Tissue-nonspecific alkaline phosphatase is activated in enterocytes by oxidative stress via changes in glycosylation.

abstract：BACKGROUND:VSL#3 is a probiotic compound that has been used in the treatment of inflammatory bowel disease. T-cell protein tyrosine phosphatase (TCPTP) is the protein product of the inflammatory bowel disease candidate gene, PTPN2, and we have previously shown that it protects epithelial barrier function. The aim of th...

journal_title：Inflammatory bowel diseases

authors： Krishnan M,Penrose HM,Shah NN,Marchelletta RR,McCole DF

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:There is limited contemporary population-based evidence on adverse birth outcomes and pregnancy-related complications for women with inflammatory bowel disease (IBD). This study provides such estimates of these risks and assesses variation by IBD type and surgical interventions. METHODS:We calculated the pr...

journal_title：Inflammatory bowel diseases

authors： Abdul Sultan A,West J,Ban L,Humes D,Tata LJ,Fleming KM,Nelson-Piercy C,Card T

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:The mechanisms responsible for the pathogenesis of peripheral arthropathies (PA) in Crohn's disease (CD) are largely unknown, although many studies indicate that genetic and environmental factors are likely to contribute to risk. METHODS:Because variants in the Fc receptor-like 3 (FcRL3) gene have recently ...

journal_title：Inflammatory bowel diseases

authors： Mendoza JL,Lana R,Martin MC,de la Concha EG,Urcelay E,Diaz-Rubio M,Abreu MT,Mitchell AA

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND:The women's health aspect of inflammatory bowel disease (IBD) is a newer area of study; childbearing issues have received little attention despite the fact that IBD affects women predominantly during their childbearing years. The aim of this study was to better understand patients' considerations about pregn...

journal_title：Inflammatory bowel diseases

authors： Marri SR,Ahn C,Buchman AL

更新日期：2007-05-01 00:00:00

abstract：BACKGROUND:Evaluating structural damage using imaging is essential for the evaluation of small intestinal Crohn's disease (CD), but it is limited by potential interobserver variation. We compared the agreement of enterography-based bowel damage measurements collected by experienced radiologists and a semi-automated ima...

journal_title：Inflammatory bowel diseases

authors： Stidham RW,Enchakalody B,Waljee AK,Higgins PDR,Wang SC,Su GL,Wasnik AP,Al-Hawary M

更新日期：2020-04-11 00:00:00

abstract：BACKGROUND:Inflammatory bowel disease (IBD)-associated dysbiosis is characterized by a loss of Faecalibacterium prausnitzii, whose supernatant exerts an anti-inflammatory effect. However, the anti-inflammatory substances in F. prausnitzii supernatant and the mechanism in ameliorating colitis in IBD have not yet been fu...

journal_title：Inflammatory bowel diseases

authors： Zhou L,Zhang M,Wang Y,Dorfman RG,Liu H,Yu T,Chen X,Tang D,Xu L,Yin Y,Pan Y,Zhou Q,Zhou Y,Yu C

更新日期：2018-08-16 00:00:00

abstract：BACKGROUND:Guidelines mandate screening for latent tuberculosis infection (LTBI) prior to anti-tumor necrosis factor (anti-TNF) therapy in patients with inflammatory bowel disease (IBD). However, many are already on immunosuppressive therapy (IST) that may affect the precision of the Tuberculin skin test (TST). Our aim...

journal_title：Inflammatory bowel diseases

authors： Shahidi N,Fu YT,Qian H,Bressler B

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:Psoriasis induced by anti-tumor necrosis factor-α (TNF) therapy has been described as a paradoxical side effect. AIM:To determine the incidence, clinical characteristics, and management of psoriasis induced by anti-TNF therapy in a large nationwide cohort of inflammatory bowel disease patients. METHODS:Pat...

journal_title：Inflammatory bowel diseases

authors： Guerra I,Pérez-Jeldres T,Iborra M,Algaba A,Monfort D,Calvet X,Chaparro M,Mañosa M,Hinojosa E,Minguez M,Ortiz de Zarate J,Márquez L,Prieto V,García-Sánchez V,Guardiola J,Rodriguez GE,Martín-Arranz MD,García-Tercero I,S

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:Immunosuppressive therapy with anti-TNF-alpha antibodies is effective in patients with inflammatory bowel disease (IBD). However, there is an increased risk for infections associated with this therapy. METHODS:Here, we report the case of a 58-year-old patient with Crohn's disease (CD) treated with steroids ...

journal_title：Inflammatory bowel diseases

authors： Beigel F,Jürgens M,Filik L,Bader L,Lück C,Göke B,Ochsenkühn T,Brand S,Seiderer J

更新日期：2009-08-01 00:00:00

abstract：:Diagnostics of inflammatory bowel diseases (IBDs) currently relies on a combination of biological and morphological tests. The current method of diagnostic remains a critical challenge for physicians in part due to their invasiveness and also for their limitations in term of diagnosis, prognosis, disease activity and ...

journal_title：Inflammatory bowel diseases

authors： Viennois E,Zhao Y,Merlin D

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:Vitamin D (25(OH)D) deficiency occurs in active Crohn's disease (CD) and may be secondary to reduced sunlight exposure and oral intake. Vitamin D-binding protein (VDBP) levels, however, fluctuate less with season and sunlight. The aim, therefore, was to examine patients with CD in remission and determine any...

journal_title：Inflammatory bowel diseases

authors： Ghaly S,Murray K,Baird A,Martin K,Prosser R,Mill J,Simms LA,Hart PH,Radford-Smith G,Bampton PA,Lawrance IC

更新日期：2016-10-01 00:00:00

abstract：:: We report our initial characterization of the immune system in C3H/HeJBir mice that spontaneously develop perianal ulceration. Analysis of lymphokine production by mucosal and systemic lymphoid cells obtained from these mice revealed higher levels of interleukin (IL)4 in supernatants of in vitro stimulated Peyer's p...

journal_title：Inflammatory bowel diseases

authors： Tonkonogy SL,Sartor BR

更新日期：1997-04-01 00:00:00

abstract：BACKGROUND:Little knowledge exists about the association between anti-tumor necrosis factor-alpha (anti-TNF-α) therapy for inflammatory bowel disease during late pregnancy and adverse birth outcomes. We aimed to examine whether treatment with anti-TNF-α during the third trimester affected preterm birth and low birth we...

journal_title：Inflammatory bowel diseases

authors： Kammerlander H,Nielsen J,Knudsen T,Kjeldsen J,Friedman S,Nørgård BM

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:The majority of studies concerning the clinical course and prognosis in ulcerative colitis (UC) are old, retrospective in design, or hospital based. We aimed to identify clinical course and prognosis in a prospective, population-based follow-up study MATERIALS AND METHODS:Patients diagnosed with inflammator...

journal_title：Inflammatory bowel diseases

authors： Henriksen M,Jahnsen J,Lygren I,Sauar J,Kjellevold Ø,Schulz T,Vatn MH,Moum B,IBSEN Study Group.

更新日期：2006-07-01 00:00:00

abstract：Background:Vitamin D3 and vitamin D receptor (VDR) are involved in the pathogenesis of inflammatory bowel disease (IBD) and bacterial infection. Claudin-2 is a junction protein that mediates paracellular water transport in epithelia. Elevation of Claudin-2 is associated with active IBD. However, VDR involved in epithel...

journal_title：Inflammatory bowel diseases

authors： Zhang YG,Lu R,Xia Y,Zhou D,Petrof E,Claud EC,Sun J

更新日期：2019-01-01 00:00:00

abstract：:Restorative proctocolectomy with ileal-pouch anal anastomosis (RPC) is the operation of choice for ulcerative colitis (UC) patients requiring surgery. It is also used for patients with familial adenomatous polyposis (FAP). Pouchitis accounts for 10% of pouch failures. It is an idiopathic inflammatory condition that ma...

journal_title：Inflammatory bowel diseases

authors： Landy J,Al-Hassi HO,McLaughlin SD,Knight SC,Ciclitira PJ,Nicholls RJ,Clark SK,Hart AL

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND:Chronic inflammation in ulcerative colitis (UC) is a sizeable risk factor for colorectal cancer (CRC). Interleukin-13 (IL-13) is elevated in the UC mucosa and may induce dysregulated signaling in neighboring intestinal epithelial cells (IECs) and thus function as a tumorogenic cytokine. METHODS:Expression o...

journal_title：Inflammatory bowel diseases

authors： Mandal D,Levine AD

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND:Cytomegalovirus (CMV) colitis can contribute to an unfavorable outcome of acute severe ulcerative colitis (ASUC). The purpose of this study was to evaluate the clinical outcomes of ASUC according to the CMV status and identify risk factors for CMV colitis in patients with ASUC. METHODS:We retrospectively an...

journal_title：Inflammatory bowel diseases

authors： Lee HS,Park SH,Kim SH,Kim J,Choi J,Lee HJ,Kim WS,Lee JM,Kwak MS,Hwang SW,Yang DH,Kim KJ,Ye BD,Byeon JS,Myung SJ,Yoon YS,Yu CS,Kim JH,Yang SK

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:Genetic variants of nucleotide-binding oligomerization domain 2 (NOD2) lead to aberrant microbial recognition and can cause chronic inflammatory diseases in patients with Crohn's disease (CD). METHODS:We utilized gene-specific siRNA mediated knockdown and expression of guanine nucleotide exchange factor H1 ...

journal_title：Inflammatory bowel diseases

authors： Zhao Y,Alonso C,Ballester I,Song JH,Chang SY,Guleng B,Arihiro S,Murray PJ,Xavier R,Kobayashi KS,Reinecker HC

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND:The role of antiviral therapy in patients with ulcerative colitis (UC) with cytomegalovirus (CMV) remains unclear. We therefore performed a systematic review and meta-analysis to assess the association between antiviral therapy and the risk of colectomy. METHODS:Multiple electronic databases were searched s...

journal_title：Inflammatory bowel diseases

authors： Shukla T,Singh S,Loftus EV Jr,Bruining DH,McCurdy JD

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND:The consistency of endoscopic and histologic findings in patients with ulcerative colitis (UC) has not been elucidated. Choice of assessment may affect study outcomes. METHODS:Post hoc analyses were performed using data from 2 randomized, controlled multicenter trials: (1) SAG-26, mesalazine granules for in...

journal_title：Inflammatory bowel diseases

authors： Wolff S,Terheggen G,Mueller R,Greinwald R,Franklin J,Kruis W

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Practical and objective instruments to assess pediatric Crohn's disease (CD) activity are required for observational research and quality improvement. The objectives were: 1) to determine the feasibility of completing the Pediatric Crohn's Disease Activity Index (PCDAI) and the Abbreviated PCDAI (APCDAI); an...

journal_title：Inflammatory bowel diseases

authors： Kappelman MD,Crandall WV,Colletti RB,Goudie A,Leibowitz IH,Duffy L,Milov DE,Kim SC,Schoen BT,Patel AS,Grunow J,Larry E,Fairbrother G,Margolis P

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Drug concentration monitoring may be useful to guide therapeutic adjustments for anti-tumor necrosis factor agents in Crohn's disease. The relationship between serum adalimumab concentrations and clinical outcomes was assessed using data from CLinical Assessment of Adalimumab Safety and Efficacy Studied as I...

journal_title：Inflammatory bowel diseases

authors： Chiu YL,Rubin DT,Vermeire S,Louis E,Robinson AM,Lomax KG,Pollack PF,Paulson SK

更新日期：2013-05-01 00:00:00

abstract：:Clinical and epidemiological studies have revealed that the incidence of colorectal cancer associated with ulcerative colitis increases with long-term chronic inflammation. Careful endoscopic observation and histological studies to check for dysplasia in the colon are important in detecting neoplasia. Current surveill...

journal_title：Inflammatory bowel diseases

authors： Matsumoto T,Iwao Y,Igarashi M,Watanabe K,Otsuka K,Watanabe T,Iizuka B,Hida N,Sada M,Chiba T,Kudo SE,Oshitani N,Nagawa H,Ajioka Y,Hibi T

更新日期：2008-02-01 00:00:00

abstract：BACKGROUND:The level of inflammatory bowel disease (IBD) training in general gastroenterology fellowship is often insufficient to prepare trainees to deliver advanced IBD care in practice. Advanced IBD fellowships have been developed to fill this training gap, but there is no established curriculum, and significant var...

journal_title：Inflammatory bowel diseases

authors： Cohen BL,Gallinger ZR,Ha C,Holubar SD,Hou JK,Kinnucan J,Mahadevan U,Moss AC,Raffals LE,Regueiro M,Szigethy E,Wolf D,Dubinsky MC,Patel A,Shah BJ,Ehrlich OG,Hanauer SB

更新日期：2020-08-20 00:00:00

abstract：BACKGROUND:Patients suffering from Crohn's disease (CD) show increased incidence of low bone mineral density. Investigating this complication is difficult because the exact etiology of CD remains elusive. Mice carrying a deletion in the tumor necrosis factor (TNF) AU-rich elements (ARE) are reported as a model for huma...

journal_title：Inflammatory bowel diseases

authors： Huybers S,Apostolaki M,van der Eerden BC,Kollias G,Naber TH,Bindels RJ,Hoenderop JG

更新日期：2008-06-01 00:00:00

abstract：INTRODUCTION:Antitumor necrosis factor (anti-TNF) medications are known to be highly efficacious in persons with moderate-to-severe inflammatory bowel disease (IBD). There is a paucity of data from population-based sources to elucidate persistence with these medications in the general population of IBD. Discontinuation...

journal_title：Inflammatory bowel diseases

authors： Targownik LE,Tennakoon A,Leung S,Lix LM,Nugent Z,Singh H,Bernstein CN

更新日期：2017-03-01 00:00:00

abstract：:: Inflammatory bowel disease is associated with a reduction in serum and red blood cell folate levels that may contribute to colonic carcinogenesis. Sulfasalazine may exacerbate such deficiencies. Indirect evidence suggests that folate supplements reduce the risk of colonic neoplasia in those using this agent, althoug...

journal_title：Inflammatory bowel diseases

authors： Meenan J,Oʼhallinan E,Scott J,Weir DG

更新日期：1996-10-01 00:00:00

abstract：BACKGROUND:Adverse drug reactions to azathioprine, the prodrug of 6-mercaptopurine, occur in 15%-38% of patients and the majority are not explained by thiopurine-S-methyltransferase (TPMT) deficiency. Azathioprine is known to induce glutathione depletion and consumption of glutathione is greater in cells with high glut...

journal_title：Inflammatory bowel diseases

authors： Stocco G,Martelossi S,Barabino A,Decorti G,Bartoli F,Montico M,Gotti A,Ventura A

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Individuals with ulcerative colitis are at high risk of developing colitis-associated cancer. 5-Aminosalicylate (5-ASA) protects from cancer by its antiinflammatory activity as well as by altering cell growth, inducing apoptosis, and reducing replication errors. So far neither 5-ASA's structural specificity ...

journal_title：Inflammatory bowel diseases

authors： Campregher C,Luciani MG,Biesenbach P,Evstatiev R,Lyakhovich A,Gasche C

更新日期：2010-04-01 00:00:00