Influence of sulfasalazine and olsalamine on colonic epithelial cell folate content in patients with ulcerative colitis.

abstract：BACKGROUND:A/JCr mice develop typhlitis in response to Helicobacter hepaticus infection, whereas C57BL/6 mice coexist with this bacterium in a "commensal" relationship and do not develop disease even during prolonged colonization. METHODS:To determine mechanisms that control this balance between responsiveness and non...

journal_title：Inflammatory bowel diseases

authors： Myles MH,Dieckgraefe BK,Criley JM,Franklin CL

更新日期：2007-07-01 00:00:00

abstract：BACKGROUND:TGFβ is a multifunctional cytokine that is critical in regulating mucosal immunity. Murine studies have revealed that disruption of canonical TGFβ signaling leads to systemic inflammation including colitis. Loeys-Dietz syndrome (LDS) results from heterozygous mutations in the genes encoding the subunits of t...

journal_title：Inflammatory bowel diseases

authors： Guerrerio AL,Frischmeyer-Guerrerio PA,Huang C,Wu Y,Haritunians T,McGovern DPB,MacCarrick GL,Brant SR,Dietz HC

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:Improved treatment approaches for ulcerative colitis (UC), including novel medications, might reduce the need for colectomy. We performed a retrospective cohort study of adult patients (age 18-64) with UC in the United States to examine time trends for colectomy and biologic use from 2007 to 2016. METHODS:W...

journal_title：Inflammatory bowel diseases

authors： Barnes EL,Jiang Y,Kappelman MD,Long MD,Sandler RS,Kinlaw AC,Herfarth HH

更新日期：2020-07-17 00:00:00

abstract：BACKGROUND:Adherence to treatment is a key condition in preventing relapses in inflammatory bowel disease (IBD). The aims of this study were specifically to study socioeconomic and psychological factors and adherence to treatment in a large cohort of patients. METHODS:A questionnaire concerning demographic, clinical, ...

journal_title：Inflammatory bowel diseases

authors： Nahon S,Lahmek P,Saas C,Durance C,Olympie A,Lesgourgues B,Gendre JP

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:Several studies suggest an increased risk of venous and arterial thromboembolism (TE) in adults with inflammatory bowel disease (IBD) compared to the general population. We performed a systematic review of studies on incidence and characteristic of TE in children with IBD. METHODS:We searched Medline, LILAC...

journal_title：Inflammatory bowel diseases

authors： Lazzerini M,Bramuzzo M,Maschio M,Martelossi S,Ventura A

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND:Epithelial barrier disturbance is thought to contribute to the pathogenesis of inflammatory bowel diseases; however, it remains unclear whether it is a primary defect participating to the onset of inflammation or only a consequence of sustained inflammation. METHODS:A time course study of epithelial barrier...

journal_title：Inflammatory bowel diseases

authors： Suenaert P,Maerten P,Van Assche G,Van Driessche W,Geboes K,Bulteel V,Simaels J,Augustijns P,Ceuppens JL,Rutgeerts P,Perrier C

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND:Inflammatory bowel disease (IBD) is a multifactorial disorder, with the innate and adaptive immune cells contributing to disease initiation and progression. However, the intricate cross-talk between immune cell lineages remains incompletely understood. The role of CD8+ T cells in IBD pathogenesis has been un...

journal_title：Inflammatory bowel diseases

authors： Jamwal DR,Marati RV,Harrison CA,Midura-Kiela MT,Figliuolo Paz VR,Besselsen DG,Ghishan FK,Kiela PR

更新日期：2020-01-06 00:00:00

abstract：BACKGROUND:Interleukin-13 (IL-13) is a multifunctional cytokine whose net principle action is to diminish inflammatory responses. Dysregulation of IL-13 production has been proposed to contribute to intestinal inflammation in inflammatory bowel disease (IBD) patients. Previous studies implicate IL-13 in IBD pathogenesi...

journal_title：Inflammatory bowel diseases

authors： Kadivar K,Ruchelli ED,Markowitz JE,Defelice ML,Strogatz ML,Kanzaria MM,Reddy KP,Baldassano RN,von Allmen D,Brown KA

更新日期：2004-09-01 00:00:00

abstract：BACKGROUND:Glycobiology is an underexplored research area in inflammatory bowel disease (IBD), and glycans are relevant to many etiological mechanisms described in IBD. Alterations in N-glycans attached to the immunoglobulin G (IgG) Fc fragment can affect molecular structure and immunological function. Recent genome-wi...

journal_title：Inflammatory bowel diseases

authors： Trbojević Akmačić I,Ventham NT,Theodoratou E,Vučković F,Kennedy NA,Krištić J,Nimmo ER,Kalla R,Drummond H,Štambuk J,Dunlop MG,Novokmet M,Aulchenko Y,Gornik O,Campbell H,Pučić Baković M,Satsangi J,Lauc G,IBD-BIOM Consor

更新日期：2015-06-01 00:00:00

abstract：:: Crohn's disease (CD) is a lifelong inflammatory condition with underlying environmental and genetic components. CD affects multiple parts of the gastrointestinal tract, and it has a growing incidence in Western societies. IL-23 receptor variants have been identified as susceptibility or resistance factors for CD in ...

journal_title：Inflammatory bowel diseases

authors： Eken A,Singh AK,Oukka M

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:Long-term enteral nutrition may maintain clinical and endoscopic remission in patients with Crohn's disease (CD). The aim of this prospective study was to investigate the impacts of long-term enteral nutrition on clinical and endoscopic disease activities and mucosal tissue cytokines in patients with quiesce...

journal_title：Inflammatory bowel diseases

authors： Yamamoto T,Nakahigashi M,Saniabadi AR,Iwata T,Maruyama Y,Umegae S,Matsumoto K

更新日期：2007-12-01 00:00:00

abstract：BACKGROUND:L-selectin (CD62L) and β(7) integrins are important for trafficking of naive T cells under steady-state conditions. The objectives of this study were to dissect the requirements for T cell-associated CD62L and β(7) integrins during initiation, progression, and regulation of chronic colitis. METHODS:Using th...

journal_title：Inflammatory bowel diseases

authors： Kurmaeva E,Boktor M,Zhang S,Bao R,Berney S,Ostanin DV

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:VSL#3 is a probiotic compound that has been used in the treatment of inflammatory bowel disease. T-cell protein tyrosine phosphatase (TCPTP) is the protein product of the inflammatory bowel disease candidate gene, PTPN2, and we have previously shown that it protects epithelial barrier function. The aim of th...

journal_title：Inflammatory bowel diseases

authors： Krishnan M,Penrose HM,Shah NN,Marchelletta RR,McCole DF

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:CALM was a randomized phase 3 trial in patients with Crohn's disease (CD) that demonstrated improved endoscopic outcomes when treatment was escalated based on cutoffs for inflammatory biomarkers, fecal calprotectin (FC), C-reactive protein (CRP), and CD Activity Index (CDAI) remission vs CDAI response alone....

journal_title：Inflammatory bowel diseases

authors： Reinisch W,Panaccione R,Bossuyt P,Baert F,Armuzzi A,Hébuterne X,Travis S,Danese S,Sandborn WJ,Schreiber S,Berg S,Zhou Q,Kligys K,Neimark E,Suleiman AA,D'Haens G,Colombel JF

更新日期：2020-09-18 00:00:00

abstract：:Diagnostics of inflammatory bowel diseases (IBDs) currently relies on a combination of biological and morphological tests. The current method of diagnostic remains a critical challenge for physicians in part due to their invasiveness and also for their limitations in term of diagnosis, prognosis, disease activity and ...

journal_title：Inflammatory bowel diseases

authors： Viennois E,Zhao Y,Merlin D

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:Chronic granulomatous disease (CGD) is a rare inherited immunodeficiency disorder characterized by inability of phagocytes to kill certain bacteria and fungi. Histology from colon biopsies of CGD patients have shown the presence of inflammation and granulomas, almost indistinguishable from the findings seen ...

journal_title：Inflammatory bowel diseases

authors： Liu S,Russo PA,Baldassano RN,Sullivan KE

更新日期：2009-08-01 00:00:00

abstract：BACKGROUND:Inflammatory bowel diseases (IBD) are characterized by intermittent relapses, and their course is heterogeneous and unpredictable. Our aim was to determine the ability of protein, metabolite, or microbial biomarkers to predict relapse in patients with quiescent disease. METHODS:This prospective study enroll...

journal_title：Inflammatory bowel diseases

authors： Borren NZ,Plichta D,Joshi AD,Bonilla G,Sadreyev R,Vlamakis H,Xavier RJ,Ananthakrishnan AN

更新日期：2020-09-18 00:00:00

abstract：BACKGROUND:Acute pancreatitis has occasionally been associated with Crohn's disease (CD), but whether a causal association exists remains unclear. We sought to determine the frequency of etiologies in a consecutive series of patients with CD with acute pancreatitis. METHODS:A centralized diagnostic index was used to i...

journal_title：Inflammatory bowel diseases

authors： Moolsintong P,Loftus EV Jr,Chari ST,Egan LJ,Tremaine WJ,Sandborn WJ

更新日期：2005-12-01 00:00:00

abstract：BACKGROUND:Optimal levels of adalimumab (ADA) have not been defined according to the ultimate goal of inflammatory bowel disease treatment--histologic and/or endoscopic healing. The aim of this study was to assess the relationship between random serum ADA levels and histologic and endoscopic healing in patients with in...

journal_title：Inflammatory bowel diseases

authors： Yarur AJ,Jain A,Hauenstein SI,Quintero MA,Barkin JS,Deshpande AR,Sussman DA,Singh S,Abreu MT

更新日期：2016-02-01 00:00:00

abstract：:Induction and maintenance of remission, mucosal healing, the avoidance of surgical intervention, and decreasing the likelihood of cancer developing are the primary therapeutic goals in ulcerative colitis (UC). For the traditional therapies, 5-aminosalicylic acid (including mesalamine), corticosteroids, and thiopurines...

journal_title：Inflammatory bowel diseases

authors： Ng SC,Kamm MA

更新日期：2009-06-01 00:00:00

abstract：:Three receptor tyrosine kinases, Tyro3, Axl, and Mertk (TAM) and their ligands Gas6 and Protein S, have emerged as potent negative regulators of innate immune responses. A number of studies using genetic ablation of TAM loci in mice have elucidated the mechanism of TAM engagement and function during the immune respons...

journal_title：Inflammatory bowel diseases

authors： Rothlin CV,Leighton JA,Ghosh S

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:Fulminant Crohn's colitis complicated by toxic dilatation of the large bowel usually requires surgery, which carries a substantial morbidity and mortality rate. METHODS:We report the case of a female with steroid refractory fulminant Crohn's colitis complicated by toxic megacolon who was successfully treate...

journal_title：Inflammatory bowel diseases

authors： Ng SC,Kamm MA

更新日期：2007-08-01 00:00:00

abstract：BACKGROUND:Microbiota is most likely essential in the pathogenesis of Crohn's disease (CD). Fecal diversion after ileocecal resection (ICR) protects against CD recurrence, whereas infusion of fecal content triggers inflammation. After ICR, the majority of patients experience endoscopic recurrence in the neoterminal ile...

journal_title：Inflammatory bowel diseases

authors： Olaisen M,Flatberg A,Granlund AVB,Røyset ES,Martinsen TC,Sandvik AK,Fossmark R

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:The postpartum period is marked by physiological and psychological stresses that may impact activity in inflammatory bowel disease. The predictors and outcomes of disease activity during this period have not been well characterized. METHODS:We performed a retrospective review of inflammatory bowel disease p...

journal_title：Inflammatory bowel diseases

authors： Yu A,Friedman S,Ananthakrishnan AN

更新日期：2020-11-19 00:00:00

abstract：:It is estimated that over one million people are living with inflammatory bowel disease (IBD) in the United States and that 20-25% of those are children. Pediatric IBD presents with more severe and extensive disease when compared to adults. As with all pediatric chronic illnesses, the patient as well as their parents ...

journal_title：Inflammatory bowel diseases

authors： Donegan A,Boyle B,Crandall W,Dotson JL,Lemont C,Moon T,Kim SC

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:It is unclear if traditional histopathology and noninvasive blood-based tests are sufficiently accurate to detect cytomegalovirus (CMV) reactivation in inflammatory bowel disease. Therefore, we assessed the diagnostic accuracy of these tests compared with immunohistochemistry (IHC) and tissue polymerase chai...

journal_title：Inflammatory bowel diseases

authors： Tandon P,James P,Cordeiro E,Mallick R,Shukla T,McCurdy JD

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:Establishing predictors of quality of life (QoL) in individuals with inflammatory bowel disease could help to identify those patients who are most likely to experience poor QoL and to target therapeutic interventions appropriately. We aimed to investigate how disease-specific QoL depends on demographic, dise...

journal_title：Inflammatory bowel diseases

authors： Han SW,McColl E,Barton JR,James P,Steen IN,Welfare MR

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Nonadherence to medications may affect disease outcomes. The aim of this article was to review methods of assessment, prevalence, and predictors of nonadherence to anti-tumor necrosis factor therapy in inflammatory bowel diseases (IBD). METHODS:Studies were identified through the electronic database of MEDL...

journal_title：Inflammatory bowel diseases

authors： Lopez A,Billioud V,Peyrin-Biroulet C,Peyrin-Biroulet L

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:The unavailability of standardized parameters in bowel ultrasonography (US) commonly used in Crohn's disease (CD) and the shortage of skilled ultrasonographers are 2 limiting factors in the use of this imaging modality around the world. The aim of this study is to evaluate interobserver agreement among exper...

journal_title：Inflammatory bowel diseases

authors： Calabrese E,Kucharzik T,Maaser C,Maconi G,Strobel D,Wilson SR,Zorzi F,Novak KL,Bruining DH,Iacucci M,Watanabe M,Lolli E,Chiaramonte C,Hanauer SB,Panaccione R,Pallone F,Ghosh S,Monteleone G

更新日期：2018-08-16 00:00:00

abstract：BACKGROUND:The optimal management of Clostridium difficile infection (CDI) in flaring inflammatory bowel disease (IBD) patients has not been defined. Limited data suggest that coadministration of immunomodulators (IM) with antibiotics (AB) results in a worse outcome. We investigated the prevalent practice among North A...

journal_title：Inflammatory bowel diseases

authors： Yanai H,Nguyen GC,Yun L,Lebwohl O,Navaneethan U,Stone CD,Ghazi L,Moayyedi P,Brooks J,Bernstein CN,Ben-Horin S

更新日期：2011-07-01 00:00:00