A genome scan in 260 inflammatory bowel disease-affected relative pairs.

abstract：BACKGROUND:Chronic inflammatory diseases are characterized by massive infiltration of innate and acquired immune cells in inflammatory sites. However, it remains unclear how these cells cooperate in the development of disease. Although bone marrow (BM) is a primary site for hematopoiesis of immune cells except T cells,...

journal_title：Inflammatory bowel diseases

authors： Nemoto Y,Kanai T,Tohda S,Totsuka T,Okamoto R,Tsuchiya K,Nakamura T,Sakamoto N,Fukuda T,Miura O,Yagita H,Watanabe M

更新日期：2008-11-01 00:00:00

abstract：BACKGROUND:Thiopurines are effective drugs in treating ulcerative colitis (UC) and Crohn's disease (CD) even if studies that specifically investigate these drugs' profile of efficacy in UC compared with CD are scarce. Our aim was to compare the profile of efficacy of thiopurines in patients with UC and CD. METHODS:We ...

journal_title：Inflammatory bowel diseases

authors： Rispo A,Testa A,De Palma GD,Donetto S,Diaferia M,Musto D,Nardone O,Maione F,Caporaso N,Castiglione F

更新日期：2015-11-01 00:00:00

abstract：INTRODUCTION:Antitumor necrosis factor (anti-TNF) medications are known to be highly efficacious in persons with moderate-to-severe inflammatory bowel disease (IBD). There is a paucity of data from population-based sources to elucidate persistence with these medications in the general population of IBD. Discontinuation...

journal_title：Inflammatory bowel diseases

authors： Targownik LE,Tennakoon A,Leung S,Lix LM,Nugent Z,Singh H,Bernstein CN

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:The goal of this study was to determine the rate of work disability, unemployment, and sick leave in an unselected inflammatory bowel disease (IBD) cohort and to measure the effect of working status and disability on the patient's health-related quality of life (HRQOL). MATERIALS AND METHODS:All eligible pa...

journal_title：Inflammatory bowel diseases

authors： Bernklev T,Jahnsen J,Henriksen M,Lygren I,Aadland E,Sauar J,Schulz T,Stray N,Vatn M,Moum B

更新日期：2006-05-01 00:00:00

abstract：:: We evaluated retrospective smoking data reported by 221 patients with ulcerative colitis in 1984 and repeated in an identical questionnaire in 1989. Reported years of smoking initiation or smoking cessation agreed to a high extent; the difference between the two questionnaires was in mean (± SD) -0.1 ± 1.5 (median, ...

journal_title：Inflammatory bowel diseases

authors： Tysk C,Järnerot G

更新日期：1995-07-01 00:00:00

abstract：:The genetic basis of antineutrophil cytoplasmic antibody, an important biomarker of inflammatory bowel disease (IBD), has never been thoroughly examined on a genome-wide scale. In this study, we performed a 2-stage genome-wide association study (GWAS) on antineutrophil cytoplasmic antibody in IBD cases. In the 2959 IB...

journal_title：Inflammatory bowel diseases

authors： Li D,Silverberg MS,Haritunians T,Dubinsky MC,Landers C,Stempak JM,Milgrom R,Guo X,Chen YD,Rotter JI,Taylor KD,McGovern DP,Targan SR

更新日期：2016-06-01 00:00:00

abstract：OBJECTIVES:Previous decision analyses of inflam matory bowel diseases (IBD) have used decision trees and Markov chains. Occasionally IBD patients present with medical problems that are difficult or even impossible to phrase in terms of such established decision tools. This article aims to introduce modeling by a time-d...

journal_title：Inflammatory bowel diseases

authors： Sonnenberg A,Gavin MW

更新日期：2000-11-01 00:00:00

abstract：:The principal investigator is responsible for everything involved in the conduct of a clinical research study. Prior to the initiation of any clinical trial, an investigator must become acquainted with the material requirements, personnel needs, and best practices involved in the conduct of the trial. Commitment to a ...

journal_title：Inflammatory bowel diseases

authors： Wolf DC,Katz S,Safdi MA,Sandler RS,Lewis JD

更新日期：2005-11-01 00:00:00

abstract：Background and aims:To assess whether obesity may affect natural history of inflammatory bowel diseases (IBD), we conducted an individual participant data (IPD) pooled analysis of placebo arms, using data from clinical trials of infliximab in IBD and using the Yale Open Data Access (YODA) Project. Methods:We obtained ...

journal_title：Inflammatory bowel diseases

authors： Singh S,Proudfoot J,Xu R,Sandborn WJ

更新日期：2018-09-15 00:00:00

abstract：BACKGROUND:The clinical presentation of the inflammatory bowel diseases (IBD) is extremely heterogenous and is characterized by various extraintestinal manifestations and complications (EIM). Increasing genetic insight for IBD and EIM shows multiple shared susceptibility loci. We hypothesize that, next to these overlap...

journal_title：Inflammatory bowel diseases

authors： van Sommeren S,Janse M,Karjalainen J,Fehrmann R,Franke L,Fu J,Weersma RK

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:The unavailability of standardized parameters in bowel ultrasonography (US) commonly used in Crohn's disease (CD) and the shortage of skilled ultrasonographers are 2 limiting factors in the use of this imaging modality around the world. The aim of this study is to evaluate interobserver agreement among exper...

journal_title：Inflammatory bowel diseases

authors： Calabrese E,Kucharzik T,Maaser C,Maconi G,Strobel D,Wilson SR,Zorzi F,Novak KL,Bruining DH,Iacucci M,Watanabe M,Lolli E,Chiaramonte C,Hanauer SB,Panaccione R,Pallone F,Ghosh S,Monteleone G

更新日期：2018-08-16 00:00:00

abstract：BACKGROUND:The optimal management of Clostridium difficile infection (CDI) in flaring inflammatory bowel disease (IBD) patients has not been defined. Limited data suggest that coadministration of immunomodulators (IM) with antibiotics (AB) results in a worse outcome. We investigated the prevalent practice among North A...

journal_title：Inflammatory bowel diseases

authors： Yanai H,Nguyen GC,Yun L,Lebwohl O,Navaneethan U,Stone CD,Ghazi L,Moayyedi P,Brooks J,Bernstein CN,Ben-Horin S

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND:Inflammatory bowel diseases (IBD) are characterized by intermittent relapses, and their course is heterogeneous and unpredictable. Our aim was to determine the ability of protein, metabolite, or microbial biomarkers to predict relapse in patients with quiescent disease. METHODS:This prospective study enroll...

journal_title：Inflammatory bowel diseases

authors： Borren NZ,Plichta D,Joshi AD,Bonilla G,Sadreyev R,Vlamakis H,Xavier RJ,Ananthakrishnan AN

更新日期：2020-09-18 00:00:00

abstract：:Potential biomarkers for Crohn's disease (CD) and ulcerative colitis (UC) were identified from two sets of full thickness pathologic samples utilizing DermArray and PharmArray DNA microarrays relative to uninvolved (Un) colon or normal colon. Seven of the over-expressed genes were verified using quantitative RT-PCR (i...

journal_title：Inflammatory bowel diseases

authors： Dooley TP,Curto EV,Reddy SP,Davis RL,Lambert GW,Wilborn TW,Elson CO

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:P-glycoprotein (P-gp), the product of the multidrug resistance gene (MDR), is an ATP-dependent transmembrane pump, which is expressed in multiple cell lineages including epithelial and hematopoetic cells. The human MDR gene is located on chromosome 7 (7q21.1), a susceptibility loci for inflammatory bowel dis...

journal_title：Inflammatory bowel diseases

authors： Staley EM,Schoeb TR,Lorenz RG

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND:MicroRNAs (miRNAs) are dysregulated in the inflammatory bowel diseases, Crohn's disease (CD) and ulcerative colitis (UC), which arise due to dysfunctional host-microbe interactions and impairment of the barrier function of the intestine. Here, we sought to determine whether circulating miRNAs are biomarkers ...

journal_title：Inflammatory bowel diseases

authors： Krissansen GW,Yang Y,McQueen FM,Leung E,Peek D,Chan YC,Print C,Dalbeth N,Williams M,Fraser AG

更新日期：2015-03-01 00:00:00

abstract：Background and aims:The postoperative course of Crohn's disease (CD) is best predicted by ileocolonoscopy. Ultrasonography (US) has been proposed as indicator for postsurgical recurrence (PSR), but further confirmation is needed. We performed a systemic review with meta-analysis to assess the pooled diagnostic accuracy...

journal_title：Inflammatory bowel diseases

authors： Rispo A,Imperatore N,Testa A,Nardone OM,Luglio G,Caporaso N,Castiglione F

更新日期：2018-04-23 00:00:00

abstract：BACKGROUND:Inflammatory bowel disease (IBD) is a multifactorial disorder, with the innate and adaptive immune cells contributing to disease initiation and progression. However, the intricate cross-talk between immune cell lineages remains incompletely understood. The role of CD8+ T cells in IBD pathogenesis has been un...

journal_title：Inflammatory bowel diseases

authors： Jamwal DR,Marati RV,Harrison CA,Midura-Kiela MT,Figliuolo Paz VR,Besselsen DG,Ghishan FK,Kiela PR

更新日期：2020-01-06 00:00:00

abstract：BACKGROUND:Advanced oxidation protein products (AOPPs) are new protein markers of oxidative stress with pro-inflammatory properties, accumulated in many pathological conditions. The issue of their enhanced formation in IBD has not been addressed yet. METHODS:The concentration of relative AOPPs (rAOPP; concentration of...

journal_title：Inflammatory bowel diseases

authors： Krzystek-Korpacka M,Neubauer K,Berdowska I,Boehm D,Zielinski B,Petryszyn P,Terlecki G,Paradowski L,Gamian A

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND:Previous research suggests a link between childhood adversities and inflammatory bowel disease (IBD); however, study limitations prevent generalization of findings. To address this, the current study uses a Canadian population-based sample to investigate the relationship between 3 childhood adversities and 2...

journal_title：Inflammatory bowel diseases

authors： Fuller-Thomson E,West KJ,Sulman J,Baird SL

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND:Children with Crohn's disease (CD) suffer from malnutrition. Understanding substrate utilization during exercise may help patients with CD sustain a healthy active lifestyle without compromising nutrition. The aim of this study was to determine whether substrate utilization and bioavailability during exercis...

journal_title：Inflammatory bowel diseases

authors： Nguyen T,Ploeger HE,Obeid J,Issenman RM,Baker JM,Takken T,Parise G,Timmons BW

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Patients suffering from Crohn's disease (CD) show increased incidence of low bone mineral density. Investigating this complication is difficult because the exact etiology of CD remains elusive. Mice carrying a deletion in the tumor necrosis factor (TNF) AU-rich elements (ARE) are reported as a model for huma...

journal_title：Inflammatory bowel diseases

authors： Huybers S,Apostolaki M,van der Eerden BC,Kollias G,Naber TH,Bindels RJ,Hoenderop JG

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND:Inflammatory bowel disease (IBD) causes serious morbidity and disability, and the incidence is increasing. The disease etiology is not well understood, though inflammatory reactions after antibiotic exposure may be associated with development of IBD. We investigated the association between IBD and prior anti...

journal_title：Inflammatory bowel diseases

authors： Troelsen FS,Jick S

更新日期：2020-02-11 00:00:00

abstract：BACKGROUND:The similar presentations in relapse of inflammatory bowel disease (IBD) and enteric infection pose substantial barriers to diagnosis and treatment. The objective of this study was to investigate the incidence, etiology, predictors, and treatment of enteric infection in patients with IBD. METHODS:We reviewe...

journal_title：Inflammatory bowel diseases

authors： Axelrad JE,Joelson A,Nobel YR,Lawlor G,Green PHR,Lichtiger S,Lebwohl B

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND:Acute pancreatitis has occasionally been associated with Crohn's disease (CD), but whether a causal association exists remains unclear. We sought to determine the frequency of etiologies in a consecutive series of patients with CD with acute pancreatitis. METHODS:A centralized diagnostic index was used to i...

journal_title：Inflammatory bowel diseases

authors： Moolsintong P,Loftus EV Jr,Chari ST,Egan LJ,Tremaine WJ,Sandborn WJ

更新日期：2005-12-01 00:00:00

abstract：BACKGROUND:The PAILOT trial was a randomized controlled trial aimed to evaluate proactive vs reactive therapeutic drug monitoring in children with Crohn's disease (CD) treated with adalimumab. Our aim in this post hoc analysis of the PAILOT trial was to assess the efficacy and safety of adalimumab combination treatment...

journal_title：Inflammatory bowel diseases

authors： Matar M,Shamir R,Turner D,Broide E,Weiss B,Ledder O,Guz-Mark A,Rinawi F,Cohen S,Topf-Olivestone C,Shaoul R,Yerushalmi B,Ben-Horin S,Assa A

更新日期：2020-10-23 00:00:00

abstract：:Crohn's disease is complicated by the development of fibrosis and stricture in approximately 30% to 50% of patients over time. The pathogenesis of fibrostenotic disease is multifactorial involving the activation of mesenchymal cells by cytokines, growth factors, and other mediators released by immune cells, epithelial...

journal_title：Inflammatory bowel diseases

authors： Li C,Kuemmerle JF

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:Cytomegalovirus (CMV) colitis can contribute to an unfavorable outcome of acute severe ulcerative colitis (ASUC). The purpose of this study was to evaluate the clinical outcomes of ASUC according to the CMV status and identify risk factors for CMV colitis in patients with ASUC. METHODS:We retrospectively an...

journal_title：Inflammatory bowel diseases

authors： Lee HS,Park SH,Kim SH,Kim J,Choi J,Lee HJ,Kim WS,Lee JM,Kwak MS,Hwang SW,Yang DH,Kim KJ,Ye BD,Byeon JS,Myung SJ,Yoon YS,Yu CS,Kim JH,Yang SK

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:We analyzed inflamed mucosal/submucosal layers of ulcerative colitis (UC = 63) and Crohn's colitis (CC = 50), and unexpectedly, we unveiled a pool of free hemoglobin alpha (Hb-α) chain. Patients with colitides have increased reactive oxidative stress (ROS), DNA oxidation products, free iron in mucosa, in pre...

journal_title：Inflammatory bowel diseases

authors： Myers JN,Schäffer MW,Korolkova OY,Williams AD,Gangula PR,MʼKoma AE

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND:Inflammatory bowel disease (IBD) is associated with a high risk of deep venous thromboembolism. However, few data are available so far on portomesenteric vein thrombosis (PMVT). The aim of this study was to describe the characteristics of PMVT in patients with IBD. METHODS:A retrospective study was conducte...

journal_title：Inflammatory bowel diseases

authors： Landman C,Nahon S,Cosnes J,Bouhnik Y,Brixi-Benmansour H,Bouguen G,Colombel JF,Savoye G,Coffin B,Abitbol V,Filippi J,Laharie D,Moreau J,Veyrac M,Allez M,Marteau P,Groupe d'Etude Thérapeutique des Affections Inflammatoires

更新日期：2013-03-01 00:00:00