Linking vitamin d deficiency to inflammatory bowel disease.

abstract：BACKGROUND:Extracellular nucleotides released in conditions of cell stress alert the immune system from tissue injury or inflammation. We hypothesized that the P2X7 receptor (P2X7-R) could regulate key elements in inflammatory bowel disease pathogenesis. METHODS:Colonoscopy samples obtained from patients with Crohn's ...

journal_title：Inflammatory bowel diseases

authors： Neves AR,Castelo-Branco MT,Figliuolo VR,Bernardazzi C,Buongusto F,Yoshimoto A,Nanini HF,Coutinho CM,Carneiro AJ,Coutinho-Silva R,de Souza HS

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:Up to 20% of patients with ulcerative colitis (UC) become steroid-dependent during their course. Thiopurines are recommended in steroid-dependent UC, but their efficacy is debated. Data exploring the use of infliximab in these patients are scarce. Aims of this study were to evaluate the effectiveness of infl...

journal_title：Inflammatory bowel diseases

authors： Armuzzi A,Pugliese D,Danese S,Rizzo G,Felice C,Marzo M,Andrisani G,Fiorino G,Sociale O,Papa A,De Vitis I,Rapaccini GL,Guidi L

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND:Blood translocation of bacterial-DNA has been described in patients with Crohn's disease (CD). The host's immune cell types cooperate to respond against bacterial insults. Some antimicrobial peptides are inducible after culture with bacterial products and a linkage has been established between them and NOD2/...

journal_title：Inflammatory bowel diseases

authors： Gutiérrez A,Holler E,Zapater P,Sempere L,Jover R,Pérez-Mateo M,Schoelmerich J,Such J,Wiest R,Francés R

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:Our objectives were to assess the differences in perforating disease behavior, disease severity, and extraintestinal manifestations (EIM) in patients with Crohn's disease (CD) by race. MATERIALS AND METHODS:We identified outpatients with CD evaluated at the University of Maryland Gastroenterology Faculty Pr...

journal_title：Inflammatory bowel diseases

authors： Cross RK,Jung C,Wasan S,Joshi G,Sawyer R,Roghmann MC

更新日期：2006-03-01 00:00:00

abstract：Background:The diagnostic work-up of pediatric irritable bowel syndrome (IBS) and functional abdominal pain-not otherwise specified (FAP-NOS) commonly includes invasive tests for discrimination from inflammatory bowel disease (IBD). As this carries a high burden on patients, an ongoing need exists for development of no...

journal_title：Inflammatory bowel diseases

authors： Bosch S,van Gaal N,Zuurbier RP,Covington JA,Wicaksono AN,Biezeveld MH,Benninga MA,Mulder CJ,de Boer NKH,de Meij TGJ

更新日期：2018-10-12 00:00:00

abstract：BACKGROUND:The hygiene hypothesis suggests an inverse relationship between the incidence of parasitic infections and chronic inflammatory bowel diseases (IBD). We investigated the therapeutic potential of Schistosoma mansoni and Ancylostoma caninum soluble proteins on experimental colitis in mice. METHODS:Colitis was ...

journal_title：Inflammatory bowel diseases

authors： Ruyssers NE,De Winter BY,De Man JG,Loukas A,Pearson MS,Weinstock JV,Van den Bossche RM,Martinet W,Pelckmans PA,Moreels TG

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND:Systems biology is a rapidly advancing field of science that allows us to look into disease mechanisms, patient diagnosis and stratification, and drug development in a completely new light. It is based on the utilization of unbiased computational systems free of the traditional experimental approaches based ...

journal_title：Inflammatory bowel diseases

authors： Fiocchi C,Iliopoulos D

更新日期：2021-01-13 00:00:00

abstract：BACKGROUND:A notable proportion of patients with inflammatory bowel disease (IBD) are switched from infliximab (IFX) to adalimumab (ADL). We investigated if immunogenicity of IFX influenced immunogenicity and clinical outcomes of later ADL therapy. METHODS:Single-center cohort study including all patients with IBD ass...

journal_title：Inflammatory bowel diseases

authors： Frederiksen MT,Ainsworth MA,Brynskov J,Thomsen OO,Bendtzen K,Steenholdt C

更新日期：2014-10-01 00:00:00

abstract：:Biologic treatments have revolutionized the way we treat inflammatory bowel disease patients (IBD). Anti-tumor necrosis factor (anti-TNF) antibodies are superior to conventional therapies to achieve sustained remission without steroids and mucosal healing. The objective of IBD treatment has evolved from symptom allevi...

journal_title：Inflammatory bowel diseases

authors： Louis E

更新日期：2018-03-19 00:00:00

abstract：BACKGROUND:Easily accessible predictors of disease course in inflammatory bowel disease (IBD) are scarce, and it remains largely unknown whether a family history of IBD predicts the course of Crohn's disease (CD) and ulcerative colitis (UC). We aimed to compare the course of disease in familial and sporadic cases of IB...

journal_title：Inflammatory bowel diseases

authors： Trier Moller F,Andersen V,Andersson M,Jess T

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:Unlike other anti-tumor necrosis factor alpha antibodies, golimumab does not deliver on its promise of effectiveness for treating patients with ulcerative colitis. We investigated the value of therapeutic drug monitoring for optimizing golimumab therapy. METHODS:We analyzed the golimumab pharmacokinetics da...

journal_title：Inflammatory bowel diseases

authors： Dreesen E,Kantasiripitak W,Detrez I,Stefanović S,Vermeire S,Ferrante M,Bouillon T,Drobne D,Gils A

更新日期：2020-03-04 00:00:00

abstract：BACKGROUND:The risk of corticosteroid-associated adverse events can limit the use of systemic corticosteroids. Oral, topically acting, second-generation corticosteroids that deliver drug to the site of inflammation, and biologic therapies, are effective treatment alternatives. The aim of this review was to evaluate the...

journal_title：Inflammatory bowel diseases

authors： Cross RK

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND:The incidence of pediatric inflammatory bowel disease (IBD) around the world is increasing. However, there is a scarcity of data on the epidemiology of pediatric IBD in the Southern Hemisphere. This study aimed to document the point prevalence of pediatric IBD in New Zealand on June 30, 2015. METHODS:All pa...

journal_title：Inflammatory bowel diseases

authors： Lopez RN,Evans HM,Appleton L,Bishop J,Chin S,Mouat S,Gearry RB,Day AS

更新日期：2017-08-01 00:00:00

abstract：:A prospective study was conducted to determine the implications of acute pouchitis on the long-term functional results of restorative proctocolectomy with J-pouch ileoanal anastomosis (IPAA). Between July 1988 and June 1996, 137 consecutive patients underwent IPAA for treatment of ulcerative colitis. 127 patients (93%...

journal_title：Inflammatory bowel diseases

authors： Hurst RD,Chung TP,Rubin M,Michelassi F

更新日期：1998-11-01 00:00:00

abstract：BACKGROUND:Many patients with Crohn's disease (CD) are treated with medications, including steroids, immunomodulators, and anti-tumor necrosis factor alpha (anti-TNF-α) agents, at the time of surgery. This study evaluated the effects of these medications on postoperative complications in CD patients. METHODS:This retr...

journal_title：Inflammatory bowel diseases

authors： Yu CS,Jung SW,Lee JL,Lim SB,Park IJ,Yoon YS,Kim CW,Yang SK,Ye BD,Park SH,Han M,Kim JC

更新日期：2019-08-20 00:00:00

abstract：BACKGROUND:To systematically determine the performance of diffusion-weighted imaging magnetic resonance enterography (DWI-MRE) for evaluating bowel inflammation in Crohn's disease and sources of heterogeneity between reported results. METHODS:We identified research studies that investigated DWI-MRE to diagnose bowel i...

journal_title：Inflammatory bowel diseases

authors： Choi SH,Kim KW,Lee JY,Kim KJ,Park SH

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:Gliotoxin, a fungal metabolite, has been known to show strong immunosuppressive properties, although its mechanisms are not completely understood. In this report, the authors investigated the mechanism whereby gliotoxin has anti-inflammatory properties in vitro and in trinitrobenzene sulfonic acid-induced co...

journal_title：Inflammatory bowel diseases

authors： Jun CD,Kim Y,Choi EY,Kim M,Park B,Youn B,Yu K,Choi KS,Yoon KH,Choi SC,Lee MS,Park KI,Choi M,Chung Y,Oh J

更新日期：2006-07-01 00:00:00

abstract：BACKGROUND:Chronic inflammation in ulcerative colitis (UC) is a sizeable risk factor for colorectal cancer (CRC). Interleukin-13 (IL-13) is elevated in the UC mucosa and may induce dysregulated signaling in neighboring intestinal epithelial cells (IECs) and thus function as a tumorogenic cytokine. METHODS:Expression o...

journal_title：Inflammatory bowel diseases

authors： Mandal D,Levine AD

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND:Although dysplasia is thought to be the precursor lesion in the development of colitis-associated colorectal cancer (CRC), a significant proportion of patients with ulcerative colitis (UC) and low-grade (LGD) or indefinite (IND) dysplasia remain cancer-free during endoscopic follow-up. There is a need for bi...

journal_title：Inflammatory bowel diseases

authors： van Schaik FD,Oldenburg B,Offerhaus GJ,Schipper ME,Vleggaar FP,Siersema PD,van Oijen MG,Ten Kate FJ

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND:PYRAMID was an international multicenter, noninterventional, postmarketing registry assessing long-term safety and effectiveness of adalimumab (Humira), as used in routine clinical practice. METHODS:Adult patients with moderately to severely active Crohn's disease with or without prior adalimumab experience...

journal_title：Inflammatory bowel diseases

authors： Loftus EV,Reinisch W,Panaccione R,Berg S,Alperovich G,Bereswill M,Kalabic J,Petersson J,Thakkar R,Robinson AM,D'Haens G

更新日期：2019-08-20 00:00:00

abstract：Background:Tumor necrosis factor alpha (TNF-α) inhibitors are linked with increased risk of reactivation of active tuberculosis. The QuantiFERON-TB Gold In-Tube test is approved for screening latent tuberculosis infection in children and adults. There are limited data on the test performance in children on long-term tr...

journal_title：Inflammatory bowel diseases

authors： Vortia E,Uko VE,Yen-Lieberman B,Frawley J,Worley SE,Danziger-Isakov L,Kaplan B,Mahajan L

更新日期：2018-03-19 00:00:00

abstract：BACKGROUND:Extracorporeal photopheresis (ECP) involves ex vivo leukocyte treatment with methoxsalen and UVA light to generate a tolerogenic response. A previous trial demonstrated that ECP permits corticosteroid withdrawal in steroid-dependent Crohn's disease (CD) patients who were in clinical remission. We studied the...

journal_title：Inflammatory bowel diseases

authors： Reinisch W,Knobler R,Rutgeerts PJ,Ochsenkühn T,Anderson F,von Tirpitz C,Kaatz M,Janneke van der Woude C,Parenti D,Mannon PJ

更新日期：2013-02-01 00:00:00

abstract：:Treatment adherence is of critical importance in the management of patients with IBD. Poor adherence can lead to increased disease activity, loss of response to therapy, and increased costs of care. It has been well established that adherence to long-term therapy for chronic illnesses is extremely poor, averaging arou...

journal_title：Inflammatory bowel diseases

authors： Herman ML,Kane SV

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:Inflammatory bowel diseases (IBDs) are associated with up-regulation of TNFα, hyperactivation of proinflammatory effector T cells (Teffs) and inefficient control by regulatory CD4(+) CD25(+) Foxp3(+) T cells (Tregs). The aim of this prospective study was to investigate the short-term impact of treatment of I...

journal_title：Inflammatory bowel diseases

authors： Boschetti G,Nancey S,Sardi F,Roblin X,Flourié B,Kaiserlian D

更新日期：2011-01-01 00:00:00

abstract：Backgrounds:We sought to describe the outcomes of endoscopic therapy of luminal strictures in patients with Crohn's disease (CD) at a large tertiary referral center. Methods:All patients who had undergone endoscopic dilation of CD strictures between January 1, 1990 and November 30, 2013 were identified. Demographics, ...

journal_title：Inflammatory bowel diseases

authors： Shivashankar R,Edakkanambeth Varayil J,Scott Harmsen W,Faubion WA,Wong Kee Song LM,Bruining DH,Schroeder KW,Kisiel J,Loftus EV Jr,Coelho Prabhu N

更新日期：2018-06-08 00:00:00

abstract：:Recent reports suggest that unfractionated heparin may be a useful adjunct in the treatment of inflammatory bowel disease (IBD). We report the successful use of subcutaneous unfractionated heparin to treat a moderate-to-severe flare of Crohn's disease during pregnancy, which was refractory to standard therapy. The pat...

journal_title：Inflammatory bowel diseases

authors： Prajapati DN,Newcomer JR,Emmons J,Abu-Hajir M,Binion DG

更新日期：2002-05-01 00:00:00

abstract：BACKGROUND:The pregnane X receptor (PXR/NR1I2) is an important regulator of xenobiotic metabolism and intestinal integrity. However, there are controversial studies on the role of PXR/NR1I2 in inflammatory bowel disease (IBD). We therefore initiated the largest analysis to date on PXR/NR1I2 gene variants in IBD patient...

journal_title：Inflammatory bowel diseases

authors： Glas J,Seiderer J,Fischer D,Tengler B,Pfennig S,Wetzke M,Beigel F,Olszak T,Weidinger M,Göke B,Ochsenkühn T,Folwaczny M,Müller-Myhsok B,Diegelmann J,Czamara D,Brand S

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND:The clinical implication of Clostridium difficile infection (CDI) in patients with ileal pouch-anal anastomosis (IPAA) for underlying inflammatory bowel disease (IBD) has not been well studied. This study was designed to investigate the cumulative incidence, risk factors, and outcome of CDI in patients with ...

journal_title：Inflammatory bowel diseases

authors： Li Y,Qian J,Queener E,Shen B

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND:Although many genetic variants are identified in association with Crohn's disease (CD), CARD15, IL23R, and ATG16L1 association with CD have been firmly confirmed in Caucasians of European ancestry. The prevalence of CD is rapidly rising in Brazil, where European ancestry is firmly admixed with natives and Af...

journal_title：Inflammatory bowel diseases

authors： Baptista ML,Amarante H,Picheth G,Sdepanian VL,Peterson N,Babasukumar U,Lima HC,Kugathasan S

更新日期：2008-05-01 00:00:00

abstract：BACKGROUND:The clinical course of ulcerative colitis (UC) is unpredictable. During recent years, the ability of fecal biomarkers to predict relapse in inflammatory bowel disease has been evaluated. The objective of this study was to assess fecal calprotectin (FC) as a predictor of disease recurrence in patients with ne...

journal_title：Inflammatory bowel diseases

authors： Lasson A,Simrén M,Stotzer PO,Isaksson S,Ohman L,Strid H

更新日期：2013-03-01 00:00:00