Abstract:
BACKGROUND:The clinical presentation of the inflammatory bowel diseases (IBD) is extremely heterogenous and is characterized by various extraintestinal manifestations and complications (EIM). Increasing genetic insight for IBD and EIM shows multiple shared susceptibility loci. We hypothesize that, next to these overlapping genetic risk loci, distinct disease pathways are shared between IBD and EIM. METHODS:The overlapping genetic risk loci for IBD and its EIM were searched in literature. We assessed shared disease pathways by performing an extensive pathway analysis by protein-protein interaction and cotranscriptional analysis, using both publicly available and newly developed databases. RESULTS:Reliable genetic data were available for primary sclerosing cholangitis, ankylosing spondylitis, decreased bone mineral density, colorectal carcinoma, gallstones, kidney stones, and deep venous thrombosis. We found an extensive overlap in genetic risk loci, especially for IBD and primary sclerosing cholangitis and ankylosing spondylitis. We identified 370 protein-protein interactions, of which 108 are statistically specific. We identified 446 statistically specific cotranscribed gene pairs. The interactions are shown to cluster in specific biological pathways. CONCLUSIONS:We show that the pathogenetic overlap between IBD and its EIM extends beyond shared risk genes to distinctive shared biological pathways. We define genetic background as a risk factor for IBD-EIM alongside known mechanisms such as malabsorption and medication. Clustering patients based on distinctive pathways may enable stratification of patients to predict development of EIM.
journal_name
Inflamm Bowel Disjournal_title
Inflammatory bowel diseasesauthors
van Sommeren S,Janse M,Karjalainen J,Fehrmann R,Franke L,Fu J,Weersma RKdoi
10.1097/MIB.0000000000000032subject
Has Abstractpub_date
2014-06-01 00:00:00pages
987-94issue
6eissn
1078-0998issn
1536-4844journal_volume
20pub_type
杂志文章,评审abstract:BACKGROUND:Current therapy for inflammatory bowel disease (IBD) patients often involves agents that suppress the immune system, placing patients at an increased risk for developing infections, of which several are potentially vaccine preventable. Many IBD patients are not being vaccinated appropriately. The aims of thi...
journal_title:Inflammatory bowel diseases
pub_type: 杂志文章,随机对照试验
doi:10.1002/ibd.21667
更新日期:2011-12-01 00:00:00
abstract:BACKGROUND:Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract, which is currently treated with injected monoclonal antibodies specific for tumor necrosis factor (TNF). We developed and characterized AVX-470, a novel polyclonal antibody specific for human TNF. We evaluated t...
journal_title:Inflammatory bowel diseases
pub_type: 杂志文章
doi:10.1097/MIB.0b013e3182a11958
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journal_title:Inflammatory bowel diseases
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journal_title:Inflammatory bowel diseases
pub_type: 杂志文章,多中心研究
doi:10.1097/MIB.0b013e31827eea5f
更新日期:2013-03-01 00:00:00
abstract:BACKGROUND AND AIMS:Poor sleep quality in Crohn's disease (CD) is associated with histologic activity and clinical relapse. We sought to characterize sleep dysfunction and determine the effect of poor sleep quality on risk for hospitalization and surgery. METHODS:Clinical data were collected for CD subjects including ...
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pub_type: 杂志文章
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更新日期:2020-07-17 00:00:00
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journal_title:Inflammatory bowel diseases
pub_type: 杂志文章
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更新日期:2016-05-01 00:00:00
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journal_title:Inflammatory bowel diseases
pub_type: 杂志文章
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更新日期:2012-05-01 00:00:00
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journal_title:Inflammatory bowel diseases
pub_type: 杂志文章
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更新日期:2011-09-01 00:00:00
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journal_title:Inflammatory bowel diseases
pub_type: 杂志文章
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journal_title:Inflammatory bowel diseases
pub_type: 杂志文章,评审
doi:10.1097/00054725-200203000-00008
更新日期:2002-03-01 00:00:00
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journal_title:Inflammatory bowel diseases
pub_type: 杂志文章
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更新日期:2006-03-01 00:00:00
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journal_title:Inflammatory bowel diseases
pub_type: 杂志文章
doi:10.1002/ibd.21489
更新日期:2011-06-01 00:00:00
abstract:BACKGROUND:To systematically determine the performance of diffusion-weighted imaging magnetic resonance enterography (DWI-MRE) for evaluating bowel inflammation in Crohn's disease and sources of heterogeneity between reported results. METHODS:We identified research studies that investigated DWI-MRE to diagnose bowel i...
journal_title:Inflammatory bowel diseases
pub_type: 杂志文章,meta分析,评审
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更新日期:2016-03-01 00:00:00
abstract:BACKGROUND:Inflammatory bowel disease (IBD)-associated dysbiosis is characterized by a loss of Faecalibacterium prausnitzii, whose supernatant exerts an anti-inflammatory effect. However, the anti-inflammatory substances in F. prausnitzii supernatant and the mechanism in ameliorating colitis in IBD have not yet been fu...
journal_title:Inflammatory bowel diseases
pub_type: 杂志文章
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更新日期:2018-08-16 00:00:00
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journal_title:Inflammatory bowel diseases
pub_type: 杂志文章
doi:10.1097/01.MIB.0000441201.10454.06
更新日期:2014-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:2021-01-02 00:00:00
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pub_type: 杂志文章
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更新日期:2018-05-18 00:00:00
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pub_type: 临床试验,杂志文章,多中心研究
doi:10.1002/ibd.21070
更新日期:2010-03-01 00:00:00
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journal_title:Inflammatory bowel diseases
pub_type: 杂志文章,meta分析,评审
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pub_type: 杂志文章,评审
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更新日期:2014-07-01 00:00:00
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journal_title:Inflammatory bowel diseases
pub_type: 杂志文章
doi:10.1097/00054725-200409000-00024
更新日期:2004-09-01 00:00:00
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pub_type: 杂志文章,meta分析,评审
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更新日期:2015-11-01 00:00:00
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journal_title:Inflammatory bowel diseases
pub_type: 杂志文章,评审
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更新日期:2002-09-01 00:00:00
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journal_title:Inflammatory bowel diseases
pub_type: 杂志文章
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更新日期:2006-07-01 00:00:00
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journal_title:Inflammatory bowel diseases
pub_type: 杂志文章
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更新日期:2015-03-01 00:00:00
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journal_title:Inflammatory bowel diseases
pub_type: 杂志文章,评审
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更新日期:2001-05-01 00:00:00
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journal_title:Inflammatory bowel diseases
pub_type: 杂志文章
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abstract:BACKGROUND:Inflammatory bowel diseases (IBD) are believed to be driven by dysregulated interactions between the host and the gut microbiota. Our goal is to characterize and infer relationships between mucosal T cells, the host tissue environment, and microbial communities in patients with IBD who will serve as basis fo...
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pub_type: 杂志文章
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journal_title:Inflammatory bowel diseases
pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章
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更新日期:2009-05-01 00:00:00