Are sTWEAK and IL-17A Levels in Inflammatory Bowel Disease Associated with Disease Activity and Etiopathogenesis?

abstract：BACKGROUND:Toll-like receptor 5 (TLR5) is implicated in the innate and adaptive immune responses that are associated with inflammatory bowel disease (IBD). In humans TLR5 is expressed on CD4(+) T cells and costimulation with flagellin potentiates effector and regulatory T cell responses. The aim of this study was to de...

journal_title：Inflammatory bowel diseases

authors： Hardenberg G,Yao Y,Piccirillo CA,Levings MK,Steiner TS

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Mucosal expression of interferon (IFN)-γ plays a pivotal role in the pathogenesis of inflammatory bowel disease (IBD) and IBD risk regions flank IFNG. The conserved IFNG rs1861494 T/C introduces a new CpG methylation site, is associated with disease severity and lack of therapeutic response in other infectio...

journal_title：Inflammatory bowel diseases

authors： Gonsky R,Deem RL,Landers CJ,Haritunians T,Yang S,Targan SR

更新日期：2014-10-01 00:00:00

abstract：PURPOSE:To describe the reported health-related quality of life (HRQOL) in children and adolescents with inflammatory bowel disease (IBD) after attending an IBD summer camp. METHODS:A prospective analysis of quality of life was completed at an overnight camp that was exclusively for patients with IBD, which was sponso...

journal_title：Inflammatory bowel diseases

authors： Shepanski MA,Hurd LB,Culton K,Markowitz JE,Mamula P,Baldassano RN

更新日期：2005-02-01 00:00:00

abstract：BACKGROUND:Mucosal healing (MH) is associated with improved clinical outcomes in patients with Crohn's disease (CD) and ulcerative colitis (UC). MH as a target for treatment has been suggested, although there is little pediatric data. The goal of this study was to evaluate MH in clinical practice in pediatric patients ...

journal_title：Inflammatory bowel diseases

authors： Santha SL,Shankar PR,Pan A,Schoen B,Kugathasan S,Sauer CG

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:Clostridium difficile infection (CDI) and Cytomegalovirus (CMV) reactivation are associated with disease exacerbations and poor outcomes in inflammatory bowel disease (IBD). Therefore, we assessed the association between these organisms in patients with IBD and the impact on colectomy. METHODS:A retrospecti...

journal_title：Inflammatory bowel diseases

authors： McCurdy JD,Enders FT,Khanna S,Bruining DH,Jones A,Killian JM,Tariq R,Smyrk TC,Loftus EV Jr

更新日期：2016-11-01 00:00:00

abstract：:Crohn's disease (CD) may affect any part of the gastrointestinal tract. When isolated to the colon, and patients become medically refractory, there are several surgical options - segmental resection, subtotal colectomy with ileorectal anastomosis, or a total proctocolectomy and end ileostomy. Unfortunately, surgery do...

journal_title：Inflammatory bowel diseases

authors： Lightner AL

更新日期：2018-02-15 00:00:00

abstract：BACKGROUND:Tumor necrosis factor alpha (TNFalpha) plays a central role in the pathology of T helper 1-mediated colitis such as Crohn's disease; however, the role of its 2 receptors in mediating pathology has not been fully explored. METHODS:Trinitrobenzene sulfonic acid colitis was used to induce colitis in mice lacki...

journal_title：Inflammatory bowel diseases

authors： Ebach DR,Newberry R,Stenson WF

更新日期：2005-06-01 00:00:00

abstract：:Inflammatory bowel disease is associated with industrialization, and its incidence has increased markedly over time. The prospect of reversing these trends motivates the search for the agent(s) involved. Modernity entails several physical and behavioral modifications that compromise both the photosynthesis of cholecal...

journal_title：Inflammatory bowel diseases

authors： Palmer MT,Weaver CT

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:Traditional techniques analyzing mouse colitis are invasive, laborious, or indirect. Development of in vivo imaging techniques for specific colitis processes would be useful for monitoring disease progression and/or treatment effectiveness. The aim was to evaluate the applicability of the chemiluminescent pr...

journal_title：Inflammatory bowel diseases

authors： Asghar MN,Emani R,Alam C,Helenius TO,Grönroos TJ,Sareila O,Din MU,Holmdahl R,Hänninen A,Toivola DM

更新日期：2014-08-01 00:00:00

abstract：:Inflammatory bowel disease (IBD) is a chronic remitting disorder with increasing incidence worldwide. The intestinal epithelial barrier plays a major role in IBD, contributing to its pathogenesis, evolution, and perpetuation over time. Until recently, studies focused on exploring the role of the intestinal epithelium ...

journal_title：Inflammatory bowel diseases

authors： Dotti I,Salas A

更新日期：2018-11-29 00:00:00

abstract：BACKGROUND:Vitamin D (25(OH)D) deficiency occurs in active Crohn's disease (CD) and may be secondary to reduced sunlight exposure and oral intake. Vitamin D-binding protein (VDBP) levels, however, fluctuate less with season and sunlight. The aim, therefore, was to examine patients with CD in remission and determine any...

journal_title：Inflammatory bowel diseases

authors： Ghaly S,Murray K,Baird A,Martin K,Prosser R,Mill J,Simms LA,Hart PH,Radford-Smith G,Bampton PA,Lawrance IC

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:The similar presentations in relapse of inflammatory bowel disease (IBD) and enteric infection pose substantial barriers to diagnosis and treatment. The objective of this study was to investigate the incidence, etiology, predictors, and treatment of enteric infection in patients with IBD. METHODS:We reviewe...

journal_title：Inflammatory bowel diseases

authors： Axelrad JE,Joelson A,Nobel YR,Lawlor G,Green PHR,Lichtiger S,Lebwohl B

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND:Data from CHARM, a 56-week, randomized controlled trial of adalimumab for patients with moderately to severely active Crohn's disease (CD), were used to evaluate outcomes of adalimumab dosage adjustment. METHODS:Patients randomized to blinded adalimumab 40 mg every other week (EOW) in CHARM were the focus o...

journal_title：Inflammatory bowel diseases

authors： Sandborn WJ,Colombel JF,Schreiber S,Plevy SE,Pollack PF,Robinson AM,Chao J,Mulani P

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Activation of cannabinoid (CB)(1) receptors results in attenuation of experimental colitis. Our aim was to examine the role of CB(2) receptors in experimental colitis using agonists (JWH133, AM1241) and an antagonist (AM630) in trinitrobenzene sulfonic acid (TNBS)-induced colitis in wildtype and CB(2) recept...

journal_title：Inflammatory bowel diseases

authors： Storr MA,Keenan CM,Zhang H,Patel KD,Makriyannis A,Sharkey KA

更新日期：2009-11-01 00:00:00

abstract：:Crohn's disease is associated with an excessive T helper (TH) type 1 inflammatory immune response. Reducing the influx of disease-associated CD4+ TH1 cells into the inflamed intestine is likely to be beneficial in preventing a disease flare-up and even possibly in reducing the effect of acute disease. Thiazolidenedion...

journal_title：Inflammatory bowel diseases

authors： Schaefer KL,Denevich S,Ma C,Cooley SR,Nakajima A,Wada K,Schlezinger J,Sherr D,Saubermann LJ

更新日期：2005-03-01 00:00:00

abstract：BACKGROUND:Unlike other anti-tumor necrosis factor alpha antibodies, golimumab does not deliver on its promise of effectiveness for treating patients with ulcerative colitis. We investigated the value of therapeutic drug monitoring for optimizing golimumab therapy. METHODS:We analyzed the golimumab pharmacokinetics da...

journal_title：Inflammatory bowel diseases

authors： Dreesen E,Kantasiripitak W,Detrez I,Stefanović S,Vermeire S,Ferrante M,Bouillon T,Drobne D,Gils A

更新日期：2020-03-04 00:00:00

abstract：:Inflammatory bowel diseases (IBD) include ulcerative colitis and Crohn's disease. The immune response in ulcerative colitis is different from the Crohn's disease. Accumulating evidence suggests that IBD results from an inappropriate inflammatory response to intestinal microbes in a genetically susceptible host. Severa...

journal_title：Inflammatory bowel diseases

authors： Fonseca-Camarillo G,Yamamoto-Furusho JK

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:The dsRNA-activated protein kinase (PKR) phosphorylates the α subunit of eukaryotic translation initiation factor 2 (eIF2α), a global regulator of protein synthesis in mammals. In addition, PKR activates several signal transduction pathways including STAT3 and AKT. PKR is activated by a number of inflammator...

journal_title：Inflammatory bowel diseases

authors： Cao SS,Song B,Kaufman RJ

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:Interleukin (IL)-6/signal transducers and activators of transcription 3 (STAT3) signaling plays an important role in the development of colitis-associated colorectal cancer (CAC). The mechanism of CAC formation remains unclear, and the relationship between miRNAs and the IL-6/STAT3 signaling pathway in the d...

journal_title：Inflammatory bowel diseases

authors： Wang A,Deng S,Chen X,Yu C,Du Q,Wu Y,Chen G,Hu L,Hu C,Li Y

更新日期：2020-03-04 00:00:00

abstract：BACKGROUND:Advanced oxidation protein products (AOPPs) are new protein markers of oxidative stress with pro-inflammatory properties, accumulated in many pathological conditions. The issue of their enhanced formation in IBD has not been addressed yet. METHODS:The concentration of relative AOPPs (rAOPP; concentration of...

journal_title：Inflammatory bowel diseases

authors： Krzystek-Korpacka M,Neubauer K,Berdowska I,Boehm D,Zielinski B,Petryszyn P,Terlecki G,Paradowski L,Gamian A

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND:Pharmacologic inhibition or genetic ablation of phosphoinositide 3-kinase gamma (PI3Kγ) has been shown to be protective against experimental colitis. However, the role of PI3Kγ in the resolution phase of colitis remains unexplored. In this study, we assess the effects of genetic knockout of PI3Kγ on the indu...

journal_title：Inflammatory bowel diseases

authors： Prescott D,Atkinson B,Döring A,Brown S,Petri B,McKay DM,Waterhouse CC

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:Cytomegalovirus (CMV) colitis can contribute to an unfavorable outcome of acute severe ulcerative colitis (ASUC). The purpose of this study was to evaluate the clinical outcomes of ASUC according to the CMV status and identify risk factors for CMV colitis in patients with ASUC. METHODS:We retrospectively an...

journal_title：Inflammatory bowel diseases

authors： Lee HS,Park SH,Kim SH,Kim J,Choi J,Lee HJ,Kim WS,Lee JM,Kwak MS,Hwang SW,Yang DH,Kim KJ,Ye BD,Byeon JS,Myung SJ,Yoon YS,Yu CS,Kim JH,Yang SK

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:Mucosal healing in ulcerative colitis leads to a decreased need for medication and decreased risk of disease relapse and colectomy. Histological healing seems to improve the disease prognosis even further. An assessment of both endoscopic and histological mucosal healing requires endoscopy, and the need for ...

journal_title：Inflammatory bowel diseases

authors： Theede K,Holck S,Ibsen P,Kallemose T,Nordgaard-Lassen I,Nielsen AM

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:Ideal biomarkers are required to be developed for the diagnosis and prediction of the treatment of inflammatory bowel disease (IBD). We have reported that alteration of N-linked oligosaccharides of immunoglobulin (Ig) G is a novel diagnostic marker of IBD. Oligosaccharide alterations of IgA, however, have no...

journal_title：Inflammatory bowel diseases

authors： Inoue T,Iijima H,Tajiri M,Shinzaki S,Shiraishi E,Hiyama S,Mukai A,Nakajima S,Iwatani H,Nishida T,Mizushima T,Yasui T,Isaka Y,Kanto T,Tsujii M,Miyoshi E,Wada Y,Takehara T

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:Crohn's disease is a heterogeneous inflammatory bowel disease. The impact of age at diagnosis on the clinical course of patients varies widely as reported in the Western literature. Using the Vienna Classification, we seek to determine whether young Crohn's disease patients in an Asian population followed a ...

journal_title：Inflammatory bowel diseases

authors： Thia KT,Luman W,Jin OC

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Extraintestinal manifestations of Crohn's disease (CD) have not previously included the central nervous system (CNS). Restless legs syndrome (RLS) is a CNS disorder that is either idiopathic or secondary to a number of diseases. The aim of this study was to determine if RLS was associated with CD because bot...

journal_title：Inflammatory bowel diseases

authors： Weinstock LB,Bosworth BP,Scherl EJ,Li E,Iroku U,Munsell MA,Mullin GE,Walters AS

更新日期：2010-02-01 00:00:00

abstract：:Intestinal fibrosis is a common and serious complication of Crohn's disease (CD) and as it can occur at any time during the disease course, it is crucial to identify patients at risk. The aim is not only to understand the pathophysiology of fibrogenesis but to be able to accurately inform subjects about their disease ...

journal_title：Inflammatory bowel diseases

authors： Rieder F,Lawrance IC,Leite A,Sans M

更新日期：2011-09-01 00:00:00

abstract：:This review summarizes how interleukin-10 (IL-10)-deficient mice have permitted new insight into the complex interaction between genes and environment underlying pathogenesis of inflammatory bowel disease (IBD). The C57BL/6J strain develops only mild typhlocolitis in response to IL-10 deficiency. In contrast, C3H/HeJB...

journal_title：Inflammatory bowel diseases

authors： Mähler M,Leiter EH

更新日期：2002-09-01 00:00:00

abstract：BACKGROUND:Childhood-onset Crohn's disease (CD) might reflect a more severe form of disease. To test this hypothesis we analyzed the long-term natural history of CD in an adult cohort of patients with childhood-onset compared to adult-onset CD. METHODS:We selected 206 childhood-onset CD patients among 2992 adult patie...

journal_title：Inflammatory bowel diseases

authors： Pigneur B,Seksik P,Viola S,Viala J,Beaugerie L,Girardet JP,Ruemmele FM,Cosnes J

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:Current therapy for inflammatory bowel disease (IBD) patients often involves agents that suppress the immune system, placing patients at an increased risk for developing infections, of which several are potentially vaccine preventable. Many IBD patients are not being vaccinated appropriately. The aims of thi...

journal_title：Inflammatory bowel diseases

authors： Wasan SK,Coukos JA,Farraye FA

更新日期：2011-12-01 00:00:00