Genome-wide association scans identify multiple confirmed susceptibility loci for Crohn's disease: lessons for study design.

abstract：BACKGROUND:Improving granulocyte function may represent an effective therapy for Crohn's disease (CD). We performed a Phase I-2 trial of sargramostim (SRG) in children with CD. METHODS:This was multicenter, open-label study in 6-16-year-old patients with moderate to severely active CD. Patients received either 4 or 6 ...

journal_title：Inflammatory bowel diseases

authors： Kelsen JR,Rosh J,Heyman M,Winter HS,Ferry G,Cohen S,Mamula P,Baldassano RN

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND:Genetic predisposition as a cause of inflammatory bowel disease (IBD) has been proven by both family and twin studies and genetic variants associated with the disease have been identified. The aim of our study was to determine the concordance rates for IBD in German twin pairs and to evaluate clinical charac...

journal_title：Inflammatory bowel diseases

authors： Spehlmann ME,Begun AZ,Burghardt J,Lepage P,Raedler A,Schreiber S

更新日期：2008-07-01 00:00:00

abstract：BACKGROUND:Noninvasive, sensitive, and specific tools for early identification of chronic inflammatory bowel disease (IBD) are needed for clinical practice. The aim was to identify new noninvasive test combinations for characterization of IBD in children and adolescents by comparing serological responses to microbial a...

journal_title：Inflammatory bowel diseases

authors： Ashorn S,Honkanen T,Kolho KL,Ashorn M,Välineva T,Wei B,Braun J,Rantala I,Luukkaala T,Iltanen S

更新日期：2009-02-01 00:00:00

abstract：BACKGROUND:Many chronic illnesses are accompanied by impaired cognitive functioning. In people with Inflammatory Bowel Disease (IBD), there is some research to suggest a decrement in verbal IQ (VIQ), when compared to people with Irritable Bowel Syndrome (IBS) and healthy controls. Although this is an important finding,...

journal_title：Inflammatory bowel diseases

authors： Dancey CP,Attree EA,Stuart G,Wilson C,Sonnet A

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND:Recently, granulocyte and monocyte adsorption apheresis (GCAP) has been shown to be safe and effective for active ulcerative colitis (UC). We analyzed the safety and efficacy of GCAP (G-1 Adacolumn) in patients with steroid-refractory and -dependent UC. G-1 Adacolumn is filled with cellulose acetate carriers...

journal_title：Inflammatory bowel diseases

authors： Naganuma M,Funakoshi S,Sakuraba A,Takagi H,Inoue N,Ogata H,Iwao Y,Ishi H,Hibi T

更新日期：2004-05-01 00:00:00

abstract：BACKGROUND:Though vedolizumab has received regulatory approval for the treatment of Crohn's disease (CD) and ulcerative colitis (UC) in adults, there is increasing off-label use in children. AIMS:To describe the experience with vedolizumab in pediatric inflammatory bowel disease (IBD) patients at 3 tertiary IBD center...

journal_title：Inflammatory bowel diseases

authors： Singh N,Rabizadeh S,Jossen J,Pittman N,Check M,Hashemi G,Phan BL,Hyams JS,Dubinsky MC

更新日期：2016-09-01 00:00:00

abstract：:The peak incidence of the inflammatory bowel diseases (IBDs) is between the second and fourth decades of life, which coincides with prime reproductive years. Unplanned or mistimed pregnancies may account for nearly half of all pregnancies and are associated with adverse consequences such as a higher risk of delayed pr...

journal_title：Inflammatory bowel diseases

authors： Limdi JK,Farraye J,Cannon R,Woodhams E,Farraye FA

更新日期：2019-09-18 00:00:00

abstract：BACKGROUND:According to the Montreal Classification, upper gastrointestinal tract phenotype L4 is uncommon in Caucasian patients with Crohn's disease (CD) but carries excess risk of recurrence. We studied the clinical course of CD in Chinese patients presenting with the L4 phenotype and factors predicting its occurrenc...

journal_title：Inflammatory bowel diseases

authors： Chow DK,Sung JJ,Wu JC,Tsoi KK,Leong RW,Chan FK

更新日期：2009-04-01 00:00:00

abstract：:Crohn's disease is associated with an excessive T helper (TH) type 1 inflammatory immune response. Reducing the influx of disease-associated CD4+ TH1 cells into the inflamed intestine is likely to be beneficial in preventing a disease flare-up and even possibly in reducing the effect of acute disease. Thiazolidenedion...

journal_title：Inflammatory bowel diseases

authors： Schaefer KL,Denevich S,Ma C,Cooley SR,Nakajima A,Wada K,Schlezinger J,Sherr D,Saubermann LJ

更新日期：2005-03-01 00:00:00

abstract：BACKGROUND:Unlike other anti-tumor necrosis factor alpha antibodies, golimumab does not deliver on its promise of effectiveness for treating patients with ulcerative colitis. We investigated the value of therapeutic drug monitoring for optimizing golimumab therapy. METHODS:We analyzed the golimumab pharmacokinetics da...

journal_title：Inflammatory bowel diseases

authors： Dreesen E,Kantasiripitak W,Detrez I,Stefanović S,Vermeire S,Ferrante M,Bouillon T,Drobne D,Gils A

更新日期：2020-03-04 00:00:00

abstract：BACKGROUND:Data from CHARM, a 56-week, randomized controlled trial of adalimumab for patients with moderately to severely active Crohn's disease (CD), were used to evaluate outcomes of adalimumab dosage adjustment. METHODS:Patients randomized to blinded adalimumab 40 mg every other week (EOW) in CHARM were the focus o...

journal_title：Inflammatory bowel diseases

authors： Sandborn WJ,Colombel JF,Schreiber S,Plevy SE,Pollack PF,Robinson AM,Chao J,Mulani P

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:The incorporation of abstracts from scientific meetings into systematic reviews and practice guidelines may reduce publication bias and delays in implementing therapeutic interventions. METHODS:All abstracts of Phase III randomized controlled trials in inflammatory bowel disease accepted at Digestive Diseas...

journal_title：Inflammatory bowel diseases

authors： Kottachchi D,Nguyen GC

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:Crohn's disease is a heterogeneous inflammatory bowel disease. The impact of age at diagnosis on the clinical course of patients varies widely as reported in the Western literature. Using the Vienna Classification, we seek to determine whether young Crohn's disease patients in an Asian population followed a ...

journal_title：Inflammatory bowel diseases

authors： Thia KT,Luman W,Jin OC

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Chronic inflammation in ulcerative colitis (UC) is a sizeable risk factor for colorectal cancer (CRC). Interleukin-13 (IL-13) is elevated in the UC mucosa and may induce dysregulated signaling in neighboring intestinal epithelial cells (IECs) and thus function as a tumorogenic cytokine. METHODS:Expression o...

journal_title：Inflammatory bowel diseases

authors： Mandal D,Levine AD

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND:Evidence supports the role of adherent invasive Escherichia coli (AIEC) in the pathogenesis of inflammatory bowel disease (IBD). However, little is known about the phylogenetic structure and origin of this group of bacteria. Multi-locus sequence typing (MLST), and fimH sequence analysis were performed to elu...

journal_title：Inflammatory bowel diseases

authors： Sepehri S,Kotlowski R,Bernstein CN,Krause DO

更新日期：2009-11-01 00:00:00

abstract：Background:Endoscopic monitoring is fundamental for evaluating the therapeutic response in IBD, but a validated endomicroscopic mucosal healing (MH) score is not available to date. However, confocal laser endomicroscopy (CLE) might define MH more precisely than conventional endoscopy. The major aim was to establish and...

journal_title：Inflammatory bowel diseases

authors： Hundorfean G,Chiriac MT,Mihai S,Hartmann A,Mudter J,Neurath MF

更新日期：2017-12-19 00:00:00

abstract：:Colitis-associated colorectal neoplasia (CRN) is a well-known complication of chronic inflammation of the colon either with ulcerative colitis (UC) or colonic Crohn's disease (CD). Studies have shown that inflammatory bowel disease (IBD) patients have an overall higher risk for colorectal dysplasia and cancer compared...

journal_title：Inflammatory bowel diseases

authors： Gaidos JK,Bickston SJ

更新日期：2016-05-01 00:00:00

abstract：:There is no standard practice in the induction of colitis by 2,4,6-trinitrobenzene sulfonic acid. In this review the current practice in 2,4,6-trinitrobenzene sulfonic acid colitis is studied using 20 recently published articles. We compare the different protocols, discuss the mechanism of disease and give recommendat...

journal_title：Inflammatory bowel diseases

authors： te Velde AA,Verstege MI,Hommes DW

更新日期：2006-10-01 00:00:00

abstract：Background and aims:To assess whether obesity may affect natural history of inflammatory bowel diseases (IBD), we conducted an individual participant data (IPD) pooled analysis of placebo arms, using data from clinical trials of infliximab in IBD and using the Yale Open Data Access (YODA) Project. Methods:We obtained ...

journal_title：Inflammatory bowel diseases

authors： Singh S,Proudfoot J,Xu R,Sandborn WJ

更新日期：2018-09-15 00:00:00

abstract：BACKGROUND:The clinical implication of Clostridium difficile infection (CDI) in patients with ileal pouch-anal anastomosis (IPAA) for underlying inflammatory bowel disease (IBD) has not been well studied. This study was designed to investigate the cumulative incidence, risk factors, and outcome of CDI in patients with ...

journal_title：Inflammatory bowel diseases

authors： Li Y,Qian J,Queener E,Shen B

更新日期：2013-02-01 00:00:00

abstract：:It is estimated that over one million people are living with inflammatory bowel disease (IBD) in the United States and that 20-25% of those are children. Pediatric IBD presents with more severe and extensive disease when compared to adults. As with all pediatric chronic illnesses, the patient as well as their parents ...

journal_title：Inflammatory bowel diseases

authors： Donegan A,Boyle B,Crandall W,Dotson JL,Lemont C,Moon T,Kim SC

更新日期：2016-05-01 00:00:00

abstract：:The limited efficacy of standard medical therapies for inflammatory bowel diseases has resulted in a continuing search for alternative treatments. Growth hormone (GH) has shown to have mutagenic and proliferative effects on intestinal cells. This study was designed to identify the effect of growth hormone on trinitrob...

journal_title：Inflammatory bowel diseases

authors： Kara E,Sungurtekin H,Sungurtekin U,Alkanat M,Ilkgul O

更新日期：2004-03-01 00:00:00

abstract：BACKGROUND:Histamine is a key immunoregulatory mediator in immediate-type hypersensitivity reactions and chronic inflammatory responses, in particular histamine suppresses proinflammatory responses to bacterial ligands, through histamine receptor 2 (H2R). The aim of this study was to investigate the effects of histamin...

journal_title：Inflammatory bowel diseases

authors： Smolinska S,Groeger D,Perez NR,Schiavi E,Ferstl R,Frei R,Konieczna P,Akdis CA,Jutel M,OʼMahony L

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:Mutations in the nucleotide oligomerization domain-2 (NOD2) gene and positive antibodies to microbial antigens have been found to be associated with the Crohn's disease (CD) phenotype, fibrostenosis. The aim of this study was to confirm these relationships in a large cohort of CD patients and to determine th...

journal_title：Inflammatory bowel diseases

authors： Ippoliti A,Devlin S,Mei L,Yang H,Papadakis KA,Vasiliauskas EA,McGovern DP,Abreu MT,Melmed G,Shaye O,Enayati P,Chen G,Choi J,Taylor K,Landers CJ,Rotter JI,Targan SR

更新日期：2010-08-01 00:00:00

abstract：:The genetic basis of antineutrophil cytoplasmic antibody, an important biomarker of inflammatory bowel disease (IBD), has never been thoroughly examined on a genome-wide scale. In this study, we performed a 2-stage genome-wide association study (GWAS) on antineutrophil cytoplasmic antibody in IBD cases. In the 2959 IB...

journal_title：Inflammatory bowel diseases

authors： Li D,Silverberg MS,Haritunians T,Dubinsky MC,Landers C,Stempak JM,Milgrom R,Guo X,Chen YD,Rotter JI,Taylor KD,McGovern DP,Targan SR

更新日期：2016-06-01 00:00:00

abstract：:Inflammatory bowel disease (IBD) has classically been associated with malnutrition and weight loss, although this has become less common with advances in treatment and greater proportions of patients attaining clinical remission. However, micronutrient deficiencies are still relatively common, particularly in CD patie...

journal_title：Inflammatory bowel diseases

authors： Hwang C,Ross V,Mahadevan U

更新日期：2012-10-01 00:00:00

abstract：INTRODUCTION:The incidence of early-onset CD in Scotland is among the highest worldwide. Three single nucleotide polymorphisms (SNPs) R702W, G908R and Leu1007finsC in the NOD2/CARD15 gene predispose to adult CD. We investigated the contribution of these variants to disease susceptibility and phenotype in the Scottish e...

journal_title：Inflammatory bowel diseases

authors： Russell RK,Drummond HE,Nimmo EE,Anderson N,Smith L,Wilson DC,Gillett PM,McGrogan P,Hassan K,Weaver LT,Bisset M,Mahdi G,Satsangi J

更新日期：2005-11-01 00:00:00

abstract：Background:Vedolizumab, an α4β7 integrin monoclonal antibody inhibiting gut lymphocyte trafficking, is an effective treatment for ulcerative colitis (UC). We evaluated the optimal position of vedolizumab in the UC treatment paradigm. Methods:Using Markov modeling, we assessed multiple algorithms for the treatment of U...

journal_title：Inflammatory bowel diseases

authors： Scott FI,Shah Y,Lasch K,Luo M,Lewis JD

更新日期：2018-01-18 00:00:00

abstract：BACKGROUND:Mucosal healing in ulcerative colitis leads to a decreased need for medication and decreased risk of disease relapse and colectomy. Histological healing seems to improve the disease prognosis even further. An assessment of both endoscopic and histological mucosal healing requires endoscopy, and the need for ...

journal_title：Inflammatory bowel diseases

authors： Theede K,Holck S,Ibsen P,Kallemose T,Nordgaard-Lassen I,Nielsen AM

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:The accuracy and utility of electronic health record (EHR)-derived phenotypes in replicating genotype-phenotype relationships have been infrequently examined. Low circulating vitamin D levels are associated with severe outcomes in inflammatory bowel disease (IBD); however, the genetic basis for vitamin D ins...

journal_title：Inflammatory bowel diseases

authors： Ananthakrishnan AN,Cagan A,Cai T,Gainer VS,Shaw SY,Churchill S,Karlson EW,Murphy SN,Kohane I,Liao KP,Xavier RJ

更新日期：2015-11-01 00:00:00