Abstract:
BACKGROUND:FTY720 is a novel reagent that possesses potent immunosuppressive activity. The immunosuppression induced by FTY720 is mediated by completely different mechanisms from those of conventional immunosuppressants, that is, by altering the tissue distribution of lymphocytes rather than inhibiting activation. In this study, we examined the efficacy of FTY720 in the treatment of chronic colitis in an interleukin-10 gene-deficient (IL-0-/-) mouse model. METHODS:FTY720 was administered orally for 4 weeks to IL-10-/- mice with clinical signs of colitis. The gross and histologic appearance of the colon and the numbers, phenotype, cytokine production, and apoptosis of lymphocytes were compared with those characteristics in a control group. RESULTS:Single-dose administration of FTY720 resulted in the sequestration of circulating lymphocytes within the secondary lymphoid tissues. Four-week administration resulted in a significant reduction of the CD4+ T lymphocytes subpopulation in the colonic lamina propria and IFN-gamma production of the colonic lymphocytes, accompanied by a significant decrease in the severity of colitis. CONCLUSIONS:Treatment of established colitis in IL-10-/- mice with FTY720 ameliorated the colitis, probably as a result of decreasing the number of lymphocytes in the colonic mucosa and an associated reduction in IFN-gamma production.
journal_name
Inflamm Bowel Disjournal_title
Inflammatory bowel diseasesauthors
Mizushima T,Ito T,Kishi D,Kai Y,Tamagawa H,Nezu R,Kiyono H,Matsuda Hdoi
10.1097/00054725-200405000-00002keywords:
subject
Has Abstractpub_date
2004-05-01 00:00:00pages
182-92issue
3eissn
1078-0998issn
1536-4844journal_volume
10pub_type
杂志文章abstract:BACKGROUND:Under experimental chronic inflammation, tumor necrosis factor (TNF)-alpha plays a role in damaging spleen marginal zone. This latter has a crucial function in mounting B cell-dependent immune responses against infections by encapsulated bacteria. In Crohn's disease (CD), a chronic inflammatory disorder wher...
journal_title:Inflammatory bowel diseases
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doi:10.1002/ibd.20374
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abstract::Inflammatory bowel diseases are chronic intestinal inflammatory diseases thought to reflect a dysregulated immune response. Although antibody-based inhibition of tumor necrosis factor-α (TNF-α) has provided relief to many inflammatory bowel diseases patients, these therapies are either ineffective in a patient subset ...
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journal_title:Inflammatory bowel diseases
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journal_title:Inflammatory bowel diseases
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journal_title:Inflammatory bowel diseases
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doi:10.1093/ibd/izy021
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,meta分析
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pub_type: 杂志文章
doi:10.1093/ibd/izaa343
更新日期:2021-01-13 00:00:00
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pub_type: 杂志文章
doi:10.1002/ibd.20992
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pub_type: 杂志文章
doi:10.1002/ibd.21626
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pub_type: 杂志文章
doi:10.1097/MIB.0000000000001211
更新日期:2017-08-01 00:00:00
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doi:10.1002/ibd.21112
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journal_title:Inflammatory bowel diseases
pub_type: 杂志文章,meta分析,评审
doi:10.1097/MIB.0000000000001073
更新日期:2017-04-01 00:00:00
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journal_title:Inflammatory bowel diseases
pub_type: 杂志文章
doi:10.1002/ibd.20966
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pub_type: 杂志文章
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journal_title:Inflammatory bowel diseases
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journal_title:Inflammatory bowel diseases
pub_type: 杂志文章
doi:10.1097/00054725-200111000-00005
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journal_title:Inflammatory bowel diseases
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2015-11-01 00:00:00
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journal_title:Inflammatory bowel diseases
pub_type: 杂志文章,随机对照试验
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更新日期:2012-08-01 00:00:00
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journal_title:Inflammatory bowel diseases
pub_type: 杂志文章
doi:10.1097/MIB.0b013e318297d741
更新日期:2013-09-01 00:00:00
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journal_title:Inflammatory bowel diseases
pub_type: 杂志文章
doi:
更新日期:1997-07-01 00:00:00
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journal_title:Inflammatory bowel diseases
pub_type: 杂志文章
doi:10.1002/ibd.21442
更新日期:2011-04-01 00:00:00
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更新日期:2020-07-17 00:00:00
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journal_title:Inflammatory bowel diseases
pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章
doi:10.1002/ibd.21211
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