1983-03-01 00:00:00
abstract::Aim of this pilot study was to correlate the human exposure to formaldehyde (F) with N-methylenvaline, a molecular adduct formed by addiction of F to the N-terminal valine in hemoglobin. A group of 21 subjects employed in a plywood factory and a laminate factory, and occupationally exposed to F, together with a group ...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2005.07.016
更新日期:2006-02-08 00:00:00
abstract::Stoichiometric conversion of methyl acetate to methanol in vitro was detected when methyl acetate was incubated with blood for 2 to 8 h. The velocity of the reaction was so fast that almost all of methyl acetate disappeared in 8 h. The methanol formation was further confirmed by means of gas-chromatography-mass spectr...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(92)90028-i
更新日期:1992-09-01 00:00:00
abstract::Nitrogen mustard (HN-2), also known as mechlorethamine, is an alkylating anticancer agent as well as blister inducing chemical warfare agent. We evaluated the cytoprotective efficacy of amifostine, DRDE-07 and their analogues, and other antidotes of mustard agents against HN-2. Administration of 1 LD(50) of HN-2 (20mg...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/j.toxlet.2009.04.015
更新日期:2009-08-10 00:00:00
abstract::The mutagenic potential of fluphenazine hydrochloride was tested on male germ cells of Drosophila melanogaster. The criterion used was sex-linked recessive lethal mutations. Oregon-K males of D. melanogaster, reared on a medium containing 0.01, 0.02 and 0.03 mg/ml of the drug, were screened for sex-linked recessive le...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(80)90050-8
更新日期:1980-12-01 00:00:00
abstract::Since guanidinoacetic acid (GAA), a precursor of creatine, is synthesized mainly in the proximal tubule of the kidney where gentamicin (GM) nephrotoxicity often occurs, GM-induced renal cell damage was investigated using GAA synthesis in tubular suspension as an indicator. Results obtained were as follows: (1) GAA syn...
journal_title:Toxicology letters
pub_type: 杂志文章
doi:10.1016/0378-4274(95)03411-0
更新日期:1995-11-15 00:00:00