Machine Learning-Based Gene Prioritization Identifies Novel Candidate Risk Genes for Inflammatory Bowel Disease.

abstract：:The principal investigator is responsible for everything involved in the conduct of a clinical research study. Prior to the initiation of any clinical trial, an investigator must become acquainted with the material requirements, personnel needs, and best practices involved in the conduct of the trial. Commitment to a ...

journal_title：Inflammatory bowel diseases

authors： Wolf DC,Katz S,Safdi MA,Sandler RS,Lewis JD

更新日期：2005-11-01 00:00:00

abstract：Background:Vitamin D3 and vitamin D receptor (VDR) are involved in the pathogenesis of inflammatory bowel disease (IBD) and bacterial infection. Claudin-2 is a junction protein that mediates paracellular water transport in epithelia. Elevation of Claudin-2 is associated with active IBD. However, VDR involved in epithel...

journal_title：Inflammatory bowel diseases

authors： Zhang YG,Lu R,Xia Y,Zhou D,Petrof E,Claud EC,Sun J

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Fibrostenosis and stricture are well-recognized endpoints in Crohn's disease (CD). We hypothesized that stricturing CD is characterized by eosinophilia and epithelial IL-33. We proposed that eosinophil exposure to IL-33 would perpetuate inflammatory chronicity and subsequent fibrostenosis. METHODS:We perfor...

journal_title：Inflammatory bowel diseases

authors： Masterson JC,Capocelli KE,Hosford L,Biette K,McNamee EN,de Zoeten EF,Harris R,Fernando SD,Jedlicka P,Protheroe C,Lee JJ,Furuta GT

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND & AIMS:Malnutrition with the accumulation of fat tissue and nonalcoholic fatty liver disease (NAFLD) are conditions associated with inflammatory bowel disease (IBD). Visceral fat and NAFLD-related liver dysfunction can both worsen intestinal inflammation. Because the Mediterranean diet (Md) has been shown to...

journal_title：Inflammatory bowel diseases

authors： Chicco F,Magrì S,Cingolani A,Paduano D,Pesenti M,Zara F,Tumbarello F,Urru E,Melis A,Casula L,Fantini MC,Usai P

更新日期：2021-01-01 00:00:00

abstract：:: We evaluated retrospective smoking data reported by 221 patients with ulcerative colitis in 1984 and repeated in an identical questionnaire in 1989. Reported years of smoking initiation or smoking cessation agreed to a high extent; the difference between the two questionnaires was in mean (± SD) -0.1 ± 1.5 (median, ...

journal_title：Inflammatory bowel diseases

authors： Tysk C,Järnerot G

更新日期：1995-07-01 00:00:00

abstract：BACKGROUND:Evidence supports the role of adherent invasive Escherichia coli (AIEC) in the pathogenesis of inflammatory bowel disease (IBD). However, little is known about the phylogenetic structure and origin of this group of bacteria. Multi-locus sequence typing (MLST), and fimH sequence analysis were performed to elu...

journal_title：Inflammatory bowel diseases

authors： Sepehri S,Kotlowski R,Bernstein CN,Krause DO

更新日期：2009-11-01 00:00:00

abstract：BACKGROUND:Establishing predictors of quality of life (QoL) in individuals with inflammatory bowel disease could help to identify those patients who are most likely to experience poor QoL and to target therapeutic interventions appropriately. We aimed to investigate how disease-specific QoL depends on demographic, dise...

journal_title：Inflammatory bowel diseases

authors： Han SW,McColl E,Barton JR,James P,Steen IN,Welfare MR

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Data from CHARM, a 56-week, randomized controlled trial of adalimumab for patients with moderately to severely active Crohn's disease (CD), were used to evaluate outcomes of adalimumab dosage adjustment. METHODS:Patients randomized to blinded adalimumab 40 mg every other week (EOW) in CHARM were the focus o...

journal_title：Inflammatory bowel diseases

authors： Sandborn WJ,Colombel JF,Schreiber S,Plevy SE,Pollack PF,Robinson AM,Chao J,Mulani P

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:In our clinical practice, women often report excess weight gain with infliximab (IFX) use. There are currently no studies investigating weight gain after antitumor necrosis factor therapy in patients with inflammatory bowel disease. The objective of this study was to evaluate the association of clinical fact...

journal_title：Inflammatory bowel diseases

authors： Christian KE,Russman KM,Rajan DP,Barr EA,Cross RK

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Increased strength of red blood cell (RBC) aggregates are present during the acute inflammatory response and contribute to erythrocyte aggregation and may lead to microvascular dysfunction. Inflammatory bowel diseases (IBDs) are characterized by damage to the bowel wall. This damage may be at least partially...

journal_title：Inflammatory bowel diseases

authors： Maharshak N,Arbel Y,Shapira I,Berliner S,Ben-Ami R,Yedgar S,Barshtein G,Dotan I

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND:Interleukin (IL)-6/signal transducers and activators of transcription 3 (STAT3) signaling plays an important role in the development of colitis-associated colorectal cancer (CAC). The mechanism of CAC formation remains unclear, and the relationship between miRNAs and the IL-6/STAT3 signaling pathway in the d...

journal_title：Inflammatory bowel diseases

authors： Wang A,Deng S,Chen X,Yu C,Du Q,Wu Y,Chen G,Hu L,Hu C,Li Y

更新日期：2020-03-04 00:00:00

abstract：BACKGROUND:Inflammatory bowel disease (IBD) patients are at increased risk of venous thromboembolism (VTE), which is most pronounced during a disease flare. We explored the cost-effectiveness of pharmacological VTE prophylaxis in an outpatient setting. METHODS:Markov decision analysis was conducted from a societal per...

journal_title：Inflammatory bowel diseases

authors： Nguyen GC,Sharma S

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:The majority of studies concerning the clinical course and prognosis in ulcerative colitis (UC) are old, retrospective in design, or hospital based. We aimed to identify clinical course and prognosis in a prospective, population-based follow-up study MATERIALS AND METHODS:Patients diagnosed with inflammator...

journal_title：Inflammatory bowel diseases

authors： Henriksen M,Jahnsen J,Lygren I,Sauar J,Kjellevold Ø,Schulz T,Vatn MH,Moum B,IBSEN Study Group.

更新日期：2006-07-01 00:00:00

abstract：BACKGROUND:Previous controversy was generated over the hypothesis that a paramyxovirus such as measles or vaccination against such viruses might be causally associated with inflammatory bowel disease (IBD). We aimed to determine if Crohn's disease (CD) or ulcerative colitis (UC) subjects are more likely to be seroposit...

journal_title：Inflammatory bowel diseases

authors： Bernstein CN,Rawsthorne P,Blanchard JF

更新日期：2007-06-01 00:00:00

abstract：BACKGROUND:Little knowledge exists about the association between anti-tumor necrosis factor-alpha (anti-TNF-α) therapy for inflammatory bowel disease during late pregnancy and adverse birth outcomes. We aimed to examine whether treatment with anti-TNF-α during the third trimester affected preterm birth and low birth we...

journal_title：Inflammatory bowel diseases

authors： Kammerlander H,Nielsen J,Knudsen T,Kjeldsen J,Friedman S,Nørgård BM

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:Ileal lesions in Crohn's disease patients are colonized by pathogenic adherent-invasive Escherichia coli (AIEC) that harbor various virulence factors involved in adhesion to and invasion of intestinal epithelial cultured cells. We investigated in a mouse model of colonic inflammation the behavior of virulent...

journal_title：Inflammatory bowel diseases

authors： Carvalho FA,Barnich N,Sauvanet P,Darcha C,Gelot A,Darfeuille-Michaud A

更新日期：2008-08-01 00:00:00

abstract：BACKGROUND:Inflammatory bowel disease (IBD) patients have a high incidence of wound and overall postoperative complications. A totally laparoscopic approach could potentially reduce these risks. We adopted totally laparoscopic total proctocolectomy (TL-TPC) using the perineal wound for extraction as the procedure of ch...

journal_title：Inflammatory bowel diseases

authors： Holder-Murray J,Zoccali M,Hurst RD,Umanskiy K,Rubin M,Fichera A

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND:The aim of the study was to assess perianal fistulas by magnetic resonance imaging (MRI) in patients with severe fistulizing Crohn's disease (CD) using maintenance antitumor necrosis factor alpha (TNF-α) therapy and to correlate MRI changes with clinical outcome. METHODS:Perineal MRI before and after a 1-ye...

journal_title：Inflammatory bowel diseases

authors： Savoye-Collet C,Savoye G,Koning E,Dacher JN,Lerebours E

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:Guidelines mandate screening for latent tuberculosis infection (LTBI) prior to anti-tumor necrosis factor (anti-TNF) therapy in patients with inflammatory bowel disease (IBD). However, many are already on immunosuppressive therapy (IST) that may affect the precision of the Tuberculin skin test (TST). Our aim...

journal_title：Inflammatory bowel diseases

authors： Shahidi N,Fu YT,Qian H,Bressler B

更新日期：2012-11-01 00:00:00

abstract：:Tolerance, the regulated inability to respond to a specific immunologic stimulant, is a physiological event important to normal immune function. Just as loss of tolerance to self-proteins results in autoimmune diseases, we assert that loss of tolerance to commensal flora in the intestinal lumen leads to inflammatory b...

journal_title：Inflammatory bowel diseases

authors： Jump RL,Levine AD

更新日期：2004-07-01 00:00:00

abstract：BACKGROUND:Increased lymphatic vessel (LV) density has been found in uninflamed intestinal wall of patients with Crohn's disease (CD). The goal of the study was to search for an association between LV density in the proximal ileal resection margin at the time of surgery and endoscopic recurrence. METHODS:Ileocolonic r...

journal_title：Inflammatory bowel diseases

authors： Rahier JF,Dubuquoy L,Colombel JF,Jouret-Mourin A,Delos M,Ferrante M,Sokol H,Hertogh GD,Salleron J,Geboes K,Desreumaux P

更新日期：2013-09-01 00:00:00

abstract：:Colitis-associated colorectal neoplasia (CRN) is a well-known complication of chronic inflammation of the colon either with ulcerative colitis (UC) or colonic Crohn's disease (CD). Studies have shown that inflammatory bowel disease (IBD) patients have an overall higher risk for colorectal dysplasia and cancer compared...

journal_title：Inflammatory bowel diseases

authors： Gaidos JK,Bickston SJ

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:The potentially high costs of care associated with inflammatory bowel disease are recognized. A knowledge-based self-management approach seems to reduce health care costs, improve disease control, and reduce indirect costs. The aim of this study was to determine whether there is a significant association bet...

journal_title：Inflammatory bowel diseases

authors： Colombara F,Martinato M,Girardin G,Gregori D

更新日期：2015-03-01 00:00:00

abstract：SUMMARY:: In recent years, heparin has emerged as a possible therapy for inflammatory bowel disease (IBD). Several recent, strongly positive, open-labeled series of heparin in both ulcerative colitis (UC) and Crohn's disease (CD) reinforce the work of Gaffney and co-workers that suggested a benefit of heparin in UC. Al...

journal_title：Inflammatory bowel diseases

authors： Korzenik JR

更新日期：1997-07-01 00:00:00

abstract：:After colectomy and ileal pouch-rectal anastomosis, pouchitis may occur. Pouchitis is a poorly defined condition with unknown etiology. The aim of this study was to develop an animal model of pouchitis. Ileal pouch-rectal anastomosis was created in Lewis and Sprague-Dawley rats. Rats were studied 4 and 8 weeks after s...

journal_title：Inflammatory bowel diseases

authors： Lichtman SN,Wang J,Hummel B,Lacey S,Sartor RB

更新日期：1998-08-01 00:00:00

abstract：:The last 12 months have seen unprecedented progress in identifying the susceptibility genes that predispose to common disease in general and Crohn's disease in particular. Success has derived from the new technique of genome-wide association scanning in large panels of cases and controls. This has itself been made pos...

journal_title：Inflammatory bowel diseases

authors： Tremelling M,Parkes M

更新日期：2007-12-01 00:00:00

abstract：BACKGROUND:Thiopurines are effective drugs in treating ulcerative colitis (UC) and Crohn's disease (CD) even if studies that specifically investigate these drugs' profile of efficacy in UC compared with CD are scarce. Our aim was to compare the profile of efficacy of thiopurines in patients with UC and CD. METHODS:We ...

journal_title：Inflammatory bowel diseases

authors： Rispo A,Testa A,De Palma GD,Donetto S,Diaferia M,Musto D,Nardone O,Maione F,Caporaso N,Castiglione F

更新日期：2015-11-01 00:00:00

abstract：OBJECTIVES:Previous decision analyses of inflam matory bowel diseases (IBD) have used decision trees and Markov chains. Occasionally IBD patients present with medical problems that are difficult or even impossible to phrase in terms of such established decision tools. This article aims to introduce modeling by a time-d...

journal_title：Inflammatory bowel diseases

authors： Sonnenberg A,Gavin MW

更新日期：2000-11-01 00:00:00

abstract：BACKGROUND:Flavaglines are a family of natural compounds shown to have anti-inflammatory and cytoprotective effects in neurons and cardiomyocytes. Flavaglines target prohibitins as ligands, which are scaffold proteins that regulate mitochondrial function, cell survival, and transcription. This study tested the therapeu...

journal_title：Inflammatory bowel diseases

authors： Han J,Zhao Q,Basmadjian C,Désaubry L,Theiss AL

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:The consistency of endoscopic and histologic findings in patients with ulcerative colitis (UC) has not been elucidated. Choice of assessment may affect study outcomes. METHODS:Post hoc analyses were performed using data from 2 randomized, controlled multicenter trials: (1) SAG-26, mesalazine granules for in...

journal_title：Inflammatory bowel diseases

authors： Wolff S,Terheggen G,Mueller R,Greinwald R,Franklin J,Kruis W

更新日期：2013-11-01 00:00:00