Abstract:
BACKGROUND:The proinflammatory effect of high-fat diet has been observed beyond the cardiovascular system, but there is little evidence to support its role in triggering inflammatory bowel disease. GPx1/2-double-knockout (DKO) mice deficient in 2 intracellular glutathione peroxidases, GPx1 and GPx2, on a C57BL/6 (B6) background, have mild ileocolitis on a conventional chow. METHODS:We fed B6 DKO mice 2 atherogenic diets to test the dietary effect on atherosclerosis and ileocolitis. Both atherogenic diets have high cholesterol-the Chol+/CA diet has cholic acid (CA), and the Chol+ diet has no CA. RESULTS:The Chol+/CA diet induced severe colitis, but not ileitis, in the DKO mice compared with the Chol+ and the Chol- control diet. On the Chol+/CA diet, the wild-type (WT) mice had levels of aortic lesions and hypercholesterolemia similar to those of DKO mice but had no intestinal pathology. The diet-associated inflammatory responses in the DKO mice included increased colonic proinflammatory serum amyloid A3 expression, plasma lipopolysaccharide, and TNF-α levels. The Chol+/CA diet lowered the expression of the unfolded protein response genes ATF6, CHOP, unspliced Xbp(U) , and Grp78/Bip, in WT and DKO mice compared with mice on the Chol- diet. CONCLUSIONS:We concluded that a cholesterol diet weakens the colon unfolded protein response, which can aggravate spontaneous colitis, leading to gut barrier breakdown. GPx has no impact on atherosclerosis without ultrahypercholesterolemia.
journal_name
Inflamm Bowel Disjournal_title
Inflammatory bowel diseasesauthors
Gao Q,Esworthy RS,Kim BW,Synold TW,Smith DD,Chu FFdoi
10.1002/ibd.21317subject
Has Abstractpub_date
2010-12-01 00:00:00pages
2043-54issue
12eissn
1078-0998issn
1536-4844journal_volume
16pub_type
杂志文章abstract:BACKGROUND:Inflammatory bowel disease (IBD) is a multifactorial disorder, with the innate and adaptive immune cells contributing to disease initiation and progression. However, the intricate cross-talk between immune cell lineages remains incompletely understood. The role of CD8+ T cells in IBD pathogenesis has been un...
journal_title:Inflammatory bowel diseases
pub_type: 杂志文章
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abstract:BACKGROUND:Inflammatory bowel disease (IBD) patients are at increased risk of venous thromboembolism (VTE), which is most pronounced during a disease flare. We explored the cost-effectiveness of pharmacological VTE prophylaxis in an outpatient setting. METHODS:Markov decision analysis was conducted from a societal per...
journal_title:Inflammatory bowel diseases
pub_type: 杂志文章,多中心研究
doi:10.1097/MIB.0b013e31829c01ef
更新日期:2013-09-01 00:00:00
abstract::As the frontiers of immunological research expand, new insights into the pathogenesis of long poorly understood diseases, such as inflammatory bowel disease (IBD), are opening up new possible avenues for treatment. Myeloid-derived cells (i.e., monocytes, macrophages, neutrophils, and dendritic cells), long believed to...
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journal_title:Inflammatory bowel diseases
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doi:10.1002/ibd.20042
更新日期:2007-04-01 00:00:00
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journal_title:Inflammatory bowel diseases
pub_type: 杂志文章,评审
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journal_title:Inflammatory bowel diseases
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journal_title:Inflammatory bowel diseases
pub_type: 杂志文章,meta分析,评审
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journal_title:Inflammatory bowel diseases
pub_type: 杂志文章,评审
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journal_title:Inflammatory bowel diseases
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pub_type: 杂志文章,多中心研究
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journal_title:Inflammatory bowel diseases
pub_type: 杂志文章
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journal_title:Inflammatory bowel diseases
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Inflammatory bowel diseases
pub_type: 杂志文章
doi:10.1097/MIB.0000000000000590
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journal_title:Inflammatory bowel diseases
pub_type: 杂志文章
doi:
更新日期:1997-01-01 00:00:00
abstract::Inflammatory bowel diseases (IBD) include ulcerative colitis and Crohn's disease. The immune response in ulcerative colitis is different from the Crohn's disease. Accumulating evidence suggests that IBD results from an inappropriate inflammatory response to intestinal microbes in a genetically susceptible host. Severa...
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pub_type: 杂志文章,评审
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doi:10.1097/MIB.0b013e318281f423
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journal_title:Inflammatory bowel diseases
pub_type: 杂志文章
doi:10.1097/MIB.0b013e31827eeaa4
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pub_type: 杂志文章
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更新日期:2014-02-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2008-07-01 00:00:00
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journal_title:Inflammatory bowel diseases
pub_type: 杂志文章
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更新日期:2006-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/ibd.21131
更新日期:2010-06-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2017-09-01 00:00:00
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journal_title:Inflammatory bowel diseases
pub_type: 杂志文章
doi:10.1097/01.mib.0000235830.94057.c6
更新日期:2006-12-01 00:00:00