Regulation of gene expression in inflammatory bowel disease and correlation with IBD drugs: screening by DNA microarrays.

abstract：BACKGROUND:Granulocyte-macrophage colony-stimulating factor (GM-CSF) therapy is effective in treating some Crohn's disease (CD) patients and protects mice from colitis induced by dextran sulfate sodium (DSS) administration. However, its mechanisms of action remain elusive. We hypothesized that GM-CSF affects intestinal...

journal_title：Inflammatory bowel diseases

authors： Bernasconi E,Favre L,Maillard MH,Bachmann D,Pythoud C,Bouzourene H,Croze E,Velichko S,Parkinson J,Michetti P,Velin D

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND:Complementary and alternative medicine (CAM) use is highly prevalent among inflammatory bowel disease (IBD patients). We assessed whether its use, both for IBD and for general health, influenced adherence to conventional medications. METHODS:We enrolled 392 IBD subjects in a prospective cohort study and cat...

journal_title：Inflammatory bowel diseases

authors： Nguyen GC,Croitoru K,Silverberg MS,Steinhart AH,Weizman AV

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:Consensus on what constitutes a quality colonoscopy report for patients with inflammatory bowel disease (IBD) is lacking. We developed a template for quality colonoscopy reporting that can be used broadly by endoscopists. METHODS:After a literature review of topics relevant to colonoscopy reporting, members...

journal_title：Inflammatory bowel diseases

authors： Devlin SM,Melmed GY,Irving PM,Rubin DT,Kornbluth A,Kozuch PL,Raffals LE,Velayos FS,Sparrow MP,Baidoo L,Bressler B,Cheifetz AS,Jones J,Kaplan GG,Siegel CA

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:High levels of patient activation (having the knowledge, skills, and confidence to effectively manage one's care), have been associated with improved outcomes in many chronic conditions. There have been few studies of the effects of activation in patients with inflammatory bowel disease (IBD). We performed a...

journal_title：Inflammatory bowel diseases

authors： Barnes EL,Long MD,Kappelman MD,Martin CF,Sandler RS

更新日期：2019-06-18 00:00:00

abstract：BACKGROUND:The impact of thiopurine (TP) use on perianal surgery is uncertain. Our aim was to determine trends in perianal surgery and the impact of timing and duration of TPs on the risk of first perianal surgery. METHODS:We identified a population-based cohort of incident cases of Crohn's disease between 1995 and 20...

journal_title：Inflammatory bowel diseases

authors： Chhaya V,Saxena S,Cecil E,Subramanian V,Curcin V,Majeed A,Pollok RC

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND:Helicobacter pylori infection is associated with a lower risk of chronic autoimmune diseases including inflammatory bowel disease (IBD). H.pylori modulates the gastric immune response, decreasing the local inflammatory response to itself. In mice, chronic Salmonellatyphimurium infection induces colitis simil...

journal_title：Inflammatory bowel diseases

authors： Higgins PD,Johnson LA,Luther J,Zhang M,Sauder KL,Blanco LP,Kao JY

更新日期：2011-06-01 00:00:00

abstract：INTRODUCTION:Concurrent cytomegalovirus (CMV) in inflammatory bowel disease-related colitis is an important yet complex clinical scenario associated with high rates of colectomy and other morbidity. This review aimed to examine the literature to produce a comprehensive diagnostic and treatment algorithm for the managem...

journal_title：Inflammatory bowel diseases

authors： Beswick L,Ye B,van Langenberg DR

更新日期：2016-12-01 00:00:00

abstract：:Inflammatory bowel disease is associated with industrialization, and its incidence has increased markedly over time. The prospect of reversing these trends motivates the search for the agent(s) involved. Modernity entails several physical and behavioral modifications that compromise both the photosynthesis of cholecal...

journal_title：Inflammatory bowel diseases

authors： Palmer MT,Weaver CT

更新日期：2013-09-01 00:00:00

abstract：:Clinical and epidemiological studies have revealed that the incidence of colorectal cancer associated with ulcerative colitis increases with long-term chronic inflammation. Careful endoscopic observation and histological studies to check for dysplasia in the colon are important in detecting neoplasia. Current surveill...

journal_title：Inflammatory bowel diseases

authors： Matsumoto T,Iwao Y,Igarashi M,Watanabe K,Otsuka K,Watanabe T,Iizuka B,Hida N,Sada M,Chiba T,Kudo SE,Oshitani N,Nagawa H,Ajioka Y,Hibi T

更新日期：2008-02-01 00:00:00

abstract：:Biologic treatments have revolutionized the way we treat inflammatory bowel disease patients (IBD). Anti-tumor necrosis factor (anti-TNF) antibodies are superior to conventional therapies to achieve sustained remission without steroids and mucosal healing. The objective of IBD treatment has evolved from symptom allevi...

journal_title：Inflammatory bowel diseases

authors： Louis E

更新日期：2018-03-19 00:00:00

abstract：BACKGROUND:Infliximab levels have been reported to be associated with mucosal healing (MH) in Crohn's disease (CD). However, whether the association differs between postinduction (week 14) and maintenance (week 30) has seldom been investigated. We aimed to analyze the association between serum infliximab trough levels ...

journal_title：Inflammatory bowel diseases

authors： Feng T,Chen B,Ungar B,Qiu Y,Zhang S,He J,Lin S,He Y,Zeng Z,Ben-Horin S,Chen M,Mao R

更新日期：2019-10-18 00:00:00

abstract：BACKGROUND:Many treatment options exist for children with inflammatory bowel disease (IBD), yet the lack of clinical guidelines for management has lead to great variation in care. The purpose of this project was to evaluate current treatment modalities in children from the Northeast US who applied to the 2010 session o...

journal_title：Inflammatory bowel diseases

authors： Rosen D,Kathy-Hoffstadter-Thal,Bao R,Tomaino J,Ceballos C,Russell GJ,Benkov KJ

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND AND AIMS:The risk, fate, and ideal management of colorectal dysplasia in inflammatory bowel disease (IBD) remain debated. We estimated the incidence, long-term outcome, and risk factors for progression of colorectal dysplasia (adenomas [adenoma-associated lesions or masses (ALMs)], flat dysplasia, and dyspla...

journal_title：Inflammatory bowel diseases

authors： Jess T,Loftus EV Jr,Velayos FS,Harmsen WS,Zinsmeister AR,Smyrk TC,Tremaine WJ,Melton LJ 3rd,Munkholm P,Sandborn WJ

更新日期：2006-08-01 00:00:00

abstract：Background and aims:The postoperative course of Crohn's disease (CD) is best predicted by ileocolonoscopy. Ultrasonography (US) has been proposed as indicator for postsurgical recurrence (PSR), but further confirmation is needed. We performed a systemic review with meta-analysis to assess the pooled diagnostic accuracy...

journal_title：Inflammatory bowel diseases

authors： Rispo A,Imperatore N,Testa A,Nardone OM,Luglio G,Caporaso N,Castiglione F

更新日期：2018-04-23 00:00:00

abstract：BACKGROUND:Activation of cannabinoid (CB)(1) receptors results in attenuation of experimental colitis. Our aim was to examine the role of CB(2) receptors in experimental colitis using agonists (JWH133, AM1241) and an antagonist (AM630) in trinitrobenzene sulfonic acid (TNBS)-induced colitis in wildtype and CB(2) recept...

journal_title：Inflammatory bowel diseases

authors： Storr MA,Keenan CM,Zhang H,Patel KD,Makriyannis A,Sharkey KA

更新日期：2009-11-01 00:00:00

abstract：BACKGROUND:A novel family of proton-sensing G protein-coupled receptors, including OGR1, GPR4, and TDAG8, was identified to be important for physiological pH homeostasis and inflammation. Thus, we determined the function of proton-sensing OGR1 in the intestinal mucosa. MTEHODS:OGR1 expression in colonic tissues was in...

journal_title：Inflammatory bowel diseases

authors： de Vallière C,Wang Y,Eloranta JJ,Vidal S,Clay I,Spalinger MR,Tcymbarevich I,Terhalle A,Ludwig MG,Suply T,Fried M,Kullak-Ublick GA,Frey-Wagner I,Scharl M,Seuwen K,Wagner CA,Rogler G

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:Ulcerative colitis (UC), a chronic, relapsing, and remitting inflammatory bowel disease, requires long-term treatment to maintain remission. In this study, the long-term safety and tolerability of mesalamine granules (MG) therapy was evaluated in the maintenance of UC remission. Previous prospective studies ...

journal_title：Inflammatory bowel diseases

authors： Lichtenstein GR,Barrett AC,Bortey E,Paterson C,Forbes WP

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:P-glycoprotein (P-gp), the product of the multidrug resistance gene (MDR), is an ATP-dependent transmembrane pump, which is expressed in multiple cell lineages including epithelial and hematopoetic cells. The human MDR gene is located on chromosome 7 (7q21.1), a susceptibility loci for inflammatory bowel dis...

journal_title：Inflammatory bowel diseases

authors： Staley EM,Schoeb TR,Lorenz RG

更新日期：2009-05-01 00:00:00

abstract：:Crohn and Rosenberg first highlighted the increased risk of colorectal cancer in ulcerative colitis in 1925. Cancer rates as high as 34 percent after 30 yrs of disease have been reported in several population-based studies, although the reported risk varies substantially. Lower rates have been reported in: population-...

journal_title：Inflammatory bowel diseases

authors： Allen PB,Kamm MA,De Cruz P,Desmond PV

更新日期：2010-11-01 00:00:00

abstract：INTRODUCTION:Antitumor necrosis factor (anti-TNF) medications are known to be highly efficacious in persons with moderate-to-severe inflammatory bowel disease (IBD). There is a paucity of data from population-based sources to elucidate persistence with these medications in the general population of IBD. Discontinuation...

journal_title：Inflammatory bowel diseases

authors： Targownik LE,Tennakoon A,Leung S,Lix LM,Nugent Z,Singh H,Bernstein CN

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:Clostridium difficile infection (CDI) is a common complication of inflammatory bowel diseases (IBDs) and is associated with worse outcome. Variable rates of colectomy have been reported among IBD complicated by CDI. We conducted a systematic review and meta-analysis of studies to assess the association betwe...

journal_title：Inflammatory bowel diseases

authors： Chen Y,Furuya-Kanamori L,Doi SA,Ananthakrishnan AN,Kirk M

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:Thiopurines are effective drugs in treating ulcerative colitis (UC) and Crohn's disease (CD) even if studies that specifically investigate these drugs' profile of efficacy in UC compared with CD are scarce. Our aim was to compare the profile of efficacy of thiopurines in patients with UC and CD. METHODS:We ...

journal_title：Inflammatory bowel diseases

authors： Rispo A,Testa A,De Palma GD,Donetto S,Diaferia M,Musto D,Nardone O,Maione F,Caporaso N,Castiglione F

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND:Caspase activation and recruitment domain 3 (CARD3) is a 61-kDa protein kinase. Recent evidence shows the importance of CARD3 in the immune response and inflammatory diseases. To elucidate its impact on inflammatory bowel disease, we studied the effects of the loss of CARD3 in the acute dextran sodium sulfat...

journal_title：Inflammatory bowel diseases

authors： Yu SJ,Liu Y,Deng Y,Zhu XY,Zhan N,Dong WG

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:We assessed whether selective granulocyte and monocyte/macrophage adsorption apheresis maintained clinical remission in asymptomatic inflammatory bowel disease (IBD) patients at significant risk of clinical relapse. METHODS:Sixty asymptomatic patients (age 18-70 years) with IBD (in clinical remission) with ...

journal_title：Inflammatory bowel diseases

authors： Maiden L,Takeuchi K,Baur R,Bjarnason I,O'Donohue J,Forgacs I,Chung-Faye G,Sanderson J,Bjarnason I

更新日期：2008-10-01 00:00:00

abstract：BACKGROUND:Endoscopic balloon dilation (EBD) is widely used to manage Crohn's disease-associated strictures. However, most studies of the safety and efficacy are small and heterogenous. We performed a combined analysis of published studies and evaluated 676 comprehensive individual participant data sets to determine th...

journal_title：Inflammatory bowel diseases

authors： Bettenworth D,Gustavsson A,Atreja A,Lopez R,Tysk C,van Assche G,Rieder F

更新日期：2017-01-01 00:00:00

abstract：:Crohn's disease and ulcerative colitis are quite often complicated with manifestations in extraintestinal organs like joints, eye, and skin. Although the etiopathogenesis of these nonmucosal complications remains unsettled, they all share the characteristic feature of inappropriate leukocyte recruitment in nonlymphati...

journal_title：Inflammatory bowel diseases

authors： Salmi M,Jalkanen S

更新日期：1998-05-01 00:00:00

abstract：:The limited efficacy of standard medical therapies for inflammatory bowel diseases has resulted in a continuing search for alternative treatments. Growth hormone (GH) has shown to have mutagenic and proliferative effects on intestinal cells. This study was designed to identify the effect of growth hormone on trinitrob...

journal_title：Inflammatory bowel diseases

authors： Kara E,Sungurtekin H,Sungurtekin U,Alkanat M,Ilkgul O

更新日期：2004-03-01 00:00:00

abstract：BACKGROUND:This study compared the efficacy of an elemental formula (EF) to a polymeric formula (PF) in inducing remission for pediatric Crohn's disease (CD). METHODS:Newly diagnosed CD children were randomized to EF or PF for 6 weeks. Change in the Pediatric Crohn's Disease Activity Index (PCDAI), fecal calprotectin,...

journal_title：Inflammatory bowel diseases

authors： Grogan JL,Casson DH,Terry A,Burdge GC,El-Matary W,Dalzell AM

更新日期：2012-02-01 00:00:00

abstract：:Presenting symptoms and their duration may affect the time that elapses prior to definitive diagnosis of inflammatory bowel disease (IBD). This study was undertaken to determine the mean duration of presenting symptoms and diagnostic lag in children with IBD. The medical records of all patients less than 19 years of a...

journal_title：Inflammatory bowel diseases

authors： Heikenen JB,Werlin SL,Brown CW,Balint JP

更新日期：1999-08-01 00:00:00

abstract：INTRODUCTION:The incidence of early-onset CD in Scotland is among the highest worldwide. Three single nucleotide polymorphisms (SNPs) R702W, G908R and Leu1007finsC in the NOD2/CARD15 gene predispose to adult CD. We investigated the contribution of these variants to disease susceptibility and phenotype in the Scottish e...

journal_title：Inflammatory bowel diseases

authors： Russell RK,Drummond HE,Nimmo EE,Anderson N,Smith L,Wilson DC,Gillett PM,McGrogan P,Hassan K,Weaver LT,Bisset M,Mahdi G,Satsangi J

更新日期：2005-11-01 00:00:00