Evidence of active cytomegalovirus infection and increased production of IL-6 in tissue specimens obtained from patients with inflammatory bowel diseases.


:Recent reports have focused interest on human cytomegalovirus (HCMV) in inflammatory bowel diseases (IBD). Our aim in this study was to examine the frequency of HCMV-infected intestinal cells in tissue sections obtained from patients with IBD, and to investigate if HCMV-infected intestinal cells produce the proinflammatory cytokine IL-6. We studied intestinal tissue sections from 13 patients with ulcerative colitis, 10 with Crohn's disease, 10 cancer patients without intestinal inflammation, and 10 samples from HCMV-infected AIDS patients. HCMV-DNA was detected by in situ hybridization in sections obtained from 12/13 patients with ulcerative colitis, in 10 with Crohn's disease, in 10/10 samples from HCMV-infected AIDS patients, but not in any of the 10 samples that were obtained from uninflamed tissues. HCMV-specific antigens were detected in samples from all HCMV-infected AIDS patients, in 11/13 sections from patients with ulcerative colitis, in 10/10 samples from patients with Crohn's disease, but not in sections from uninflamed tissues. Cells were double positive for an HCMV early antigen and IL-6 in 10/13 sections from patients with ulcerative colitis, in all patients with Crohn's disease, and in 4/10 samples from AIDS patients. In conclusion, these results suggest that active HCMV infection in the intestine is very frequent in patients with IBD, and may contribute to the inflammatory process through an increased production of IL-6.


Inflamm Bowel Dis


Rahbar A,Boström L,Lagerstedt U,Magnusson I,Söderberg-Naucler C,Sundqvist VA





Has Abstract


2003-05-01 00:00:00












  • Regulation of gene expression in inflammatory bowel disease and correlation with IBD drugs: screening by DNA microarrays.

    abstract::Potential biomarkers for Crohn's disease (CD) and ulcerative colitis (UC) were identified from two sets of full thickness pathologic samples utilizing DermArray and PharmArray DNA microarrays relative to uninvolved (Un) colon or normal colon. Seven of the over-expressed genes were verified using quantitative RT-PCR (i...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Dooley TP,Curto EV,Reddy SP,Davis RL,Lambert GW,Wilborn TW,Elson CO

    更新日期:2004-01-01 00:00:00

  • IFNG rs1861494 polymorphism is associated with IBD disease severity and functional changes in both IFNG methylation and protein secretion.

    abstract:BACKGROUND:Mucosal expression of interferon (IFN)-γ plays a pivotal role in the pathogenesis of inflammatory bowel disease (IBD) and IBD risk regions flank IFNG. The conserved IFNG rs1861494 T/C introduces a new CpG methylation site, is associated with disease severity and lack of therapeutic response in other infectio...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Gonsky R,Deem RL,Landers CJ,Haritunians T,Yang S,Targan SR

    更新日期:2014-10-01 00:00:00

  • Treatment patterns, complications, and disease relapse in a real-world population of patients with moderate-to-severe ulcerative colitis initiating immunomodulator therapy.

    abstract:BACKGROUND:Immunomodulator (IM) treatments in ulcerative colitis (UC) are not curative and carry increased risk of complications, sometimes leading to therapy changes, reduced treatment benefits, and eventual relapse. We assessed patterns of IM utilization and therapy changes, complications, and disease relapse in a re...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Loftus EV Jr,Davis KL,Wang CC,Dastani H,Luo A

    更新日期:2014-08-01 00:00:00

  • Menstrual cycle changes in women with inflammatory bowel disease: a study from the ocean state Crohn's and colitis area registry.

    abstract:BACKGROUND:The effect of the inflammatory bowel diseases (IBD) on menstrual function is largely unknown. The aims of this study were to determine whether changes in menstrual function occur in the year before IBD diagnosis or in the initial years after diagnosis. METHODS:Women aged 18 years and older in the Ocean Stat...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Saha S,Zhao YQ,Shah SA,Esposti SD,Lidofsky S,Salih S,Bright R,Law M,Moniz H,Flowers N,Merrick M,Sands BE

    更新日期:2014-03-01 00:00:00

  • Upper gastrointestinal tract phenotype of Crohn's disease is associated with early surgery and further hospitalization.

    abstract:BACKGROUND:According to the Montreal Classification, upper gastrointestinal tract phenotype L4 is uncommon in Caucasian patients with Crohn's disease (CD) but carries excess risk of recurrence. We studied the clinical course of CD in Chinese patients presenting with the L4 phenotype and factors predicting its occurrenc...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Chow DK,Sung JJ,Wu JC,Tsoi KK,Leong RW,Chan FK

    更新日期:2009-04-01 00:00:00

  • Crohn's disease runs a more aggressive course in young Asian patients.

    abstract:BACKGROUND:Crohn's disease is a heterogeneous inflammatory bowel disease. The impact of age at diagnosis on the clinical course of patients varies widely as reported in the Western literature. Using the Vienna Classification, we seek to determine whether young Crohn's disease patients in an Asian population followed a ...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Thia KT,Luman W,Jin OC

    更新日期:2006-01-01 00:00:00

  • Crohn's disease is associated with restless legs syndrome.

    abstract:BACKGROUND:Extraintestinal manifestations of Crohn's disease (CD) have not previously included the central nervous system (CNS). Restless legs syndrome (RLS) is a CNS disorder that is either idiopathic or secondary to a number of diseases. The aim of this study was to determine if RLS was associated with CD because bot...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Weinstock LB,Bosworth BP,Scherl EJ,Li E,Iroku U,Munsell MA,Mullin GE,Walters AS

    更新日期:2010-02-01 00:00:00

  • Open-label study of adalimumab in patients with ulcerative colitis including those with prior loss of response or intolerance to infliximab.

    abstract:BACKGROUND:The aim of this study was to assess the clinical benefit and tolerability of adalimumab, a fully human monoclonal antibody to tumor necrosis factor (TNF), in patients with ulcerative colitis (UC). METHODS:Patients with active UC, including those who had lost response or developed intolerance to the chimeric...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Afif W,Leighton JA,Hanauer SB,Loftus EV Jr,Faubion WA,Pardi DS,Tremaine WJ,Kane SV,Bruining DH,Cohen RD,Rubin DT,Hanson KA,Sandborn WJ

    更新日期:2009-09-01 00:00:00

  • Phase I trial of sargramostim in pediatric Crohn's disease.

    abstract:BACKGROUND:Improving granulocyte function may represent an effective therapy for Crohn's disease (CD). We performed a Phase I-2 trial of sargramostim (SRG) in children with CD. METHODS:This was multicenter, open-label study in 6-16-year-old patients with moderate to severely active CD. Patients received either 4 or 6 ...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章,多中心研究


    authors: Kelsen JR,Rosh J,Heyman M,Winter HS,Ferry G,Cohen S,Mamula P,Baldassano RN

    更新日期:2010-07-01 00:00:00

  • Use of thiopurine testing in the management of inflammatory bowel diseases in clinical practice: a worldwide survey of experts.

    abstract:BACKGROUND:We performed a worldwide survey to evaluate the extent to which gastroenterologists who are experts in the field of inflammatory bowel diseases (IBDs) are utilizing thiopurine metabolism in practice. METHODS:This was a Web-based cross-sectional survey consisting of 12 multiple-choice and open-ended question...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Roblin X,Oussalah A,Chevaux JB,Sparrow M,Peyrin-Biroulet L

    更新日期:2011-12-01 00:00:00

  • The Incidence and Prevalence of Anxiety, Depression, and Post-traumatic Stress Disorder in a National Cohort of US Veterans With Inflammatory Bowel Disease.

    abstract:BACKGROUND:Patients with inflammatory bowel disease (IBD) are more susceptible to mental health problems than the general population; however, temporal trends in psychiatric diagnoses' incidence or prevalence in the United States are lacking. We sought to identify these trends among patients with IBD using national Vet...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Thakur ER,Sansgiry S,Kramer JR,Waljee AK,Gaidos JK,Feagins LA,Govani SM,Dindo L,El-Serag HB,Hou JK

    更新日期:2020-08-20 00:00:00

  • Serum adalimumab concentration and clinical remission in patients with Crohn's disease.

    abstract:BACKGROUND:Drug concentration monitoring may be useful to guide therapeutic adjustments for anti-tumor necrosis factor agents in Crohn's disease. The relationship between serum adalimumab concentrations and clinical outcomes was assessed using data from CLinical Assessment of Adalimumab Safety and Efficacy Studied as I...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章,随机对照试验


    authors: Chiu YL,Rubin DT,Vermeire S,Louis E,Robinson AM,Lomax KG,Pollack PF,Paulson SK

    更新日期:2013-05-01 00:00:00

  • Potential Use of Human Stem Cell-Derived Intestinal Organoids to Study Inflammatory Bowel Diseases.

    abstract::Inflammatory bowel disease (IBD) is a chronic remitting disorder with increasing incidence worldwide. The intestinal epithelial barrier plays a major role in IBD, contributing to its pathogenesis, evolution, and perpetuation over time. Until recently, studies focused on exploring the role of the intestinal epithelium ...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章,评审


    authors: Dotti I,Salas A

    更新日期:2018-11-29 00:00:00

  • CARD3 deficiency protects against colitis through reduced epithelial cell apoptosis.

    abstract:BACKGROUND:Caspase activation and recruitment domain 3 (CARD3) is a 61-kDa protein kinase. Recent evidence shows the importance of CARD3 in the immune response and inflammatory diseases. To elucidate its impact on inflammatory bowel disease, we studied the effects of the loss of CARD3 in the acute dextran sodium sulfat...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Yu SJ,Liu Y,Deng Y,Zhu XY,Zhan N,Dong WG

    更新日期:2015-04-01 00:00:00

  • Enteral feeding therapy for newly diagnosed pediatric Crohn's disease: a double-blind randomized controlled trial with two years follow-up.

    abstract:BACKGROUND:This study compared the efficacy of an elemental formula (EF) to a polymeric formula (PF) in inducing remission for pediatric Crohn's disease (CD). METHODS:Newly diagnosed CD children were randomized to EF or PF for 6 weeks. Change in the Pediatric Crohn's Disease Activity Index (PCDAI), fecal calprotectin,...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章,随机对照试验


    authors: Grogan JL,Casson DH,Terry A,Burdge GC,El-Matary W,Dalzell AM

    更新日期:2012-02-01 00:00:00

  • Childhood Maltreatment Is Associated with Ulcerative Colitis but Not Crohn's Disease: Findings from a Population-based Study.

    abstract:BACKGROUND:Previous research suggests a link between childhood adversities and inflammatory bowel disease (IBD); however, study limitations prevent generalization of findings. To address this, the current study uses a Canadian population-based sample to investigate the relationship between 3 childhood adversities and 2...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Fuller-Thomson E,West KJ,Sulman J,Baird SL

    更新日期:2015-11-01 00:00:00

  • Contraception, Venous Thromboembolism, and Inflammatory Bowel Disease: What Clinicians (and Patients) Should Know.

    abstract::The peak incidence of the inflammatory bowel diseases (IBDs) is between the second and fourth decades of life, which coincides with prime reproductive years. Unplanned or mistimed pregnancies may account for nearly half of all pregnancies and are associated with adverse consequences such as a higher risk of delayed pr...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Limdi JK,Farraye J,Cannon R,Woodhams E,Farraye FA

    更新日期:2019-09-18 00:00:00

  • A Population Pharmacokinetic and Exposure-Response Model of Golimumab for Targeting Endoscopic Remission in Patients With Ulcerative Colitis.

    abstract:BACKGROUND:Unlike other anti-tumor necrosis factor alpha antibodies, golimumab does not deliver on its promise of effectiveness for treating patients with ulcerative colitis. We investigated the value of therapeutic drug monitoring for optimizing golimumab therapy. METHODS:We analyzed the golimumab pharmacokinetics da...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Dreesen E,Kantasiripitak W,Detrez I,Stefanović S,Vermeire S,Ferrante M,Bouillon T,Drobne D,Gils A

    更新日期:2020-03-04 00:00:00

  • Multiple Cytokine Profiling: A New Model to Predict Response to Tumor Necrosis Factor Antagonists in Ulcerative Colitis Patients.

    abstract:BACKGROUND AND AIMS:Ulcerative colitis (UC) is a form of inflammatory bowel disease, and antibodies against tumor necrosis factor (anti-TNF) are used for treatment. Many patients are refractory or lose response to anti-TNF, and predicting response would be an extremely valuable clinical tool. Unlike most biomarkers, cy...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Obraztsov IV,Shirokikh KE,Obraztsova OI,Shapina MV,Wang MH,Khalif IL

    更新日期:2019-02-21 00:00:00

  • How to Optimize Colon Cancer Surveillance in Inflammatory Bowel Disease Patients.

    abstract::Colitis-associated colorectal neoplasia (CRN) is a well-known complication of chronic inflammation of the colon either with ulcerative colitis (UC) or colonic Crohn's disease (CD). Studies have shown that inflammatory bowel disease (IBD) patients have an overall higher risk for colorectal dysplasia and cancer compared...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章,评审


    authors: Gaidos JK,Bickston SJ

    更新日期:2016-05-01 00:00:00

  • Risk Factors and Clinical Outcomes Associated with Cytomegalovirus Colitis in Patients with Acute Severe Ulcerative Colitis.

    abstract:BACKGROUND:Cytomegalovirus (CMV) colitis can contribute to an unfavorable outcome of acute severe ulcerative colitis (ASUC). The purpose of this study was to evaluate the clinical outcomes of ASUC according to the CMV status and identify risk factors for CMV colitis in patients with ASUC. METHODS:We retrospectively an...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Lee HS,Park SH,Kim SH,Kim J,Choi J,Lee HJ,Kim WS,Lee JM,Kwak MS,Hwang SW,Yang DH,Kim KJ,Ye BD,Byeon JS,Myung SJ,Yoon YS,Yu CS,Kim JH,Yang SK

    更新日期:2016-04-01 00:00:00

  • Quality and publication success of abstracts of randomized clinical trials in inflammatory bowel disease presented at Digestive Disease Week.

    abstract:BACKGROUND:The incorporation of abstracts from scientific meetings into systematic reviews and practice guidelines may reduce publication bias and delays in implementing therapeutic interventions. METHODS:All abstracts of Phase III randomized controlled trials in inflammatory bowel disease accepted at Digestive Diseas...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Kottachchi D,Nguyen GC

    更新日期:2010-06-01 00:00:00

  • Hospital Admissions, Biological Therapy, and Surgery in Familial and Sporadic Cases of Inflammatory Bowel Disease: A Population-Based Cohort Study 1977-2011.

    abstract:BACKGROUND:Easily accessible predictors of disease course in inflammatory bowel disease (IBD) are scarce, and it remains largely unknown whether a family history of IBD predicts the course of Crohn's disease (CD) and ulcerative colitis (UC). We aimed to compare the course of disease in familial and sporadic cases of IB...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Trier Moller F,Andersen V,Andersson M,Jess T

    更新日期:2015-12-01 00:00:00

  • Roles of T cell-associated L-selectin and β7 integrins during induction and regulation of chronic colitis.

    abstract:BACKGROUND:L-selectin (CD62L) and β(7) integrins are important for trafficking of naive T cells under steady-state conditions. The objectives of this study were to dissect the requirements for T cell-associated CD62L and β(7) integrins during initiation, progression, and regulation of chronic colitis. METHODS:Using th...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Kurmaeva E,Boktor M,Zhang S,Bao R,Berney S,Ostanin DV

    更新日期:2013-11-01 00:00:00

  • Retinoic acid contributes to the induction of IL-12-hypoproducing dendritic cells.

    abstract:BACKGROUND:Vitamin A is an important regulator of the human immune system, especially in the gut. Recent studies have revealed that retinoic acid (RA) in gut-associated dendritic cells (DCs) enhances the transforming growth factor (TGF)-beta-dependent conversion of naïve T cells into regulatory T (Treg) cells. Thus, RA...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Wada Y,Hisamatsu T,Kamada N,Okamoto S,Hibi T

    更新日期:2009-10-01 00:00:00

  • Recommendations for Quality Colonoscopy Reporting for Patients with Inflammatory Bowel Disease: Results from a RAND Appropriateness Panel.

    abstract:BACKGROUND:Consensus on what constitutes a quality colonoscopy report for patients with inflammatory bowel disease (IBD) is lacking. We developed a template for quality colonoscopy reporting that can be used broadly by endoscopists. METHODS:After a literature review of topics relevant to colonoscopy reporting, members...

    journal_title:Inflammatory bowel diseases

    pub_type: 共识发展会议,杂志文章


    authors: Devlin SM,Melmed GY,Irving PM,Rubin DT,Kornbluth A,Kozuch PL,Raffals LE,Velayos FS,Sparrow MP,Baidoo L,Bressler B,Cheifetz AS,Jones J,Kaplan GG,Siegel CA

    更新日期:2016-06-01 00:00:00

  • Incidence and Predictors of Flares in the Postpartum Year Among Women With Inflammatory Bowel Disease.

    abstract:BACKGROUND:The postpartum period is marked by physiological and psychological stresses that may impact activity in inflammatory bowel disease. The predictors and outcomes of disease activity during this period have not been well characterized. METHODS:We performed a retrospective review of inflammatory bowel disease p...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Yu A,Friedman S,Ananthakrishnan AN

    更新日期:2020-11-19 00:00:00

  • The Management of Intestinal Penetrating Crohn's Disease.

    abstract::Crohn's disease (CD) leads to the development of complications through progressive uncontrolled inflammation and the transmural involvement of the bowel wall. Most of the available literature on penetrating CD focuses on the perianal phenotype. The management of nonperianal penetrating complications poses its own set ...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章,评审


    authors: Hirten RP,Shah S,Sachar DB,Colombel JF

    更新日期:2018-03-19 00:00:00

  • The Natural History, Treatments, and Outcomes of Portal Vein Thrombosis in Patients With Inflammatory Bowel Disease.

    abstract:BACKGROUND:Portal vein thrombosis (PVT) is a poorly described complication of inflammatory bowel disease (IBD). We sought to better characterize presentations, compare treatments, and assess outcomes in IBD-related PVT. METHODS:We conducted a retrospective investigation of IBD-related PVT at our institution. Multivari...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Naymagon L,Tremblay D,Zubizarreta N,Moshier E,Naymagon S,Mascarenhas J,Schiano T

    更新日期:2021-01-19 00:00:00

  • Prior Helicobacter pylori infection ameliorates Salmonella typhimurium-induced colitis: mucosal crosstalk between stomach and distal intestine.

    abstract:BACKGROUND:Helicobacter pylori infection is associated with a lower risk of chronic autoimmune diseases including inflammatory bowel disease (IBD). H.pylori modulates the gastric immune response, decreasing the local inflammatory response to itself. In mice, chronic Salmonellatyphimurium infection induces colitis simil...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Higgins PD,Johnson LA,Luther J,Zhang M,Sauder KL,Blanco LP,Kao JY

    更新日期:2011-06-01 00:00:00