Abstract:
BACKGROUND:Psoriasis induced by anti-tumor necrosis factor-α (TNF) therapy has been described as a paradoxical side effect. AIM:To determine the incidence, clinical characteristics, and management of psoriasis induced by anti-TNF therapy in a large nationwide cohort of inflammatory bowel disease patients. METHODS:Patients with inflammatory bowel disease were identified from the Spanish prospectively maintained Estudio Nacional en Enfermedad Inflamatoria Intestinal sobre Determinantes genéticos y Ambientales registry of Grupo Español de Trabajo en Enfermedad de Croh y Colitis Ulcerosa. Patients who developed psoriasis by anti-TNF drugs were the cases, whereas patients treated with anti-TNFs without psoriasis were controls. Cox regression analysis was performed to identify predictive factors. RESULTS:Anti-TNF-induced psoriasis was reported in 125 of 7415 patients treated with anti-TNFs (1.7%; 95% CI, 1.4-2). The incidence rate of psoriasis is 0.5% (95% CI, 0.4-0.6) per patient-year. In the multivariate analysis, the female sex (HR 1.9; 95% CI, 1.3-2.9) and being a smoker/former smoker (HR 2.1; 95% CI, 1.4-3.3) were associated with an increased risk of psoriasis. The age at start of anti-TNF therapy, type of inflammatory bowel disease, Montreal Classification, and first anti-TNF drug used were not associated with the risk of psoriasis. Topical steroids were the most frequent treatment (70%), achieving clinical response in 78% of patients. Patients switching to another anti-TNF agent resulted in 60% presenting recurrence of psoriasis. In 45 patients (37%), the anti-TNF therapy had to be definitely withdrawn. CONCLUSIONS:The incidence rate of psoriasis induced by anti-TNF therapy is higher in women and in smokers/former smokers. In most patients, skin lesions were controlled with topical steroids. More than half of patients switching to another anti-TNF agent had recurrence of psoriasis. In most patients, the anti-TNF therapy could be maintained.
journal_name
Inflamm Bowel Disjournal_title
Inflammatory bowel diseasesauthors
Guerra I,Pérez-Jeldres T,Iborra M,Algaba A,Monfort D,Calvet X,Chaparro M,Mañosa M,Hinojosa E,Minguez M,Ortiz de Zarate J,Márquez L,Prieto V,García-Sánchez V,Guardiola J,Rodriguez GE,Martín-Arranz MD,García-Tercero I,Sdoi
10.1097/MIB.0000000000000757subject
Has Abstractpub_date
2016-04-01 00:00:00pages
894-901issue
4eissn
1078-0998issn
1536-4844journal_volume
22pub_type
杂志文章,多中心研究abstract:BACKGROUND:Crohn's disease (CD) and ulcerative colitis (UC) are inflammatory bowel diseases (IBDs) presumably caused by dysregulated immune responses to the gut microbiota. Genetic association studies have implicated dozens of chromosomal regions or loci in IBD susceptibility. The next challenge is to explain the indiv...
journal_title:Inflammatory bowel diseases
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journal_title:Inflammatory bowel diseases
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journal_title:Inflammatory bowel diseases
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journal_title:Inflammatory bowel diseases
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更新日期:1997-04-01 00:00:00
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journal_title:Inflammatory bowel diseases
pub_type: 杂志文章
doi:10.1097/01.mib.0000183419.17563.17
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journal_title:Inflammatory bowel diseases
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journal_title:Inflammatory bowel diseases
pub_type: 临床试验,杂志文章
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更新日期:2005-04-01 00:00:00
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pub_type: 杂志文章,多中心研究
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journal_title:Inflammatory bowel diseases
pub_type: 杂志文章,多中心研究
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journal_title:Inflammatory bowel diseases
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journal_title:Inflammatory bowel diseases
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doi:10.1002/ibd.20787
更新日期:2009-04-01 00:00:00
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更新日期:2016-05-01 00:00:00
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journal_title:Inflammatory bowel diseases
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journal_title:Inflammatory bowel diseases
pub_type: 杂志文章,多中心研究
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journal_title:Inflammatory bowel diseases
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journal_title:Inflammatory bowel diseases
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journal_title:Inflammatory bowel diseases
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