Adverse Pregnancy Outcomes Among Women with Inflammatory Bowel Disease: A Population-Based Study from England.

abstract：BACKGROUND:Inflammatory bowel disease (IBD) is proposed to result from a dysregulated mucosal immune response to the colonic flora in genetically susceptible individuals. Enterotoxigenic Bacteroides fragilis (ETBF), a molecular subclass of the common human commensal, B. fragilis, has been associated with IBD. This stud...

journal_title：Inflammatory bowel diseases

authors： Rabizadeh S,Rhee KJ,Wu S,Huso D,Gan CM,Golub JE,Wu X,Zhang M,Sears CL

更新日期：2007-12-01 00:00:00

abstract：BACKGROUND:Inflammatory bowel disease (IBD) is characterized by a chronic inflammation of the gut, partly driven by defects in the expression and function of pattern recognition receptors, including the IFI16 protein. Because this protein is a target for autoantibodies and its aberrant expression was reported in coloni...

journal_title：Inflammatory bowel diseases

authors： Caneparo V,Pastorelli L,Pisani LF,Bruni B,Prodam F,Boldorini R,Roggenbuck D,Vecchi M,Landolfo S,Gariglio M,De Andrea M

更新日期：2016-12-01 00:00:00

abstract：:Our aims were to assess the impact on health-related quality of life (HRQOL) of a controlled ileal release (CIR) formulation of budesonide in active Crohn's disease (CD) and further define the role of HRQOL, using the Inflammatory Bowel Disease Questionnaire (IBDQ), in assessing outcome in CD. A randomized trial was c...

journal_title：Inflammatory bowel diseases

authors： Irvine EJ,Greenberg GR,Feagan BG,Martin F,Sutherland LR,Thomson AB,Nilsson LG,Persson T

更新日期：2000-08-01 00:00:00

abstract：BACKGROUND:Chemokines regulate the pathways that restrict homing of specific subsets of immune cells, and thereby fine tune the immune response at specific lymphoid and peripheral tissues. CCL2 is a chemokine that induces migration of monocytes, memory T cells, and dendritic cells. Previously, we demonstrated that pM l...

journal_title：Inflammatory bowel diseases

authors： Maharshak N,Hart G,Ron E,Zelman E,Sagiv A,Arber N,Brazowski E,Margalit R,Elinav E,Shachar I

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:A common feature of preclinical models of colitis is that the time-course, magnitude, and persistence of inflammation vary considerably within the experimental animal group. Accordingly, noninvasive, serial quantification of colonic inflammation could advantageously guide dosing regimens and assess drug effi...

journal_title：Inflammatory bowel diseases

authors： Pohlmann A,Tilling LC,Robinson A,Woolmer O,McCleary S,Kruidenier L,Warnock LC,Lewis HD,Hobson AR,James MF

更新日期：2009-04-01 00:00:00

abstract：:Inflammatory bowel disease (IBD) has classically been associated with malnutrition and weight loss, although this has become less common with advances in treatment and greater proportions of patients attaining clinical remission. However, micronutrient deficiencies are still relatively common, particularly in CD patie...

journal_title：Inflammatory bowel diseases

authors： Hwang C,Ross V,Mahadevan U

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND:Inflammatory bowel disease (IBD) is increasingly diagnosed in ethnic and racial minorities. Ileal pouch-anal anastomosis (IPAA) has become the treatment of choice for ulcerative colitis (UC) patients requiring surgery. Few studies have characterized the natural history of IPAA and the pouch outcomes in the H...

journal_title：Inflammatory bowel diseases

authors： Lian L,Moore L,Wu XJ,He XS,Lan P,Shen B

更新日期：2011-04-01 00:00:00

abstract：BACKGROUND:Our objectives were to assess the differences in perforating disease behavior, disease severity, and extraintestinal manifestations (EIM) in patients with Crohn's disease (CD) by race. MATERIALS AND METHODS:We identified outpatients with CD evaluated at the University of Maryland Gastroenterology Faculty Pr...

journal_title：Inflammatory bowel diseases

authors： Cross RK,Jung C,Wasan S,Joshi G,Sawyer R,Roghmann MC

更新日期：2006-03-01 00:00:00

abstract：BACKGROUND:Chronic inflammatory diseases are characterized by massive infiltration of innate and acquired immune cells in inflammatory sites. However, it remains unclear how these cells cooperate in the development of disease. Although bone marrow (BM) is a primary site for hematopoiesis of immune cells except T cells,...

journal_title：Inflammatory bowel diseases

authors： Nemoto Y,Kanai T,Tohda S,Totsuka T,Okamoto R,Tsuchiya K,Nakamura T,Sakamoto N,Fukuda T,Miura O,Yagita H,Watanabe M

更新日期：2008-11-01 00:00:00

abstract：BACKGROUND:Mesalazine preparations are widely used to treat mild to moderately severe ulcerative colitis (UC). We compared once-daily administration of oral mesalazine in patients with quiescent UC with the established 3-times-daily prescription, assessing the efficacy and safety of each method in maintaining remission...

journal_title：Inflammatory bowel diseases

authors： Watanabe M,Hanai H,Nishino H,Yokoyama T,Terada T,Suzuki Y

更新日期：2013-07-01 00:00:00

abstract：:Eukaryotic cells take up macromolecules and particles from the surrounding milieu and also internalize membrane proteins via a precise process of endocytosis. The role of endocytosis in diverse physiological processes such as cell adhesion, cell signaling, tissue remodeling, and healing is well recognized. The epithel...

journal_title：Inflammatory bowel diseases

authors： Nighot P,Ma T

更新日期：2021-01-19 00:00:00

abstract：:Intestinal fibrosis is a common and serious complication of Crohn's disease (CD) and as it can occur at any time during the disease course, it is crucial to identify patients at risk. The aim is not only to understand the pathophysiology of fibrogenesis but to be able to accurately inform subjects about their disease ...

journal_title：Inflammatory bowel diseases

authors： Rieder F,Lawrance IC,Leite A,Sans M

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND:Flavaglines are a family of natural compounds shown to have anti-inflammatory and cytoprotective effects in neurons and cardiomyocytes. Flavaglines target prohibitins as ligands, which are scaffold proteins that regulate mitochondrial function, cell survival, and transcription. This study tested the therapeu...

journal_title：Inflammatory bowel diseases

authors： Han J,Zhao Q,Basmadjian C,Désaubry L,Theiss AL

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:A subset of patients with ulcerative colitis (UC) will require colectomy within a few years of diagnosis. Thus, our aim was to determine the clinical predictors of early colectomy among patients with UC who are hospitalized with an acute flare. METHODS:Using population-based surveillance (1996-2009), all ad...

journal_title：Inflammatory bowel diseases

authors： Al-Darmaki A,Hubbard J,Seow CH,Leung Y,Novak K,Shaheen AA,Panaccione R,Kaplan GG

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:Chronic inflammation in ulcerative colitis (UC) is a sizeable risk factor for colorectal cancer (CRC). Interleukin-13 (IL-13) is elevated in the UC mucosa and may induce dysregulated signaling in neighboring intestinal epithelial cells (IECs) and thus function as a tumorogenic cytokine. METHODS:Expression o...

journal_title：Inflammatory bowel diseases

authors： Mandal D,Levine AD

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND:The hygiene hypothesis suggests an inverse relationship between the incidence of parasitic infections and chronic inflammatory bowel diseases (IBD). We investigated the therapeutic potential of Schistosoma mansoni and Ancylostoma caninum soluble proteins on experimental colitis in mice. METHODS:Colitis was ...

journal_title：Inflammatory bowel diseases

authors： Ruyssers NE,De Winter BY,De Man JG,Loukas A,Pearson MS,Weinstock JV,Van den Bossche RM,Martinet W,Pelckmans PA,Moreels TG

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND AND AIMS:There is evidence that several inflammatory diseases are associated with increased cardiovascular risk. Whether this is true for inflammatory bowel diseases remains controversial. We aimed to assess this risk, corrected for the effects of conventional vascular risk factors and IBD disease activity. ...

journal_title：Inflammatory bowel diseases

authors： Card TR,Zittan E,Nguyen GC,Grainge MJ

更新日期：2020-07-03 00:00:00

abstract：BACKGROUND:Disappearance of macroscopic mucosal inflammation predicts long-term outcome in Crohn's disease (CD). It can be assessed by ileocolonoscopy, which is, however, an invasive and expensive procedure. Disease activity indices do not correlate well with endoscopic activity and noninvasive markers have a low sensi...

journal_title：Inflammatory bowel diseases

authors： Bodelier AG,Smolinska A,Baranska A,Dallinga JW,Mujagic Z,Vanhees K,van den Heuvel T,Masclee AA,Jonkers D,Pierik MJ,van Schooten FJ

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:Psoriasis induced by anti-tumor necrosis factor-α (TNF) therapy has been described as a paradoxical side effect. AIM:To determine the incidence, clinical characteristics, and management of psoriasis induced by anti-TNF therapy in a large nationwide cohort of inflammatory bowel disease patients. METHODS:Pat...

journal_title：Inflammatory bowel diseases

authors： Guerra I,Pérez-Jeldres T,Iborra M,Algaba A,Monfort D,Calvet X,Chaparro M,Mañosa M,Hinojosa E,Minguez M,Ortiz de Zarate J,Márquez L,Prieto V,García-Sánchez V,Guardiola J,Rodriguez GE,Martín-Arranz MD,García-Tercero I,S

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:Genetic predisposition as a cause of inflammatory bowel disease (IBD) has been proven by both family and twin studies and genetic variants associated with the disease have been identified. The aim of our study was to determine the concordance rates for IBD in German twin pairs and to evaluate clinical charac...

journal_title：Inflammatory bowel diseases

authors： Spehlmann ME,Begun AZ,Burghardt J,Lepage P,Raedler A,Schreiber S

更新日期：2008-07-01 00:00:00

abstract：BACKGROUND:The pregnane X receptor (PXR/NR1I2) is an important regulator of xenobiotic metabolism and intestinal integrity. However, there are controversial studies on the role of PXR/NR1I2 in inflammatory bowel disease (IBD). We therefore initiated the largest analysis to date on PXR/NR1I2 gene variants in IBD patient...

journal_title：Inflammatory bowel diseases

authors： Glas J,Seiderer J,Fischer D,Tengler B,Pfennig S,Wetzke M,Beigel F,Olszak T,Weidinger M,Göke B,Ochsenkühn T,Folwaczny M,Müller-Myhsok B,Diegelmann J,Czamara D,Brand S

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND:Ideal biomarkers are required to be developed for the diagnosis and prediction of the treatment of inflammatory bowel disease (IBD). We have reported that alteration of N-linked oligosaccharides of immunoglobulin (Ig) G is a novel diagnostic marker of IBD. Oligosaccharide alterations of IgA, however, have no...

journal_title：Inflammatory bowel diseases

authors： Inoue T,Iijima H,Tajiri M,Shinzaki S,Shiraishi E,Hiyama S,Mukai A,Nakajima S,Iwatani H,Nishida T,Mizushima T,Yasui T,Isaka Y,Kanto T,Tsujii M,Miyoshi E,Wada Y,Takehara T

更新日期：2012-09-01 00:00:00

abstract：Background:Anastomotic recurrence is frequent in patients with Crohn's disease (CD) following ileocecal resection. The degree of endoscopic recurrence, quantified by the Rutgeerts score (RS), is correlated with the risk of clinical and surgical recurrence. Noninvasive modalities such as capsule endoscopy (CE), magnetic...

journal_title：Inflammatory bowel diseases

authors： Yung DE,Har-Noy O,Tham YS,Ben-Horin S,Eliakim R,Koulaouzidis A,Kopylov U

更新日期：2017-12-19 00:00:00

abstract：BACKGROUND:Blood translocation of bacterial-DNA has been described in patients with Crohn's disease (CD). The host's immune cell types cooperate to respond against bacterial insults. Some antimicrobial peptides are inducible after culture with bacterial products and a linkage has been established between them and NOD2/...

journal_title：Inflammatory bowel diseases

authors： Gutiérrez A,Holler E,Zapater P,Sempere L,Jover R,Pérez-Mateo M,Schoelmerich J,Such J,Wiest R,Francés R

更新日期：2011-08-01 00:00:00

abstract：:The complex and yet unknown etiology of Crohn's disease (CD) might consist of various disease endophenotypes, each of which represent their own pathogenesis. This review focuses on the disease endophenotype linked to polymorphisms in the nucleotide-binding oligomerization domain containing 2 (NOD2) protein and on the ...

journal_title：Inflammatory bowel diseases

authors： Jensen SR,Nielsen OH,Brix S

更新日期：2011-11-01 00:00:00

abstract：:Chemokines, a large family of small chemoattractive cytokines, and their receptors play an integral role in the regulation of the immune response and homeostasis. The ability of chemokines to attract specific populations of immune cells sets them apart from other chemoattractants. Chemokines produced within the gastro...

journal_title：Inflammatory bowel diseases

authors： Zimmerman NP,Vongsa RA,Wendt MK,Dwinell MB

更新日期：2008-07-01 00:00:00

abstract：BACKGROUND:Patients suffering from Crohn's disease (CD) show increased incidence of low bone mineral density. Investigating this complication is difficult because the exact etiology of CD remains elusive. Mice carrying a deletion in the tumor necrosis factor (TNF) AU-rich elements (ARE) are reported as a model for huma...

journal_title：Inflammatory bowel diseases

authors： Huybers S,Apostolaki M,van der Eerden BC,Kollias G,Naber TH,Bindels RJ,Hoenderop JG

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND:Faecalibacterium prausnitzii comprises 2 phylogroups, whose abundance in healthy and diseased gut and in conjunction with Escherichia coli has not yet been studied. This work aims to determine the contribution of F. prausnitzii phylogroups I and II in intestinal disease and to assess their potential diagnost...

journal_title：Inflammatory bowel diseases

authors： Lopez-Siles M,Martinez-Medina M,Surís-Valls R,Aldeguer X,Sabat-Mir M,Duncan SH,Flint HJ,Garcia-Gil LJ

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:FTY720 is a novel reagent that possesses potent immunosuppressive activity. The immunosuppression induced by FTY720 is mediated by completely different mechanisms from those of conventional immunosuppressants, that is, by altering the tissue distribution of lymphocytes rather than inhibiting activation. In t...

journal_title：Inflammatory bowel diseases

authors： Mizushima T,Ito T,Kishi D,Kai Y,Tamagawa H,Nezu R,Kiyono H,Matsuda H

更新日期：2004-05-01 00:00:00

abstract：BACKGROUND/AIMS:The plant sterol guggulsterone has been shown to have anti-inflammatory properties. It remains unknown, however, whether guggulsterone is effective for the treatment of inflammatory bowel disease (IBD). Therefore, we investigated anti-inflammatory effects of guggulsterone on intestinal epithelial cells ...

journal_title：Inflammatory bowel diseases

authors： Cheon JH,Kim JS,Kim JM,Kim N,Jung HC,Song IS

更新日期：2006-12-01 00:00:00