Etiopathogenesis of inflammatory bowel disease: the importance of the pediatric perspective.

abstract：BACKGROUND:The role of antiviral therapy in patients with ulcerative colitis (UC) with cytomegalovirus (CMV) remains unclear. We therefore performed a systematic review and meta-analysis to assess the association between antiviral therapy and the risk of colectomy. METHODS:Multiple electronic databases were searched s...

journal_title：Inflammatory bowel diseases

authors： Shukla T,Singh S,Loftus EV Jr,Bruining DH,McCurdy JD

更新日期：2015-11-01 00:00:00

abstract：Background:Standard outpatient induction dosing of infliximab (IFX) may not be effective in hospitalized ulcerative colitis (UC) patients with higher inflammatory burden and colectomy risk. Our aim was to determine whether initial IFX induction dose affects 30-day colectomy rate and other disease-related outcomes. Met...

journal_title：Inflammatory bowel diseases

authors： Shah SC,Naymagon S,Panchal HJ,Sands BE,Cohen BL,Dubinsky MC

更新日期：2018-02-15 00:00:00

abstract：BACKGROUND:Obesity is associated with systemic and intestine-specific inflammation and alterations in gut microbiota, which in turn impact mucosal immunity. Nonetheless, a specific role of obesity and its interaction with genetics in the progression of Crohn's disease (CD) is unclear. METHODS:We conducted a cross-sect...

journal_title：Inflammatory bowel diseases

authors： Pringle PL,Stewart KO,Peloquin JM,Sturgeon HC,Nguyen D,Sauk J,Garber JJ,Yajnik V,Ananthakrishnan AN,Chan AT,Xavier RJ,Khalili H

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:Recent animal studies and clinical trials suggest that thiazolidinediones, a class of oral antidiabetic agents, are efficacious in reducing inflammation, yet no studies have evaluated their effectiveness in preventing flares. We examined the association between thiazolidinedione use and ulcerative colitis (U...

journal_title：Inflammatory bowel diseases

authors： Lund JL,Stürmer T,Porter CQ,Sandler RS,Kappelman MD

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:Ulcerative colitis is associated with increased colon permeability resulting in bacterial translocation into the lamina propria. We investigate the importance of the Toll-like receptor (TLR) regulating protein IL-1 receptor-associated kinase M (IRAK-M) using the erosive dextran sulfate sodium (DSS)-induced m...

journal_title：Inflammatory bowel diseases

authors： Berglund M,Melgar S,Kobayashi KS,Flavell RA,Hörnquist EH,Hultgren OH

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND:Our previous study showed that nephrolithiasis is a common complication in ulcerative colitis patients after ileal pouch anal anastomosis (IPAA). However, the pathogenesis of nephrolithiasis in IPAA patients has not been studied. The aim of this study was to compare urine and serum metabolic compositions in ...

journal_title：Inflammatory bowel diseases

authors： Arora Z,Mukewar S,Lopez R,Camino D,Shen B,Hall P

更新日期：2017-05-01 00:00:00

abstract：:Colitis-associated colorectal neoplasia (CRN) is a well-known complication of chronic inflammation of the colon either with ulcerative colitis (UC) or colonic Crohn's disease (CD). Studies have shown that inflammatory bowel disease (IBD) patients have an overall higher risk for colorectal dysplasia and cancer compared...

journal_title：Inflammatory bowel diseases

authors： Gaidos JK,Bickston SJ

更新日期：2016-05-01 00:00:00

abstract：:Recent reports suggest that unfractionated heparin may be a useful adjunct in the treatment of inflammatory bowel disease (IBD). We report the successful use of subcutaneous unfractionated heparin to treat a moderate-to-severe flare of Crohn's disease during pregnancy, which was refractory to standard therapy. The pat...

journal_title：Inflammatory bowel diseases

authors： Prajapati DN,Newcomer JR,Emmons J,Abu-Hajir M,Binion DG

更新日期：2002-05-01 00:00:00

abstract：BACKGROUND:Mucosal healing in ulcerative colitis leads to a decreased need for medication and decreased risk of disease relapse and colectomy. Histological healing seems to improve the disease prognosis even further. An assessment of both endoscopic and histological mucosal healing requires endoscopy, and the need for ...

journal_title：Inflammatory bowel diseases

authors： Theede K,Holck S,Ibsen P,Kallemose T,Nordgaard-Lassen I,Nielsen AM

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:A novel family of proton-sensing G protein-coupled receptors, including OGR1, GPR4, and TDAG8, was identified to be important for physiological pH homeostasis and inflammation. Thus, we determined the function of proton-sensing OGR1 in the intestinal mucosa. MTEHODS:OGR1 expression in colonic tissues was in...

journal_title：Inflammatory bowel diseases

authors： de Vallière C,Wang Y,Eloranta JJ,Vidal S,Clay I,Spalinger MR,Tcymbarevich I,Terhalle A,Ludwig MG,Suply T,Fried M,Kullak-Ublick GA,Frey-Wagner I,Scharl M,Seuwen K,Wagner CA,Rogler G

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:The incidence of inflammatory bowel disease (IBD) has increased over the past several decades with a corresponding increase in the number of patients on combination immunosuppressive therapy including corticosteroids, anti-metabolites and biologic agents. The exact incidence of pneumocystis jiroveci pneumoni...

journal_title：Inflammatory bowel diseases

authors： Okafor PN,Nunes DP,Farraye FA

更新日期：2013-07-01 00:00:00

abstract：Background:Clinical trials investigating the use of cannabinoid drugs for the treatment of intestinal inflammation are anticipated secondary to preclinical literature demonstrating efficacy in reducing inflammation. Methods:We systematically reviewed publications on the benefit of drugs targeting the endo-cannabinoid ...

journal_title：Inflammatory bowel diseases

authors： Couch DG,Maudslay H,Doleman B,Lund JN,O'Sullivan SE

更新日期：2018-03-19 00:00:00

abstract：BACKGROUND:Apolipoprotein E (ApoE) mediates potent antiinflammatory and immunomodulatory properties in addition to its roles in regulating cholesterol transport and metabolism. However, its role in the intestine, specifically during inflammation, is largely unknown. METHODS:Mice (C57BL/6 or ApoE-deficient [ApoE-KO] mi...

journal_title：Inflammatory bowel diseases

authors： Singh V,Kumar M,San Yeoh B,Xiao X,Saha P,Kennett MJ,Vijay-Kumar M

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:According to the Montreal Classification, upper gastrointestinal tract phenotype L4 is uncommon in Caucasian patients with Crohn's disease (CD) but carries excess risk of recurrence. We studied the clinical course of CD in Chinese patients presenting with the L4 phenotype and factors predicting its occurrenc...

journal_title：Inflammatory bowel diseases

authors： Chow DK,Sung JJ,Wu JC,Tsoi KK,Leong RW,Chan FK

更新日期：2009-04-01 00:00:00

abstract：INTRODUCTION:Concurrent cytomegalovirus (CMV) in inflammatory bowel disease-related colitis is an important yet complex clinical scenario associated with high rates of colectomy and other morbidity. This review aimed to examine the literature to produce a comprehensive diagnostic and treatment algorithm for the managem...

journal_title：Inflammatory bowel diseases

authors： Beswick L,Ye B,van Langenberg DR

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:If dysplasia is found on biopsies during surveillance colonoscopy for ulcerative colitis (UC), many experts recommend colectomy given the substantial risk of synchronous colon cancer. The objective was to learn if UC patients' perceptions of their colon cancer risk and if their preferences for elective colec...

journal_title：Inflammatory bowel diseases

authors： Siegel CA,Schwartz LM,Woloshin S,Cole EB,Rubin DT,Vay T,Baars J,Sands BE

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND:Psoriasis induced by anti-tumor necrosis factor-α (TNF) therapy has been described as a paradoxical side effect. AIM:To determine the incidence, clinical characteristics, and management of psoriasis induced by anti-TNF therapy in a large nationwide cohort of inflammatory bowel disease patients. METHODS:Pat...

journal_title：Inflammatory bowel diseases

authors： Guerra I,Pérez-Jeldres T,Iborra M,Algaba A,Monfort D,Calvet X,Chaparro M,Mañosa M,Hinojosa E,Minguez M,Ortiz de Zarate J,Márquez L,Prieto V,García-Sánchez V,Guardiola J,Rodriguez GE,Martín-Arranz MD,García-Tercero I,S

更新日期：2016-04-01 00:00:00

abstract：Background:Social media is commonly used among the adolescent and young adult population, including those with chronic diseases. For adults, these platforms have been shown to be a major source of health information. Our aims were to explore how youth with inflammatory bowel disease (IBD) use social media for (1) disea...

journal_title：Inflammatory bowel diseases

authors： Szeto W,van der Bent A,Petty CR,Reich J,Farraye F,Fishman LN

更新日期：2018-05-18 00:00:00

abstract：BACKGROUND:Inflammatory bowel diseases (IBDs) are characterized by various degrees of mucosal surface damage and subsequent impairment of the intestinal barrier function. Resealing of the epithelial barrier requires intestinal cell migration and proliferation. Galectins are increasingly recognized as novel regulators o...

journal_title：Inflammatory bowel diseases

authors： Paclik D,Lohse K,Wiedenmann B,Dignass AU,Sturm A

更新日期：2008-10-01 00:00:00

abstract：BACKGROUND:Chronic inflammatory diseases are characterized by massive infiltration of innate and acquired immune cells in inflammatory sites. However, it remains unclear how these cells cooperate in the development of disease. Although bone marrow (BM) is a primary site for hematopoiesis of immune cells except T cells,...

journal_title：Inflammatory bowel diseases

authors： Nemoto Y,Kanai T,Tohda S,Totsuka T,Okamoto R,Tsuchiya K,Nakamura T,Sakamoto N,Fukuda T,Miura O,Yagita H,Watanabe M

更新日期：2008-11-01 00:00:00

abstract：BACKGROUND:Adverse drug reactions to azathioprine, the prodrug of 6-mercaptopurine, occur in 15%-38% of patients and the majority are not explained by thiopurine-S-methyltransferase (TPMT) deficiency. Azathioprine is known to induce glutathione depletion and consumption of glutathione is greater in cells with high glut...

journal_title：Inflammatory bowel diseases

authors： Stocco G,Martelossi S,Barabino A,Decorti G,Bartoli F,Montico M,Gotti A,Ventura A

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Osteoporosis is a well-known complication of Crohn's disease (CD). Osteoprotegerin (OPG) concentration is elevated in patients with CD compared to healthy controls. Long-term infliximab (IFX) maintenance therapy improves the patients' bone mineral density. The effect of IFX on bone metabolism has not yet bee...

journal_title：Inflammatory bowel diseases

authors： Miheller P,Muzes G,Rácz K,Blázovits A,Lakatos P,Herszényi L,Tulassay Z

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND:Adherence to treatment is a key condition in preventing relapses in inflammatory bowel disease (IBD). The aims of this study were specifically to study socioeconomic and psychological factors and adherence to treatment in a large cohort of patients. METHODS:A questionnaire concerning demographic, clinical, ...

journal_title：Inflammatory bowel diseases

authors： Nahon S,Lahmek P,Saas C,Durance C,Olympie A,Lesgourgues B,Gendre JP

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:The mucus gel layer (MGL) lining the colon is integral to exclusion of bacteria and maintaining intestinal homeostasis in health and disease. Some MGL defects allowing bacteria to directly contact the colonic surface are commonly observed in ulcerative colitis (UC). The major macromolecular component of the ...

journal_title：Inflammatory bowel diseases

authors： Olli KE,Rapp C,O'Connell L,Collins CB,McNamee EN,Jensen O,Jedlicka P,Allison KC,Goldberg MS,Gerich ME,Frank DN,Ir D,Robertson CE,Evans CM,Aherne CM

更新日期：2020-08-20 00:00:00

abstract：BACKGROUND:There is limited contemporary population-based evidence on adverse birth outcomes and pregnancy-related complications for women with inflammatory bowel disease (IBD). This study provides such estimates of these risks and assesses variation by IBD type and surgical interventions. METHODS:We calculated the pr...

journal_title：Inflammatory bowel diseases

authors： Abdul Sultan A,West J,Ban L,Humes D,Tata LJ,Fleming KM,Nelson-Piercy C,Card T

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:Ileal lesions in Crohn's disease patients are colonized by pathogenic adherent-invasive Escherichia coli (AIEC) that harbor various virulence factors involved in adhesion to and invasion of intestinal epithelial cultured cells. We investigated in a mouse model of colonic inflammation the behavior of virulent...

journal_title：Inflammatory bowel diseases

authors： Carvalho FA,Barnich N,Sauvanet P,Darcha C,Gelot A,Darfeuille-Michaud A

更新日期：2008-08-01 00:00:00

abstract：BACKGROUND:Inflammatory bowel disease (IBD) has a remitting and relapsing disease course; however, relatively little is understood regarding how inflammatory damage in acute colitis influences the microbiota, epithelial barrier, and immune function in subsequent colitis. METHODS:Mice were administered trinitrobenzene ...

journal_title：Inflammatory bowel diseases

authors： Wardill HR,Choo JM,Dmochowska N,Mavrangelos C,Campaniello MA,Bowen JM,Rogers GB,Hughes PA

更新日期：2019-06-18 00:00:00

abstract：BACKGROUND:Although dysplasia is thought to be the precursor lesion in the development of colitis-associated colorectal cancer (CRC), a significant proportion of patients with ulcerative colitis (UC) and low-grade (LGD) or indefinite (IND) dysplasia remain cancer-free during endoscopic follow-up. There is a need for bi...

journal_title：Inflammatory bowel diseases

authors： van Schaik FD,Oldenburg B,Offerhaus GJ,Schipper ME,Vleggaar FP,Siersema PD,van Oijen MG,Ten Kate FJ

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND:Gliotoxin, a fungal metabolite, has been known to show strong immunosuppressive properties, although its mechanisms are not completely understood. In this report, the authors investigated the mechanism whereby gliotoxin has anti-inflammatory properties in vitro and in trinitrobenzene sulfonic acid-induced co...

journal_title：Inflammatory bowel diseases

authors： Jun CD,Kim Y,Choi EY,Kim M,Park B,Youn B,Yu K,Choi KS,Yoon KH,Choi SC,Lee MS,Park KI,Choi M,Chung Y,Oh J

更新日期：2006-07-01 00:00:00

abstract：:Dendritic cells (DCs) play a key role in discriminating between commensal microorganisms and potentially harmful pathogens and in maintaining the balance between tolerance and active immunity. The regulatory role of DC is of particular importance in the gut where the immune system lies in intimate contact with the hig...

journal_title：Inflammatory bowel diseases

authors： Ng SC,Kamm MA,Stagg AJ,Knight SC

更新日期：2010-10-01 00:00:00