Mucosal Healing in Clinical Practice: A Single-Center Pediatric IBD Experience.

abstract：BACKGROUND:Children with inflammatory bowel disease (IBD) undergo imaging using ionizing radiation and may be exposed to high cumulative radiation. We hypothesized that children with IBD have high exposure to radiation from medical imaging. METHODS:An Institutional Review Board (IRB)-approved retrospective chart revie...

journal_title：Inflammatory bowel diseases

authors： Sauer CG,Kugathasan S,Martin DR,Applegate KE

更新日期：2011-11-01 00:00:00

abstract：:Recent reports have focused interest on human cytomegalovirus (HCMV) in inflammatory bowel diseases (IBD). Our aim in this study was to examine the frequency of HCMV-infected intestinal cells in tissue sections obtained from patients with IBD, and to investigate if HCMV-infected intestinal cells produce the proinflamm...

journal_title：Inflammatory bowel diseases

authors： Rahbar A,Boström L,Lagerstedt U,Magnusson I,Söderberg-Naucler C,Sundqvist VA

更新日期：2003-05-01 00:00:00

abstract：:Lymphocyte migration is at the heart of chronic inflammatory ailments, including inflammatory bowel disease (IBD). Whereas naïve lymphocytes migrate to all secondary lymphoid organs, they are mostly excluded from nonlymphoid peripheral tissues. Upon activation, lymphocytes change their pattern of adhesion receptors an...

journal_title：Inflammatory bowel diseases

authors： Mora JR

更新日期：2008-02-01 00:00:00

abstract：BACKGROUND:Mucosal expression of interferon (IFN)-γ plays a pivotal role in the pathogenesis of inflammatory bowel disease (IBD) and IBD risk regions flank IFNG. The conserved IFNG rs1861494 T/C introduces a new CpG methylation site, is associated with disease severity and lack of therapeutic response in other infectio...

journal_title：Inflammatory bowel diseases

authors： Gonsky R,Deem RL,Landers CJ,Haritunians T,Yang S,Targan SR

更新日期：2014-10-01 00:00:00

abstract：SUMMARY:: In recent years, heparin has emerged as a possible therapy for inflammatory bowel disease (IBD). Several recent, strongly positive, open-labeled series of heparin in both ulcerative colitis (UC) and Crohn's disease (CD) reinforce the work of Gaffney and co-workers that suggested a benefit of heparin in UC. Al...

journal_title：Inflammatory bowel diseases

authors： Korzenik JR

更新日期：1997-07-01 00:00:00

abstract：BACKGROUND:Chronic inflammation in ulcerative colitis (UC) is a sizeable risk factor for colorectal cancer (CRC). Interleukin-13 (IL-13) is elevated in the UC mucosa and may induce dysregulated signaling in neighboring intestinal epithelial cells (IECs) and thus function as a tumorogenic cytokine. METHODS:Expression o...

journal_title：Inflammatory bowel diseases

authors： Mandal D,Levine AD

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND:FTY720 is a novel reagent that possesses potent immunosuppressive activity. The immunosuppression induced by FTY720 is mediated by completely different mechanisms from those of conventional immunosuppressants, that is, by altering the tissue distribution of lymphocytes rather than inhibiting activation. In t...

journal_title：Inflammatory bowel diseases

authors： Mizushima T,Ito T,Kishi D,Kai Y,Tamagawa H,Nezu R,Kiyono H,Matsuda H

更新日期：2004-05-01 00:00:00

abstract：BACKGROUND:The risk of corticosteroid-associated adverse events can limit the use of systemic corticosteroids. Oral, topically acting, second-generation corticosteroids that deliver drug to the site of inflammation, and biologic therapies, are effective treatment alternatives. The aim of this review was to evaluate the...

journal_title：Inflammatory bowel diseases

authors： Cross RK

更新日期：2017-10-01 00:00:00

abstract：:Most conventional forms of drug therapy suppress or modify the host immunoinflammatory response and neglect the other contributor to disease pathogenesis-the environmental microflora. Probiotics are live microbial food ingredients that alter the enteric microflora and have a beneficial effect on health. The rationale ...

journal_title：Inflammatory bowel diseases

authors： Shanahan F

更新日期：2000-05-01 00:00:00

abstract：:Natural killer T (NKT) cells are a subset of lymphocytes that express cell surface molecules of both conventional T cells and natural killer cells and share the features of both innate and adaptive immune cells. NKT cells have been proposed to make both protective and pathogenic contributions to inflammatory bowel dis...

journal_title：Inflammatory bowel diseases

authors： van Dieren JM,van der Woude CJ,Kuipers EJ,Escher JC,Samsom JN,Blumberg RS,Nieuwenhuis EE

更新日期：2007-09-01 00:00:00

abstract：:The aim of this study was to describe the clinical course of Crohn's disease (CD) in a well-defined, homogeneous groups of patients. A total of 480 patients with CD were followed up from diagnosis up to 20 years. Definitions of patient subgroups were made according to the Vienna Classification. Markov chain analysis w...

journal_title：Inflammatory bowel diseases

authors： Veloso FT,Ferreira JT,Barros L,Almeida S

更新日期：2001-11-01 00:00:00

abstract：BACKGROUND:Although dysplasia is thought to be the precursor lesion in the development of colitis-associated colorectal cancer (CRC), a significant proportion of patients with ulcerative colitis (UC) and low-grade (LGD) or indefinite (IND) dysplasia remain cancer-free during endoscopic follow-up. There is a need for bi...

journal_title：Inflammatory bowel diseases

authors： van Schaik FD,Oldenburg B,Offerhaus GJ,Schipper ME,Vleggaar FP,Siersema PD,van Oijen MG,Ten Kate FJ

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND:Acute pancreatitis has occasionally been associated with Crohn's disease (CD), but whether a causal association exists remains unclear. We sought to determine the frequency of etiologies in a consecutive series of patients with CD with acute pancreatitis. METHODS:A centralized diagnostic index was used to i...

journal_title：Inflammatory bowel diseases

authors： Moolsintong P,Loftus EV Jr,Chari ST,Egan LJ,Tremaine WJ,Sandborn WJ

更新日期：2005-12-01 00:00:00

abstract：BACKGROUND:A subset of patients with ulcerative colitis (UC) will require colectomy within a few years of diagnosis. Thus, our aim was to determine the clinical predictors of early colectomy among patients with UC who are hospitalized with an acute flare. METHODS:Using population-based surveillance (1996-2009), all ad...

journal_title：Inflammatory bowel diseases

authors： Al-Darmaki A,Hubbard J,Seow CH,Leung Y,Novak K,Shaheen AA,Panaccione R,Kaplan GG

更新日期：2017-08-01 00:00:00

abstract：:Mesalamine has a well-established role in the management of ulcerative colitis. However, its role in the management of Crohn's disease (CD) is less clear. Studies evaluating its therapeutic value in CD have produced both positive and negative results. Meta-analyses have not clarified the situation, possibly because th...

journal_title：Inflammatory bowel diseases

authors： Hanauer SB

更新日期：2005-06-01 00:00:00

abstract：BACKGROUND:Chemokines regulate the pathways that restrict homing of specific subsets of immune cells, and thereby fine tune the immune response at specific lymphoid and peripheral tissues. CCL2 is a chemokine that induces migration of monocytes, memory T cells, and dendritic cells. Previously, we demonstrated that pM l...

journal_title：Inflammatory bowel diseases

authors： Maharshak N,Hart G,Ron E,Zelman E,Sagiv A,Arber N,Brazowski E,Margalit R,Elinav E,Shachar I

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:The effect of the inflammatory bowel diseases (IBD) on menstrual function is largely unknown. The aims of this study were to determine whether changes in menstrual function occur in the year before IBD diagnosis or in the initial years after diagnosis. METHODS:Women aged 18 years and older in the Ocean Stat...

journal_title：Inflammatory bowel diseases

authors： Saha S,Zhao YQ,Shah SA,Esposti SD,Lidofsky S,Salih S,Bright R,Law M,Moniz H,Flowers N,Merrick M,Sands BE

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:Though vedolizumab has received regulatory approval for the treatment of Crohn's disease (CD) and ulcerative colitis (UC) in adults, there is increasing off-label use in children. AIMS:To describe the experience with vedolizumab in pediatric inflammatory bowel disease (IBD) patients at 3 tertiary IBD center...

journal_title：Inflammatory bowel diseases

authors： Singh N,Rabizadeh S,Jossen J,Pittman N,Check M,Hashemi G,Phan BL,Hyams JS,Dubinsky MC

更新日期：2016-09-01 00:00:00

abstract：:Inflammatory bowel disease (IBD) is a chronic intestinal disorder comprising 2 distinct but often overlapping diseases: Crohn's disease and ulcerative colitis. Although much research to identify the etiology of IBD has focused on genetic constitution, infectious causes, and immune dysregulation, its exact cause and pa...

journal_title：Inflammatory bowel diseases

authors： Ibrahim CB,Aroniadis OC,Brandt LJ

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND:Chronic granulomatous disease (CGD) is a rare inherited immunodeficiency disorder characterized by inability of phagocytes to kill certain bacteria and fungi. Histology from colon biopsies of CGD patients have shown the presence of inflammation and granulomas, almost indistinguishable from the findings seen ...

journal_title：Inflammatory bowel diseases

authors： Liu S,Russo PA,Baldassano RN,Sullivan KE

更新日期：2009-08-01 00:00:00

abstract：:A prospective study was conducted to determine the implications of acute pouchitis on the long-term functional results of restorative proctocolectomy with J-pouch ileoanal anastomosis (IPAA). Between July 1988 and June 1996, 137 consecutive patients underwent IPAA for treatment of ulcerative colitis. 127 patients (93%...

journal_title：Inflammatory bowel diseases

authors： Hurst RD,Chung TP,Rubin M,Michelassi F

更新日期：1998-11-01 00:00:00

abstract：BACKGROUND:Thiopurines are effective drugs in treating ulcerative colitis (UC) and Crohn's disease (CD) even if studies that specifically investigate these drugs' profile of efficacy in UC compared with CD are scarce. Our aim was to compare the profile of efficacy of thiopurines in patients with UC and CD. METHODS:We ...

journal_title：Inflammatory bowel diseases

authors： Rispo A,Testa A,De Palma GD,Donetto S,Diaferia M,Musto D,Nardone O,Maione F,Caporaso N,Castiglione F

更新日期：2015-11-01 00:00:00

abstract：:Inflammatory bowel disease is associated with industrialization, and its incidence has increased markedly over time. The prospect of reversing these trends motivates the search for the agent(s) involved. Modernity entails several physical and behavioral modifications that compromise both the photosynthesis of cholecal...

journal_title：Inflammatory bowel diseases

authors： Palmer MT,Weaver CT

更新日期：2013-09-01 00:00:00

abstract：Background:Suicide is a leading cause of death worldwide. Transition from suicidal ideation (SI) to suicide attempt is high within a year of SI onset. The risk of suicide and SI is elevated in persons with inflammatory bowel disease (IBD) versus the general population. We aimed to validate the Patient Heath Questionnai...

journal_title：Inflammatory bowel diseases

authors： Litster B,Bernstein CN,Graff LA,Walker JR,Fisk JD,Patten SB,Bolton JM,Sareen J,El-Gabalawy R,Marrie RA

更新日期：2018-07-12 00:00:00

abstract：BACKGROUND:Epithelial barrier disturbance is thought to contribute to the pathogenesis of inflammatory bowel diseases; however, it remains unclear whether it is a primary defect participating to the onset of inflammation or only a consequence of sustained inflammation. METHODS:A time course study of epithelial barrier...

journal_title：Inflammatory bowel diseases

authors： Suenaert P,Maerten P,Van Assche G,Van Driessche W,Geboes K,Bulteel V,Simaels J,Augustijns P,Ceuppens JL,Rutgeerts P,Perrier C

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND:Although anti-tumor necrosis factor (TNF) agents are effective in patients with inflammatory bowel disease (IBD), many patients either do not respond to anti-TNF treatment or lose response over time. The aim of this study was to determine factors associated with response to anti-TNF therapy in IBD. METHODS:...

journal_title：Inflammatory bowel diseases

authors： Yoon SM,Haritunians T,Chhina S,Liu Z,Yang S,Landers C,Li D,Ye BD,Shih D,Vasiliauskas EA,Ippoliti A,Rabizadeh S,Targan SR,Melmed GY,McGovern DPB

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:Differentiating between enteric infection and relapse of inflammatory bowel disease (IBD) is a common clinical challenge. Few studies have evaluated the impact of multiplex gastrointestinal polymerase chain reaction (GI PCR) pathogen panels on clinical practice compared to stool culture. Our aim was to compa...

journal_title：Inflammatory bowel diseases

authors： Hong S,Zaki TA,Main M,Hine AM,Chang S,Hudesman D,Axelrad JE

更新日期：2021-01-02 00:00:00

abstract：BACKGROUND:Establishing predictors of quality of life (QoL) in individuals with inflammatory bowel disease could help to identify those patients who are most likely to experience poor QoL and to target therapeutic interventions appropriately. We aimed to investigate how disease-specific QoL depends on demographic, dise...

journal_title：Inflammatory bowel diseases

authors： Han SW,McColl E,Barton JR,James P,Steen IN,Welfare MR

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Genetic susceptibility may play a more important role in the etiology of early-onset inflammatory bowel disease (IBD) than in late-onset IBD, and therefore pediatric-onset IBD patients can be expected to have a higher frequency of gene mutations. We aimed to determine genotypes and phenotypes of patients wit...

journal_title：Inflammatory bowel diseases

authors： de Ridder L,Weersma RK,Dijkstra G,van der Steege G,Benninga MA,Nolte IM,Taminiau JA,Hommes DW,Stokkers PC

更新日期：2007-09-01 00:00:00

abstract：:The complex and yet unknown etiology of Crohn's disease (CD) might consist of various disease endophenotypes, each of which represent their own pathogenesis. This review focuses on the disease endophenotype linked to polymorphisms in the nucleotide-binding oligomerization domain containing 2 (NOD2) protein and on the ...

journal_title：Inflammatory bowel diseases

authors： Jensen SR,Nielsen OH,Brix S

更新日期：2011-11-01 00:00:00