Early Surgery Versus Biologic Therapy in Limited Nonstricturing Ileocecal Crohn's Disease-A Decision-making Analysis.

abstract：BACKGROUND:Clostridium difficile infection (CDI) is common in patients with inflammatory bowel disease (IBD), often leading to diagnostic confusion and delays in IBD therapy escalation. This study sought to assess outcomes after CDI in IBD patients exposed to new or escalated immunosuppressive therapy. METHODS:This mu...

journal_title：Inflammatory bowel diseases

authors： Lukin DJ,Lawlor G,Hudesman DP,Durbin L,Axelrad JE,Passi M,Cavaliere K,Coburn E,Loftus M,Jen H,Feathers A,Rosen MH,Malter LB,Swaminath A,IBD-ReMEdY Study (Research, Mentoring, Education New York).

更新日期：2019-03-14 00:00:00

abstract：BACKGROUND:The incidence of inflammatory bowel disease (IBD) has increased over the past several decades with a corresponding increase in the number of patients on combination immunosuppressive therapy including corticosteroids, anti-metabolites and biologic agents. The exact incidence of pneumocystis jiroveci pneumoni...

journal_title：Inflammatory bowel diseases

authors： Okafor PN,Nunes DP,Farraye FA

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:Nonadherence to medications may affect disease outcomes. The aim of this article was to review methods of assessment, prevalence, and predictors of nonadherence to anti-tumor necrosis factor therapy in inflammatory bowel diseases (IBD). METHODS:Studies were identified through the electronic database of MEDL...

journal_title：Inflammatory bowel diseases

authors： Lopez A,Billioud V,Peyrin-Biroulet C,Peyrin-Biroulet L

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:Inflammatory bowel disease (IBD)-associated dysbiosis is characterized by a loss of Faecalibacterium prausnitzii, whose supernatant exerts an anti-inflammatory effect. However, the anti-inflammatory substances in F. prausnitzii supernatant and the mechanism in ameliorating colitis in IBD have not yet been fu...

journal_title：Inflammatory bowel diseases

authors： Zhou L,Zhang M,Wang Y,Dorfman RG,Liu H,Yu T,Chen X,Tang D,Xu L,Yin Y,Pan Y,Zhou Q,Zhou Y,Yu C

更新日期：2018-08-16 00:00:00

abstract：BACKGROUND:The genetic influence on disease course in inflammatory bowel disease (IBD) remains unknown. We therefore aimed to study longitudinal concordance for clinical characteristics and longitudinal stability using the Montreal Classification in an IBD twin population. METHODS:A total of 158 twins with ulcerative ...

journal_title：Inflammatory bowel diseases

authors： Halfvarson J,Jess T,Bodin L,Järnerot G,Munkholm P,Binder V,Tysk C

更新日期：2007-12-01 00:00:00

abstract：BACKGROUND:Pharmacologic inhibition or genetic ablation of phosphoinositide 3-kinase gamma (PI3Kγ) has been shown to be protective against experimental colitis. However, the role of PI3Kγ in the resolution phase of colitis remains unexplored. In this study, we assess the effects of genetic knockout of PI3Kγ on the indu...

journal_title：Inflammatory bowel diseases

authors： Prescott D,Atkinson B,Döring A,Brown S,Petri B,McKay DM,Waterhouse CC

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:Vitamin D insufficiency has been suggested to be associated with high risk of Crohn's disease (CD). In France, where food fortification is limited, the major source of vitamin D is through sun exposure. The aim of this work was to analyze the relationship between residential sun exposure and the risk of inci...

journal_title：Inflammatory bowel diseases

authors： Jantchou P,Clavel-Chapelon F,Racine A,Kvaskoff M,Carbonnel F,Boutron-Ruault MC

更新日期：2014-01-01 00:00:00

abstract：:Crohn and Rosenberg first highlighted the increased risk of colorectal cancer in ulcerative colitis in 1925. Cancer rates as high as 34 percent after 30 yrs of disease have been reported in several population-based studies, although the reported risk varies substantially. Lower rates have been reported in: population-...

journal_title：Inflammatory bowel diseases

authors： Allen PB,Kamm MA,De Cruz P,Desmond PV

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND:Antimicrobial peptides (AMPs) maintain a sterile environment in intestinal crypts, limiting microbial colonization and invasion. Decreased AMP expression is proposed to increase the risk for inflammatory bowel disease. Expression and function of inducible AMPs, human β-defensin 2 and 3 (hBD-2 and hBD-3), rem...

journal_title：Inflammatory bowel diseases

authors： Meisch JP,Nishimura M,Vogel RM,Sung HC,Bednarchik BA,Ghosh SK,Fu P,McCormick T,Weinberg A,Levine AD

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND:Clostridium difficile infection (CDI) is a common complication of inflammatory bowel diseases (IBDs) and is associated with worse outcome. Variable rates of colectomy have been reported among IBD complicated by CDI. We conducted a systematic review and meta-analysis of studies to assess the association betwe...

journal_title：Inflammatory bowel diseases

authors： Chen Y,Furuya-Kanamori L,Doi SA,Ananthakrishnan AN,Kirk M

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:Crohn's disease is a heterogeneous inflammatory bowel disease. The impact of age at diagnosis on the clinical course of patients varies widely as reported in the Western literature. Using the Vienna Classification, we seek to determine whether young Crohn's disease patients in an Asian population followed a ...

journal_title：Inflammatory bowel diseases

authors： Thia KT,Luman W,Jin OC

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Blood translocation of bacterial-DNA has been described in patients with Crohn's disease (CD). The host's immune cell types cooperate to respond against bacterial insults. Some antimicrobial peptides are inducible after culture with bacterial products and a linkage has been established between them and NOD2/...

journal_title：Inflammatory bowel diseases

authors： Gutiérrez A,Holler E,Zapater P,Sempere L,Jover R,Pérez-Mateo M,Schoelmerich J,Such J,Wiest R,Francés R

更新日期：2011-08-01 00:00:00

abstract：PURPOSE:To describe the reported health-related quality of life (HRQOL) in children and adolescents with inflammatory bowel disease (IBD) after attending an IBD summer camp. METHODS:A prospective analysis of quality of life was completed at an overnight camp that was exclusively for patients with IBD, which was sponso...

journal_title：Inflammatory bowel diseases

authors： Shepanski MA,Hurd LB,Culton K,Markowitz JE,Mamula P,Baldassano RN

更新日期：2005-02-01 00:00:00

abstract：:Crohn's disease is associated with an excessive T helper (TH) type 1 inflammatory immune response. Reducing the influx of disease-associated CD4+ TH1 cells into the inflamed intestine is likely to be beneficial in preventing a disease flare-up and even possibly in reducing the effect of acute disease. Thiazolidenedion...

journal_title：Inflammatory bowel diseases

authors： Schaefer KL,Denevich S,Ma C,Cooley SR,Nakajima A,Wada K,Schlezinger J,Sherr D,Saubermann LJ

更新日期：2005-03-01 00:00:00

abstract：:The genetic basis of antineutrophil cytoplasmic antibody, an important biomarker of inflammatory bowel disease (IBD), has never been thoroughly examined on a genome-wide scale. In this study, we performed a 2-stage genome-wide association study (GWAS) on antineutrophil cytoplasmic antibody in IBD cases. In the 2959 IB...

journal_title：Inflammatory bowel diseases

authors： Li D,Silverberg MS,Haritunians T,Dubinsky MC,Landers C,Stempak JM,Milgrom R,Guo X,Chen YD,Rotter JI,Taylor KD,McGovern DP,Targan SR

更新日期：2016-06-01 00:00:00

abstract：:Diagnostics of inflammatory bowel diseases (IBDs) currently relies on a combination of biological and morphological tests. The current method of diagnostic remains a critical challenge for physicians in part due to their invasiveness and also for their limitations in term of diagnosis, prognosis, disease activity and ...

journal_title：Inflammatory bowel diseases

authors： Viennois E,Zhao Y,Merlin D

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:The aim of this study was to develop a shortened Crohn's Disease Activity Index (CDAI). METHODS:A short CDAI was developed retrospectively using patient-level data from four budesonide clinical trials to select variables from the full CDAI which best predicted health-related quality of life as measured by t...

journal_title：Inflammatory bowel diseases

authors： Thia K,Faubion WA Jr,Loftus EV Jr,Persson T,Persson A,Sandborn WJ

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Patients with inflammatory bowel disease (IBD) have identified a need for more information about their disease. PURPOSE:To assess the effect of an educational intervention on health-related quality of life (HRQOL) in patients with IBD. METHODS:Consecutive ambulatory IBD patients were randomized to receive ...

journal_title：Inflammatory bowel diseases

authors： Borgaonkar MR,Townson G,Donnelly M,Irvine EJ

更新日期：2002-07-01 00:00:00

abstract：BACKGROUND:Establishing predictors of quality of life (QoL) in individuals with inflammatory bowel disease could help to identify those patients who are most likely to experience poor QoL and to target therapeutic interventions appropriately. We aimed to investigate how disease-specific QoL depends on demographic, dise...

journal_title：Inflammatory bowel diseases

authors： Han SW,McColl E,Barton JR,James P,Steen IN,Welfare MR

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Inflammatory bowel disease (IBD) patients are at increased risk of venous thromboembolism (VTE), which is most pronounced during a disease flare. We explored the cost-effectiveness of pharmacological VTE prophylaxis in an outpatient setting. METHODS:Markov decision analysis was conducted from a societal per...

journal_title：Inflammatory bowel diseases

authors： Nguyen GC,Sharma S

更新日期：2013-09-01 00:00:00

abstract：:Inflammatory bowel diseases (IBD) include ulcerative colitis and Crohn's disease. The immune response in ulcerative colitis is different from the Crohn's disease. Accumulating evidence suggests that IBD results from an inappropriate inflammatory response to intestinal microbes in a genetically susceptible host. Severa...

journal_title：Inflammatory bowel diseases

authors： Fonseca-Camarillo G,Yamamoto-Furusho JK

更新日期：2015-09-01 00:00:00

abstract：Background:Kidney disease has been reported in adults with inflammatory bowel disease (IBD) and is regarded an extraintestinal manifestation or more rarely a side effect of the medical treatment. Methods:In this cross-sectional study we describe the extent of kidney pathology in a cohort of 56 children with IBD. Blood...

journal_title：Inflammatory bowel diseases

authors： Lauritzen D,Andreassen BU,Heegaard NHH,Klinge LG,Walsted AM,Neland M,Nielsen RG,Wittenhagen P

更新日期：2018-11-29 00:00:00

abstract：:Natural killer T (NKT) cells are a subset of lymphocytes that express cell surface molecules of both conventional T cells and natural killer cells and share the features of both innate and adaptive immune cells. NKT cells have been proposed to make both protective and pathogenic contributions to inflammatory bowel dis...

journal_title：Inflammatory bowel diseases

authors： van Dieren JM,van der Woude CJ,Kuipers EJ,Escher JC,Samsom JN,Blumberg RS,Nieuwenhuis EE

更新日期：2007-09-01 00:00:00

abstract：BACKGROUND:Although anti-tumor necrosis factor (TNF) agents are effective in patients with inflammatory bowel disease (IBD), many patients either do not respond to anti-TNF treatment or lose response over time. The aim of this study was to determine factors associated with response to anti-TNF therapy in IBD. METHODS:...

journal_title：Inflammatory bowel diseases

authors： Yoon SM,Haritunians T,Chhina S,Liu Z,Yang S,Landers C,Li D,Ye BD,Shih D,Vasiliauskas EA,Ippoliti A,Rabizadeh S,Targan SR,Melmed GY,McGovern DPB

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:Chronic granulomatous disease (CGD) is a rare inherited immunodeficiency disorder characterized by inability of phagocytes to kill certain bacteria and fungi. Histology from colon biopsies of CGD patients have shown the presence of inflammation and granulomas, almost indistinguishable from the findings seen ...

journal_title：Inflammatory bowel diseases

authors： Liu S,Russo PA,Baldassano RN,Sullivan KE

更新日期：2009-08-01 00:00:00

abstract：BACKGROUND:Adipose tissue is recognized as a compartment secreting highly active molecules. Creeping fat represents a characteristic feature of Crohn's disease (CD). Proinflammatory or anti-inflammatory adipose-derived secretory products, now generally called adipocytokines, may play a role in the pathogenesis of CD. ...

journal_title：Inflammatory bowel diseases

authors： Paul G,Schäffler A,Neumeier M,Fürst A,Bataillle F,Buechler C,Müller-Ladner U,Schölmerich J,Rogler G,Herfarth H

更新日期：2006-06-01 00:00:00

abstract：BACKGROUND:Inflammatory bowel diseases (IBDs) are characterized by various degrees of mucosal surface damage and subsequent impairment of the intestinal barrier function. Resealing of the epithelial barrier requires intestinal cell migration and proliferation. Galectins are increasingly recognized as novel regulators o...

journal_title：Inflammatory bowel diseases

authors： Paclik D,Lohse K,Wiedenmann B,Dignass AU,Sturm A

更新日期：2008-10-01 00:00:00

abstract：:Germ-free (GF) interleukin 10-deficient (IL-10) mice develop chronic colitis after colonization by normal enteric bacteria. Muc2 is the major structural component of the protective colonic mucus. Our aim was to determine whether primary or induced aberrations in Muc2 synthesis occur in GF IL-10 mice that develop colit...

journal_title：Inflammatory bowel diseases

authors： Schwerbrock NM,Makkink MK,van der Sluis M,Büller HA,Einerhand AW,Sartor RB,Dekker J

更新日期：2004-11-01 00:00:00

abstract：BACKGROUND:The relative contribution of psychological factors to the onset and course of inflammatory bowel diseases (IBD) is a matter of constant debate since its beginning, as is the clinical need and the efficacy of psychotherapeutic interventions. However, the perspective of patients with IBD has largely been ignor...

journal_title：Inflammatory bowel diseases

authors： Klag T,Mazurak N,Fantasia L,Schwille-Kiuntke J,Kirschniak A,Falch C,Goetz M,Malek NP,Enck P,Wehkamp J

更新日期：2017-10-01 00:00:00

abstract：:: We sought to characterize the incidence, nature, and course of liver disease in children with inflammatory bowel disease (IBD). Chart review identified 555 subjects (318 Crohn's disease [CD], 237 ulcerative colitis [UC]). An alanine aminotransferase measurement of ≥80 U/L was used to identify the presence of a hepat...

journal_title：Inflammatory bowel diseases

authors： Hyams J,Markowitz J,Treem W,Davis P,Grancher K,Daum F

更新日期：1995-04-01 00:00:00