Distinct Anti-IFI16 and Anti-GP2 Antibodies in Inflammatory Bowel Disease and Their Variation with Infliximab Therapy.

abstract：BACKGROUND:The relative contribution of psychological factors to the onset and course of inflammatory bowel diseases (IBD) is a matter of constant debate since its beginning, as is the clinical need and the efficacy of psychotherapeutic interventions. However, the perspective of patients with IBD has largely been ignor...

journal_title：Inflammatory bowel diseases

authors： Klag T,Mazurak N,Fantasia L,Schwille-Kiuntke J,Kirschniak A,Falch C,Goetz M,Malek NP,Enck P,Wehkamp J

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND:Vitamin D insufficiency has been suggested to be associated with high risk of Crohn's disease (CD). In France, where food fortification is limited, the major source of vitamin D is through sun exposure. The aim of this work was to analyze the relationship between residential sun exposure and the risk of inci...

journal_title：Inflammatory bowel diseases

authors： Jantchou P,Clavel-Chapelon F,Racine A,Kvaskoff M,Carbonnel F,Boutron-Ruault MC

更新日期：2014-01-01 00:00:00

abstract：:Three receptor tyrosine kinases, Tyro3, Axl, and Mertk (TAM) and their ligands Gas6 and Protein S, have emerged as potent negative regulators of innate immune responses. A number of studies using genetic ablation of TAM loci in mice have elucidated the mechanism of TAM engagement and function during the immune respons...

journal_title：Inflammatory bowel diseases

authors： Rothlin CV,Leighton JA,Ghosh S

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:Many treatment options exist for children with inflammatory bowel disease (IBD), yet the lack of clinical guidelines for management has lead to great variation in care. The purpose of this project was to evaluate current treatment modalities in children from the Northeast US who applied to the 2010 session o...

journal_title：Inflammatory bowel diseases

authors： Rosen D,Kathy-Hoffstadter-Thal,Bao R,Tomaino J,Ceballos C,Russell GJ,Benkov KJ

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND:Malignant transformation in ulcerative colitis (UC) is associated with pronounced chromosomal instability, reflected by aneuploidy. Although aneuploidy can precede primary cancer diagnosis in UC for more than a decade, little is known of its cellular consequences. METHODS:Whole-genome gene expression analys...

journal_title：Inflammatory bowel diseases

authors： Gerling M,Nousiainen K,Hautaniemi S,Krüger S,Fritzsche B,Homann N,Bruch HP,Auer G,Roblick UJ,Ried T,Habermann JK

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:Various physician- and patient-reported instruments exist for quantification of disease activity in inflammatory bowel diseases (IBD) but none are widely used in routine clinical practice. A simple patient-reported outcome measure might help inform clinical decision making. We evaluated a patient-reported 0 ...

journal_title：Inflammatory bowel diseases

authors： Subramanian S,Asher R,Weston W,Rimmer M,McConville A,Malin A,Jackson R,Collins P,Probert C,Dibb M,Rhodes JM

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND:Mucosal expression of interferon (IFN)-γ plays a pivotal role in the pathogenesis of inflammatory bowel disease (IBD) and IBD risk regions flank IFNG. The conserved IFNG rs1861494 T/C introduces a new CpG methylation site, is associated with disease severity and lack of therapeutic response in other infectio...

journal_title：Inflammatory bowel diseases

authors： Gonsky R,Deem RL,Landers CJ,Haritunians T,Yang S,Targan SR

更新日期：2014-10-01 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) develops in ulcerative colitis (UC) and Crohn's disease. However, there is scarce reporting on the onset of UC in patients with NAFLD. A 44-year-old man was diagnosed with UC and referred to us in 2019. His height was 166.0 cm, and body weight was 86.3 kg. The waist circumferen...

journal_title：Inflammatory bowel diseases

authors： Chiba M,Nakane K,Abe H,Komatsu M,Tozawa H

更新日期：2019-10-18 00:00:00

abstract：BACKGROUND:Mucosal dye spraying (chromoendoscopy [CE]) has been shown in controlled studies to enhance lesion detection in colitis surveillance. Narrow band imaging (NBI) potentially offers a more convenient mode of highlighting mucosal lesions. The primary objectives of this study were to compare CE and NBI in colitis...

journal_title：Inflammatory bowel diseases

authors： Efthymiou M,Allen PB,Taylor AC,Desmond PV,Jayasakera C,De Cruz P,Kamm MA

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:The objectives of this study were to determine the prevalence and incidence of inflammatory bowel disease (IBD) in a representative Lebanese cohort and to describe practice prevalence trends, disease characteristics, and impact on quality of life (QoL) of IBD patients in Lebanon. METHODS:All of a university...

journal_title：Inflammatory bowel diseases

authors： Abdul-Baki H,ElHajj I,El-Zahabi LM,Azar C,Aoun E,Zantout H,Nasreddine W,Ayyach B,Mourad FH,Soweid A,Barada KA,Sharara AI

更新日期：2007-04-01 00:00:00

abstract：BACKGROUND:Acute pancreatitis has occasionally been associated with Crohn's disease (CD), but whether a causal association exists remains unclear. We sought to determine the frequency of etiologies in a consecutive series of patients with CD with acute pancreatitis. METHODS:A centralized diagnostic index was used to i...

journal_title：Inflammatory bowel diseases

authors： Moolsintong P,Loftus EV Jr,Chari ST,Egan LJ,Tremaine WJ,Sandborn WJ

更新日期：2005-12-01 00:00:00

abstract：BACKGROUND:Endoscopic balloon dilation (EBD) is widely used to manage Crohn's disease-associated strictures. However, most studies of the safety and efficacy are small and heterogenous. We performed a combined analysis of published studies and evaluated 676 comprehensive individual participant data sets to determine th...

journal_title：Inflammatory bowel diseases

authors： Bettenworth D,Gustavsson A,Atreja A,Lopez R,Tysk C,van Assche G,Rieder F

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Mutations in the nucleotide oligomerization domain-2 (NOD2) gene and positive antibodies to microbial antigens have been found to be associated with the Crohn's disease (CD) phenotype, fibrostenosis. The aim of this study was to confirm these relationships in a large cohort of CD patients and to determine th...

journal_title：Inflammatory bowel diseases

authors： Ippoliti A,Devlin S,Mei L,Yang H,Papadakis KA,Vasiliauskas EA,McGovern DP,Abreu MT,Melmed G,Shaye O,Enayati P,Chen G,Choi J,Taylor K,Landers CJ,Rotter JI,Targan SR

更新日期：2010-08-01 00:00:00

abstract：:The role of endoscopy in inflammatory bowel disease (IBD) has grown over the last decade in both diagnostic and therapeutic realms. It aids in the initial diagnosis of the disease and also in the assessment of the extent and severity of disease. IBD is associated with development of multiple complications such as stri...

journal_title：Inflammatory bowel diseases

authors： Tharian B,George N,Navaneethan U

更新日期：2016-05-01 00:00:00

abstract：:A prospective study was conducted to determine the implications of acute pouchitis on the long-term functional results of restorative proctocolectomy with J-pouch ileoanal anastomosis (IPAA). Between July 1988 and June 1996, 137 consecutive patients underwent IPAA for treatment of ulcerative colitis. 127 patients (93%...

journal_title：Inflammatory bowel diseases

authors： Hurst RD,Chung TP,Rubin M,Michelassi F

更新日期：1998-11-01 00:00:00

abstract：BACKGROUND:The mechanisms responsible for the pathogenesis of peripheral arthropathies (PA) in Crohn's disease (CD) are largely unknown, although many studies indicate that genetic and environmental factors are likely to contribute to risk. METHODS:Because variants in the Fc receptor-like 3 (FcRL3) gene have recently ...

journal_title：Inflammatory bowel diseases

authors： Mendoza JL,Lana R,Martin MC,de la Concha EG,Urcelay E,Diaz-Rubio M,Abreu MT,Mitchell AA

更新日期：2009-09-01 00:00:00

abstract：:Crohn's disease and ulcerative colitis are quite often complicated with manifestations in extraintestinal organs like joints, eye, and skin. Although the etiopathogenesis of these nonmucosal complications remains unsettled, they all share the characteristic feature of inappropriate leukocyte recruitment in nonlymphati...

journal_title：Inflammatory bowel diseases

authors： Salmi M,Jalkanen S

更新日期：1998-05-01 00:00:00

abstract：Background:The diagnostic work-up of pediatric irritable bowel syndrome (IBS) and functional abdominal pain-not otherwise specified (FAP-NOS) commonly includes invasive tests for discrimination from inflammatory bowel disease (IBD). As this carries a high burden on patients, an ongoing need exists for development of no...

journal_title：Inflammatory bowel diseases

authors： Bosch S,van Gaal N,Zuurbier RP,Covington JA,Wicaksono AN,Biezeveld MH,Benninga MA,Mulder CJ,de Boer NKH,de Meij TGJ

更新日期：2018-10-12 00:00:00

abstract：BACKGROUND:FTY720 is a novel reagent that possesses potent immunosuppressive activity. The immunosuppression induced by FTY720 is mediated by completely different mechanisms from those of conventional immunosuppressants, that is, by altering the tissue distribution of lymphocytes rather than inhibiting activation. In t...

journal_title：Inflammatory bowel diseases

authors： Mizushima T,Ito T,Kishi D,Kai Y,Tamagawa H,Nezu R,Kiyono H,Matsuda H

更新日期：2004-05-01 00:00:00

abstract：BACKGROUND:Little knowledge exists about the association between anti-tumor necrosis factor-alpha (anti-TNF-α) therapy for inflammatory bowel disease during late pregnancy and adverse birth outcomes. We aimed to examine whether treatment with anti-TNF-α during the third trimester affected preterm birth and low birth we...

journal_title：Inflammatory bowel diseases

authors： Kammerlander H,Nielsen J,Knudsen T,Kjeldsen J,Friedman S,Nørgård BM

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:Psoriasis induced by anti-tumor necrosis factor-α (TNF) therapy has been described as a paradoxical side effect. AIM:To determine the incidence, clinical characteristics, and management of psoriasis induced by anti-TNF therapy in a large nationwide cohort of inflammatory bowel disease patients. METHODS:Pat...

journal_title：Inflammatory bowel diseases

authors： Guerra I,Pérez-Jeldres T,Iborra M,Algaba A,Monfort D,Calvet X,Chaparro M,Mañosa M,Hinojosa E,Minguez M,Ortiz de Zarate J,Márquez L,Prieto V,García-Sánchez V,Guardiola J,Rodriguez GE,Martín-Arranz MD,García-Tercero I,S

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:Outcomes are suboptimal in ulcerative colitis (UC). Telemedicine for UC is feasible and improves outcomes. Our goals were to evaluate a home telemanagement system for UC (UC HAT) on disease activity, quality of life (QoL), and adherence compared to best available care (BAC) in a randomized, controlled trial....

journal_title：Inflammatory bowel diseases

authors： Cross RK,Cheevers N,Rustgi A,Langenberg P,Finkelstein J

更新日期：2012-06-01 00:00:00

abstract：OBJECTIVES:Studies aimed at establishing which characteristics of patients with ulcerative proctitis could be predictive of the extension of inflammation have failed to provide conclusive results. The aim of the study was to evaluate the prognostic role of clinical and therapeutic parameters in patients with proctitis....

journal_title：Inflammatory bowel diseases

authors： Pica R,Paoluzi OA,Iacopini F,Marcheggiano A,Crispino P,Rivera M,Bella A,Consolazio A,Paoluzi P

更新日期：2004-11-01 00:00:00

abstract：Background:We assessed the comparative efficacy of different dysplasia detection techniques in patients with ulcerative colitis (UC) through a network meta-analysis and rated the quality of evidence using GRADE approach. Methods:Through a systematic literature review of multiple databases through June 30, 2017, we ide...

journal_title：Inflammatory bowel diseases

authors： Bessissow T,Dulai PS,Restellini S,Landry T,Bisschops R,Murad MH,Singh S

更新日期：2018-11-29 00:00:00

abstract：:Lymphocyte migration is at the heart of chronic inflammatory ailments, including inflammatory bowel disease (IBD). Whereas naïve lymphocytes migrate to all secondary lymphoid organs, they are mostly excluded from nonlymphoid peripheral tissues. Upon activation, lymphocytes change their pattern of adhesion receptors an...

journal_title：Inflammatory bowel diseases

authors： Mora JR

更新日期：2008-02-01 00:00:00

abstract：:This review summarizes the current phenotypic classifications of inflammatory bowel disease (IBD) and outlines their implications for diagnosis, therapy, prognosis, clinical trial design, and genotype-phenotype correlations. ...

journal_title：Inflammatory bowel diseases

authors： Walfish A,Sachar D

更新日期：2007-12-01 00:00:00

abstract：BACKGROUND:Crohn's disease (CD)-associated dysbiosis could predispose patients to relapse. Gut microbiota composition of patients from the prospective cohort study designed to identify predictive factors of clinical relapse after infliximab discontinuation (STORI Study) was investigated to determine the impact of dysbi...

journal_title：Inflammatory bowel diseases

authors： Rajca S,Grondin V,Louis E,Vernier-Massouille G,Grimaud JC,Bouhnik Y,Laharie D,Dupas JL,Pillant H,Picon L,Veyrac M,Flamant M,Savoye G,Jian R,Devos M,Paintaud G,Piver E,Allez M,Mary JY,Sokol H,Colombel JF,Seksik P

更新日期：2014-06-01 00:00:00

abstract：:It is estimated that over one million people are living with inflammatory bowel disease (IBD) in the United States and that 20-25% of those are children. Pediatric IBD presents with more severe and extensive disease when compared to adults. As with all pediatric chronic illnesses, the patient as well as their parents ...

journal_title：Inflammatory bowel diseases

authors： Donegan A,Boyle B,Crandall W,Dotson JL,Lemont C,Moon T,Kim SC

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:Crohn's disease (CD) is an intractable inflammatory bowel disease of unknown cause. Recent genome-wide association studies of CD in Korean and Japanese populations suggested marginal sharing of susceptibility loci between Caucasian and Asian populations. As the 7 identified loci altogether explain 5.31% of t...

journal_title：Inflammatory bowel diseases

authors： Yang SK,Hong M,Choi H,Zhao W,Jung Y,Haritunians T,Ye BD,Kim KJ,Park SH,Lee I,Kim WH,Cheon JH,Kim YH,Jang BI,Kim HS,Choi JH,Koo JS,Lee JH,Jung SA,Shin HD,Kang D,Youn HS,Taylor KD,Rotter JI,Liu J,McGovern

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Microbiota is most likely essential in the pathogenesis of Crohn's disease (CD). Fecal diversion after ileocecal resection (ICR) protects against CD recurrence, whereas infusion of fecal content triggers inflammation. After ICR, the majority of patients experience endoscopic recurrence in the neoterminal ile...

journal_title：Inflammatory bowel diseases

authors： Olaisen M,Flatberg A,Granlund AVB,Røyset ES,Martinsen TC,Sandvik AK,Fossmark R

更新日期：2021-01-01 00:00:00