Overexpression of ATP-activated P2X7 receptors in the intestinal mucosa is implicated in the pathogenesis of Crohn's disease.

abstract：BACKGROUND:High levels of patient activation (having the knowledge, skills, and confidence to effectively manage one's care), have been associated with improved outcomes in many chronic conditions. There have been few studies of the effects of activation in patients with inflammatory bowel disease (IBD). We performed a...

journal_title：Inflammatory bowel diseases

authors： Barnes EL,Long MD,Kappelman MD,Martin CF,Sandler RS

更新日期：2019-06-18 00:00:00

abstract：:Chronic inflammatory bowel disease (IBD) presents as two major clinical forms, Crohn's disease (CD) and ulcerative colitis (UC). Genetic epidemiological studies and animal models suggest that inherited factors play significant roles in the susceptibility to both forms of IBD. From four genome-wide scans, putative susc...

journal_title：Inflammatory bowel diseases

authors： Ma Y,Ohmen JD,Li Z,Bentley LG,McElree C,Pressman S,Targan SR,Fischel-Ghodsian N,Rotter JI,Yang H

更新日期：1999-11-01 00:00:00

abstract：:Recent reports have focused interest on human cytomegalovirus (HCMV) in inflammatory bowel diseases (IBD). Our aim in this study was to examine the frequency of HCMV-infected intestinal cells in tissue sections obtained from patients with IBD, and to investigate if HCMV-infected intestinal cells produce the proinflamm...

journal_title：Inflammatory bowel diseases

authors： Rahbar A,Boström L,Lagerstedt U,Magnusson I,Söderberg-Naucler C,Sundqvist VA

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND:Infliximab levels have been reported to be associated with mucosal healing (MH) in Crohn's disease (CD). However, whether the association differs between postinduction (week 14) and maintenance (week 30) has seldom been investigated. We aimed to analyze the association between serum infliximab trough levels ...

journal_title：Inflammatory bowel diseases

authors： Feng T,Chen B,Ungar B,Qiu Y,Zhang S,He J,Lin S,He Y,Zeng Z,Ben-Horin S,Chen M,Mao R

更新日期：2019-10-18 00:00:00

abstract：BACKGROUND:Individuals with ulcerative colitis are at high risk of developing colitis-associated cancer. 5-Aminosalicylate (5-ASA) protects from cancer by its antiinflammatory activity as well as by altering cell growth, inducing apoptosis, and reducing replication errors. So far neither 5-ASA's structural specificity ...

journal_title：Inflammatory bowel diseases

authors： Campregher C,Luciani MG,Biesenbach P,Evstatiev R,Lyakhovich A,Gasche C

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND:The widespread use of the Internet allows for unique research opportunities. We aimed to develop and follow an Internet-based cohort (e-cohort) of patients with self-reported inflammatory bowel diseases (IBD) over time. METHODS:We established an e-cohort of adults with IBD (CCFA Partners) by recruiting thro...

journal_title：Inflammatory bowel diseases

authors： Long MD,Kappelman MD,Martin CF,Lewis JD,Mayer L,Kinneer PM,Sandler RS

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:Patients with Crohn's disease (CD) with small bowel strictures are at risk of surgery. Double-balloon enteroscopy (DBE) can evaluate the status of the small intestine, and retrograde contrast through the scope enables the surgeon to obtain information beyond the reach of the scope. This study aimed to examin...

journal_title：Inflammatory bowel diseases

authors： Okazaki N,Inokuchi T,Hiraoka S,Ohmori M,Takashima S,Takei D,Sugihara Y,Takahara M,Harada K,Kawano S,Okada H,Kato J

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Inflammatory bowel disease (IBD) and endometriosis are immune-mediated chronic inflammatory disorders affecting young women. The clinical significance of concomitant endometriosis on the course of IBD has not been previously studied. The aim of this study was to determine whether women with concomitant endom...

journal_title：Inflammatory bowel diseases

authors： Lee KK,Jharap B,Maser EA,Colombel JF

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:This study compared the efficacy of an elemental formula (EF) to a polymeric formula (PF) in inducing remission for pediatric Crohn's disease (CD). METHODS:Newly diagnosed CD children were randomized to EF or PF for 6 weeks. Change in the Pediatric Crohn's Disease Activity Index (PCDAI), fecal calprotectin,...

journal_title：Inflammatory bowel diseases

authors： Grogan JL,Casson DH,Terry A,Burdge GC,El-Matary W,Dalzell AM

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND:Improving granulocyte function may represent an effective therapy for Crohn's disease (CD). We performed a Phase I-2 trial of sargramostim (SRG) in children with CD. METHODS:This was multicenter, open-label study in 6-16-year-old patients with moderate to severely active CD. Patients received either 4 or 6 ...

journal_title：Inflammatory bowel diseases

authors： Kelsen JR,Rosh J,Heyman M,Winter HS,Ferry G,Cohen S,Mamula P,Baldassano RN

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND:Granulocyte-macrophage colony-stimulating factor (GM-CSF) therapy is effective in treating some Crohn's disease (CD) patients and protects mice from colitis induced by dextran sulfate sodium (DSS) administration. However, its mechanisms of action remain elusive. We hypothesized that GM-CSF affects intestinal...

journal_title：Inflammatory bowel diseases

authors： Bernasconi E,Favre L,Maillard MH,Bachmann D,Pythoud C,Bouzourene H,Croze E,Velichko S,Parkinson J,Michetti P,Velin D

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND:Inflammation-associated lymphangiogenesis (IAL) is frequently observed in inflammatory bowel diseases. IAL is believed to limit inflammation by enhancing fluid and immune cell clearance. Although monocytes/macrophages (MΦ) are known to contribute to intestinal pathology in inflammatory bowel disease, their r...

journal_title：Inflammatory bowel diseases

authors： Becker F,Kurmaeva E,Gavins FN,Stevenson EV,Navratil AR,Jin L,Tsunoda I,Orr AW,Alexander JS,Ostanin DV

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:Immunomodulator (IM) treatments in ulcerative colitis (UC) are not curative and carry increased risk of complications, sometimes leading to therapy changes, reduced treatment benefits, and eventual relapse. We assessed patterns of IM utilization and therapy changes, complications, and disease relapse in a re...

journal_title：Inflammatory bowel diseases

authors： Loftus EV Jr,Davis KL,Wang CC,Dastani H,Luo A

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:Antimicrobial peptides (AMPs) maintain a sterile environment in intestinal crypts, limiting microbial colonization and invasion. Decreased AMP expression is proposed to increase the risk for inflammatory bowel disease. Expression and function of inducible AMPs, human β-defensin 2 and 3 (hBD-2 and hBD-3), rem...

journal_title：Inflammatory bowel diseases

authors： Meisch JP,Nishimura M,Vogel RM,Sung HC,Bednarchik BA,Ghosh SK,Fu P,McCormick T,Weinberg A,Levine AD

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND:L-arginine (L-Arg) is the substrate for both inducible nitric oxide (NO) synthase (NOS2) and arginase (ARG) enzymes. L-Arg is actively transported into cells by means of cationic amino acid transporter (SLC7) proteins. We have linked L-Arg and arginase 1 activity to epithelial restitution. Our aim was to det...

journal_title：Inflammatory bowel diseases

authors： Coburn LA,Horst SN,Allaman MM,Brown CT,Williams CS,Hodges ME,Druce JP,Beaulieu DB,Schwartz DA,Wilson KT

更新日期：2016-08-01 00:00:00

abstract：:: Primary nonresponse and primary nonremission are important limitations of tumor necrosis factor (TNF) antagonists, occurring in 10% to 40% and 50% to 80% of patients with inflammatory bowel disease, respectively. The magnitude of primary nonresponse differs between phase III clinical trials and cohort studies, indic...

journal_title：Inflammatory bowel diseases

authors： Papamichael K,Gils A,Rutgeerts P,Levesque BG,Vermeire S,Sandborn WJ,Vande Casteele N

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Chronic inflammatory diseases are characterized by massive infiltration of innate and acquired immune cells in inflammatory sites. However, it remains unclear how these cells cooperate in the development of disease. Although bone marrow (BM) is a primary site for hematopoiesis of immune cells except T cells,...

journal_title：Inflammatory bowel diseases

authors： Nemoto Y,Kanai T,Tohda S,Totsuka T,Okamoto R,Tsuchiya K,Nakamura T,Sakamoto N,Fukuda T,Miura O,Yagita H,Watanabe M

更新日期：2008-11-01 00:00:00

abstract：BACKGROUND:Inflammatory bowel disease (IBD) is proposed to result from a dysregulated mucosal immune response to the colonic flora in genetically susceptible individuals. Enterotoxigenic Bacteroides fragilis (ETBF), a molecular subclass of the common human commensal, B. fragilis, has been associated with IBD. This stud...

journal_title：Inflammatory bowel diseases

authors： Rabizadeh S,Rhee KJ,Wu S,Huso D,Gan CM,Golub JE,Wu X,Zhang M,Sears CL

更新日期：2007-12-01 00:00:00

abstract：BACKGROUND:Inflammatory bowel disease is a chronic inflammatory disorder of the gastrointestinal tract that significantly impacts the health-related quality of life (HR-QOL). A decreased HR-QOL has been demonstrated in patients with active disease compared with patients in remission. In this cross-sectional study, we e...

journal_title：Inflammatory bowel diseases

authors： Zhang CK,Hewett J,Hemming J,Grant T,Zhao H,Abraham C,Oikonomou I,Kanakia M,Cho JH,Proctor DD

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:The efficacy of anti-tumor necrosis factor monoclonal antibody (anti-TNF mAb) for Crohn's disease (CD) is well established, and anti-interleukin-6 receptor (anti-IL-6R) mAb has also been reported to be effective in CD. It is, however, unclear if the efficacy and mechanisms of both agents are different in CD ...

journal_title：Inflammatory bowel diseases

authors： Terabe F,Fujimoto M,Serada S,Shinzaki S,Iijima H,Tsujii M,Hayashi N,Nomura S,Kawahata H,Jang MH,Miyasaka M,Mihara M,Ohsugi Y,Kishimoto T,Naka T

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND:Circulating chromogranin A (CgA) levels, a marker for neuroendocrine tumors including carcinoids, have recently been found elevated in some patients with inflammatory bowel disease (IBD), although their significance is unclear. Therefore, we aimed to evaluate CgA levels and their possible relationship with c...

journal_title：Inflammatory bowel diseases

authors： Sciola V,Massironi S,Conte D,Caprioli F,Ferrero S,Ciafardini C,Peracchi M,Bardella MT,Piodi L

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND:Recent animal studies and clinical trials suggest that thiazolidinediones, a class of oral antidiabetic agents, are efficacious in reducing inflammation, yet no studies have evaluated their effectiveness in preventing flares. We examined the association between thiazolidinedione use and ulcerative colitis (U...

journal_title：Inflammatory bowel diseases

authors： Lund JL,Stürmer T,Porter CQ,Sandler RS,Kappelman MD

更新日期：2011-03-01 00:00:00

abstract：:The aim of this study was to describe the clinical course of Crohn's disease (CD) in a well-defined, homogeneous groups of patients. A total of 480 patients with CD were followed up from diagnosis up to 20 years. Definitions of patient subgroups were made according to the Vienna Classification. Markov chain analysis w...

journal_title：Inflammatory bowel diseases

authors： Veloso FT,Ferreira JT,Barros L,Almeida S

更新日期：2001-11-01 00:00:00

abstract：BACKGROUND:The incidence of inflammatory bowel disease (IBD) has increased over the past several decades with a corresponding increase in the number of patients on combination immunosuppressive therapy including corticosteroids, anti-metabolites and biologic agents. The exact incidence of pneumocystis jiroveci pneumoni...

journal_title：Inflammatory bowel diseases

authors： Okafor PN,Nunes DP,Farraye FA

更新日期：2013-07-01 00:00:00

abstract：:Restorative proctocolectomy with ileal-pouch anal anastomosis (RPC) is the operation of choice for ulcerative colitis (UC) patients requiring surgery. It is also used for patients with familial adenomatous polyposis (FAP). Pouchitis accounts for 10% of pouch failures. It is an idiopathic inflammatory condition that ma...

journal_title：Inflammatory bowel diseases

authors： Landy J,Al-Hassi HO,McLaughlin SD,Knight SC,Ciclitira PJ,Nicholls RJ,Clark SK,Hart AL

更新日期：2012-06-01 00:00:00

abstract：:After 20 years of successful targeting of pro-inflammatory cytokines for the treatment of IBD, an alternative therapeutic strategy has emerged, based on several decades of advances in understanding the pathogenesis of IBD. The targeting of molecules involved in leukocyte traffic has recently become a safe and effectiv...

journal_title：Inflammatory bowel diseases

authors： Pérez-Jeldres T,Tyler CJ,Boyer JD,Karuppuchamy T,Bamias G,Dulai PS,Boland BS,Sandborn WJ,Patel DR,Rivera-Nieves J

更新日期：2019-01-10 00:00:00

abstract：BACKGROUND:The potentially high costs of care associated with inflammatory bowel disease are recognized. A knowledge-based self-management approach seems to reduce health care costs, improve disease control, and reduce indirect costs. The aim of this study was to determine whether there is a significant association bet...

journal_title：Inflammatory bowel diseases

authors： Colombara F,Martinato M,Girardin G,Gregori D

更新日期：2015-03-01 00:00:00

abstract：:MicroRNAs (miRNAs) are single-stranded RNA molecules, which influence the translation of messenger RNA and hence protein synthesis. The altered expression of miRNAs in disease states in cancer and autoimmune diseases including inflammatory bowel disease is providing new insights into disease pathogenesis. This underst...

journal_title：Inflammatory bowel diseases

authors： Whiteoak SR,Felwick R,Sanchez-Elsner T,Fraser Cummings JR

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND:The optimal management of Clostridium difficile infection (CDI) in flaring inflammatory bowel disease (IBD) patients has not been defined. Limited data suggest that coadministration of immunomodulators (IM) with antibiotics (AB) results in a worse outcome. We investigated the prevalent practice among North A...

journal_title：Inflammatory bowel diseases

authors： Yanai H,Nguyen GC,Yun L,Lebwohl O,Navaneethan U,Stone CD,Ghazi L,Moayyedi P,Brooks J,Bernstein CN,Ben-Horin S

更新日期：2011-07-01 00:00:00

abstract：:Citrullination is a posttranslational modification of proteins mediated by a specific family of enzymes called peptidylarginine deiminases (PAD). Dysregulation of these enzymes is involved in the etiology of various diseases, from cancer to autoimmune disorders. In inflammatory bowel disease (IBD), data for a role of ...

journal_title：Inflammatory bowel diseases

authors： Dragoni G,De Hertogh G,Vermeire S

更新日期：2021-01-01 00:00:00