Intestinal antiinflammatory effects of thiazolidenedione peroxisome proliferator-activated receptor-gamma ligands on T helper type 1 chemokine regulation include nontranscriptional control mechanisms.

abstract：BACKGROUND:Infliximab is efficacious in the management of moderate to severe Crohn's disease (CD). There are limited data regarding performance of infliximab in patients who require reinitiation of maintenance dosing following previous irregular exposure. METHODS:This was a retrospective, observational study of CD pat...

journal_title：Inflammatory bowel diseases

authors： Stein DJ,Ananthakrishnan AN,Issa M,Williams JB,Beaulieu DB,Zadvornova Y,Ward A,Johnson K,Knox JF,Skaros S,Binion DG

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND:Chronic inflammatory diseases are characterized by massive infiltration of innate and acquired immune cells in inflammatory sites. However, it remains unclear how these cells cooperate in the development of disease. Although bone marrow (BM) is a primary site for hematopoiesis of immune cells except T cells,...

journal_title：Inflammatory bowel diseases

authors： Nemoto Y,Kanai T,Tohda S,Totsuka T,Okamoto R,Tsuchiya K,Nakamura T,Sakamoto N,Fukuda T,Miura O,Yagita H,Watanabe M

更新日期：2008-11-01 00:00:00

abstract：Background:Both muscle-related complaints and elevated serum creatine kinase (CK) levels have been reported in patients with inflammatory bowel disease (IBD) treated with infliximab (IFX), mainly as case reports. The aim of this study was to investigate the effect of IFX therapy on serum CK levels in a cohort of Greek ...

journal_title：Inflammatory bowel diseases

authors： Theodoraki E,Orfanoudaki E,Foteinogiannopoulou K,Koutroubakis IE

更新日期：2018-05-18 00:00:00

abstract：Background:Sarcopenia is associated with increased morbidity and mortality in oncologic and transplant surgery. It has a high incidence in chronic inflammatory states including inflammatory bowel disease (IBD). The validity of existing data in IBD and of sarcopenia's correlation with surgical outcomes is limited. Meth...

journal_title：Inflammatory bowel diseases

authors： Ryan E,McNicholas D,Creavin B,Kelly ME,Walsh T,Beddy D

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Easily accessible predictors of disease course in inflammatory bowel disease (IBD) are scarce, and it remains largely unknown whether a family history of IBD predicts the course of Crohn's disease (CD) and ulcerative colitis (UC). We aimed to compare the course of disease in familial and sporadic cases of IB...

journal_title：Inflammatory bowel diseases

authors： Trier Moller F,Andersen V,Andersson M,Jess T

更新日期：2015-12-01 00:00:00

abstract：:Inflammatory bowel diseases are chronic intestinal inflammatory diseases thought to reflect a dysregulated immune response. Although antibody-based inhibition of tumor necrosis factor-α (TNF-α) has provided relief to many inflammatory bowel diseases patients, these therapies are either ineffective in a patient subset ...

journal_title：Inflammatory bowel diseases

authors： Collins CB,Strassheim D,Aherne CM,Yeckes AR,Jedlicka P,de Zoeten EF

更新日期：2014-04-01 00:00:00

abstract：INTRODUCTION:The incidence of early-onset CD in Scotland is among the highest worldwide. Three single nucleotide polymorphisms (SNPs) R702W, G908R and Leu1007finsC in the NOD2/CARD15 gene predispose to adult CD. We investigated the contribution of these variants to disease susceptibility and phenotype in the Scottish e...

journal_title：Inflammatory bowel diseases

authors： Russell RK,Drummond HE,Nimmo EE,Anderson N,Smith L,Wilson DC,Gillett PM,McGrogan P,Hassan K,Weaver LT,Bisset M,Mahdi G,Satsangi J

更新日期：2005-11-01 00:00:00

abstract：:Potential biomarkers for Crohn's disease (CD) and ulcerative colitis (UC) were identified from two sets of full thickness pathologic samples utilizing DermArray and PharmArray DNA microarrays relative to uninvolved (Un) colon or normal colon. Seven of the over-expressed genes were verified using quantitative RT-PCR (i...

journal_title：Inflammatory bowel diseases

authors： Dooley TP,Curto EV,Reddy SP,Davis RL,Lambert GW,Wilborn TW,Elson CO

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Infliximab is an effective therapy for inflammatory bowel disease (IBD). However, more than 50% of patients lose response. Empiric dose intensification is not effective for all patients because not all patients have objective disease activity or subtherapeutic drug level. The aim was to determine how an obje...

journal_title：Inflammatory bowel diseases

authors： Huang VW,Prosser C,Kroeker KI,Wang H,Shalapay C,Dhami N,Fedorak DK,Halloran B,Dieleman LA,Goodman KJ,Fedorak RN

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:Surgery is the preferred option for patients with symptomatic localized fibrostenotic ileocecal Crohn's disease (CD) but not for those with predominantly active inflammation without obstruction. The benefit of early surgery in patients with a limited nonstricturing ileocecal CD over biologic treatment is sti...

journal_title：Inflammatory bowel diseases

authors： Broide E,Eindor-Abarbanel A,Naftali T,Shirin H,Shalem T,Richter V,Matalon S,Leshno M

更新日期：2020-10-23 00:00:00

abstract：BACKGROUND:Mesalamine is the first-line drug for the treatment of ulcerative colitis (UC). We directly compared the efficacy and safety of two mesalamine formulations for the induction of remission in patients with UC. METHODS:In a multicenter, double-blind, randomized study, 229 patients with mild-to-moderate active ...

journal_title：Inflammatory bowel diseases

authors： Ito H,Iida M,Matsumoto T,Suzuki Y,Sasaki H,Yoshida T,Takano Y,Hibi T

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:Childhood-onset Crohn's disease (CD) might reflect a more severe form of disease. To test this hypothesis we analyzed the long-term natural history of CD in an adult cohort of patients with childhood-onset compared to adult-onset CD. METHODS:We selected 206 childhood-onset CD patients among 2992 adult patie...

journal_title：Inflammatory bowel diseases

authors： Pigneur B,Seksik P,Viola S,Viala J,Beaugerie L,Girardet JP,Ruemmele FM,Cosnes J

更新日期：2010-06-01 00:00:00

abstract：:Dendritic cells (DCs) play a key role in discriminating between commensal microorganisms and potentially harmful pathogens and in maintaining the balance between tolerance and active immunity. The regulatory role of DC is of particular importance in the gut where the immune system lies in intimate contact with the hig...

journal_title：Inflammatory bowel diseases

authors： Ng SC,Kamm MA,Stagg AJ,Knight SC

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND:Endoscopic balloon dilation (EBD) is an effective method for treating stricture-related obstruction in Crohn's disease. We aimed to identify factors predictive of successful avoidance of surgery, including endoscopic features, in patients undergoing balloon dilation. METHODS:We performed a retrospective rev...

journal_title：Inflammatory bowel diseases

authors： Reutemann BA,Turkeltaub JA,Al-Hawary M,Waljee AK,Higgins PDR,Stidham RW

更新日期：2017-10-01 00:00:00

abstract：:Recent reports suggest that unfractionated heparin may be a useful adjunct in the treatment of inflammatory bowel disease (IBD). We report the successful use of subcutaneous unfractionated heparin to treat a moderate-to-severe flare of Crohn's disease during pregnancy, which was refractory to standard therapy. The pat...

journal_title：Inflammatory bowel diseases

authors： Prajapati DN,Newcomer JR,Emmons J,Abu-Hajir M,Binion DG

更新日期：2002-05-01 00:00:00

abstract：Background:Understanding of the prevalence, pathophysiology, and management of fecal incontinence (FI) in inflammatory bowel disease (IBD) patients without an ileal pouch anal anastomosis (IPAA) is suboptimal. We conducted a systematic review and meta-analysis on the prevalence, pathophysiology, and management of prima...

journal_title：Inflammatory bowel diseases

authors： Gu P,Kuenzig ME,Kaplan GG,Pimentel M,Rezaie A

更新日期：2018-05-18 00:00:00

abstract：BACKGROUND:We have developed a technique for measuring fecal excretion of human DNA by assuming that luminal desquamation of epithelial and inflammatory cells increases in damaged colonic mucosa. However, the clinical usefulness of this technique in the follow-up of patients with ulcerative colitis has not been establi...

journal_title：Inflammatory bowel diseases

authors： Casellas F,Borruel N,Antolín M,Varela E,Torrejón A,Armadans L,Guarner F,Malagelada JR

更新日期：2007-04-01 00:00:00

abstract：BACKGROUND:Inflammatory bowel disease (IBD) patients have a high incidence of wound and overall postoperative complications. A totally laparoscopic approach could potentially reduce these risks. We adopted totally laparoscopic total proctocolectomy (TL-TPC) using the perineal wound for extraction as the procedure of ch...

journal_title：Inflammatory bowel diseases

authors： Holder-Murray J,Zoccali M,Hurst RD,Umanskiy K,Rubin M,Fichera A

更新日期：2012-05-01 00:00:00

abstract：OBJECTIVES:Previous decision analyses of inflam matory bowel diseases (IBD) have used decision trees and Markov chains. Occasionally IBD patients present with medical problems that are difficult or even impossible to phrase in terms of such established decision tools. This article aims to introduce modeling by a time-d...

journal_title：Inflammatory bowel diseases

authors： Sonnenberg A,Gavin MW

更新日期：2000-11-01 00:00:00

abstract：:A prospective study was conducted to determine the implications of acute pouchitis on the long-term functional results of restorative proctocolectomy with J-pouch ileoanal anastomosis (IPAA). Between July 1988 and June 1996, 137 consecutive patients underwent IPAA for treatment of ulcerative colitis. 127 patients (93%...

journal_title：Inflammatory bowel diseases

authors： Hurst RD,Chung TP,Rubin M,Michelassi F

更新日期：1998-11-01 00:00:00

abstract：OBJECTIVES:Studies aimed at establishing which characteristics of patients with ulcerative proctitis could be predictive of the extension of inflammation have failed to provide conclusive results. The aim of the study was to evaluate the prognostic role of clinical and therapeutic parameters in patients with proctitis....

journal_title：Inflammatory bowel diseases

authors： Pica R,Paoluzi OA,Iacopini F,Marcheggiano A,Crispino P,Rivera M,Bella A,Consolazio A,Paoluzi P

更新日期：2004-11-01 00:00:00

abstract：:Mesalamine has a well-established role in the management of ulcerative colitis. However, its role in the management of Crohn's disease (CD) is less clear. Studies evaluating its therapeutic value in CD have produced both positive and negative results. Meta-analyses have not clarified the situation, possibly because th...

journal_title：Inflammatory bowel diseases

authors： Hanauer SB

更新日期：2005-06-01 00:00:00

abstract：:Stigma in patients suffering from chronic disease is associated with worse clinical outcomes and secondary medical issues such as depression, anxiety, and decreased quality of life. We believe various forms of stigma can have different clinical significance in patients with inflammatory bowel disease (IBD). With furth...

journal_title：Inflammatory bowel diseases

authors： Guo L,Rohde J,Farraye FA

更新日期：2020-06-18 00:00:00

abstract：BACKGROUND:Pharmacologic inhibition or genetic ablation of phosphoinositide 3-kinase gamma (PI3Kγ) has been shown to be protective against experimental colitis. However, the role of PI3Kγ in the resolution phase of colitis remains unexplored. In this study, we assess the effects of genetic knockout of PI3Kγ on the indu...

journal_title：Inflammatory bowel diseases

authors： Prescott D,Atkinson B,Döring A,Brown S,Petri B,McKay DM,Waterhouse CC

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:Iron is an important nutrient for both the host and colonizing bacteria. Oral iron supplementation may impact the composition of the microbiota and can be particularly damaging to patients suffering from inflammatory bowel disease (IBD). However, patients with IBD may require iron supplementation to treat th...

journal_title：Inflammatory bowel diseases

authors： Constante M,Fragoso G,Lupien-Meilleur J,Calvé A,Santos MM

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:We analyzed inflamed mucosal/submucosal layers of ulcerative colitis (UC = 63) and Crohn's colitis (CC = 50), and unexpectedly, we unveiled a pool of free hemoglobin alpha (Hb-α) chain. Patients with colitides have increased reactive oxidative stress (ROS), DNA oxidation products, free iron in mucosa, in pre...

journal_title：Inflammatory bowel diseases

authors： Myers JN,Schäffer MW,Korolkova OY,Williams AD,Gangula PR,MʼKoma AE

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND:Disappearance of macroscopic mucosal inflammation predicts long-term outcome in Crohn's disease (CD). It can be assessed by ileocolonoscopy, which is, however, an invasive and expensive procedure. Disease activity indices do not correlate well with endoscopic activity and noninvasive markers have a low sensi...

journal_title：Inflammatory bowel diseases

authors： Bodelier AG,Smolinska A,Baranska A,Dallinga JW,Mujagic Z,Vanhees K,van den Heuvel T,Masclee AA,Jonkers D,Pierik MJ,van Schooten FJ

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:Psoriasis induced by anti-tumor necrosis factor-α (TNF) therapy has been described as a paradoxical side effect. AIM:To determine the incidence, clinical characteristics, and management of psoriasis induced by anti-TNF therapy in a large nationwide cohort of inflammatory bowel disease patients. METHODS:Pat...

journal_title：Inflammatory bowel diseases

authors： Guerra I,Pérez-Jeldres T,Iborra M,Algaba A,Monfort D,Calvet X,Chaparro M,Mañosa M,Hinojosa E,Minguez M,Ortiz de Zarate J,Márquez L,Prieto V,García-Sánchez V,Guardiola J,Rodriguez GE,Martín-Arranz MD,García-Tercero I,S

更新日期：2016-04-01 00:00:00

abstract：:An interleukin (IL)-10 family cytokine, IL-22 is characterized by several unique biological properties, including 1) the target restricted to innate cells; 2) the distinct expression pattern between large and small intestines; 3) alteration of the cellular source depending on several factors; 4) the dual abilities to ...

journal_title：Inflammatory bowel diseases

authors： Mizoguchi A

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:High levels of patient activation (having the knowledge, skills, and confidence to effectively manage one's care), have been associated with improved outcomes in many chronic conditions. There have been few studies of the effects of activation in patients with inflammatory bowel disease (IBD). We performed a...

journal_title：Inflammatory bowel diseases

authors： Barnes EL,Long MD,Kappelman MD,Martin CF,Sandler RS

更新日期：2019-06-18 00:00:00