Population-based case-control study of measles, mumps, and rubella and inflammatory bowel disease.

abstract：Background:Endoscopic monitoring is fundamental for evaluating the therapeutic response in IBD, but a validated endomicroscopic mucosal healing (MH) score is not available to date. However, confocal laser endomicroscopy (CLE) might define MH more precisely than conventional endoscopy. The major aim was to establish and...

journal_title：Inflammatory bowel diseases

authors： Hundorfean G,Chiriac MT,Mihai S,Hartmann A,Mudter J,Neurath MF

更新日期：2017-12-19 00:00:00

abstract：BACKGROUND:A/JCr mice develop typhlitis in response to Helicobacter hepaticus infection, whereas C57BL/6 mice coexist with this bacterium in a "commensal" relationship and do not develop disease even during prolonged colonization. METHODS:To determine mechanisms that control this balance between responsiveness and non...

journal_title：Inflammatory bowel diseases

authors： Myles MH,Dieckgraefe BK,Criley JM,Franklin CL

更新日期：2007-07-01 00:00:00

abstract：BACKGROUND:Multi-matrix (MMx), a new delivery system for mesalazine, seems to release 5-aminosalicyclic acid (5-ASA) preferentially in the sigmoid colon. This study had 2 objectives: (1) to evaluate the therapeutic response to MMx in patients with active left-sided disease and (2) to gain additional insights as to how ...

journal_title：Inflammatory bowel diseases

authors： Prantera C,Viscido A,Biancone L,Francavilla A,Giglio L,Campieri M

更新日期：2005-05-01 00:00:00

abstract：BACKGROUND:Crohn's disease (CD) and ulcerative colitis (UC) are inflammatory bowel diseases (IBDs) presumably caused by dysregulated immune responses to the gut microbiota. Genetic association studies have implicated dozens of chromosomal regions or loci in IBD susceptibility. The next challenge is to explain the indiv...

journal_title：Inflammatory bowel diseases

authors： Labbé C,Boucher G,Foisy S,Alikashani A,Nkwimi H,David G,Beaudoin M,Goyette P,Charron G,Xavier RJ,Rioux JD

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND:Increased strength of red blood cell (RBC) aggregates are present during the acute inflammatory response and contribute to erythrocyte aggregation and may lead to microvascular dysfunction. Inflammatory bowel diseases (IBDs) are characterized by damage to the bowel wall. This damage may be at least partially...

journal_title：Inflammatory bowel diseases

authors： Maharshak N,Arbel Y,Shapira I,Berliner S,Ben-Ami R,Yedgar S,Barshtein G,Dotan I

更新日期：2009-05-01 00:00:00

abstract：OBJECTIVE:Our goal in this multicentric prospective study was 2-fold: first, to test the diagnostic accuracy of ultrasound, color Doppler imaging (CDI), and contrast-enhanced ultrasound (CEUS) in identifying disease activity in patients with Crohn's disease (CD) compared with endoscopy as the reference standard; and, s...

journal_title：Inflammatory bowel diseases

authors： Ripollés T,Poza J,Suarez Ferrer C,Martínez-Pérez MJ,Martín-Algíbez A,de Las Heras Paez B

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:We assessed whether selective granulocyte and monocyte/macrophage adsorption apheresis maintained clinical remission in asymptomatic inflammatory bowel disease (IBD) patients at significant risk of clinical relapse. METHODS:Sixty asymptomatic patients (age 18-70 years) with IBD (in clinical remission) with ...

journal_title：Inflammatory bowel diseases

authors： Maiden L,Takeuchi K,Baur R,Bjarnason I,O'Donohue J,Forgacs I,Chung-Faye G,Sanderson J,Bjarnason I

更新日期：2008-10-01 00:00:00

abstract：BACKGROUND:Apolipoprotein E (ApoE) mediates potent antiinflammatory and immunomodulatory properties in addition to its roles in regulating cholesterol transport and metabolism. However, its role in the intestine, specifically during inflammation, is largely unknown. METHODS:Mice (C57BL/6 or ApoE-deficient [ApoE-KO] mi...

journal_title：Inflammatory bowel diseases

authors： Singh V,Kumar M,San Yeoh B,Xiao X,Saha P,Kennett MJ,Vijay-Kumar M

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:Genetic variants of nucleotide-binding oligomerization domain 2 (NOD2) lead to aberrant microbial recognition and can cause chronic inflammatory diseases in patients with Crohn's disease (CD). METHODS:We utilized gene-specific siRNA mediated knockdown and expression of guanine nucleotide exchange factor H1 ...

journal_title：Inflammatory bowel diseases

authors： Zhao Y,Alonso C,Ballester I,Song JH,Chang SY,Guleng B,Arihiro S,Murray PJ,Xavier R,Kobayashi KS,Reinecker HC

更新日期：2012-04-01 00:00:00

abstract：:The risk of colorectal cancer in patients with long-standing ulcerative colitis or colonic Crohn's disease is increased. Patients with long-standing ulcerative colitis are offered enrollment into programs of endoscopic surveillance. Although direct evidence for a protective effect of surveillance against death from co...

journal_title：Inflammatory bowel diseases

authors： Collins PD

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:Vedolizumab is a gut-selective biologic that has shown efficacy in ulcerative colitis (UC) and Crohn's disease (CD). We studied the pharmacokinetics, pharmacodynamics, safety, tolerability, and efficacy of a new formulation of vedolizumab produced by an improved manufacturing process. METHODS:UC patients we...

journal_title：Inflammatory bowel diseases

authors： Parikh A,Leach T,Wyant T,Scholz C,Sankoh S,Mould DR,Ponich T,Fox I,Feagan BG

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND:There has been a dramatic increase in investigations on the potential mechanistic role of the intestinal microbiota in various diseases and factors modulating intestinal microbial composition. We recently reported on intestinal microbial shifts after smoking cessation in humans. In this study, we aimed to co...

journal_title：Inflammatory bowel diseases

authors： Biedermann L,Brülisauer K,Zeitz J,Frei P,Scharl M,Vavricka SR,Fried M,Loessner MJ,Rogler G,Schuppler M

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND:Wiskott-Aldrich syndrome protein-deficient patients and mice are immunodeficient and can develop inflammatory bowel disease. The intestinal microbiome is critical to the development of colitis in most animal models, in which Helicobacter spp. have been implicated in disease pathogenesis. We sought to determi...

journal_title：Inflammatory bowel diseases

authors： Nguyen DD,Muthupalani S,Goettel JA,Eston MA,Mobley M,Taylor NS,McCabe A,Marin R,Snapper SB,Fox JG

更新日期：2013-09-01 00:00:00

abstract：Background:Both muscle-related complaints and elevated serum creatine kinase (CK) levels have been reported in patients with inflammatory bowel disease (IBD) treated with infliximab (IFX), mainly as case reports. The aim of this study was to investigate the effect of IFX therapy on serum CK levels in a cohort of Greek ...

journal_title：Inflammatory bowel diseases

authors： Theodoraki E,Orfanoudaki E,Foteinogiannopoulou K,Koutroubakis IE

更新日期：2018-05-18 00:00:00

abstract：BACKGROUND:The consistency of endoscopic and histologic findings in patients with ulcerative colitis (UC) has not been elucidated. Choice of assessment may affect study outcomes. METHODS:Post hoc analyses were performed using data from 2 randomized, controlled multicenter trials: (1) SAG-26, mesalazine granules for in...

journal_title：Inflammatory bowel diseases

authors： Wolff S,Terheggen G,Mueller R,Greinwald R,Franklin J,Kruis W

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Childhood-onset Crohn's disease (CD) might reflect a more severe form of disease. To test this hypothesis we analyzed the long-term natural history of CD in an adult cohort of patients with childhood-onset compared to adult-onset CD. METHODS:We selected 206 childhood-onset CD patients among 2992 adult patie...

journal_title：Inflammatory bowel diseases

authors： Pigneur B,Seksik P,Viola S,Viala J,Beaugerie L,Girardet JP,Ruemmele FM,Cosnes J

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:Evidence supports the role of adherent invasive Escherichia coli (AIEC) in the pathogenesis of inflammatory bowel disease (IBD). However, little is known about the phylogenetic structure and origin of this group of bacteria. Multi-locus sequence typing (MLST), and fimH sequence analysis were performed to elu...

journal_title：Inflammatory bowel diseases

authors： Sepehri S,Kotlowski R,Bernstein CN,Krause DO

更新日期：2009-11-01 00:00:00

abstract：BACKGROUND:Fibrostenosis and stricture are well-recognized endpoints in Crohn's disease (CD). We hypothesized that stricturing CD is characterized by eosinophilia and epithelial IL-33. We proposed that eosinophil exposure to IL-33 would perpetuate inflammatory chronicity and subsequent fibrostenosis. METHODS:We perfor...

journal_title：Inflammatory bowel diseases

authors： Masterson JC,Capocelli KE,Hosford L,Biette K,McNamee EN,de Zoeten EF,Harris R,Fernando SD,Jedlicka P,Protheroe C,Lee JJ,Furuta GT

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:Cytomegalovirus (CMV) colitis can contribute to an unfavorable outcome of acute severe ulcerative colitis (ASUC). The purpose of this study was to evaluate the clinical outcomes of ASUC according to the CMV status and identify risk factors for CMV colitis in patients with ASUC. METHODS:We retrospectively an...

journal_title：Inflammatory bowel diseases

authors： Lee HS,Park SH,Kim SH,Kim J,Choi J,Lee HJ,Kim WS,Lee JM,Kwak MS,Hwang SW,Yang DH,Kim KJ,Ye BD,Byeon JS,Myung SJ,Yoon YS,Yu CS,Kim JH,Yang SK

更新日期：2016-04-01 00:00:00

abstract：:As the frontiers of immunological research expand, new insights into the pathogenesis of long poorly understood diseases, such as inflammatory bowel disease (IBD), are opening up new possible avenues for treatment. Myeloid-derived cells (i.e., monocytes, macrophages, neutrophils, and dendritic cells), long believed to...

journal_title：Inflammatory bowel diseases

authors： Leal MC,Däbritz J

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:Mesalamine is the first-line drug for the treatment of ulcerative colitis (UC). We directly compared the efficacy and safety of two mesalamine formulations for the induction of remission in patients with UC. METHODS:In a multicenter, double-blind, randomized study, 229 patients with mild-to-moderate active ...

journal_title：Inflammatory bowel diseases

authors： Ito H,Iida M,Matsumoto T,Suzuki Y,Sasaki H,Yoshida T,Takano Y,Hibi T

更新日期：2010-09-01 00:00:00

abstract：:Inflammatory bowel diseases (IBD), Crohn's disease and ulcerative colitis, are poorly understood disorders affecting the intestinal tract. The current model for disease suggests that genetically susceptible patients develop intolerance to gut microflora, and chronic inflammation develops as a result of environmental i...

journal_title：Inflammatory bowel diseases

authors： Wang W,Jovel J,Halloran B,Wine E,Patterson J,Ford G,OʼKeefe S,Meng B,Song D,Zhang Y,Tian Z,Wasilenko ST,Rahbari M,Reza S,Mitchell T,Jordan T,Carpenter E,Madsen K,Fedorak R,Dielemann LA,Ka-Shu Wong G,Mason AL

更新日期：2015-06-01 00:00:00

abstract：INTRODUCTION:Antitumor necrosis factor (anti-TNF) medications are known to be highly efficacious in persons with moderate-to-severe inflammatory bowel disease (IBD). There is a paucity of data from population-based sources to elucidate persistence with these medications in the general population of IBD. Discontinuation...

journal_title：Inflammatory bowel diseases

authors： Targownik LE,Tennakoon A,Leung S,Lix LM,Nugent Z,Singh H,Bernstein CN

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND AND AIMS:Poor sleep quality in Crohn's disease (CD) is associated with histologic activity and clinical relapse. We sought to characterize sleep dysfunction and determine the effect of poor sleep quality on risk for hospitalization and surgery. METHODS:Clinical data were collected for CD subjects including ...

journal_title：Inflammatory bowel diseases

authors： Sofia MA,Lipowska AM,Zmeter N,Perez E,Kavitt R,Rubin DT

更新日期：2020-07-17 00:00:00

abstract：BACKGROUND:Fecal biomarkers are used increasingly to monitor Crohn's disease (CD). However, the relative accuracy of different markers in identifying inflammation has been poorly evaluated. We evaluated fecal calprotectin (FC), lactoferrin (FL), and S100A12 (FS) using endoscopic validation in a prospective study of the...

journal_title：Inflammatory bowel diseases

authors： Wright EK,Kamm MA,De Cruz P,Hamilton AL,Ritchie KJ,Keenan JI,Leach S,Burgess L,Aitchison A,Gorelik A,Liew D,Day AS,Gearry RB

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:Psoriasis induced by anti-tumor necrosis factor-α (TNF) therapy has been described as a paradoxical side effect. AIM:To determine the incidence, clinical characteristics, and management of psoriasis induced by anti-TNF therapy in a large nationwide cohort of inflammatory bowel disease patients. METHODS:Pat...

journal_title：Inflammatory bowel diseases

authors： Guerra I,Pérez-Jeldres T,Iborra M,Algaba A,Monfort D,Calvet X,Chaparro M,Mañosa M,Hinojosa E,Minguez M,Ortiz de Zarate J,Márquez L,Prieto V,García-Sánchez V,Guardiola J,Rodriguez GE,Martín-Arranz MD,García-Tercero I,S

更新日期：2016-04-01 00:00:00

abstract：:Dendritic cells (DCs) play a key role in discriminating between commensal microorganisms and potentially harmful pathogens and in maintaining the balance between tolerance and active immunity. The regulatory role of DC is of particular importance in the gut where the immune system lies in intimate contact with the hig...

journal_title：Inflammatory bowel diseases

authors： Ng SC,Kamm MA,Stagg AJ,Knight SC

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND:The clinical course of ulcerative colitis (UC) is unpredictable. During recent years, the ability of fecal biomarkers to predict relapse in inflammatory bowel disease has been evaluated. The objective of this study was to assess fecal calprotectin (FC) as a predictor of disease recurrence in patients with ne...

journal_title：Inflammatory bowel diseases

authors： Lasson A,Simrén M,Stotzer PO,Isaksson S,Ohman L,Strid H

更新日期：2013-03-01 00:00:00

abstract：:After colectomy and ileal pouch-rectal anastomosis, pouchitis may occur. Pouchitis is a poorly defined condition with unknown etiology. The aim of this study was to develop an animal model of pouchitis. Ileal pouch-rectal anastomosis was created in Lewis and Sprague-Dawley rats. Rats were studied 4 and 8 weeks after s...

journal_title：Inflammatory bowel diseases

authors： Lichtman SN,Wang J,Hummel B,Lacey S,Sartor RB

更新日期：1998-08-01 00:00:00

abstract：BACKGROUND:The risk of suicide is increased among people with inflammatory bowel disease (IBD); however, most of the evidence regarding this association comes from studies of all-cause mortality, with small numbers of people who have committed suicide, or from clinical case reports. The current study examined the assoc...

journal_title：Inflammatory bowel diseases

authors： Gradus JL,Qin P,Lincoln AK,Miller M,Lawler E,Sørensen HT,Lash TL

更新日期：2010-12-01 00:00:00