Colorectal cancer in ulcerative colitis: survival in patients with and without colorectal cancer symptoms.

abstract：:Inflammatory bowel disease is associated with industrialization, and its incidence has increased markedly over time. The prospect of reversing these trends motivates the search for the agent(s) involved. Modernity entails several physical and behavioral modifications that compromise both the photosynthesis of cholecal...

journal_title：Inflammatory bowel diseases

authors： Palmer MT,Weaver CT

更新日期：2013-09-01 00:00:00

abstract：Background:Vedolizumab, an α4β7 integrin monoclonal antibody inhibiting gut lymphocyte trafficking, is an effective treatment for ulcerative colitis (UC). We evaluated the optimal position of vedolizumab in the UC treatment paradigm. Methods:Using Markov modeling, we assessed multiple algorithms for the treatment of U...

journal_title：Inflammatory bowel diseases

authors： Scott FI,Shah Y,Lasch K,Luo M,Lewis JD

更新日期：2018-01-18 00:00:00

abstract：BACKGROUND:A North American genome-wide single nucleotide polymorphism (SNP) association study identified IL23R as a novel inflammatory bowel disease (IBD) susceptibility gene. Association was reported with multiple risk variants in the centromeric portion of IL23R in 3 large independent cohorts. The aims of this study...

journal_title：Inflammatory bowel diseases

authors： Cummings JR,Ahmad T,Geremia A,Beckly J,Cooney R,Hancock L,Pathan S,Guo C,Cardon LR,Jewell DP

更新日期：2007-09-01 00:00:00

abstract：BACKGROUND:Endoscopic balloon dilation (EBD) is widely used to manage Crohn's disease-associated strictures. However, most studies of the safety and efficacy are small and heterogenous. We performed a combined analysis of published studies and evaluated 676 comprehensive individual participant data sets to determine th...

journal_title：Inflammatory bowel diseases

authors： Bettenworth D,Gustavsson A,Atreja A,Lopez R,Tysk C,van Assche G,Rieder F

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Various physician- and patient-reported instruments exist for quantification of disease activity in inflammatory bowel diseases (IBD) but none are widely used in routine clinical practice. A simple patient-reported outcome measure might help inform clinical decision making. We evaluated a patient-reported 0 ...

journal_title：Inflammatory bowel diseases

authors： Subramanian S,Asher R,Weston W,Rimmer M,McConville A,Malin A,Jackson R,Collins P,Probert C,Dibb M,Rhodes JM

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND:Mucosal expression of interferon (IFN)-γ plays a pivotal role in the pathogenesis of inflammatory bowel disease (IBD) and IBD risk regions flank IFNG. The conserved IFNG rs1861494 T/C introduces a new CpG methylation site, is associated with disease severity and lack of therapeutic response in other infectio...

journal_title：Inflammatory bowel diseases

authors： Gonsky R,Deem RL,Landers CJ,Haritunians T,Yang S,Targan SR

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND:We aimed to identify the levels of soluble tumor necrosis factor-like weak inducer of apoptosis (sTWEAK) and interleukin 17A (IL-17A) in inflammatory bowel disease (IBD) and to examine their relationship with disease activity. METHODS:A total of 92 patients with IBD, in which 54 patients were diagnosed with...

journal_title：Inflammatory bowel diseases

authors： Kaplan M,Yuksel M,Ates I,Yaln Kilic ZM,Kilic H,Ates H,Kayacetin E

更新日期：2016-03-01 00:00:00

abstract：:Inflammatory bowel disease (IBD) has classically been associated with malnutrition and weight loss, although this has become less common with advances in treatment and greater proportions of patients attaining clinical remission. However, micronutrient deficiencies are still relatively common, particularly in CD patie...

journal_title：Inflammatory bowel diseases

authors： Hwang C,Ross V,Mahadevan U

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND:Evidence supports the role of adherent invasive Escherichia coli (AIEC) in the pathogenesis of inflammatory bowel disease (IBD). However, little is known about the phylogenetic structure and origin of this group of bacteria. Multi-locus sequence typing (MLST), and fimH sequence analysis were performed to elu...

journal_title：Inflammatory bowel diseases

authors： Sepehri S,Kotlowski R,Bernstein CN,Krause DO

更新日期：2009-11-01 00:00:00

abstract：:Corticosteroids, and more recently biologics, have been the mainstay of therapy for patients with inflammatory bowel disease. Unfortunately, both are fraught with side effects and limited by lack of efficacy or loss of response. Many patients ultimately succumb to medically refractory disease and require an operation....

journal_title：Inflammatory bowel diseases

authors： Lightner AL

更新日期：2018-07-12 00:00:00

abstract：BACKGROUND:Inflammatory bowel diseases (IBDs) are associated with up-regulation of TNFα, hyperactivation of proinflammatory effector T cells (Teffs) and inefficient control by regulatory CD4(+) CD25(+) Foxp3(+) T cells (Tregs). The aim of this prospective study was to investigate the short-term impact of treatment of I...

journal_title：Inflammatory bowel diseases

authors： Boschetti G,Nancey S,Sardi F,Roblin X,Flourié B,Kaiserlian D

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Extracellular nucleotides released in conditions of cell stress alert the immune system from tissue injury or inflammation. We hypothesized that the P2X7 receptor (P2X7-R) could regulate key elements in inflammatory bowel disease pathogenesis. METHODS:Colonoscopy samples obtained from patients with Crohn's ...

journal_title：Inflammatory bowel diseases

authors： Neves AR,Castelo-Branco MT,Figliuolo VR,Bernardazzi C,Buongusto F,Yoshimoto A,Nanini HF,Coutinho CM,Carneiro AJ,Coutinho-Silva R,de Souza HS

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:The similar presentations in relapse of inflammatory bowel disease (IBD) and enteric infection pose substantial barriers to diagnosis and treatment. The objective of this study was to investigate the incidence, etiology, predictors, and treatment of enteric infection in patients with IBD. METHODS:We reviewe...

journal_title：Inflammatory bowel diseases

authors： Axelrad JE,Joelson A,Nobel YR,Lawlor G,Green PHR,Lichtiger S,Lebwohl B

更新日期：2017-06-01 00:00:00

abstract：:Inflammatory bowel diseases (IBD) include ulcerative colitis and Crohn's disease. The immune response in ulcerative colitis is different from the Crohn's disease. Accumulating evidence suggests that IBD results from an inappropriate inflammatory response to intestinal microbes in a genetically susceptible host. Severa...

journal_title：Inflammatory bowel diseases

authors： Fonseca-Camarillo G,Yamamoto-Furusho JK

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:Interleukin-13 (IL-13) is a multifunctional cytokine whose net principle action is to diminish inflammatory responses. Dysregulation of IL-13 production has been proposed to contribute to intestinal inflammation in inflammatory bowel disease (IBD) patients. Previous studies implicate IL-13 in IBD pathogenesi...

journal_title：Inflammatory bowel diseases

authors： Kadivar K,Ruchelli ED,Markowitz JE,Defelice ML,Strogatz ML,Kanzaria MM,Reddy KP,Baldassano RN,von Allmen D,Brown KA

更新日期：2004-09-01 00:00:00

abstract：Background:Endoscopic monitoring is fundamental for evaluating the therapeutic response in IBD, but a validated endomicroscopic mucosal healing (MH) score is not available to date. However, confocal laser endomicroscopy (CLE) might define MH more precisely than conventional endoscopy. The major aim was to establish and...

journal_title：Inflammatory bowel diseases

authors： Hundorfean G,Chiriac MT,Mihai S,Hartmann A,Mudter J,Neurath MF

更新日期：2017-12-19 00:00:00

abstract：BACKGROUND:Data from CHARM, a 56-week, randomized controlled trial of adalimumab for patients with moderately to severely active Crohn's disease (CD), were used to evaluate outcomes of adalimumab dosage adjustment. METHODS:Patients randomized to blinded adalimumab 40 mg every other week (EOW) in CHARM were the focus o...

journal_title：Inflammatory bowel diseases

authors： Sandborn WJ,Colombel JF,Schreiber S,Plevy SE,Pollack PF,Robinson AM,Chao J,Mulani P

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:MicroRNAs (miRNAs) are dysregulated in the inflammatory bowel diseases, Crohn's disease (CD) and ulcerative colitis (UC), which arise due to dysfunctional host-microbe interactions and impairment of the barrier function of the intestine. Here, we sought to determine whether circulating miRNAs are biomarkers ...

journal_title：Inflammatory bowel diseases

authors： Krissansen GW,Yang Y,McQueen FM,Leung E,Peek D,Chan YC,Print C,Dalbeth N,Williams M,Fraser AG

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND:Psoriasis induced by anti-tumor necrosis factor-α (TNF) therapy has been described as a paradoxical side effect. AIM:To determine the incidence, clinical characteristics, and management of psoriasis induced by anti-TNF therapy in a large nationwide cohort of inflammatory bowel disease patients. METHODS:Pat...

journal_title：Inflammatory bowel diseases

authors： Guerra I,Pérez-Jeldres T,Iborra M,Algaba A,Monfort D,Calvet X,Chaparro M,Mañosa M,Hinojosa E,Minguez M,Ortiz de Zarate J,Márquez L,Prieto V,García-Sánchez V,Guardiola J,Rodriguez GE,Martín-Arranz MD,García-Tercero I,S

更新日期：2016-04-01 00:00:00

abstract：:Chronic inflammatory bowel disease (IBD) presents as two major clinical forms, Crohn's disease (CD) and ulcerative colitis (UC). Genetic epidemiological studies and animal models suggest that inherited factors play significant roles in the susceptibility to both forms of IBD. From four genome-wide scans, putative susc...

journal_title：Inflammatory bowel diseases

authors： Ma Y,Ohmen JD,Li Z,Bentley LG,McElree C,Pressman S,Targan SR,Fischel-Ghodsian N,Rotter JI,Yang H

更新日期：1999-11-01 00:00:00

abstract：:: Crohn's disease (CD) is a lifelong inflammatory condition with underlying environmental and genetic components. CD affects multiple parts of the gastrointestinal tract, and it has a growing incidence in Western societies. IL-23 receptor variants have been identified as susceptibility or resistance factors for CD in ...

journal_title：Inflammatory bowel diseases

authors： Eken A,Singh AK,Oukka M

更新日期：2014-03-01 00:00:00

abstract：:Inflammatory bowel disease (IBD) has been increasingly diagnosed in children and adults. Similarly, acute and chronic pancreatitis are increasingly prevalent conditions with potentially devastating consequences. There is a growing body of literature linking these 2 conditions. The purpose of this review is to provide ...

journal_title：Inflammatory bowel diseases

authors： Srinath AI,Gupta N,Husain SZ

更新日期：2016-02-01 00:00:00

abstract：OBJECTIVES:Studies aimed at establishing which characteristics of patients with ulcerative proctitis could be predictive of the extension of inflammation have failed to provide conclusive results. The aim of the study was to evaluate the prognostic role of clinical and therapeutic parameters in patients with proctitis....

journal_title：Inflammatory bowel diseases

authors： Pica R,Paoluzi OA,Iacopini F,Marcheggiano A,Crispino P,Rivera M,Bella A,Consolazio A,Paoluzi P

更新日期：2004-11-01 00:00:00

abstract：BACKGROUND:To systematically determine the performance of diffusion-weighted imaging magnetic resonance enterography (DWI-MRE) for evaluating bowel inflammation in Crohn's disease and sources of heterogeneity between reported results. METHODS:We identified research studies that investigated DWI-MRE to diagnose bowel i...

journal_title：Inflammatory bowel diseases

authors： Choi SH,Kim KW,Lee JY,Kim KJ,Park SH

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:Genetic predisposition as a cause of inflammatory bowel disease (IBD) has been proven by both family and twin studies and genetic variants associated with the disease have been identified. The aim of our study was to determine the concordance rates for IBD in German twin pairs and to evaluate clinical charac...

journal_title：Inflammatory bowel diseases

authors： Spehlmann ME,Begun AZ,Burghardt J,Lepage P,Raedler A,Schreiber S

更新日期：2008-07-01 00:00:00

abstract：BACKGROUND:Infliximab is an effective therapy for inflammatory bowel disease (IBD). However, more than 50% of patients lose response. Empiric dose intensification is not effective for all patients because not all patients have objective disease activity or subtherapeutic drug level. The aim was to determine how an obje...

journal_title：Inflammatory bowel diseases

authors： Huang VW,Prosser C,Kroeker KI,Wang H,Shalapay C,Dhami N,Fedorak DK,Halloran B,Dieleman LA,Goodman KJ,Fedorak RN

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:The proinflammatory effect of high-fat diet has been observed beyond the cardiovascular system, but there is little evidence to support its role in triggering inflammatory bowel disease. GPx1/2-double-knockout (DKO) mice deficient in 2 intracellular glutathione peroxidases, GPx1 and GPx2, on a C57BL/6 (B6) b...

journal_title：Inflammatory bowel diseases

authors： Gao Q,Esworthy RS,Kim BW,Synold TW,Smith DD,Chu FF

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:Crohn's disease (CD)-associated dysbiosis could predispose patients to relapse. Gut microbiota composition of patients from the prospective cohort study designed to identify predictive factors of clinical relapse after infliximab discontinuation (STORI Study) was investigated to determine the impact of dysbi...

journal_title：Inflammatory bowel diseases

authors： Rajca S,Grondin V,Louis E,Vernier-Massouille G,Grimaud JC,Bouhnik Y,Laharie D,Dupas JL,Pillant H,Picon L,Veyrac M,Flamant M,Savoye G,Jian R,Devos M,Paintaud G,Piver E,Allez M,Mary JY,Sokol H,Colombel JF,Seksik P

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:The accuracy and utility of electronic health record (EHR)-derived phenotypes in replicating genotype-phenotype relationships have been infrequently examined. Low circulating vitamin D levels are associated with severe outcomes in inflammatory bowel disease (IBD); however, the genetic basis for vitamin D ins...

journal_title：Inflammatory bowel diseases

authors： Ananthakrishnan AN,Cagan A,Cai T,Gainer VS,Shaw SY,Churchill S,Karlson EW,Murphy SN,Kohane I,Liao KP,Xavier RJ

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND:Severe mucosal tissue damage requiring efficient wound healing is a main feature of inflammatory bowel disease but excessive tissue repair promotes fibrosis. The clinical investigation of fibrosis is confined to the limited amount of biological material available from patients. This makes the establishment o...

journal_title：Inflammatory bowel diseases

authors： Hausmann M,Rechsteiner T,Caj M,Benden C,Fried M,Boehler A,Rogler G

更新日期：2013-10-01 00:00:00