Immunoregulatory Pathways Involved in Inflammatory Bowel Disease.

Abstract:

:Inflammatory bowel diseases (IBD) include ulcerative colitis and Crohn's disease. The immune response in ulcerative colitis is different from the Crohn's disease. Accumulating evidence suggests that IBD results from an inappropriate inflammatory response to intestinal microbes in a genetically susceptible host. Several immunoregulatory abnormalities have been reported in patients with IBD, including the ratio of proinflammatory (tumor necrosis factor alpha, IL-6, IL-1-β) to immunoregulatory cytokines (IL-10, TGF-β, IL-35) and selective activation of T-helper (Th) lymphocyte subsets (Th1, Th2, Th9, Th17, and regulatory T cells). The purpose of this review is to show the immunoregulatory pathways (regulatory cells and cytokines) involved in IBD published in recent years.

journal_name

Inflamm Bowel Dis

authors

Fonseca-Camarillo G,Yamamoto-Furusho JK

doi

10.1097/MIB.0000000000000477

subject

Has Abstract

pub_date

2015-09-01 00:00:00

pages

2188-93

issue

9

eissn

1078-0998

issn

1536-4844

journal_volume

21

pub_type

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