IBD Systems Biology Is Here to Stay.

abstract：:We report genome-wide linkage results using model-free linkage analysis (Allegro) of 358 autosomal microsatellites in 260 new inflammatory bowel disease-affected relative pairs from 139 Caucasian families, including 108 Crohn's disease-affected relative pairs and 72 ulcerative colitis-affected relative pairs. Our resu...

journal_title：Inflammatory bowel diseases

authors： Barmada MM,Brant SR,Nicolae DL,Achkar JP,Panhuysen CI,Bayless TM,Cho JH,Duerr RH

更新日期：2004-09-01 00:00:00

abstract：BACKGROUND:The risk of suicide is increased among people with inflammatory bowel disease (IBD); however, most of the evidence regarding this association comes from studies of all-cause mortality, with small numbers of people who have committed suicide, or from clinical case reports. The current study examined the assoc...

journal_title：Inflammatory bowel diseases

authors： Gradus JL,Qin P,Lincoln AK,Miller M,Lawler E,Sørensen HT,Lash TL

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:Various physician- and patient-reported instruments exist for quantification of disease activity in inflammatory bowel diseases (IBD) but none are widely used in routine clinical practice. A simple patient-reported outcome measure might help inform clinical decision making. We evaluated a patient-reported 0 ...

journal_title：Inflammatory bowel diseases

authors： Subramanian S,Asher R,Weston W,Rimmer M,McConville A,Malin A,Jackson R,Collins P,Probert C,Dibb M,Rhodes JM

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND:The inflammatory bowel diseases (IBDs) are chronic inflammatory disorders, associated with genetic, immunologic, and environmental factors. Although hundreds of genes are implicated in IBD etiology, it is likely that additional genes play a role in the disease process. We developed a machine learning-based g...

journal_title：Inflammatory bowel diseases

authors： Isakov O,Dotan I,Ben-Shachar S

更新日期：2017-09-01 00:00:00

abstract：:The peak incidence of the inflammatory bowel diseases (IBDs) is between the second and fourth decades of life, which coincides with prime reproductive years. Unplanned or mistimed pregnancies may account for nearly half of all pregnancies and are associated with adverse consequences such as a higher risk of delayed pr...

journal_title：Inflammatory bowel diseases

authors： Limdi JK,Farraye J,Cannon R,Woodhams E,Farraye FA

更新日期：2019-09-18 00:00:00

abstract：BACKGROUND:Advanced oxidation protein products (AOPPs) are new protein markers of oxidative stress with pro-inflammatory properties, accumulated in many pathological conditions. The issue of their enhanced formation in IBD has not been addressed yet. METHODS:The concentration of relative AOPPs (rAOPP; concentration of...

journal_title：Inflammatory bowel diseases

authors： Krzystek-Korpacka M,Neubauer K,Berdowska I,Boehm D,Zielinski B,Petryszyn P,Terlecki G,Paradowski L,Gamian A

更新日期：2008-06-01 00:00:00

abstract：INTRODUCTION:Antitumor necrosis factor (anti-TNF) medications are known to be highly efficacious in persons with moderate-to-severe inflammatory bowel disease (IBD). There is a paucity of data from population-based sources to elucidate persistence with these medications in the general population of IBD. Discontinuation...

journal_title：Inflammatory bowel diseases

authors： Targownik LE,Tennakoon A,Leung S,Lix LM,Nugent Z,Singh H,Bernstein CN

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:CEACAM1, CEACAM5, and CEACAM6 represent 3 of the CEACAM (carcinoembryonic antigen-related cell adhesion molecule) subfamily members expressed on intestinal epithelial cells (IECs). Deficiency in their expression, as seen in inflammatory bowel disease (IBD), results in the lack of activation of CD8+ regulator...

journal_title：Inflammatory bowel diseases

authors： Roda G,Dahan S,Mezzanotte L,Caponi A,Roth-Walter F,Pinn D,Mayer L

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND:Easily accessible predictors of disease course in inflammatory bowel disease (IBD) are scarce, and it remains largely unknown whether a family history of IBD predicts the course of Crohn's disease (CD) and ulcerative colitis (UC). We aimed to compare the course of disease in familial and sporadic cases of IB...

journal_title：Inflammatory bowel diseases

authors： Trier Moller F,Andersen V,Andersson M,Jess T

更新日期：2015-12-01 00:00:00

abstract：Background:Patients requiring optimization of therapy for suboptimal response and/or targeting more robust outcomes may eventually reach high serum levels. Data evaluating the relationship between infliximab concentration and toxicity are limited. The aim of this study was to evaluate the frequency of adverse events (A...

journal_title：Inflammatory bowel diseases

authors： Greener T,Kabakchiev B,Steinhart AH,Silverberg MS

更新日期：2018-07-12 00:00:00

abstract：BACKGROUND:Mesenchymal stem cells (MSCs) have demonstrated significant potentials for the treatment of inflammatory bowel disease. Clinical feasible methods to individually document the MSC recruitment to intestinal mucosa is lacking. Here, we proposed that endomicroscopy could noninvasively track MSCs in vivo at cellu...

journal_title：Inflammatory bowel diseases

authors： Li M,Zhang YX,Zhang Z,Zhou XY,Zuo XL,Cong Y,Li YQ

更新日期：2015-09-01 00:00:00

abstract：:Inflammatory bowel disease (IBD) is now recognized as a common chronic disease affecting children and adolescents. This article will review recent advances made in the fields of genetics, epidemiology, gut ecology, and immunology regarding the etiopathogenesis of IBD, with particular emphasis on the contributions made...

journal_title：Inflammatory bowel diseases

authors： Oliva-Hemker M,Fiocchi C

更新日期：2002-03-01 00:00:00

abstract：INTRODUCTION:Concurrent cytomegalovirus (CMV) in inflammatory bowel disease-related colitis is an important yet complex clinical scenario associated with high rates of colectomy and other morbidity. This review aimed to examine the literature to produce a comprehensive diagnostic and treatment algorithm for the managem...

journal_title：Inflammatory bowel diseases

authors： Beswick L,Ye B,van Langenberg DR

更新日期：2016-12-01 00:00:00

abstract：:Inflammatory bowel diseases (IBD) include ulcerative colitis and Crohn's disease. The immune response in ulcerative colitis is different from the Crohn's disease. Accumulating evidence suggests that IBD results from an inappropriate inflammatory response to intestinal microbes in a genetically susceptible host. Severa...

journal_title：Inflammatory bowel diseases

authors： Fonseca-Camarillo G,Yamamoto-Furusho JK

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:Children with Crohn's disease (CD) suffer from malnutrition. Understanding substrate utilization during exercise may help patients with CD sustain a healthy active lifestyle without compromising nutrition. The aim of this study was to determine whether substrate utilization and bioavailability during exercis...

journal_title：Inflammatory bowel diseases

authors： Nguyen T,Ploeger HE,Obeid J,Issenman RM,Baker JM,Takken T,Parise G,Timmons BW

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Mucosa-associated Escherichia coli are abundant in inflammatory bowel disease (IBD), but whether these bacteria gain intracellular access within the mucosa is uncertain. If E. coli does gain intracellular access, the contribution of bacterial pathogenicity to this requires further elucidation. This study aim...

journal_title：Inflammatory bowel diseases

authors： Elliott TR,Hudspith BN,Wu G,Cooley M,Parkes G,Quiñones B,Randall L,Mandrell RE,Fagerquist CK,Brostoff J,Rayment NB,Boussioutas A,Petrovska L,Sanderson JD

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:Many chronic illnesses are accompanied by impaired cognitive functioning. In people with Inflammatory Bowel Disease (IBD), there is some research to suggest a decrement in verbal IQ (VIQ), when compared to people with Irritable Bowel Syndrome (IBS) and healthy controls. Although this is an important finding,...

journal_title：Inflammatory bowel diseases

authors： Dancey CP,Attree EA,Stuart G,Wilson C,Sonnet A

更新日期：2009-06-01 00:00:00

abstract：:Inflammatory bowel disease is associated with industrialization, and its incidence has increased markedly over time. The prospect of reversing these trends motivates the search for the agent(s) involved. Modernity entails several physical and behavioral modifications that compromise both the photosynthesis of cholecal...

journal_title：Inflammatory bowel diseases

authors： Palmer MT,Weaver CT

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:Patients suffering from Crohn's disease (CD) show increased incidence of low bone mineral density. Investigating this complication is difficult because the exact etiology of CD remains elusive. Mice carrying a deletion in the tumor necrosis factor (TNF) AU-rich elements (ARE) are reported as a model for huma...

journal_title：Inflammatory bowel diseases

authors： Huybers S,Apostolaki M,van der Eerden BC,Kollias G,Naber TH,Bindels RJ,Hoenderop JG

更新日期：2008-06-01 00:00:00

abstract：:Nephrotoxicity has been described in some patients with inflammatory bowel disease (IBD) treated with 5-aminosalicylic acid (5-ASA). Studies with 5-ASA treatment in which serum creatinine or creatinine clearance was measured regularly show that nephrotoxicity is exceptional (mean rate of only 0.26% per patient-year). ...

journal_title：Inflammatory bowel diseases

authors： Gisbert JP,González-Lama Y,Maté J

更新日期：2007-05-01 00:00:00

abstract：BACKGROUND:Crohn's disease is a heterogeneous disease, and several classification systems have been developed to classify the patients in more homogeneous groups. Our aim was to assess the intra- and interobserver variation when classifying patients according to the widely used Vifenna classification. METHODS:Ten rand...

journal_title：Inflammatory bowel diseases

authors： Riis L,Munkholm P,Binder V,Skovgaard LT,Langholz E

更新日期：2005-07-01 00:00:00

abstract：:Anorexia, malnutrition, altered body composition and development of mesenteric obesity are well known features of inflammatory bowel disease (IBD). Recent data suggest that dysregulation of protein secretion by white adipose tissue is involved in these manifestations of patients with IBD. Adipocytes are recently recog...

journal_title：Inflammatory bowel diseases

authors： Karmiris K,Koutroubakis IE,Kouroumalis EA

更新日期：2005-09-01 00:00:00

abstract：BACKGROUND:Recent animal studies and clinical trials suggest that thiazolidinediones, a class of oral antidiabetic agents, are efficacious in reducing inflammation, yet no studies have evaluated their effectiveness in preventing flares. We examined the association between thiazolidinedione use and ulcerative colitis (U...

journal_title：Inflammatory bowel diseases

authors： Lund JL,Stürmer T,Porter CQ,Sandler RS,Kappelman MD

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:We aimed to determine the prevalence of adverse childhood experiences (ACEs) in persons with inflammatory bowel disease (IBD) and whether having ACEs was associated with health care utilization post-IBD diagnosis. METHOD:Three hundred forty-five participants from the population-based Manitoba IBD Cohort Stu...

journal_title：Inflammatory bowel diseases

authors： Witges KM,Bernstein CN,Sexton KA,Afifi T,Walker JR,Nugent Z,Lix LM

更新日期：2019-09-18 00:00:00

abstract：BACKGROUND:The Crohn's Disease Activity Index (CDAI) has been criticized for being weakly correlated with bowel inflammation. We assessed correlation between Simple Endoscopic Score for Crohn's Disease (SES-CD) and individual CDAI items stratified by disease location to better understand this relationship. METHODS:We ...

journal_title：Inflammatory bowel diseases

authors： Lewis JD,Rutgeerts P,Feagan BG,D'haens G,Danese S,Colombel JF,Reinisch W,Rubin DT,Selinger C,Bewtra M,Barcomb L,Lacerda AP,Wallace K,Butler JW,Wu M,Zhou Q,Liao X,Sandborn WJ

更新日期：2020-01-06 00:00:00

abstract：BACKGROUND:Mesalamine suppositories are first-line therapy in active ulcerative proctitis; the standard regime still recommends multiple doses per day. The primary objective of this study was to show the noninferiority of once-daily administration of a novel 1 g mesalamine suppository versus thrice-daily administration...

journal_title：Inflammatory bowel diseases

authors： Andus T,Kocjan A,Müser M,Baranovsky A,Mikhailova TL,Zvyagintseva TD,Dorofeyev AE,Lozynskyy YS,Cascorbi I,Stolte M,Vieth M,Dilger K,Mohrbacher R,Greinwald R,International Salofalk Suppository OD Study Group.

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND:Long-term enteral nutrition may maintain clinical and endoscopic remission in patients with Crohn's disease (CD). The aim of this prospective study was to investigate the impacts of long-term enteral nutrition on clinical and endoscopic disease activities and mucosal tissue cytokines in patients with quiesce...

journal_title：Inflammatory bowel diseases

authors： Yamamoto T,Nakahigashi M,Saniabadi AR,Iwata T,Maruyama Y,Umegae S,Matsumoto K

更新日期：2007-12-01 00:00:00

abstract：BACKGROUND:Inflammatory bowel disease (IBD) causes serious morbidity and disability, and the incidence is increasing. The disease etiology is not well understood, though inflammatory reactions after antibiotic exposure may be associated with development of IBD. We investigated the association between IBD and prior anti...

journal_title：Inflammatory bowel diseases

authors： Troelsen FS,Jick S

更新日期：2020-02-11 00:00:00

abstract：Background and aims:To assess whether obesity may affect natural history of inflammatory bowel diseases (IBD), we conducted an individual participant data (IPD) pooled analysis of placebo arms, using data from clinical trials of infliximab in IBD and using the Yale Open Data Access (YODA) Project. Methods:We obtained ...

journal_title：Inflammatory bowel diseases

authors： Singh S,Proudfoot J,Xu R,Sandborn WJ

更新日期：2018-09-15 00:00:00

abstract：BACKGROUND:The purpose of the study was to determine the role of fecal calprotectin and lactoferrin in the prediction of inflammatory bowel disease relapses, both in patients with ulcerative colitis (UC) and Crohn's disease (CD), in a large, long-term, follow-up study. METHODS:The prospective multicenter study include...

journal_title：Inflammatory bowel diseases

authors： Gisbert JP,Bermejo F,Pérez-Calle JL,Taxonera C,Vera I,McNicholl AG,Algaba A,López P,López-Palacios N,Calvo M,González-Lama Y,Carneros JA,Velasco M,Maté J

更新日期：2009-08-01 00:00:00