Quality and publication success of abstracts of randomized clinical trials in inflammatory bowel disease presented at Digestive Disease Week.


BACKGROUND:The incorporation of abstracts from scientific meetings into systematic reviews and practice guidelines may reduce publication bias and delays in implementing therapeutic interventions. METHODS:All abstracts of Phase III randomized controlled trials in inflammatory bowel disease accepted at Digestive Disease Week (1998-2003) were identified. MedLine, PubMed (1997-current), EMBASE, and Google Scholar were searched for subsequent full publications. Characteristics of methodology and outcomes of the abstracts and articles were analyzed. RESULTS:The 5-year cumulative publication rate of the 82 eligible abstracts was 78%. Abstracts that presented negative results were less likely to be published than those with positive findings, particularly after the first 2 years (hazard ratio 6.45; 95% confidence interval [CI]: 2.22-18.7) with 5-year cumulative publication rates of (50% versus 91%, respectively, P < 0.001). The median time to publication was longer for negative than positive abstracts (58 versus 26 months, P < 0.001). Abstracts selected for oral presentation were more likely to be published than poster presentations (89% versus 69%; P = 0.03). A change in primary outcome results was observed in 28% (n = 18) of abstracts compared to that in the final publication, and 6% (n = 4) had a statistically significant change resulting in a change of study conclusions. CONCLUSIONS:Our findings suggest that the use of abstract data would enable detection and mitigation of publication bias. Improving the uniformity and quality of abstract reporting of randomized clinical trials at scientific meetings may facilitate their incorporation in practice guidelines and systematic reviews.


Inflamm Bowel Dis


Kottachchi D,Nguyen GC




Has Abstract


2010-06-01 00:00:00












  • Use of Complementary and Alternative Medicine for Inflammatory Bowel Disease Is Associated with Worse Adherence to Conventional Therapy: The COMPLIANT Study.

    abstract:BACKGROUND:Complementary and alternative medicine (CAM) use is highly prevalent among inflammatory bowel disease (IBD patients). We assessed whether its use, both for IBD and for general health, influenced adherence to conventional medications. METHODS:We enrolled 392 IBD subjects in a prospective cohort study and cat...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Nguyen GC,Croitoru K,Silverberg MS,Steinhart AH,Weizman AV

    更新日期:2016-06-01 00:00:00

  • Approach to corticosteroid-dependent and corticosteroid-refractory Crohn's disease.

    abstract::Corticosteroids are considered a drug of choice for the treatment of patients with moderately to severely active Crohn's disease (CD), an inflammatory bowel disease characterized by chronic recurrent flares of disease activity. However, among patients receiving corticosteroid therapy for induction of remission, 20% ha...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章,评审


    authors: Lichtenstein GR

    更新日期:2001-05-01 00:00:00

  • Etiopathogenesis of Nephrolithiasis in Ulcerative Colitis Patients with the Ileal Pouch Anal Anastomosis.

    abstract:BACKGROUND:Our previous study showed that nephrolithiasis is a common complication in ulcerative colitis patients after ileal pouch anal anastomosis (IPAA). However, the pathogenesis of nephrolithiasis in IPAA patients has not been studied. The aim of this study was to compare urine and serum metabolic compositions in ...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Arora Z,Mukewar S,Lopez R,Camino D,Shen B,Hall P

    更新日期:2017-05-01 00:00:00

  • Epidemiology of inflammatory bowel disease in a German twin cohort: results of a nationwide study.

    abstract:BACKGROUND:Genetic predisposition as a cause of inflammatory bowel disease (IBD) has been proven by both family and twin studies and genetic variants associated with the disease have been identified. The aim of our study was to determine the concordance rates for IBD in German twin pairs and to evaluate clinical charac...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Spehlmann ME,Begun AZ,Burghardt J,Lepage P,Raedler A,Schreiber S

    更新日期:2008-07-01 00:00:00

  • Atherogenic diets exacerbate colitis in mice deficient in glutathione peroxidase.

    abstract:BACKGROUND:The proinflammatory effect of high-fat diet has been observed beyond the cardiovascular system, but there is little evidence to support its role in triggering inflammatory bowel disease. GPx1/2-double-knockout (DKO) mice deficient in 2 intracellular glutathione peroxidases, GPx1 and GPx2, on a C57BL/6 (B6) b...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Gao Q,Esworthy RS,Kim BW,Synold TW,Smith DD,Chu FF

    更新日期:2010-12-01 00:00:00

  • Incidence, Clinical Characteristics, and Management of Psoriasis Induced by Anti-TNF Therapy in Patients with Inflammatory Bowel Disease: A Nationwide Cohort Study.

    abstract:BACKGROUND:Psoriasis induced by anti-tumor necrosis factor-α (TNF) therapy has been described as a paradoxical side effect. AIM:To determine the incidence, clinical characteristics, and management of psoriasis induced by anti-TNF therapy in a large nationwide cohort of inflammatory bowel disease patients. METHODS:Pat...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章,多中心研究


    authors: Guerra I,Pérez-Jeldres T,Iborra M,Algaba A,Monfort D,Calvet X,Chaparro M,Mañosa M,Hinojosa E,Minguez M,Ortiz de Zarate J,Márquez L,Prieto V,García-Sánchez V,Guardiola J,Rodriguez GE,Martín-Arranz MD,García-Tercero I,S

    更新日期:2016-04-01 00:00:00

  • Fecal calprotectin and lactoferrin for the prediction of inflammatory bowel disease relapse.

    abstract:BACKGROUND:The purpose of the study was to determine the role of fecal calprotectin and lactoferrin in the prediction of inflammatory bowel disease relapses, both in patients with ulcerative colitis (UC) and Crohn's disease (CD), in a large, long-term, follow-up study. METHODS:The prospective multicenter study include...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章,多中心研究


    authors: Gisbert JP,Bermejo F,Pérez-Calle JL,Taxonera C,Vera I,McNicholl AG,Algaba A,López P,López-Palacios N,Calvo M,González-Lama Y,Carneros JA,Velasco M,Maté J

    更新日期:2009-08-01 00:00:00

  • Pancreas duct abnormalities in patients with ulcerative colitis: a magnetic resonance pancreatography study.

    abstract:BACKGROUND:The presumed etiology and prevalence of pancreatic abnormalities in patients with ulcerative colitis (UC) have been controversial. We conducted a controlled (cross-sectional) study of patients with UC compared with non-UC controls to determine the prevalence of pancreatic duct abnormalities in patients with ...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Toda N,Akahane M,Kiryu S,Matsubara Y,Yamaji Y,Okamoto M,Minagawa N,Ohgi K,Komatsu Y,Yahagi N,Yoshida H,Kawabe T,Ohtomo K,Omata M

    更新日期:2005-10-01 00:00:00

  • Volatile Organic Compounds in Exhaled Air as Novel Marker for Disease Activity in Crohn's Disease: A Metabolomic Approach.

    abstract:BACKGROUND:Disappearance of macroscopic mucosal inflammation predicts long-term outcome in Crohn's disease (CD). It can be assessed by ileocolonoscopy, which is, however, an invasive and expensive procedure. Disease activity indices do not correlate well with endoscopic activity and noninvasive markers have a low sensi...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Bodelier AG,Smolinska A,Baranska A,Dallinga JW,Mujagic Z,Vanhees K,van den Heuvel T,Masclee AA,Jonkers D,Pierik MJ,van Schooten FJ

    更新日期:2015-08-01 00:00:00

  • Splenic function and IgM-memory B cells in Crohn's disease patients treated with infliximab.

    abstract:BACKGROUND:Under experimental chronic inflammation, tumor necrosis factor (TNF)-alpha plays a role in damaging spleen marginal zone. This latter has a crucial function in mounting B cell-dependent immune responses against infections by encapsulated bacteria. In Crohn's disease (CD), a chronic inflammatory disorder wher...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Di Sabatino A,Rosado MM,Cazzola P,Biancheri P,Tinozzi FP,Laera MR,Cantoro L,Vanoli A,Carsetti R,Corazza GR

    更新日期:2008-05-01 00:00:00

  • Homing imprinting and immunomodulation in the gut: role of dendritic cells and retinoids.

    abstract::Lymphocyte migration is at the heart of chronic inflammatory ailments, including inflammatory bowel disease (IBD). Whereas naïve lymphocytes migrate to all secondary lymphoid organs, they are mostly excluded from nonlymphoid peripheral tissues. Upon activation, lymphocytes change their pattern of adhesion receptors an...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章,评审


    authors: Mora JR

    更新日期:2008-02-01 00:00:00

  • Treatment patterns, complications, and disease relapse in a real-world population of patients with moderate-to-severe ulcerative colitis initiating immunomodulator therapy.

    abstract:BACKGROUND:Immunomodulator (IM) treatments in ulcerative colitis (UC) are not curative and carry increased risk of complications, sometimes leading to therapy changes, reduced treatment benefits, and eventual relapse. We assessed patterns of IM utilization and therapy changes, complications, and disease relapse in a re...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Loftus EV Jr,Davis KL,Wang CC,Dastani H,Luo A

    更新日期:2014-08-01 00:00:00

  • The effect of recombinant human growth hormone (rhGH) on trinitrobenzene sulfonic acid-induced colitis in rats: an experimental study.

    abstract::The limited efficacy of standard medical therapies for inflammatory bowel diseases has resulted in a continuing search for alternative treatments. Growth hormone (GH) has shown to have mutagenic and proliferative effects on intestinal cells. This study was designed to identify the effect of growth hormone on trinitrob...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Kara E,Sungurtekin H,Sungurtekin U,Alkanat M,Ilkgul O

    更新日期:2004-03-01 00:00:00

  • Antibiotic Use in Childhood and Adolescence and Risk of Inflammatory Bowel Disease: A Case-Control Study in the UK Clinical Practice Research Datalink.

    abstract:BACKGROUND:Inflammatory bowel disease (IBD) causes serious morbidity and disability, and the incidence is increasing. The disease etiology is not well understood, though inflammatory reactions after antibiotic exposure may be associated with development of IBD. We investigated the association between IBD and prior anti...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Troelsen FS,Jick S

    更新日期:2020-02-11 00:00:00

  • Predictors of fibrostenotic Crohn's disease.

    abstract::Intestinal fibrosis is a common and serious complication of Crohn's disease (CD) and as it can occur at any time during the disease course, it is crucial to identify patients at risk. The aim is not only to understand the pathophysiology of fibrogenesis but to be able to accurately inform subjects about their disease ...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章,评审


    authors: Rieder F,Lawrance IC,Leite A,Sans M

    更新日期:2011-09-01 00:00:00

  • Multi-"-Omics" Profiling in Patients With Quiescent Inflammatory Bowel Disease Identifies Biomarkers Predicting Relapse.

    abstract:BACKGROUND:Inflammatory bowel diseases (IBD) are characterized by intermittent relapses, and their course is heterogeneous and unpredictable. Our aim was to determine the ability of protein, metabolite, or microbial biomarkers to predict relapse in patients with quiescent disease. METHODS:This prospective study enroll...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Borren NZ,Plichta D,Joshi AD,Bonilla G,Sadreyev R,Vlamakis H,Xavier RJ,Ananthakrishnan AN

    更新日期:2020-09-18 00:00:00

  • Contribution of the novel inflammatory bowel disease gene IL23R to disease susceptibility and phenotype.

    abstract:BACKGROUND:A North American genome-wide single nucleotide polymorphism (SNP) association study identified IL23R as a novel inflammatory bowel disease (IBD) susceptibility gene. Association was reported with multiple risk variants in the centromeric portion of IL23R in 3 large independent cohorts. The aims of this study...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Cummings JR,Ahmad T,Geremia A,Beckly J,Cooney R,Hancock L,Pathan S,Guo C,Cardon LR,Jewell DP

    更新日期:2007-09-01 00:00:00

  • On the role of ischemia in the pathogenesis of IBD: a review.

    abstract::Inflammatory bowel disease (IBD) is a chronic intestinal disorder comprising 2 distinct but often overlapping diseases: Crohn's disease and ulcerative colitis. Although much research to identify the etiology of IBD has focused on genetic constitution, infectious causes, and immune dysregulation, its exact cause and pa...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章,评审


    authors: Ibrahim CB,Aroniadis OC,Brandt LJ

    更新日期:2010-04-01 00:00:00

  • Interrogating the Gut-Brain Axis in the Context of Inflammatory Bowel Disease: A Translational Approach.

    abstract::This review examines preclinical and clinical studies relevant to our understanding of how the bidirectional gut-brain axis influences the natural history of inflammatory bowel disease. Preclinical studies provide proof of concept that preexisting behavioral illness, such as depression, results in increased susceptibi...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Collins SM

    更新日期:2020-03-04 00:00:00

  • Indicators of clinical response to treatment with six-mercaptopurine or azathioprine in patients with inflammatory bowel disease.

    abstract:OBJECTIVES:There is some uncertainty regarding how to best dose and therapeutically monitor 6-mercaptopurine or azathioprine in patients with inflammatory bowel disease. The purpose of this study was to assess the relation between clinical response, 6-mercaptopurine metabolite levels, relative leukopenia, and drug dose...

    journal_title:Inflammatory bowel diseases

    pub_type: 临床试验,杂志文章


    authors: Achkar JP,Stevens T,Easley K,Brzezinski A,Seidner D,Lashner B

    更新日期:2004-07-01 00:00:00

  • Pneumocystis jiroveci pneumonia in inflammatory bowel disease: when should prophylaxis be considered?

    abstract:BACKGROUND:The incidence of inflammatory bowel disease (IBD) has increased over the past several decades with a corresponding increase in the number of patients on combination immunosuppressive therapy including corticosteroids, anti-metabolites and biologic agents. The exact incidence of pneumocystis jiroveci pneumoni...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章,评审


    authors: Okafor PN,Nunes DP,Farraye FA

    更新日期:2013-07-01 00:00:00

  • Characterizing Clinical Features and Creating a Gene Expression Profile Associated With Pain Burden in Children With Inflammatory Bowel Disease.

    abstract:BACKGROUND:There is often dissociation between inflammatory activity and abdominal pain in children with inflammatory bowel disease (IBD), suggesting other factors may play a role in the pain experience. METHODS:Patients (8 to 17 years) newly diagnosed with IBD were enrolled in the ALLAY Study: Assessing Risk Factors ...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Grossi V,Hyams JS,Glidden NC,Knight BE,Young EE

    更新日期:2020-07-17 00:00:00

  • Tyro3, Axl, and Mertk receptor signaling in inflammatory bowel disease and colitis-associated cancer.

    abstract::Three receptor tyrosine kinases, Tyro3, Axl, and Mertk (TAM) and their ligands Gas6 and Protein S, have emerged as potent negative regulators of innate immune responses. A number of studies using genetic ablation of TAM loci in mice have elucidated the mechanism of TAM engagement and function during the immune respons...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章,评审


    authors: Rothlin CV,Leighton JA,Ghosh S

    更新日期:2014-08-01 00:00:00

  • Enhanced formation of advanced oxidation protein products in IBD.

    abstract:BACKGROUND:Advanced oxidation protein products (AOPPs) are new protein markers of oxidative stress with pro-inflammatory properties, accumulated in many pathological conditions. The issue of their enhanced formation in IBD has not been addressed yet. METHODS:The concentration of relative AOPPs (rAOPP; concentration of...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Krzystek-Korpacka M,Neubauer K,Berdowska I,Boehm D,Zielinski B,Petryszyn P,Terlecki G,Paradowski L,Gamian A

    更新日期:2008-06-01 00:00:00

  • Assessing the Optimal Position for Vedolizumab in the Treatment of Ulcerative Colitis: A Simulation Model.

    abstract:Background:Vedolizumab, an α4β7 integrin monoclonal antibody inhibiting gut lymphocyte trafficking, is an effective treatment for ulcerative colitis (UC). We evaluated the optimal position of vedolizumab in the UC treatment paradigm. Methods:Using Markov modeling, we assessed multiple algorithms for the treatment of U...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Scott FI,Shah Y,Lasch K,Luo M,Lewis JD

    更新日期:2018-01-18 00:00:00

  • Relative role of methylator and tumor suppressor pathways in ulcerative colitis-associated colon cancer.

    abstract:BACKGROUND:Chronic ulcerative colitis (UC) is associated with an increased colorectal cancer risk which may be secondary to repetitive mucosal injury. Both epigenetic methylation and the classic adenoma-to-carcinoma sequence have been implicated in this malignant transformation, but the underlying molecular mechanisms ...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Sanchez JA,Dejulius KL,Bronner M,Church JM,Kalady MF

    更新日期:2011-09-01 00:00:00

  • Poor Sleep Quality in Crohn's Disease Is Associated With Disease Activity and Risk for Hospitalization or Surgery.

    abstract:BACKGROUND AND AIMS:Poor sleep quality in Crohn's disease (CD) is associated with histologic activity and clinical relapse. We sought to characterize sleep dysfunction and determine the effect of poor sleep quality on risk for hospitalization and surgery. METHODS:Clinical data were collected for CD subjects including ...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Sofia MA,Lipowska AM,Zmeter N,Perez E,Kavitt R,Rubin DT

    更新日期:2020-07-17 00:00:00

  • Rapid Infliximab Infusion in Children with Inflammatory Bowel Disease: A Multicenter North American Experience.

    abstract:BACKGROUND:Infliximab (IFX) infusion may lead to development of anti-IFX antibodies, and subsequent infusion reactions (IRs). The safety of rapid IFX infusion administered over 60 minutes has been under-investigated in children with inflammatory bowel disease. In a multicenter study, the frequency and nature of rapid i...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章,多中心研究


    authors: El-Matary W,Dykes DMH,Bauman L,Elkadri A,Carroll MW,Izaguirre MR,deBruyn J,Samson CM,Crim AM,Ali S,Grossman A

    更新日期:2017-12-01 00:00:00

  • Physician density and hospitalization for inflammatory bowel disease.

    abstract:BACKGROUND:Inflammatory bowel diseases (IBDs) are chronic illnesses that require frequent and regular healthcare contact. Regular maintenance care may reduce complications or the need for hospitalization. Availability of physicians may be an important determinant of IBD hospitalizations. METHODS:Using 2008 inpatient d...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Ananthakrishnan AN,McGinley EL,Binion DG,Saeian K

    更新日期:2011-02-01 00:00:00

  • Metronidazole or Rifaximin for Treatment of Clostridium difficile in Pediatric Patients with Inflammatory Bowel Disease: A Randomized Clinical Trial.

    abstract:BACKGROUND:Interestingly, Clostridium difficile infection (CDI) worsens the course of inflammatory bowel disease (IBD); however, there is a paucity of data regarding the treatment of CDI in this group of patients. METHODS:This was a prospective, single-blind trial. Children with flare of IBD and CDI were randomly assi...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章,随机对照试验


    authors: Gawronska A,Banasiuk M,Lachowicz D,Pituch H,Albrecht P,Banaszkiewicz A

    更新日期:2017-12-01 00:00:00