Quality and publication success of abstracts of randomized clinical trials in inflammatory bowel disease presented at Digestive Disease Week.

abstract：OBJECTIVES:There is some uncertainty regarding how to best dose and therapeutically monitor 6-mercaptopurine or azathioprine in patients with inflammatory bowel disease. The purpose of this study was to assess the relation between clinical response, 6-mercaptopurine metabolite levels, relative leukopenia, and drug dose...

journal_title：Inflammatory bowel diseases

authors： Achkar JP,Stevens T,Easley K,Brzezinski A,Seidner D,Lashner B

更新日期：2004-07-01 00:00:00

abstract：:We report genome-wide linkage results using model-free linkage analysis (Allegro) of 358 autosomal microsatellites in 260 new inflammatory bowel disease-affected relative pairs from 139 Caucasian families, including 108 Crohn's disease-affected relative pairs and 72 ulcerative colitis-affected relative pairs. Our resu...

journal_title：Inflammatory bowel diseases

authors： Barmada MM,Brant SR,Nicolae DL,Achkar JP,Panhuysen CI,Bayless TM,Cho JH,Duerr RH

更新日期：2004-09-01 00:00:00

abstract：BACKGROUND:Mesenchymal stem cells (MSCs) have demonstrated significant potentials for the treatment of inflammatory bowel disease. Clinical feasible methods to individually document the MSC recruitment to intestinal mucosa is lacking. Here, we proposed that endomicroscopy could noninvasively track MSCs in vivo at cellu...

journal_title：Inflammatory bowel diseases

authors： Li M,Zhang YX,Zhang Z,Zhou XY,Zuo XL,Cong Y,Li YQ

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:Infliximab is efficacious in the management of moderate to severe Crohn's disease (CD). There are limited data regarding performance of infliximab in patients who require reinitiation of maintenance dosing following previous irregular exposure. METHODS:This was a retrospective, observational study of CD pat...

journal_title：Inflammatory bowel diseases

authors： Stein DJ,Ananthakrishnan AN,Issa M,Williams JB,Beaulieu DB,Zadvornova Y,Ward A,Johnson K,Knox JF,Skaros S,Binion DG

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND:Circulating chromogranin A (CgA) levels, a marker for neuroendocrine tumors including carcinoids, have recently been found elevated in some patients with inflammatory bowel disease (IBD), although their significance is unclear. Therefore, we aimed to evaluate CgA levels and their possible relationship with c...

journal_title：Inflammatory bowel diseases

authors： Sciola V,Massironi S,Conte D,Caprioli F,Ferrero S,Ciafardini C,Peracchi M,Bardella MT,Piodi L

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND:There is limited contemporary population-based evidence on adverse birth outcomes and pregnancy-related complications for women with inflammatory bowel disease (IBD). This study provides such estimates of these risks and assesses variation by IBD type and surgical interventions. METHODS:We calculated the pr...

journal_title：Inflammatory bowel diseases

authors： Abdul Sultan A,West J,Ban L,Humes D,Tata LJ,Fleming KM,Nelson-Piercy C,Card T

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:CEACAM1, CEACAM5, and CEACAM6 represent 3 of the CEACAM (carcinoembryonic antigen-related cell adhesion molecule) subfamily members expressed on intestinal epithelial cells (IECs). Deficiency in their expression, as seen in inflammatory bowel disease (IBD), results in the lack of activation of CD8+ regulator...

journal_title：Inflammatory bowel diseases

authors： Roda G,Dahan S,Mezzanotte L,Caponi A,Roth-Walter F,Pinn D,Mayer L

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND:Fibrostenosis and stricture are well-recognized endpoints in Crohn's disease (CD). We hypothesized that stricturing CD is characterized by eosinophilia and epithelial IL-33. We proposed that eosinophil exposure to IL-33 would perpetuate inflammatory chronicity and subsequent fibrostenosis. METHODS:We perfor...

journal_title：Inflammatory bowel diseases

authors： Masterson JC,Capocelli KE,Hosford L,Biette K,McNamee EN,de Zoeten EF,Harris R,Fernando SD,Jedlicka P,Protheroe C,Lee JJ,Furuta GT

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:As the American population is aging, the number of older people with inflammatory bowel disease is increasing. We used clinical data from the Sinai-Helmsley Alliance for Research Excellence (SHARE), a prospective cohort, to examine disease and treatment differences in older adults. METHODS:We performed a cr...

journal_title：Inflammatory bowel diseases

authors： Kochar B,Long MD,Galanko J,Raffals LE,Ananthakrishnan A,Sandler RS

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND:Toll-like receptor 5 (TLR5) is implicated in the innate and adaptive immune responses that are associated with inflammatory bowel disease (IBD). In humans TLR5 is expressed on CD4(+) T cells and costimulation with flagellin potentiates effector and regulatory T cell responses. The aim of this study was to de...

journal_title：Inflammatory bowel diseases

authors： Hardenberg G,Yao Y,Piccirillo CA,Levings MK,Steiner TS

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:The unavailability of standardized parameters in bowel ultrasonography (US) commonly used in Crohn's disease (CD) and the shortage of skilled ultrasonographers are 2 limiting factors in the use of this imaging modality around the world. The aim of this study is to evaluate interobserver agreement among exper...

journal_title：Inflammatory bowel diseases

authors： Calabrese E,Kucharzik T,Maaser C,Maconi G,Strobel D,Wilson SR,Zorzi F,Novak KL,Bruining DH,Iacucci M,Watanabe M,Lolli E,Chiaramonte C,Hanauer SB,Panaccione R,Pallone F,Ghosh S,Monteleone G

更新日期：2018-08-16 00:00:00

abstract：BACKGROUND:Fulminant Crohn's colitis complicated by toxic dilatation of the large bowel usually requires surgery, which carries a substantial morbidity and mortality rate. METHODS:We report the case of a female with steroid refractory fulminant Crohn's colitis complicated by toxic megacolon who was successfully treate...

journal_title：Inflammatory bowel diseases

authors： Ng SC,Kamm MA

更新日期：2007-08-01 00:00:00

abstract：BACKGROUND:High doses of mesalazine usually result in an inconvenient dosage schedule and reduced compliance. The goal of this trial was to compare the effects of mesalazine 4 g daily given as prolonged-release granules in packets of 1 g with that of prolonged-release tablets of 0.5 g. METHODS:Two hundred twenty-seven...

journal_title：Inflammatory bowel diseases

authors： Farup PG,Hinterleitner TA,Lukás M,Hébuterne X,Rachmilewitz D,Campieri M,Meier R,Keller R,Rathbone B,Oddsson E

更新日期：2001-08-01 00:00:00

abstract：BACKGROUND:Histamine is a key immunoregulatory mediator in immediate-type hypersensitivity reactions and chronic inflammatory responses, in particular histamine suppresses proinflammatory responses to bacterial ligands, through histamine receptor 2 (H2R). The aim of this study was to investigate the effects of histamin...

journal_title：Inflammatory bowel diseases

authors： Smolinska S,Groeger D,Perez NR,Schiavi E,Ferstl R,Frei R,Konieczna P,Akdis CA,Jutel M,OʼMahony L

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:Wiskott-Aldrich syndrome protein-deficient patients and mice are immunodeficient and can develop inflammatory bowel disease. The intestinal microbiome is critical to the development of colitis in most animal models, in which Helicobacter spp. have been implicated in disease pathogenesis. We sought to determi...

journal_title：Inflammatory bowel diseases

authors： Nguyen DD,Muthupalani S,Goettel JA,Eston MA,Mobley M,Taylor NS,McCabe A,Marin R,Snapper SB,Fox JG

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:Interleukin-13 (IL-13) is a multifunctional cytokine whose net principle action is to diminish inflammatory responses. Dysregulation of IL-13 production has been proposed to contribute to intestinal inflammation in inflammatory bowel disease (IBD) patients. Previous studies implicate IL-13 in IBD pathogenesi...

journal_title：Inflammatory bowel diseases

authors： Kadivar K,Ruchelli ED,Markowitz JE,Defelice ML,Strogatz ML,Kanzaria MM,Reddy KP,Baldassano RN,von Allmen D,Brown KA

更新日期：2004-09-01 00:00:00

abstract：BACKGROUND:Ideal biomarkers are required to be developed for the diagnosis and prediction of the treatment of inflammatory bowel disease (IBD). We have reported that alteration of N-linked oligosaccharides of immunoglobulin (Ig) G is a novel diagnostic marker of IBD. Oligosaccharide alterations of IgA, however, have no...

journal_title：Inflammatory bowel diseases

authors： Inoue T,Iijima H,Tajiri M,Shinzaki S,Shiraishi E,Hiyama S,Mukai A,Nakajima S,Iwatani H,Nishida T,Mizushima T,Yasui T,Isaka Y,Kanto T,Tsujii M,Miyoshi E,Wada Y,Takehara T

更新日期：2012-09-01 00:00:00

abstract：Background:We quantified loss of response (LOR) to vedolizumab (VDZ) in clinical practice and assessed the effectiveness of VDZ dose intensification for managing LOR. Methods:Retrospective review (May 2014-December 2016) of a prospectively maintained inflammatory bowel disease (IBD) registry. Kaplan-Meier estimates we...

journal_title：Inflammatory bowel diseases

authors： Shmidt E,Kochhar G,Hartke J,Chilukuri P,Meserve J,Chaudrey K,Koliani-Pace JL,Hirten R,Faleck D,Barocas M,Luo M,Lasch K,Boland BS,Singh S,Vande Casteele N,Sagi SV,Fischer M,Chang S,Bohm M,Lukin D,Sultan K,Swamina

更新日期：2018-10-12 00:00:00

abstract：BACKGROUND:Aside from cases of backwash ileitis, the ileal mucosa of patients with ulcerative colitis (UC), an idiotypic inflammatory bowel disease, has received little attention despite the fact that colitis is known to trigger alterations in morphology and/or functions of the small intestine remotely. METHODS:The il...

journal_title：Inflammatory bowel diseases

authors： Sedghi S,Barreau F,Morilla I,Montcuquet N,Cazals-Hatem D,Pedruzzi E,Rannou E,Tréton X,Hugot JP,Ogier-Denis E,Daniel F

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:Ulcerative colitis (UC) negatively affects health-related quality of life (HRQoL), but population-based and long-term data on this topic are scarce. Our aim was to determine the HRQoL in UC patients after a 10-year disease duration. METHODS:UC patients from a population-based inception cohort met at a presc...

journal_title：Inflammatory bowel diseases

authors： Hoivik ML,Moum B,Solberg IC,Cvancarova M,Hoie O,Vatn MH,Bernklev T,IBSEN Study Group.

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND:Chemokines regulate the pathways that restrict homing of specific subsets of immune cells, and thereby fine tune the immune response at specific lymphoid and peripheral tissues. CCL2 is a chemokine that induces migration of monocytes, memory T cells, and dendritic cells. Previously, we demonstrated that pM l...

journal_title：Inflammatory bowel diseases

authors： Maharshak N,Hart G,Ron E,Zelman E,Sagiv A,Arber N,Brazowski E,Margalit R,Elinav E,Shachar I

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:Minimally invasive surgery for Crohn's ileocolitis is well established but few data exist regarding laparoscopic techniques for Crohn's colitis. We aimed to describe outcomes associated with minimally invasive surgery for Crohn's colitis, including predictors of conversion to laparotomy and postoperative com...

journal_title：Inflammatory bowel diseases

authors： Holubar SD,Dozois EJ,Privitera A,Pemberton JH,Cima RR,Larson DW

更新日期：2010-11-01 00:00:00

abstract：:Crohn's disease is associated with an excessive T helper (TH) type 1 inflammatory immune response. Reducing the influx of disease-associated CD4+ TH1 cells into the inflamed intestine is likely to be beneficial in preventing a disease flare-up and even possibly in reducing the effect of acute disease. Thiazolidenedion...

journal_title：Inflammatory bowel diseases

authors： Schaefer KL,Denevich S,Ma C,Cooley SR,Nakajima A,Wada K,Schlezinger J,Sherr D,Saubermann LJ

更新日期：2005-03-01 00:00:00

abstract：BACKGROUND:Establishing predictors of quality of life (QoL) in individuals with inflammatory bowel disease could help to identify those patients who are most likely to experience poor QoL and to target therapeutic interventions appropriately. We aimed to investigate how disease-specific QoL depends on demographic, dise...

journal_title：Inflammatory bowel diseases

authors： Han SW,McColl E,Barton JR,James P,Steen IN,Welfare MR

更新日期：2005-01-01 00:00:00

abstract：:: Pericarditis occurs rarely in association with inflammatory bowel disease. Because life-threatening complications may occur, pericarditis should be suspected in patients who present with chest symptoms. We report the case of a 28-year-old patient with ulcerative colitis who presented with pericarditis during an acti...

journal_title：Inflammatory bowel diseases

authors： Hinterreiter M,Allinger S,Punzengruber C,Knoflach P

更新日期：1995-10-01 00:00:00

abstract：BACKGROUND:The genetic influence on disease course in inflammatory bowel disease (IBD) remains unknown. We therefore aimed to study longitudinal concordance for clinical characteristics and longitudinal stability using the Montreal Classification in an IBD twin population. METHODS:A total of 158 twins with ulcerative ...

journal_title：Inflammatory bowel diseases

authors： Halfvarson J,Jess T,Bodin L,Järnerot G,Munkholm P,Binder V,Tysk C

更新日期：2007-12-01 00:00:00

abstract：:Chemokines, a large family of small chemoattractive cytokines, and their receptors play an integral role in the regulation of the immune response and homeostasis. The ability of chemokines to attract specific populations of immune cells sets them apart from other chemoattractants. Chemokines produced within the gastro...

journal_title：Inflammatory bowel diseases

authors： Zimmerman NP,Vongsa RA,Wendt MK,Dwinell MB

更新日期：2008-07-01 00:00:00

abstract：BACKGROUND:It is unclear if traditional histopathology and noninvasive blood-based tests are sufficiently accurate to detect cytomegalovirus (CMV) reactivation in inflammatory bowel disease. Therefore, we assessed the diagnostic accuracy of these tests compared with immunohistochemistry (IHC) and tissue polymerase chai...

journal_title：Inflammatory bowel diseases

authors： Tandon P,James P,Cordeiro E,Mallick R,Shukla T,McCurdy JD

更新日期：2017-04-01 00:00:00

abstract：:Potential biomarkers for Crohn's disease (CD) and ulcerative colitis (UC) were identified from two sets of full thickness pathologic samples utilizing DermArray and PharmArray DNA microarrays relative to uninvolved (Un) colon or normal colon. Seven of the over-expressed genes were verified using quantitative RT-PCR (i...

journal_title：Inflammatory bowel diseases

authors： Dooley TP,Curto EV,Reddy SP,Davis RL,Lambert GW,Wilborn TW,Elson CO

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Host-microbe interactions at the intestinal mucosal-luminal interface (MLI) are critical factors in the biology of inflammatory bowel disease (IBD). METHODS:To address this issue, we performed a series of investigations integrating analysis of the bacteria and metaproteome at the MLI of Crohn's disease, ulc...

journal_title：Inflammatory bowel diseases

authors： Presley LL,Ye J,Li X,Leblanc J,Zhang Z,Ruegger PM,Allard J,McGovern D,Ippoliti A,Roth B,Cui X,Jeske DR,Elashoff D,Goodglick L,Braun J,Borneman J

更新日期：2012-03-01 00:00:00