Use of Complementary and Alternative Medicine for Inflammatory Bowel Disease Is Associated with Worse Adherence to Conventional Therapy: The COMPLIANT Study.

abstract：BACKGROUND:Anti-tumor necrosis factor-α (anti-TNF-α) treatments are increasingly used to treat pediatric Crohn's disease, even without a prior trial of immunomodulators, but the cost-effectiveness of such treatment algorithms has not been formally examined. Drug plan decision-makers require evidence of cost-effectivene...

journal_title：Inflammatory bowel diseases

authors： Bashir NS,Walters TD,Griffiths AM,Ito S,Ungar WJ

更新日期：2020-07-17 00:00:00

abstract：BACKGROUND:A North American genome-wide single nucleotide polymorphism (SNP) association study identified IL23R as a novel inflammatory bowel disease (IBD) susceptibility gene. Association was reported with multiple risk variants in the centromeric portion of IL23R in 3 large independent cohorts. The aims of this study...

journal_title：Inflammatory bowel diseases

authors： Cummings JR,Ahmad T,Geremia A,Beckly J,Cooney R,Hancock L,Pathan S,Guo C,Cardon LR,Jewell DP

更新日期：2007-09-01 00:00:00

abstract：BACKGROUND:Although infliximab is widely accepted as a therapeutic option for inflammatory bowel disease, its therapeutic efficacy for the treatment of intestinal Behçet's disease (BD) is unknown. We investigated the short-term and long-term response rates to infliximab in intestinal BD and predictive factors of sustai...

journal_title：Inflammatory bowel diseases

authors： Lee JH,Cheon JH,Jeon SW,Ye BD,Yang SK,Kim YH,Lee KM,Im JP,Kim JS,Lee CK,Kim HJ,Kim EY,Kim KO,Jang BI,Kim WH

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:Crohn's disease is a heterogeneous disease, and several classification systems have been developed to classify the patients in more homogeneous groups. Our aim was to assess the intra- and interobserver variation when classifying patients according to the widely used Vifenna classification. METHODS:Ten rand...

journal_title：Inflammatory bowel diseases

authors： Riis L,Munkholm P,Binder V,Skovgaard LT,Langholz E

更新日期：2005-07-01 00:00:00

abstract：Background:Colorectal cancer (CRC) is a major cause of cancer-related deaths, and tumor-related comorbidities additionally lower life quality and survival. Mutations in the tumor suppressor adenomatous polyposis coli (APC) are associated with sporadic CRC and familial adenomatous polyposis (FAP), which results in the g...

journal_title：Inflammatory bowel diseases

authors： Saul D,Schilling AF,Kosinsky RL

更新日期：2018-10-12 00:00:00

abstract：BACKGROUND:The accuracy and utility of electronic health record (EHR)-derived phenotypes in replicating genotype-phenotype relationships have been infrequently examined. Low circulating vitamin D levels are associated with severe outcomes in inflammatory bowel disease (IBD); however, the genetic basis for vitamin D ins...

journal_title：Inflammatory bowel diseases

authors： Ananthakrishnan AN,Cagan A,Cai T,Gainer VS,Shaw SY,Churchill S,Karlson EW,Murphy SN,Kohane I,Liao KP,Xavier RJ

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND:Psoriasis induced by anti-tumor necrosis factor-α (TNF) therapy has been described as a paradoxical side effect. AIM:To determine the incidence, clinical characteristics, and management of psoriasis induced by anti-TNF therapy in a large nationwide cohort of inflammatory bowel disease patients. METHODS:Pat...

journal_title：Inflammatory bowel diseases

authors： Guerra I,Pérez-Jeldres T,Iborra M,Algaba A,Monfort D,Calvet X,Chaparro M,Mañosa M,Hinojosa E,Minguez M,Ortiz de Zarate J,Márquez L,Prieto V,García-Sánchez V,Guardiola J,Rodriguez GE,Martín-Arranz MD,García-Tercero I,S

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:The clinical presentation of the inflammatory bowel diseases (IBD) is extremely heterogenous and is characterized by various extraintestinal manifestations and complications (EIM). Increasing genetic insight for IBD and EIM shows multiple shared susceptibility loci. We hypothesize that, next to these overlap...

journal_title：Inflammatory bowel diseases

authors： van Sommeren S,Janse M,Karjalainen J,Fehrmann R,Franke L,Fu J,Weersma RK

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:Differentiating ulcerative colitis (UC) from Crohn's colitis (CC) can be difficult and may lead to inaccurate diagnoses in up to 30% of inflammatory bowel disease (IBD) patients. Much of the diagnostic uncertainty arises from the overlap of clinical and histologic features. Matrix-assisted laser desorption/i...

journal_title：Inflammatory bowel diseases

authors： M'Koma AE,Seeley EH,Washington MK,Schwartz DA,Muldoon RL,Herline AJ,Wise PE,Caprioli RM

更新日期：2011-04-01 00:00:00

abstract：BACKGROUND:Ulcerative colitis (UC) negatively affects health-related quality of life (HRQoL), but population-based and long-term data on this topic are scarce. Our aim was to determine the HRQoL in UC patients after a 10-year disease duration. METHODS:UC patients from a population-based inception cohort met at a presc...

journal_title：Inflammatory bowel diseases

authors： Hoivik ML,Moum B,Solberg IC,Cvancarova M,Hoie O,Vatn MH,Bernklev T,IBSEN Study Group.

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND:L-selectin (CD62L) and β(7) integrins are important for trafficking of naive T cells under steady-state conditions. The objectives of this study were to dissect the requirements for T cell-associated CD62L and β(7) integrins during initiation, progression, and regulation of chronic colitis. METHODS:Using th...

journal_title：Inflammatory bowel diseases

authors： Kurmaeva E,Boktor M,Zhang S,Bao R,Berney S,Ostanin DV

更新日期：2013-11-01 00:00:00

abstract：INTRODUCTION:The incidence of early-onset CD in Scotland is among the highest worldwide. Three single nucleotide polymorphisms (SNPs) R702W, G908R and Leu1007finsC in the NOD2/CARD15 gene predispose to adult CD. We investigated the contribution of these variants to disease susceptibility and phenotype in the Scottish e...

journal_title：Inflammatory bowel diseases

authors： Russell RK,Drummond HE,Nimmo EE,Anderson N,Smith L,Wilson DC,Gillett PM,McGrogan P,Hassan K,Weaver LT,Bisset M,Mahdi G,Satsangi J

更新日期：2005-11-01 00:00:00

abstract：:The role of endoscopy in inflammatory bowel disease (IBD) has grown over the last decade in both diagnostic and therapeutic realms. It aids in the initial diagnosis of the disease and also in the assessment of the extent and severity of disease. IBD is associated with development of multiple complications such as stri...

journal_title：Inflammatory bowel diseases

authors： Tharian B,George N,Navaneethan U

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:Patients suffering from Crohn's disease (CD) show increased incidence of low bone mineral density. Investigating this complication is difficult because the exact etiology of CD remains elusive. Mice carrying a deletion in the tumor necrosis factor (TNF) AU-rich elements (ARE) are reported as a model for huma...

journal_title：Inflammatory bowel diseases

authors： Huybers S,Apostolaki M,van der Eerden BC,Kollias G,Naber TH,Bindels RJ,Hoenderop JG

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND:Thiopurines are effective drugs in treating ulcerative colitis (UC) and Crohn's disease (CD) even if studies that specifically investigate these drugs' profile of efficacy in UC compared with CD are scarce. Our aim was to compare the profile of efficacy of thiopurines in patients with UC and CD. METHODS:We ...

journal_title：Inflammatory bowel diseases

authors： Rispo A,Testa A,De Palma GD,Donetto S,Diaferia M,Musto D,Nardone O,Maione F,Caporaso N,Castiglione F

更新日期：2015-11-01 00:00:00

abstract：:Crohn disease and ulcerative colitis are complex immune-mediated diseases that are characterized by a heterogeneity in presentation and clinical course. Although various clinical covariates predict adverse outcomes in these patients, they are insufficiently informative. The gut microbiome likely plays a central role i...

journal_title：Inflammatory bowel diseases

authors： Ananthakrishnan AN

更新日期：2020-09-18 00:00:00

abstract：BACKGROUND:The goal of this study was to determine the rate of work disability, unemployment, and sick leave in an unselected inflammatory bowel disease (IBD) cohort and to measure the effect of working status and disability on the patient's health-related quality of life (HRQOL). MATERIALS AND METHODS:All eligible pa...

journal_title：Inflammatory bowel diseases

authors： Bernklev T,Jahnsen J,Henriksen M,Lygren I,Aadland E,Sauar J,Schulz T,Stray N,Vatn M,Moum B

更新日期：2006-05-01 00:00:00

abstract：BACKGROUND:High levels of patient activation (having the knowledge, skills, and confidence to effectively manage one's care), have been associated with improved outcomes in many chronic conditions. There have been few studies of the effects of activation in patients with inflammatory bowel disease (IBD). We performed a...

journal_title：Inflammatory bowel diseases

authors： Barnes EL,Long MD,Kappelman MD,Martin CF,Sandler RS

更新日期：2019-06-18 00:00:00

abstract：:This review summarizes how interleukin-10 (IL-10)-deficient mice have permitted new insight into the complex interaction between genes and environment underlying pathogenesis of inflammatory bowel disease (IBD). The C57BL/6J strain develops only mild typhlocolitis in response to IL-10 deficiency. In contrast, C3H/HeJB...

journal_title：Inflammatory bowel diseases

authors： Mähler M,Leiter EH

更新日期：2002-09-01 00:00:00

abstract：BACKGROUND:Data from CHARM, a 56-week, randomized controlled trial of adalimumab for patients with moderately to severely active Crohn's disease (CD), were used to evaluate outcomes of adalimumab dosage adjustment. METHODS:Patients randomized to blinded adalimumab 40 mg every other week (EOW) in CHARM were the focus o...

journal_title：Inflammatory bowel diseases

authors： Sandborn WJ,Colombel JF,Schreiber S,Plevy SE,Pollack PF,Robinson AM,Chao J,Mulani P

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Inflammatory bowel disease (IBD) is a multifactorial disorder, with the innate and adaptive immune cells contributing to disease initiation and progression. However, the intricate cross-talk between immune cell lineages remains incompletely understood. The role of CD8+ T cells in IBD pathogenesis has been un...

journal_title：Inflammatory bowel diseases

authors： Jamwal DR,Marati RV,Harrison CA,Midura-Kiela MT,Figliuolo Paz VR,Besselsen DG,Ghishan FK,Kiela PR

更新日期：2020-01-06 00:00:00

abstract：BACKGROUND:Apolipoprotein E (ApoE) mediates potent antiinflammatory and immunomodulatory properties in addition to its roles in regulating cholesterol transport and metabolism. However, its role in the intestine, specifically during inflammation, is largely unknown. METHODS:Mice (C57BL/6 or ApoE-deficient [ApoE-KO] mi...

journal_title：Inflammatory bowel diseases

authors： Singh V,Kumar M,San Yeoh B,Xiao X,Saha P,Kennett MJ,Vijay-Kumar M

更新日期：2016-04-01 00:00:00

abstract：:Three receptor tyrosine kinases, Tyro3, Axl, and Mertk (TAM) and their ligands Gas6 and Protein S, have emerged as potent negative regulators of innate immune responses. A number of studies using genetic ablation of TAM loci in mice have elucidated the mechanism of TAM engagement and function during the immune respons...

journal_title：Inflammatory bowel diseases

authors： Rothlin CV,Leighton JA,Ghosh S

更新日期：2014-08-01 00:00:00

abstract：:Corticosteroids are considered a drug of choice for the treatment of patients with moderately to severely active Crohn's disease (CD), an inflammatory bowel disease characterized by chronic recurrent flares of disease activity. However, among patients receiving corticosteroid therapy for induction of remission, 20% ha...

journal_title：Inflammatory bowel diseases

authors： Lichtenstein GR

更新日期：2001-05-01 00:00:00

abstract：:Recent reports suggest that unfractionated heparin may be a useful adjunct in the treatment of inflammatory bowel disease (IBD). We report the successful use of subcutaneous unfractionated heparin to treat a moderate-to-severe flare of Crohn's disease during pregnancy, which was refractory to standard therapy. The pat...

journal_title：Inflammatory bowel diseases

authors： Prajapati DN,Newcomer JR,Emmons J,Abu-Hajir M,Binion DG

更新日期：2002-05-01 00:00:00

abstract：SUMMARY:: Crohn's disease of the terminal ileum usually recurs after an ileocolonic resection. To compare the length and the disease behavior of recurrent ileitis with the presurgical disease characteristics, we studied 31 consecutive patients who had recurrent Crohn's disease symptoms and who had undergone an ileoceca...

journal_title：Inflammatory bowel diseases

authors： Dʼhaens G,Baert F,Gasparaitis A,Hanauer S

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:Drug concentration monitoring may be useful to guide therapeutic adjustments for anti-tumor necrosis factor agents in Crohn's disease. The relationship between serum adalimumab concentrations and clinical outcomes was assessed using data from CLinical Assessment of Adalimumab Safety and Efficacy Studied as I...

journal_title：Inflammatory bowel diseases

authors： Chiu YL,Rubin DT,Vermeire S,Louis E,Robinson AM,Lomax KG,Pollack PF,Paulson SK

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:Inflammatory bowel disease (IBD) is associated with a high risk of deep venous thromboembolism. However, few data are available so far on portomesenteric vein thrombosis (PMVT). The aim of this study was to describe the characteristics of PMVT in patients with IBD. METHODS:A retrospective study was conducte...

journal_title：Inflammatory bowel diseases

authors： Landman C,Nahon S,Cosnes J,Bouhnik Y,Brixi-Benmansour H,Bouguen G,Colombel JF,Savoye G,Coffin B,Abitbol V,Filippi J,Laharie D,Moreau J,Veyrac M,Allez M,Marteau P,Groupe d'Etude Thérapeutique des Affections Inflammatoires

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:The efficacy of anti-tumor necrosis factor monoclonal antibody (anti-TNF mAb) for Crohn's disease (CD) is well established, and anti-interleukin-6 receptor (anti-IL-6R) mAb has also been reported to be effective in CD. It is, however, unclear if the efficacy and mechanisms of both agents are different in CD ...

journal_title：Inflammatory bowel diseases

authors： Terabe F,Fujimoto M,Serada S,Shinzaki S,Iijima H,Tsujii M,Hayashi N,Nomura S,Kawahata H,Jang MH,Miyasaka M,Mihara M,Ohsugi Y,Kishimoto T,Naka T

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND:Inflammatory bowel disease is a chronic inflammatory disorder of the gastrointestinal tract that significantly impacts the health-related quality of life (HR-QOL). A decreased HR-QOL has been demonstrated in patients with active disease compared with patients in remission. In this cross-sectional study, we e...

journal_title：Inflammatory bowel diseases

authors： Zhang CK,Hewett J,Hemming J,Grant T,Zhao H,Abraham C,Oikonomou I,Kanakia M,Cho JH,Proctor DD

更新日期：2013-07-01 00:00:00