Knowledge of Fecal Calprotectin and Infliximab Trough Levels Alters Clinical Decision-making for IBD Outpatients on Maintenance Infliximab Therapy.

abstract：BACKGROUND:Mucosal healing (MH) is associated with improved clinical outcomes in patients with Crohn's disease (CD) and ulcerative colitis (UC). MH as a target for treatment has been suggested, although there is little pediatric data. The goal of this study was to evaluate MH in clinical practice in pediatric patients ...

journal_title：Inflammatory bowel diseases

authors： Santha SL,Shankar PR,Pan A,Schoen B,Kugathasan S,Sauer CG

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:Chemokines regulate the pathways that restrict homing of specific subsets of immune cells, and thereby fine tune the immune response at specific lymphoid and peripheral tissues. CCL2 is a chemokine that induces migration of monocytes, memory T cells, and dendritic cells. Previously, we demonstrated that pM l...

journal_title：Inflammatory bowel diseases

authors： Maharshak N,Hart G,Ron E,Zelman E,Sagiv A,Arber N,Brazowski E,Margalit R,Elinav E,Shachar I

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:Inflammatory bowel disease (IBD) is a multifactorial disorder, with the innate and adaptive immune cells contributing to disease initiation and progression. However, the intricate cross-talk between immune cell lineages remains incompletely understood. The role of CD8+ T cells in IBD pathogenesis has been un...

journal_title：Inflammatory bowel diseases

authors： Jamwal DR,Marati RV,Harrison CA,Midura-Kiela MT,Figliuolo Paz VR,Besselsen DG,Ghishan FK,Kiela PR

更新日期：2020-01-06 00:00:00

abstract：BACKGROUND:Intestinal stenosis is a frequent complication of Crohn's disease, often leading to repeated bowel obstruction and surgery. The prevalence of small bowel stenosis has ranged from 20% to 40% and from 7% to 15% in patients with colonic disease. Although balloon dilation is the initial preferred approach, many ...

journal_title：Inflammatory bowel diseases

authors： Swaminath A,Lichtiger S

更新日期：2008-02-01 00:00:00

abstract：Background:We quantified loss of response (LOR) to vedolizumab (VDZ) in clinical practice and assessed the effectiveness of VDZ dose intensification for managing LOR. Methods:Retrospective review (May 2014-December 2016) of a prospectively maintained inflammatory bowel disease (IBD) registry. Kaplan-Meier estimates we...

journal_title：Inflammatory bowel diseases

authors： Shmidt E,Kochhar G,Hartke J,Chilukuri P,Meserve J,Chaudrey K,Koliani-Pace JL,Hirten R,Faleck D,Barocas M,Luo M,Lasch K,Boland BS,Singh S,Vande Casteele N,Sagi SV,Fischer M,Chang S,Bohm M,Lukin D,Sultan K,Swamina

更新日期：2018-10-12 00:00:00

abstract：BACKGROUND:The proinflammatory effect of high-fat diet has been observed beyond the cardiovascular system, but there is little evidence to support its role in triggering inflammatory bowel disease. GPx1/2-double-knockout (DKO) mice deficient in 2 intracellular glutathione peroxidases, GPx1 and GPx2, on a C57BL/6 (B6) b...

journal_title：Inflammatory bowel diseases

authors： Gao Q,Esworthy RS,Kim BW,Synold TW,Smith DD,Chu FF

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:Crohn's disease is a heterogeneous disease, and several classification systems have been developed to classify the patients in more homogeneous groups. Our aim was to assess the intra- and interobserver variation when classifying patients according to the widely used Vifenna classification. METHODS:Ten rand...

journal_title：Inflammatory bowel diseases

authors： Riis L,Munkholm P,Binder V,Skovgaard LT,Langholz E

更新日期：2005-07-01 00:00:00

abstract：BACKGROUND:Differentiating between enteric infection and relapse of inflammatory bowel disease (IBD) is a common clinical challenge. Few studies have evaluated the impact of multiplex gastrointestinal polymerase chain reaction (GI PCR) pathogen panels on clinical practice compared to stool culture. Our aim was to compa...

journal_title：Inflammatory bowel diseases

authors： Hong S,Zaki TA,Main M,Hine AM,Chang S,Hudesman D,Axelrad JE

更新日期：2021-01-02 00:00:00

abstract：BACKGROUND:Malignant transformation in ulcerative colitis (UC) is associated with pronounced chromosomal instability, reflected by aneuploidy. Although aneuploidy can precede primary cancer diagnosis in UC for more than a decade, little is known of its cellular consequences. METHODS:Whole-genome gene expression analys...

journal_title：Inflammatory bowel diseases

authors： Gerling M,Nousiainen K,Hautaniemi S,Krüger S,Fritzsche B,Homann N,Bruch HP,Auer G,Roblick UJ,Ried T,Habermann JK

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:Individuals with ulcerative colitis are at high risk of developing colitis-associated cancer. 5-Aminosalicylate (5-ASA) protects from cancer by its antiinflammatory activity as well as by altering cell growth, inducing apoptosis, and reducing replication errors. So far neither 5-ASA's structural specificity ...

journal_title：Inflammatory bowel diseases

authors： Campregher C,Luciani MG,Biesenbach P,Evstatiev R,Lyakhovich A,Gasche C

更新日期：2010-04-01 00:00:00

abstract：PURPOSE:To describe the reported health-related quality of life (HRQOL) in children and adolescents with inflammatory bowel disease (IBD) after attending an IBD summer camp. METHODS:A prospective analysis of quality of life was completed at an overnight camp that was exclusively for patients with IBD, which was sponso...

journal_title：Inflammatory bowel diseases

authors： Shepanski MA,Hurd LB,Culton K,Markowitz JE,Mamula P,Baldassano RN

更新日期：2005-02-01 00:00:00

abstract：BACKGROUND:The dsRNA-activated protein kinase (PKR) phosphorylates the α subunit of eukaryotic translation initiation factor 2 (eIF2α), a global regulator of protein synthesis in mammals. In addition, PKR activates several signal transduction pathways including STAT3 and AKT. PKR is activated by a number of inflammator...

journal_title：Inflammatory bowel diseases

authors： Cao SS,Song B,Kaufman RJ

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:Differentiating ulcerative colitis (UC) from Crohn's colitis (CC) can be difficult and may lead to inaccurate diagnoses in up to 30% of inflammatory bowel disease (IBD) patients. Much of the diagnostic uncertainty arises from the overlap of clinical and histologic features. Matrix-assisted laser desorption/i...

journal_title：Inflammatory bowel diseases

authors： M'Koma AE,Seeley EH,Washington MK,Schwartz DA,Muldoon RL,Herline AJ,Wise PE,Caprioli RM

更新日期：2011-04-01 00:00:00

abstract：BACKGROUND:Ulcerative colitis (UC) negatively affects health-related quality of life (HRQoL), but population-based and long-term data on this topic are scarce. Our aim was to determine the HRQoL in UC patients after a 10-year disease duration. METHODS:UC patients from a population-based inception cohort met at a presc...

journal_title：Inflammatory bowel diseases

authors： Hoivik ML,Moum B,Solberg IC,Cvancarova M,Hoie O,Vatn MH,Bernklev T,IBSEN Study Group.

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND:To investigate the contribution of multidrug resistance 1 (MDR1) gene pharmacogenetics (G2677T/A and C3435T) to the efficacy of azathioprine in inducing remission in patients with Crohn's disease (CD). METHODS:A cohort of 327 unrelated Spanish patients with CD recruited from a single center was studied. All...

journal_title：Inflammatory bowel diseases

authors： Mendoza JL,Urcelay E,Lana R,Martín MC,López N,Guijarro LG,Mayol JA,Taxonera C,de la Concha EG,Peña AS,Díaz-Rubio M

更新日期：2007-05-01 00:00:00

abstract：:Dendritic cells (DCs) play a key role in discriminating between commensal microorganisms and potentially harmful pathogens and in maintaining the balance between tolerance and active immunity. The regulatory role of DC is of particular importance in the gut where the immune system lies in intimate contact with the hig...

journal_title：Inflammatory bowel diseases

authors： Ng SC,Kamm MA,Stagg AJ,Knight SC

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND:Inflammatory bowel disease (IBD) causes serious morbidity and disability, and the incidence is increasing. The disease etiology is not well understood, though inflammatory reactions after antibiotic exposure may be associated with development of IBD. We investigated the association between IBD and prior anti...

journal_title：Inflammatory bowel diseases

authors： Troelsen FS,Jick S

更新日期：2020-02-11 00:00:00

abstract：BACKGROUND:Obesity is associated with systemic and intestine-specific inflammation and alterations in gut microbiota, which in turn impact mucosal immunity. Nonetheless, a specific role of obesity and its interaction with genetics in the progression of Crohn's disease (CD) is unclear. METHODS:We conducted a cross-sect...

journal_title：Inflammatory bowel diseases

authors： Pringle PL,Stewart KO,Peloquin JM,Sturgeon HC,Nguyen D,Sauk J,Garber JJ,Yajnik V,Ananthakrishnan AN,Chan AT,Xavier RJ,Khalili H

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:Faecalibacterium prausnitzii comprises 2 phylogroups, whose abundance in healthy and diseased gut and in conjunction with Escherichia coli has not yet been studied. This work aims to determine the contribution of F. prausnitzii phylogroups I and II in intestinal disease and to assess their potential diagnost...

journal_title：Inflammatory bowel diseases

authors： Lopez-Siles M,Martinez-Medina M,Surís-Valls R,Aldeguer X,Sabat-Mir M,Duncan SH,Flint HJ,Garcia-Gil LJ

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Complementary and alternative medicine (CAM) use is highly prevalent among inflammatory bowel disease (IBD patients). We assessed whether its use, both for IBD and for general health, influenced adherence to conventional medications. METHODS:We enrolled 392 IBD subjects in a prospective cohort study and cat...

journal_title：Inflammatory bowel diseases

authors： Nguyen GC,Croitoru K,Silverberg MS,Steinhart AH,Weizman AV

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:Portal vein thrombosis (PVT) is a poorly described complication of inflammatory bowel disease (IBD). We sought to better characterize presentations, compare treatments, and assess outcomes in IBD-related PVT. METHODS:We conducted a retrospective investigation of IBD-related PVT at our institution. Multivari...

journal_title：Inflammatory bowel diseases

authors： Naymagon L,Tremblay D,Zubizarreta N,Moshier E,Naymagon S,Mascarenhas J,Schiano T

更新日期：2021-01-19 00:00:00

abstract：BACKGROUND:Ileal lesions in Crohn's disease patients are colonized by pathogenic adherent-invasive Escherichia coli (AIEC) that harbor various virulence factors involved in adhesion to and invasion of intestinal epithelial cultured cells. We investigated in a mouse model of colonic inflammation the behavior of virulent...

journal_title：Inflammatory bowel diseases

authors： Carvalho FA,Barnich N,Sauvanet P,Darcha C,Gelot A,Darfeuille-Michaud A

更新日期：2008-08-01 00:00:00

abstract：BACKGROUND:The aim of the study was to assess perianal fistulas by magnetic resonance imaging (MRI) in patients with severe fistulizing Crohn's disease (CD) using maintenance antitumor necrosis factor alpha (TNF-α) therapy and to correlate MRI changes with clinical outcome. METHODS:Perineal MRI before and after a 1-ye...

journal_title：Inflammatory bowel diseases

authors： Savoye-Collet C,Savoye G,Koning E,Dacher JN,Lerebours E

更新日期：2011-08-01 00:00:00

abstract：Background:Vedolizumab, an α4β7 integrin monoclonal antibody inhibiting gut lymphocyte trafficking, is an effective treatment for ulcerative colitis (UC). We evaluated the optimal position of vedolizumab in the UC treatment paradigm. Methods:Using Markov modeling, we assessed multiple algorithms for the treatment of U...

journal_title：Inflammatory bowel diseases

authors： Scott FI,Shah Y,Lasch K,Luo M,Lewis JD

更新日期：2018-01-18 00:00:00

abstract：:Crohn's disease is an idiopathic, chronic inflammatory disorder of the digestive tract with heterogeneous clinical presentations. Crohn's is currently not a curable disease, and patients are faced with a lifetime of recurrent disease flare-ups and remissions. Management strategies for Crohn's must therefore be targete...

journal_title：Inflammatory bowel diseases

authors： Lichtenstein GR,Hanauer SB,Kane SV,Present DH

更新日期：2004-07-01 00:00:00

abstract：BACKGROUND:Evidence supports the role of adherent invasive Escherichia coli (AIEC) in the pathogenesis of inflammatory bowel disease (IBD). However, little is known about the phylogenetic structure and origin of this group of bacteria. Multi-locus sequence typing (MLST), and fimH sequence analysis were performed to elu...

journal_title：Inflammatory bowel diseases

authors： Sepehri S,Kotlowski R,Bernstein CN,Krause DO

更新日期：2009-11-01 00:00:00

abstract：:Recent reports have focused interest on human cytomegalovirus (HCMV) in inflammatory bowel diseases (IBD). Our aim in this study was to examine the frequency of HCMV-infected intestinal cells in tissue sections obtained from patients with IBD, and to investigate if HCMV-infected intestinal cells produce the proinflamm...

journal_title：Inflammatory bowel diseases

authors： Rahbar A,Boström L,Lagerstedt U,Magnusson I,Söderberg-Naucler C,Sundqvist VA

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND:We assessed whether selective granulocyte and monocyte/macrophage adsorption apheresis maintained clinical remission in asymptomatic inflammatory bowel disease (IBD) patients at significant risk of clinical relapse. METHODS:Sixty asymptomatic patients (age 18-70 years) with IBD (in clinical remission) with ...

journal_title：Inflammatory bowel diseases

authors： Maiden L,Takeuchi K,Baur R,Bjarnason I,O'Donohue J,Forgacs I,Chung-Faye G,Sanderson J,Bjarnason I

更新日期：2008-10-01 00:00:00

abstract：BACKGROUND:Although dysplasia is thought to be the precursor lesion in the development of colitis-associated colorectal cancer (CRC), a significant proportion of patients with ulcerative colitis (UC) and low-grade (LGD) or indefinite (IND) dysplasia remain cancer-free during endoscopic follow-up. There is a need for bi...

journal_title：Inflammatory bowel diseases

authors： van Schaik FD,Oldenburg B,Offerhaus GJ,Schipper ME,Vleggaar FP,Siersema PD,van Oijen MG,Ten Kate FJ

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND:There is a recognized association between pediatric inflammatory bowel disease (IBD) and cerebral thromboembolic events (CTEs). Historical reporting had described the association as strongest between ulcerative colitis (UC), rather than Crohn's disease (CD). We describe the incidence and outcome of CTE in pe...

journal_title：Inflammatory bowel diseases

authors： Barclay AR,Keightley JM,Horrocks I,Garrick V,McGrogan P,Russell RK

更新日期：2010-04-01 00:00:00