Immunochip analysis identification of 6 additional susceptibility loci for Crohn's disease in Koreans.

abstract：BACKGROUND:Fecal biomarkers are used increasingly to monitor Crohn's disease (CD). However, the relative accuracy of different markers in identifying inflammation has been poorly evaluated. We evaluated fecal calprotectin (FC), lactoferrin (FL), and S100A12 (FS) using endoscopic validation in a prospective study of the...

journal_title：Inflammatory bowel diseases

authors： Wright EK,Kamm MA,De Cruz P,Hamilton AL,Ritchie KJ,Keenan JI,Leach S,Burgess L,Aitchison A,Gorelik A,Liew D,Day AS,Gearry RB

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:High levels of patient activation (having the knowledge, skills, and confidence to effectively manage one's care), have been associated with improved outcomes in many chronic conditions. There have been few studies of the effects of activation in patients with inflammatory bowel disease (IBD). We performed a...

journal_title：Inflammatory bowel diseases

authors： Barnes EL,Long MD,Kappelman MD,Martin CF,Sandler RS

更新日期：2019-06-18 00:00:00

abstract：:Chemokines, a large family of small chemoattractive cytokines, and their receptors play an integral role in the regulation of the immune response and homeostasis. The ability of chemokines to attract specific populations of immune cells sets them apart from other chemoattractants. Chemokines produced within the gastro...

journal_title：Inflammatory bowel diseases

authors： Zimmerman NP,Vongsa RA,Wendt MK,Dwinell MB

更新日期：2008-07-01 00:00:00

abstract：BACKGROUND:The PAILOT trial was a randomized controlled trial aimed to evaluate proactive vs reactive therapeutic drug monitoring in children with Crohn's disease (CD) treated with adalimumab. Our aim in this post hoc analysis of the PAILOT trial was to assess the efficacy and safety of adalimumab combination treatment...

journal_title：Inflammatory bowel diseases

authors： Matar M,Shamir R,Turner D,Broide E,Weiss B,Ledder O,Guz-Mark A,Rinawi F,Cohen S,Topf-Olivestone C,Shaoul R,Yerushalmi B,Ben-Horin S,Assa A

更新日期：2020-10-23 00:00:00

abstract：BACKGROUND:Childhood-onset Crohn's disease (CD) might reflect a more severe form of disease. To test this hypothesis we analyzed the long-term natural history of CD in an adult cohort of patients with childhood-onset compared to adult-onset CD. METHODS:We selected 206 childhood-onset CD patients among 2992 adult patie...

journal_title：Inflammatory bowel diseases

authors： Pigneur B,Seksik P,Viola S,Viala J,Beaugerie L,Girardet JP,Ruemmele FM,Cosnes J

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:We have developed a technique for measuring fecal excretion of human DNA by assuming that luminal desquamation of epithelial and inflammatory cells increases in damaged colonic mucosa. However, the clinical usefulness of this technique in the follow-up of patients with ulcerative colitis has not been establi...

journal_title：Inflammatory bowel diseases

authors： Casellas F,Borruel N,Antolín M,Varela E,Torrejón A,Armadans L,Guarner F,Malagelada JR

更新日期：2007-04-01 00:00:00

abstract：BACKGROUND:Advanced oxidation protein products (AOPPs) are new protein markers of oxidative stress with pro-inflammatory properties, accumulated in many pathological conditions. The issue of their enhanced formation in IBD has not been addressed yet. METHODS:The concentration of relative AOPPs (rAOPP; concentration of...

journal_title：Inflammatory bowel diseases

authors： Krzystek-Korpacka M,Neubauer K,Berdowska I,Boehm D,Zielinski B,Petryszyn P,Terlecki G,Paradowski L,Gamian A

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND:Mucosal healing (MH) is associated with improved clinical outcomes in patients with Crohn's disease (CD) and ulcerative colitis (UC). MH as a target for treatment has been suggested, although there is little pediatric data. The goal of this study was to evaluate MH in clinical practice in pediatric patients ...

journal_title：Inflammatory bowel diseases

authors： Santha SL,Shankar PR,Pan A,Schoen B,Kugathasan S,Sauer CG

更新日期：2017-08-01 00:00:00

abstract：:Natural killer T (NKT) cells are a subset of lymphocytes that express cell surface molecules of both conventional T cells and natural killer cells and share the features of both innate and adaptive immune cells. NKT cells have been proposed to make both protective and pathogenic contributions to inflammatory bowel dis...

journal_title：Inflammatory bowel diseases

authors： van Dieren JM,van der Woude CJ,Kuipers EJ,Escher JC,Samsom JN,Blumberg RS,Nieuwenhuis EE

更新日期：2007-09-01 00:00:00

abstract：:Diagnostics of inflammatory bowel diseases (IBDs) currently relies on a combination of biological and morphological tests. The current method of diagnostic remains a critical challenge for physicians in part due to their invasiveness and also for their limitations in term of diagnosis, prognosis, disease activity and ...

journal_title：Inflammatory bowel diseases

authors： Viennois E,Zhao Y,Merlin D

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:Evidence supports the role of adherent invasive Escherichia coli (AIEC) in the pathogenesis of inflammatory bowel disease (IBD). However, little is known about the phylogenetic structure and origin of this group of bacteria. Multi-locus sequence typing (MLST), and fimH sequence analysis were performed to elu...

journal_title：Inflammatory bowel diseases

authors： Sepehri S,Kotlowski R,Bernstein CN,Krause DO

更新日期：2009-11-01 00:00:00

abstract：BACKGROUND:Patients with inflammatory bowel disease (IBD) have identified a need for more information about their disease. PURPOSE:To assess the effect of an educational intervention on health-related quality of life (HRQOL) in patients with IBD. METHODS:Consecutive ambulatory IBD patients were randomized to receive ...

journal_title：Inflammatory bowel diseases

authors： Borgaonkar MR,Townson G,Donnelly M,Irvine EJ

更新日期：2002-07-01 00:00:00

abstract：BACKGROUND:If dysplasia is found on biopsies during surveillance colonoscopy for ulcerative colitis (UC), many experts recommend colectomy given the substantial risk of synchronous colon cancer. The objective was to learn if UC patients' perceptions of their colon cancer risk and if their preferences for elective colec...

journal_title：Inflammatory bowel diseases

authors： Siegel CA,Schwartz LM,Woloshin S,Cole EB,Rubin DT,Vay T,Baars J,Sands BE

更新日期：2010-10-01 00:00:00

abstract：PURPOSE:To describe the reported health-related quality of life (HRQOL) in children and adolescents with inflammatory bowel disease (IBD) after attending an IBD summer camp. METHODS:A prospective analysis of quality of life was completed at an overnight camp that was exclusively for patients with IBD, which was sponso...

journal_title：Inflammatory bowel diseases

authors： Shepanski MA,Hurd LB,Culton K,Markowitz JE,Mamula P,Baldassano RN

更新日期：2005-02-01 00:00:00

abstract：BACKGROUND:The women's health aspect of inflammatory bowel disease (IBD) is a newer area of study; childbearing issues have received little attention despite the fact that IBD affects women predominantly during their childbearing years. The aim of this study was to better understand patients' considerations about pregn...

journal_title：Inflammatory bowel diseases

authors： Marri SR,Ahn C,Buchman AL

更新日期：2007-05-01 00:00:00

abstract：BACKGROUND:Fistulas are a common complication of Crohn's disease (CD) and are difficult to treat effectively. This study aimed to assess the effects of fistula on annual costs of healthcare and resource utilization for patients with CD. METHODS:A retrospective analysis, using the PharMetrics database, of patients with...

journal_title：Inflammatory bowel diseases

authors： Cohen RD,Waters HC,Tang B,Rahman MI

更新日期：2008-12-01 00:00:00

abstract：:Crohn disease and ulcerative colitis are complex immune-mediated diseases that are characterized by a heterogeneity in presentation and clinical course. Although various clinical covariates predict adverse outcomes in these patients, they are insufficiently informative. The gut microbiome likely plays a central role i...

journal_title：Inflammatory bowel diseases

authors： Ananthakrishnan AN

更新日期：2020-09-18 00:00:00

abstract：BACKGROUND:The optimal management of Clostridium difficile infection (CDI) in flaring inflammatory bowel disease (IBD) patients has not been defined. Limited data suggest that coadministration of immunomodulators (IM) with antibiotics (AB) results in a worse outcome. We investigated the prevalent practice among North A...

journal_title：Inflammatory bowel diseases

authors： Yanai H,Nguyen GC,Yun L,Lebwohl O,Navaneethan U,Stone CD,Ghazi L,Moayyedi P,Brooks J,Bernstein CN,Ben-Horin S

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND:The use of stress management psychotherapy is hypothesized to produce greater improvement in disease course and disease-specific quality of life (IBDQ) compared to usual medical care alone in patients with ulcerative colitis (UC) or Crohn's disease (CD) showing high levels of stress (based on the Perceived S...

journal_title：Inflammatory bowel diseases

authors： Boye B,Lundin KE,Jantschek G,Leganger S,Mokleby K,Tangen T,Jantschek I,Pripp AH,Wojniusz S,Dahlstroem A,Rivenes AC,Benninghoven D,Hausken T,Roseth A,Kunzendorf S,Wilhelmsen I,Sharpe M,Blomhoff S,Malt UF,Jahnsen J

更新日期：2011-09-01 00:00:00

abstract：:Dendritic cells (DCs) play a key role in discriminating between commensal microorganisms and potentially harmful pathogens and in maintaining the balance between tolerance and active immunity. The regulatory role of DC is of particular importance in the gut where the immune system lies in intimate contact with the hig...

journal_title：Inflammatory bowel diseases

authors： Ng SC,Kamm MA,Stagg AJ,Knight SC

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND:Ileal lesions in Crohn's disease patients are colonized by pathogenic adherent-invasive Escherichia coli (AIEC) that harbor various virulence factors involved in adhesion to and invasion of intestinal epithelial cultured cells. We investigated in a mouse model of colonic inflammation the behavior of virulent...

journal_title：Inflammatory bowel diseases

authors： Carvalho FA,Barnich N,Sauvanet P,Darcha C,Gelot A,Darfeuille-Michaud A

更新日期：2008-08-01 00:00:00

abstract：:: Primary nonresponse and primary nonremission are important limitations of tumor necrosis factor (TNF) antagonists, occurring in 10% to 40% and 50% to 80% of patients with inflammatory bowel disease, respectively. The magnitude of primary nonresponse differs between phase III clinical trials and cohort studies, indic...

journal_title：Inflammatory bowel diseases

authors： Papamichael K,Gils A,Rutgeerts P,Levesque BG,Vermeire S,Sandborn WJ,Vande Casteele N

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:The incidence of very early onset inflammatory bowel disease (VEOIBD) is increasing, yet the phenotype and natural history of VEOIBD are not well described. METHODS:We performed a retrospective cohort study of patients diagnosed with VEOIBD (6 years of age and younger) between 2008 and 2013 at 25 North Amer...

journal_title：Inflammatory bowel diseases

authors： Kerur B,Benchimol EI,Fiedler K,Stahl M,Hyams J,Stephens M,Lu Y,Pfefferkorn M,Alkhouri R,Strople J,Kelsen J,Siebold L,Goyal A,Rosh JR,LeLeiko N,Van Limbergen J,Guerrerio AL,Maltz R,Karam L,Crowley E,Griffiths A,H

更新日期：2020-05-09 00:00:00

abstract：BACKGROUND:Noninvasive, sensitive, and specific tools for early identification of chronic inflammatory bowel disease (IBD) are needed for clinical practice. The aim was to identify new noninvasive test combinations for characterization of IBD in children and adolescents by comparing serological responses to microbial a...

journal_title：Inflammatory bowel diseases

authors： Ashorn S,Honkanen T,Kolho KL,Ashorn M,Välineva T,Wei B,Braun J,Rantala I,Luukkaala T,Iltanen S

更新日期：2009-02-01 00:00:00

abstract：BACKGROUND:Differentiating ulcerative colitis (UC) from Crohn's colitis (CC) can be difficult and may lead to inaccurate diagnoses in up to 30% of inflammatory bowel disease (IBD) patients. Much of the diagnostic uncertainty arises from the overlap of clinical and histologic features. Matrix-assisted laser desorption/i...

journal_title：Inflammatory bowel diseases

authors： M'Koma AE,Seeley EH,Washington MK,Schwartz DA,Muldoon RL,Herline AJ,Wise PE,Caprioli RM

更新日期：2011-04-01 00:00:00

abstract：BACKGROUND:Mesalamine, 5-aminosalicylic acid (5-ASA), is a potent antioxidant and is known to enhance peroxisome proliferator-activated receptor γ activity in the intestine. Our previous studies suggested reduced Phosphoinositide 3-Kinase (PI3K)/β-catenin signaling as a mechanism for 5-ASA chemoprevention in chronic ul...

journal_title：Inflammatory bowel diseases

authors： Managlia E,Katzman RB,Brown JB,Barrett TA

更新日期：2013-09-01 00:00:00

abstract：Background:Kidney disease has been reported in adults with inflammatory bowel disease (IBD) and is regarded an extraintestinal manifestation or more rarely a side effect of the medical treatment. Methods:In this cross-sectional study we describe the extent of kidney pathology in a cohort of 56 children with IBD. Blood...

journal_title：Inflammatory bowel diseases

authors： Lauritzen D,Andreassen BU,Heegaard NHH,Klinge LG,Walsted AM,Neland M,Nielsen RG,Wittenhagen P

更新日期：2018-11-29 00:00:00

abstract：BACKGROUND:Female patients receiving immunosuppressive therapy may be at increased risk for human papillomavirus (HPV) infection and cervical neoplasia. METHODS:We administered the 3-dose HPV vaccine Gardasil to 37 females aged 9 to 26 years with inflammatory bowel disease (IBD) prescribed immunosuppressive therapy (p...

journal_title：Inflammatory bowel diseases

authors： Jacobson DL,Bousvaros A,Ashworth L,Carey R,Shrier LA,Burchett SK,Renna H,Lu Y

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:Mesenchymal stem cells (MSCs) have demonstrated significant potentials for the treatment of inflammatory bowel disease. Clinical feasible methods to individually document the MSC recruitment to intestinal mucosa is lacking. Here, we proposed that endomicroscopy could noninvasively track MSCs in vivo at cellu...

journal_title：Inflammatory bowel diseases

authors： Li M,Zhang YX,Zhang Z,Zhou XY,Zuo XL,Cong Y,Li YQ

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:Wiskott-Aldrich syndrome protein-deficient patients and mice are immunodeficient and can develop inflammatory bowel disease. The intestinal microbiome is critical to the development of colitis in most animal models, in which Helicobacter spp. have been implicated in disease pathogenesis. We sought to determi...

journal_title：Inflammatory bowel diseases

authors： Nguyen DD,Muthupalani S,Goettel JA,Eston MA,Mobley M,Taylor NS,McCabe A,Marin R,Snapper SB,Fox JG

更新日期：2013-09-01 00:00:00