Endocytosis of Intestinal Tight Junction Proteins: In Time and Space.

abstract：BACKGROUND:Individuals with ulcerative colitis are at high risk of developing colitis-associated cancer. 5-Aminosalicylate (5-ASA) protects from cancer by its antiinflammatory activity as well as by altering cell growth, inducing apoptosis, and reducing replication errors. So far neither 5-ASA's structural specificity ...

journal_title：Inflammatory bowel diseases

authors： Campregher C,Luciani MG,Biesenbach P,Evstatiev R,Lyakhovich A,Gasche C

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND:Crohn's disease (CD)-associated dysbiosis could predispose patients to relapse. Gut microbiota composition of patients from the prospective cohort study designed to identify predictive factors of clinical relapse after infliximab discontinuation (STORI Study) was investigated to determine the impact of dysbi...

journal_title：Inflammatory bowel diseases

authors： Rajca S,Grondin V,Louis E,Vernier-Massouille G,Grimaud JC,Bouhnik Y,Laharie D,Dupas JL,Pillant H,Picon L,Veyrac M,Flamant M,Savoye G,Jian R,Devos M,Paintaud G,Piver E,Allez M,Mary JY,Sokol H,Colombel JF,Seksik P

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:Minimally invasive surgery for Crohn's ileocolitis is well established but few data exist regarding laparoscopic techniques for Crohn's colitis. We aimed to describe outcomes associated with minimally invasive surgery for Crohn's colitis, including predictors of conversion to laparotomy and postoperative com...

journal_title：Inflammatory bowel diseases

authors： Holubar SD,Dozois EJ,Privitera A,Pemberton JH,Cima RR,Larson DW

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND:Optimal levels of adalimumab (ADA) have not been defined according to the ultimate goal of inflammatory bowel disease treatment--histologic and/or endoscopic healing. The aim of this study was to assess the relationship between random serum ADA levels and histologic and endoscopic healing in patients with in...

journal_title：Inflammatory bowel diseases

authors： Yarur AJ,Jain A,Hauenstein SI,Quintero MA,Barkin JS,Deshpande AR,Sussman DA,Singh S,Abreu MT

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND:Fulminant Crohn's colitis complicated by toxic dilatation of the large bowel usually requires surgery, which carries a substantial morbidity and mortality rate. METHODS:We report the case of a female with steroid refractory fulminant Crohn's colitis complicated by toxic megacolon who was successfully treate...

journal_title：Inflammatory bowel diseases

authors： Ng SC,Kamm MA

更新日期：2007-08-01 00:00:00

abstract：BACKGROUND:Inflammatory bowel diseases (IBD) are believed to be driven by dysregulated interactions between the host and the gut microbiota. Our goal is to characterize and infer relationships between mucosal T cells, the host tissue environment, and microbial communities in patients with IBD who will serve as basis fo...

journal_title：Inflammatory bowel diseases

authors： Tang MS,Bowcutt R,Leung JM,Wolff MJ,Gundra UM,Hudesman D,Malter LB,Poles MA,Chen LA,Pei Z,Neto AG,Abidi WM,Ullman T,Mayer L,Bonneau RA,Cho I,Loke P

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND:This study examines the resources utilization in patients with Crohn's disease (CD) during the year before (Y - 1) and after (Y + 1) starting treatment with adalimumab and the drug's efficiency. METHODS:Observational, multicenter, prospective cohort study of patients with CD naive to biological drugs. The p...

journal_title：Inflammatory bowel diseases

authors： Saro C,Ceballos D,Muñoz F,De la Coba C,Aguilar MD,Lázaro P,Iglesias-Flores E,Barreiro-de Acosta M,Hernández-Durán MD,Barrio J,Riestra S,Fernández Salazar L,EFICADEC Researchers Group.

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND:Magnetic resonance enteroclysis (MRE) is a recently introduced imaging technique that assesses the small bowel with similar sensitivity and specificity as the fluoroscopically performed conventional enteroclysis. Magnetic resonance imaging colonography (MRC) seems to be a promising technique for polyp assess...

journal_title：Inflammatory bowel diseases

authors： Schreyer AG,Gölder S,Scheibl K,Völk M,Lenhart M,Timmer A,Schölmerich J,Feuerbach S,Rogler G,Herfarth H,Seitz J

更新日期：2005-04-01 00:00:00

abstract：BACKGROUND:Endoscopic balloon dilation (EBD) is an effective method for treating stricture-related obstruction in Crohn's disease. We aimed to identify factors predictive of successful avoidance of surgery, including endoscopic features, in patients undergoing balloon dilation. METHODS:We performed a retrospective rev...

journal_title：Inflammatory bowel diseases

authors： Reutemann BA,Turkeltaub JA,Al-Hawary M,Waljee AK,Higgins PDR,Stidham RW

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND:Chemokines regulate the pathways that restrict homing of specific subsets of immune cells, and thereby fine tune the immune response at specific lymphoid and peripheral tissues. CCL2 is a chemokine that induces migration of monocytes, memory T cells, and dendritic cells. Previously, we demonstrated that pM l...

journal_title：Inflammatory bowel diseases

authors： Maharshak N,Hart G,Ron E,Zelman E,Sagiv A,Arber N,Brazowski E,Margalit R,Elinav E,Shachar I

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:Anxiety is linked with adverse health-related outcomes and increased health-seeking behaviors among patients with chronic illness. Yet, this relationship has received little attention in pediatric inflammatory bowel disease. The aim of this study was to examine whether anxiety symptoms predicted youth at inc...

journal_title：Inflammatory bowel diseases

authors： Reigada LC,Satpute A,Hoogendoorn CJ,Cohen BH,Lai J,Bao R,Dubinsky MC,Benkov KJ

更新日期：2016-09-01 00:00:00

abstract：:: We sought to characterize the incidence, nature, and course of liver disease in children with inflammatory bowel disease (IBD). Chart review identified 555 subjects (318 Crohn's disease [CD], 237 ulcerative colitis [UC]). An alanine aminotransferase measurement of ≥80 U/L was used to identify the presence of a hepat...

journal_title：Inflammatory bowel diseases

authors： Hyams J,Markowitz J,Treem W,Davis P,Grancher K,Daum F

更新日期：1995-04-01 00:00:00

abstract：BACKGROUND:A high-fat diet is a risk factor for the development of inflammatory bowel disease (IBD) in humans. Deoxycholate (DOC) is increased in the colonic contents in response to a high-fat diet. Thus, an elevated level of DOC in the colonic lumen may play a role in the natural course of development of IBD. METHODS...

journal_title：Inflammatory bowel diseases

authors： Bernstein H,Holubec H,Bernstein C,Ignatenko N,Gerner E,Dvorak K,Besselsen D,Ramsey L,Dall'Agnol M,Blohm-Mangone KA,Padilla-Torres J,Cui H,Garewal H,Payne CM

更新日期：2006-04-01 00:00:00

abstract：Background:Standard outpatient induction dosing of infliximab (IFX) may not be effective in hospitalized ulcerative colitis (UC) patients with higher inflammatory burden and colectomy risk. Our aim was to determine whether initial IFX induction dose affects 30-day colectomy rate and other disease-related outcomes. Met...

journal_title：Inflammatory bowel diseases

authors： Shah SC,Naymagon S,Panchal HJ,Sands BE,Cohen BL,Dubinsky MC

更新日期：2018-02-15 00:00:00

abstract：Background:Understanding of the prevalence, pathophysiology, and management of fecal incontinence (FI) in inflammatory bowel disease (IBD) patients without an ileal pouch anal anastomosis (IPAA) is suboptimal. We conducted a systematic review and meta-analysis on the prevalence, pathophysiology, and management of prima...

journal_title：Inflammatory bowel diseases

authors： Gu P,Kuenzig ME,Kaplan GG,Pimentel M,Rezaie A

更新日期：2018-05-18 00:00:00

abstract：:Gastrointestinal disorders, although clinically heterogeneous, share pathogenic mechanisms, including genetic susceptibility, impaired gut barrier function, altered microbiota, and environmental triggers (infections, social and behavioral factors, epigenetic control, and diet). Gut microbiota has been studied for infl...

journal_title：Inflammatory bowel diseases

authors： Putignani L,Del Chierico F,Vernocchi P,Cicala M,Cucchiara S,Dallapiccola B,Dysbiotrack Study Group.

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND:We analyzed inflamed mucosal/submucosal layers of ulcerative colitis (UC = 63) and Crohn's colitis (CC = 50), and unexpectedly, we unveiled a pool of free hemoglobin alpha (Hb-α) chain. Patients with colitides have increased reactive oxidative stress (ROS), DNA oxidation products, free iron in mucosa, in pre...

journal_title：Inflammatory bowel diseases

authors： Myers JN,Schäffer MW,Korolkova OY,Williams AD,Gangula PR,MʼKoma AE

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND:Fibrostenosis and stricture are well-recognized endpoints in Crohn's disease (CD). We hypothesized that stricturing CD is characterized by eosinophilia and epithelial IL-33. We proposed that eosinophil exposure to IL-33 would perpetuate inflammatory chronicity and subsequent fibrostenosis. METHODS:We perfor...

journal_title：Inflammatory bowel diseases

authors： Masterson JC,Capocelli KE,Hosford L,Biette K,McNamee EN,de Zoeten EF,Harris R,Fernando SD,Jedlicka P,Protheroe C,Lee JJ,Furuta GT

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:Clostridium difficile infection (CDI) is common in patients with inflammatory bowel disease (IBD), often leading to diagnostic confusion and delays in IBD therapy escalation. This study sought to assess outcomes after CDI in IBD patients exposed to new or escalated immunosuppressive therapy. METHODS:This mu...

journal_title：Inflammatory bowel diseases

authors： Lukin DJ,Lawlor G,Hudesman DP,Durbin L,Axelrad JE,Passi M,Cavaliere K,Coburn E,Loftus M,Jen H,Feathers A,Rosen MH,Malter LB,Swaminath A,IBD-ReMEdY Study (Research, Mentoring, Education New York).

更新日期：2019-03-14 00:00:00

abstract：:Restorative proctocolectomy with ileal-pouch anal anastomosis (RPC) is the operation of choice for ulcerative colitis (UC) patients requiring surgery. It is also used for patients with familial adenomatous polyposis (FAP). Pouchitis accounts for 10% of pouch failures. It is an idiopathic inflammatory condition that ma...

journal_title：Inflammatory bowel diseases

authors： Landy J,Al-Hassi HO,McLaughlin SD,Knight SC,Ciclitira PJ,Nicholls RJ,Clark SK,Hart AL

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND:Portal vein thrombosis (PVT) is a poorly described complication of inflammatory bowel disease (IBD). We sought to better characterize presentations, compare treatments, and assess outcomes in IBD-related PVT. METHODS:We conducted a retrospective investigation of IBD-related PVT at our institution. Multivari...

journal_title：Inflammatory bowel diseases

authors： Naymagon L,Tremblay D,Zubizarreta N,Moshier E,Naymagon S,Mascarenhas J,Schiano T

更新日期：2021-01-19 00:00:00

abstract：BACKGROUND:Various physician- and patient-reported instruments exist for quantification of disease activity in inflammatory bowel diseases (IBD) but none are widely used in routine clinical practice. A simple patient-reported outcome measure might help inform clinical decision making. We evaluated a patient-reported 0 ...

journal_title：Inflammatory bowel diseases

authors： Subramanian S,Asher R,Weston W,Rimmer M,McConville A,Malin A,Jackson R,Collins P,Probert C,Dibb M,Rhodes JM

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND:A notable proportion of patients with inflammatory bowel disease (IBD) are switched from infliximab (IFX) to adalimumab (ADL). We investigated if immunogenicity of IFX influenced immunogenicity and clinical outcomes of later ADL therapy. METHODS:Single-center cohort study including all patients with IBD ass...

journal_title：Inflammatory bowel diseases

authors： Frederiksen MT,Ainsworth MA,Brynskov J,Thomsen OO,Bendtzen K,Steenholdt C

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND:Inflammatory bowel disease (IBD) patients are at increased risk of venous thromboembolism (VTE), which is most pronounced during a disease flare. We explored the cost-effectiveness of pharmacological VTE prophylaxis in an outpatient setting. METHODS:Markov decision analysis was conducted from a societal per...

journal_title：Inflammatory bowel diseases

authors： Nguyen GC,Sharma S

更新日期：2013-09-01 00:00:00

abstract：:Treatment adherence is of critical importance in the management of patients with IBD. Poor adherence can lead to increased disease activity, loss of response to therapy, and increased costs of care. It has been well established that adherence to long-term therapy for chronic illnesses is extremely poor, averaging arou...

journal_title：Inflammatory bowel diseases

authors： Herman ML,Kane SV

更新日期：2015-12-01 00:00:00

abstract：:Crohn's disease is an idiopathic, chronic inflammatory disorder of the digestive tract with heterogeneous clinical presentations. Crohn's is currently not a curable disease, and patients are faced with a lifetime of recurrent disease flare-ups and remissions. Management strategies for Crohn's must therefore be targete...

journal_title：Inflammatory bowel diseases

authors： Lichtenstein GR,Hanauer SB,Kane SV,Present DH

更新日期：2004-07-01 00:00:00

abstract：BACKGROUND:This study aimed to evaluate the feasibility, acceptability, and effectiveness of a mindfulness-based intervention for patients with inflammatory bowel disease (MI-IBD). DESIGN:Treatment-as-usual control versus mindfulness-based stress reduction intervention. METHODS:Sixty patients participated in either t...

journal_title：Inflammatory bowel diseases

authors： Neilson K,Ftanou M,Monshat K,Salzberg M,Bell S,Kamm MA,Connell W,Knowles SR,Sevar K,Mancuso SG,Castle D

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:The dinitrofluorobenzene/dinitrosulfonic acid (DNFB/DNS) model was originally described as an experimental model of intestinal inflammation resembling human ulcerative colitis (UC). Due to the absence of acceptable UC experimental models for pharmacological preclinical assays, here we examine the immune resp...

journal_title：Inflammatory bowel diseases

authors： Bailón E,Cueto-Sola M,Utrilla P,Nieto A,Garrido-Mesa N,Celada A,Zarzuelo A,Xaus J,Gálvez J,Comalada M

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND:Mesalamine suppositories are first-line therapy in active ulcerative proctitis; the standard regime still recommends multiple doses per day. The primary objective of this study was to show the noninferiority of once-daily administration of a novel 1 g mesalamine suppository versus thrice-daily administration...

journal_title：Inflammatory bowel diseases

authors： Andus T,Kocjan A,Müser M,Baranovsky A,Mikhailova TL,Zvyagintseva TD,Dorofeyev AE,Lozynskyy YS,Cascorbi I,Stolte M,Vieth M,Dilger K,Mohrbacher R,Greinwald R,International Salofalk Suppository OD Study Group.

更新日期：2010-11-01 00:00:00

abstract：:The role of endoscopy in inflammatory bowel disease (IBD) has grown over the last decade in both diagnostic and therapeutic realms. It aids in the initial diagnosis of the disease and also in the assessment of the extent and severity of disease. IBD is associated with development of multiple complications such as stri...

journal_title：Inflammatory bowel diseases

authors： Tharian B,George N,Navaneethan U

更新日期：2016-05-01 00:00:00