Menstrual cycle changes in women with inflammatory bowel disease: a study from the ocean state Crohn's and colitis area registry.


BACKGROUND:The effect of the inflammatory bowel diseases (IBD) on menstrual function is largely unknown. The aims of this study were to determine whether changes in menstrual function occur in the year before IBD diagnosis or in the initial years after diagnosis. METHODS:Women aged 18 years and older in the Ocean State Crohn's and Colitis Area Registry with at least 2 years of follow-up were eligible for this study. All patients were enrolled within 6 months of IBD diagnosis and followed prospectively. Menstrual cycle characteristics were retrospectively assessed. To assess for changes over time, general linear models for correlated data were used for continuous outcomes, and generalized estimating equations were used for discrete outcomes. RESULTS:One hundred twenty-one patients were studied. Twenty-five percent of patients experienced a change in cycle interval in the year before IBD diagnosis and 21% experienced a change in the duration of flow. Among women with dysmenorrhea, 40% experienced a change in the intensity of their menstrual pain and 31% experienced a change in its duration. Overall cycle regularity increased over time. Quality of life was significantly lower in women without regular cycles across all time points. CONCLUSIONS:Changes in menstrual function occur frequently in the year before IBD diagnosis; therefore, screening for menstrual irregularities should be considered in women with newly diagnosed IBD. Patients can be reassured that cycles typically become more regular over time.


Inflamm Bowel Dis


Saha S,Zhao YQ,Shah SA,Esposti SD,Lidofsky S,Salih S,Bright R,Law M,Moniz H,Flowers N,Merrick M,Sands BE




Has Abstract


2014-03-01 00:00:00












  • Segmental Resection versus Total Proctocolectomy for Crohn's Colitis: What is the Best Operation in the Setting of Medically Refractory Disease or Dysplasia?

    abstract::Crohn's disease (CD) may affect any part of the gastrointestinal tract. When isolated to the colon, and patients become medically refractory, there are several surgical options - segmental resection, subtotal colectomy with ileorectal anastomosis, or a total proctocolectomy and end ileostomy. Unfortunately, surgery do...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章,评审


    authors: Lightner AL

    更新日期:2018-02-15 00:00:00

  • Using optical markers of nondysplastic rectal epithelial cells to identify patients with ulcerative colitis-associated neoplasia.

    abstract:BACKGROUND:Current surveillance guidelines for patients with long-standing ulcerative colitis (UC) recommend repeated colonoscopy with random biopsies, which is time-consuming, discomforting, and expensive. A less invasive strategy is to identify neoplasia by analyzing biomarkers from the more accessible rectum to pred...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Bista RK,Brentnall TA,Bronner MP,Langmead CJ,Brand RE,Liu Y

    更新日期:2011-12-01 00:00:00

  • A Population Pharmacokinetic and Exposure-Response Model of Golimumab for Targeting Endoscopic Remission in Patients With Ulcerative Colitis.

    abstract:BACKGROUND:Unlike other anti-tumor necrosis factor alpha antibodies, golimumab does not deliver on its promise of effectiveness for treating patients with ulcerative colitis. We investigated the value of therapeutic drug monitoring for optimizing golimumab therapy. METHODS:We analyzed the golimumab pharmacokinetics da...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Dreesen E,Kantasiripitak W,Detrez I,Stefanović S,Vermeire S,Ferrante M,Bouillon T,Drobne D,Gils A

    更新日期:2020-03-04 00:00:00

  • Co-prescribing azathiopurine or 6-mercaptopurine and 5-aminosalicylate compounds in ulcerative colitis.

    abstract:BACKGROUND:A total of 254 senior consultant gastroenterologists with valid e-mail addresses were identified from the membership list of the British Society of Gastroenterology (BSG) 2007. METHODS:They were sent by e-mail a questionnaire which dealt with aspects of clinical practice and addressed cancer prevention in u...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Mayberry H,Moshkovska T,Mayberry JF

    更新日期:2009-02-01 00:00:00

  • Fecal calprotectin and lactoferrin for the prediction of inflammatory bowel disease relapse.

    abstract:BACKGROUND:The purpose of the study was to determine the role of fecal calprotectin and lactoferrin in the prediction of inflammatory bowel disease relapses, both in patients with ulcerative colitis (UC) and Crohn's disease (CD), in a large, long-term, follow-up study. METHODS:The prospective multicenter study include...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章,多中心研究


    authors: Gisbert JP,Bermejo F,Pérez-Calle JL,Taxonera C,Vera I,McNicholl AG,Algaba A,López P,López-Palacios N,Calvo M,González-Lama Y,Carneros JA,Velasco M,Maté J

    更新日期:2009-08-01 00:00:00

  • Cell Trafficking Interference in Inflammatory Bowel Disease: Therapeutic Interventions Based on Basic Pathogenesis Concepts.

    abstract::After 20 years of successful targeting of pro-inflammatory cytokines for the treatment of IBD, an alternative therapeutic strategy has emerged, based on several decades of advances in understanding the pathogenesis of IBD. The targeting of molecules involved in leukocyte traffic has recently become a safe and effectiv...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章,评审


    authors: Pérez-Jeldres T,Tyler CJ,Boyer JD,Karuppuchamy T,Bamias G,Dulai PS,Boland BS,Sandborn WJ,Patel DR,Rivera-Nieves J

    更新日期:2019-01-10 00:00:00

  • Effect of 2 psychotherapies on depression and disease activity in pediatric Crohn's disease.

    abstract:BACKGROUND:Crohn's disease (CD) is associated with depression. It is unclear if psychosocial interventions offer benefit for depressive symptoms during active CD. In this secondary analysis of a larger study of treating depression in pediatric inflammatory bowel disease, we assessed whether cognitive behavioral therapy...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章,随机对照试验


    authors: Szigethy E,Youk AO,Gonzalez-Heydrich J,Bujoreanu SI,Weisz J,Fairclough D,Ducharme P,Jones N,Lotrich F,Keljo D,Srinath A,Bousvaros A,Kupfer D,DeMaso DR

    更新日期:2015-06-01 00:00:00

  • Treatment patterns, complications, and disease relapse in a real-world population of patients with moderate-to-severe ulcerative colitis initiating immunomodulator therapy.

    abstract:BACKGROUND:Immunomodulator (IM) treatments in ulcerative colitis (UC) are not curative and carry increased risk of complications, sometimes leading to therapy changes, reduced treatment benefits, and eventual relapse. We assessed patterns of IM utilization and therapy changes, complications, and disease relapse in a re...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Loftus EV Jr,Davis KL,Wang CC,Dastani H,Luo A

    更新日期:2014-08-01 00:00:00

  • Length and type of recurrent ileitis after ileal resection correlate with presurgical features in Crohn's disease.

    abstract:SUMMARY:: Crohn's disease of the terminal ileum usually recurs after an ileocolonic resection. To compare the length and the disease behavior of recurrent ileitis with the presurgical disease characteristics, we studied 31 consecutive patients who had recurrent Crohn's disease symptoms and who had undergone an ileoceca...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Dʼhaens G,Baert F,Gasparaitis A,Hanauer S

    更新日期:1997-01-01 00:00:00

  • Bile acid malabsorption deactivates pregnane X receptor in patients with Crohn's disease.

    abstract:BACKGROUND:Recent studies have suggested that the downregulation of pregnane X receptor (PXR) may contribute to the susceptibility and exacerbation of Crohn's disease (CD). Because bile acid malabsorption is one of the features of CD and bile acids are potential activators of PXR, we explored the relationship between b...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Iwamoto J,Saito Y,Honda A,Miyazaki T,Ikegami T,Matsuzaki Y

    更新日期:2013-05-01 00:00:00

  • Profiling adipocytokine secretion from creeping fat in Crohn's disease.

    abstract:BACKGROUND:Adipose tissue is recognized as a compartment secreting highly active molecules. Creeping fat represents a characteristic feature of Crohn's disease (CD). Proinflammatory or anti-inflammatory adipose-derived secretory products, now generally called adipocytokines, may play a role in the pathogenesis of CD. ...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Paul G,Schäffler A,Neumeier M,Fürst A,Bataillle F,Buechler C,Müller-Ladner U,Schölmerich J,Rogler G,Herfarth H

    更新日期:2006-06-01 00:00:00

  • Toward an Algorithm for the Diagnosis and Management of CMV in Patients with Colitis.

    abstract:INTRODUCTION:Concurrent cytomegalovirus (CMV) in inflammatory bowel disease-related colitis is an important yet complex clinical scenario associated with high rates of colectomy and other morbidity. This review aimed to examine the literature to produce a comprehensive diagnostic and treatment algorithm for the managem...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章,评审


    authors: Beswick L,Ye B,van Langenberg DR

    更新日期:2016-12-01 00:00:00

  • TNFRSF1B Is Associated with ANCA in IBD.

    abstract::The genetic basis of antineutrophil cytoplasmic antibody, an important biomarker of inflammatory bowel disease (IBD), has never been thoroughly examined on a genome-wide scale. In this study, we performed a 2-stage genome-wide association study (GWAS) on antineutrophil cytoplasmic antibody in IBD cases. In the 2959 IB...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章,meta分析


    authors: Li D,Silverberg MS,Haritunians T,Dubinsky MC,Landers C,Stempak JM,Milgrom R,Guo X,Chen YD,Rotter JI,Taylor KD,McGovern DP,Targan SR

    更新日期:2016-06-01 00:00:00

  • CCL2 (pM levels) as a therapeutic agent in Inflammatory Bowel Disease models in mice.

    abstract:BACKGROUND:Chemokines regulate the pathways that restrict homing of specific subsets of immune cells, and thereby fine tune the immune response at specific lymphoid and peripheral tissues. CCL2 is a chemokine that induces migration of monocytes, memory T cells, and dendritic cells. Previously, we demonstrated that pM l...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Maharshak N,Hart G,Ron E,Zelman E,Sagiv A,Arber N,Brazowski E,Margalit R,Elinav E,Shachar I

    更新日期:2010-09-01 00:00:00

  • Changes of OPG and RANKL concentrations in Crohn's disease after infliximab therapy.

    abstract:BACKGROUND:Osteoporosis is a well-known complication of Crohn's disease (CD). Osteoprotegerin (OPG) concentration is elevated in patients with CD compared to healthy controls. Long-term infliximab (IFX) maintenance therapy improves the patients' bone mineral density. The effect of IFX on bone metabolism has not yet bee...

    journal_title:Inflammatory bowel diseases

    pub_type: 临床试验,杂志文章


    authors: Miheller P,Muzes G,Rácz K,Blázovits A,Lakatos P,Herszényi L,Tulassay Z

    更新日期:2007-11-01 00:00:00

  • Health-related quality of life improves in children and adolescents with inflammatory bowel disease after attending a camp sponsored by the Crohn's and Colitis Foundation of America.

    abstract:PURPOSE:To describe the reported health-related quality of life (HRQOL) in children and adolescents with inflammatory bowel disease (IBD) after attending an IBD summer camp. METHODS:A prospective analysis of quality of life was completed at an overnight camp that was exclusively for patients with IBD, which was sponso...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Shepanski MA,Hurd LB,Culton K,Markowitz JE,Mamula P,Baldassano RN

    更新日期:2005-02-01 00:00:00

  • Changes in the Abundance of Faecalibacterium prausnitzii Phylogroups I and II in the Intestinal Mucosa of Inflammatory Bowel Disease and Patients with Colorectal Cancer.

    abstract:BACKGROUND:Faecalibacterium prausnitzii comprises 2 phylogroups, whose abundance in healthy and diseased gut and in conjunction with Escherichia coli has not yet been studied. This work aims to determine the contribution of F. prausnitzii phylogroups I and II in intestinal disease and to assess their potential diagnost...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Lopez-Siles M,Martinez-Medina M,Surís-Valls R,Aldeguer X,Sabat-Mir M,Duncan SH,Flint HJ,Garcia-Gil LJ

    更新日期:2016-01-01 00:00:00

  • Gliotoxin reduces the severity of trinitrobenzene sulfonic acid-induced colitis in mice: evidence of the connection between heme oxygenase-1 and the nuclear factor-kappaB pathway in vitro and in vivo.

    abstract:BACKGROUND:Gliotoxin, a fungal metabolite, has been known to show strong immunosuppressive properties, although its mechanisms are not completely understood. In this report, the authors investigated the mechanism whereby gliotoxin has anti-inflammatory properties in vitro and in trinitrobenzene sulfonic acid-induced co...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Jun CD,Kim Y,Choi EY,Kim M,Park B,Youn B,Yu K,Choi KS,Yoon KH,Choi SC,Lee MS,Park KI,Choi M,Chung Y,Oh J

    更新日期:2006-07-01 00:00:00

  • On the role of ischemia in the pathogenesis of IBD: a review.

    abstract::Inflammatory bowel disease (IBD) is a chronic intestinal disorder comprising 2 distinct but often overlapping diseases: Crohn's disease and ulcerative colitis. Although much research to identify the etiology of IBD has focused on genetic constitution, infectious causes, and immune dysregulation, its exact cause and pa...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章,评审


    authors: Ibrahim CB,Aroniadis OC,Brandt LJ

    更新日期:2010-04-01 00:00:00

  • Linking vitamin d deficiency to inflammatory bowel disease.

    abstract::Inflammatory bowel disease is associated with industrialization, and its incidence has increased markedly over time. The prospect of reversing these trends motivates the search for the agent(s) involved. Modernity entails several physical and behavioral modifications that compromise both the photosynthesis of cholecal...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章,评审


    authors: Palmer MT,Weaver CT

    更新日期:2013-09-01 00:00:00

  • Point Prevalence of Pediatric Inflammatory Bowel Disease in New Zealand in 2015: Initial Results from the PINZ Study.

    abstract:BACKGROUND:The incidence of pediatric inflammatory bowel disease (IBD) around the world is increasing. However, there is a scarcity of data on the epidemiology of pediatric IBD in the Southern Hemisphere. This study aimed to document the point prevalence of pediatric IBD in New Zealand on June 30, 2015. METHODS:All pa...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Lopez RN,Evans HM,Appleton L,Bishop J,Chin S,Mouat S,Gearry RB,Day AS

    更新日期:2017-08-01 00:00:00

  • Pericarditis complicating ulcerative colitis.

    abstract::: Pericarditis occurs rarely in association with inflammatory bowel disease. Because life-threatening complications may occur, pericarditis should be suspected in patients who present with chest symptoms. We report the case of a 28-year-old patient with ulcerative colitis who presented with pericarditis during an acti...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Hinterreiter M,Allinger S,Punzengruber C,Knoflach P

    更新日期:1995-10-01 00:00:00

  • Cost-effectiveness and Clinical Outcomes of Early Anti-Tumor Necrosis Factor-α Intervention in Pediatric Crohn's Disease.

    abstract:BACKGROUND:Anti-tumor necrosis factor-α (anti-TNF-α) treatments are increasingly used to treat pediatric Crohn's disease, even without a prior trial of immunomodulators, but the cost-effectiveness of such treatment algorithms has not been formally examined. Drug plan decision-makers require evidence of cost-effectivene...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Bashir NS,Walters TD,Griffiths AM,Ito S,Ungar WJ

    更新日期:2020-07-17 00:00:00

  • Incidence of and impact of medications on colectomy in newly diagnosed ulcerative colitis in the era of biologics.

    abstract:BACKGROUND:The cumulative incidence of colectomy and the impact of 5-aminosalicylates (5-ASA), azathioprine, and antitumor necrosis factor (TNF) treatment on the long-term need for surgery are unknown in ulcerative colitis (UC) in the era of biologics. METHODS:This was an observational study of a referral center cohor...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Williet N,Pillot C,Oussalah A,Billioud V,Chevaux JB,Bresler L,Bigard MA,Gueant JL,Peyrin-Biroulet L

    更新日期:2012-09-01 00:00:00

  • A new oral delivery system for 5-ASA: preliminary clinical findings for MMx.

    abstract:BACKGROUND:Multi-matrix (MMx), a new delivery system for mesalazine, seems to release 5-aminosalicyclic acid (5-ASA) preferentially in the sigmoid colon. This study had 2 objectives: (1) to evaluate the therapeutic response to MMx in patients with active left-sided disease and (2) to gain additional insights as to how ...

    journal_title:Inflammatory bowel diseases

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Prantera C,Viscido A,Biancone L,Francavilla A,Giglio L,Campieri M

    更新日期:2005-05-01 00:00:00

  • Clinically Significant Small Bowel Crohn's Disease Might Only be Detected by Capsule Endoscopy.

    abstract:Background:In Crohn's disease (CD) a small bowel study-in addition to colonoscopy-is considered necessary for diagnosis/staging. In this study we re-examined the role of capsule endoscopy (CE), colonoscopy, imaging tests [magnetic resonance enterography/computed tomographic enterography (MRE/CTE)], and inflammatory mar...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Sorrentino D,Nguyen VQ

    更新日期:2018-06-08 00:00:00

  • Acute Colitis Drives Tolerance by Persistently Altering the Epithelial Barrier and Innate and Adaptive Immunity.

    abstract:BACKGROUND:Inflammatory bowel disease (IBD) has a remitting and relapsing disease course; however, relatively little is understood regarding how inflammatory damage in acute colitis influences the microbiota, epithelial barrier, and immune function in subsequent colitis. METHODS:Mice were administered trinitrobenzene ...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Wardill HR,Choo JM,Dmochowska N,Mavrangelos C,Campaniello MA,Bowen JM,Rogers GB,Hughes PA

    更新日期:2019-06-18 00:00:00

  • Inflammatory bowel disease associates with proinflammatory potential of the immunoglobulin G glycome.

    abstract:BACKGROUND:Glycobiology is an underexplored research area in inflammatory bowel disease (IBD), and glycans are relevant to many etiological mechanisms described in IBD. Alterations in N-glycans attached to the immunoglobulin G (IgG) Fc fragment can affect molecular structure and immunological function. Recent genome-wi...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Trbojević Akmačić I,Ventham NT,Theodoratou E,Vučković F,Kennedy NA,Krištić J,Nimmo ER,Kalla R,Drummond H,Štambuk J,Dunlop MG,Novokmet M,Aulchenko Y,Gornik O,Campbell H,Pučić Baković M,Satsangi J,Lauc G,IBD-BIOM Consor

    更新日期:2015-06-01 00:00:00

  • Roles of T cell-associated L-selectin and β7 integrins during induction and regulation of chronic colitis.

    abstract:BACKGROUND:L-selectin (CD62L) and β(7) integrins are important for trafficking of naive T cells under steady-state conditions. The objectives of this study were to dissect the requirements for T cell-associated CD62L and β(7) integrins during initiation, progression, and regulation of chronic colitis. METHODS:Using th...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Kurmaeva E,Boktor M,Zhang S,Bao R,Berney S,Ostanin DV

    更新日期:2013-11-01 00:00:00

  • Dosage adjustment during long-term adalimumab treatment for Crohn's disease: clinical efficacy and pharmacoeconomics.

    abstract:BACKGROUND:Data from CHARM, a 56-week, randomized controlled trial of adalimumab for patients with moderately to severely active Crohn's disease (CD), were used to evaluate outcomes of adalimumab dosage adjustment. METHODS:Patients randomized to blinded adalimumab 40 mg every other week (EOW) in CHARM were the focus o...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章,随机对照试验


    authors: Sandborn WJ,Colombel JF,Schreiber S,Plevy SE,Pollack PF,Robinson AM,Chao J,Mulani P

    更新日期:2011-01-01 00:00:00