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Upper gastrointestinal tract phenotype of Crohn's disease is associated with early surgery and further hospitalization.

Abstract：

BACKGROUND:According to the Montreal Classification, upper gastrointestinal tract phenotype L4 is uncommon in Caucasian patients with Crohn's disease (CD) but carries excess risk of recurrence. We studied the clinical course of CD in Chinese patients presenting with the L4 phenotype and factors predicting its occurrence upon longitudinal follow-up. METHODS:This prospective cohort study included 132 Chinese CD patients (median age at diagnosis, 30.0 years, range: 14.0-77.0 years) who were followed for 770 person-years. Demographic data including disease behavior and location, details of surgery, and hospitalization were collected. The Kaplan-Meier method was used to estimate the probabilities of further hospitalization and major surgery followed by Cox proportional hazards regression to determine if clinical variables independently predicted the endpoints. RESULTS:The L4 phenotype was found in 30 (22.7%) patients at presentation. There were significantly more stricturing (46.7% versus 18.6%) and penetrating (30.0% versus 3.9%) phenotypes in the L4 group than in the non-L4 group (P < 0.0001). The 3-year cumulative probability of further hospitalization was 86.9% (95% confidence interval [CI]: 73.8%-100.0%) in the L4 group as compared with 49.3% (95% CI: 39.3%-59.3%) in the non-L4 group (log-rank test, P < 0.0001). The L4 phenotype independently predicted further hospitalization (adjusted hazards ratio [HR]: 2.1; 95% CI: 1.3-3.5). The cumulative probability of major surgery was significantly higher in the L4 than in the non-L4 group (P < 0.0001). Eighteen (17.6%) patients developed the L4 phenotype on follow-up and the stricturing phenotype predicted its occurrence (adjusted HR: 5.5; 95% CI: 2.2-14.0). CONCLUSIONS:Chinese CD patients more often had the L4 phenotype, which predicted the need of subsequent hospitalization.

journal_name

Inflamm Bowel Dis

journal_title

Inflammatory bowel diseases

authors

Chow DK,Sung JJ,Wu JC,Tsoi KK,Leong RW,Chan FK

doi

10.1002/ibd.20804

subject

Has Abstract

pub_date

2009-04-01 00:00:00

pages

551-7

issue

eissn

1078-0998

issn

1536-4844

journal_volume

pub_type

杂志文章

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Upper gastrointestinal tract phenotype of Crohn's disease is associated with early surgery and further hospitalization.