Incidence and Predictors of Flares in the Postpartum Year Among Women With Inflammatory Bowel Disease.

abstract：BACKGROUND:Adverse drug reactions to azathioprine, the prodrug of 6-mercaptopurine, occur in 15%-38% of patients and the majority are not explained by thiopurine-S-methyltransferase (TPMT) deficiency. Azathioprine is known to induce glutathione depletion and consumption of glutathione is greater in cells with high glut...

journal_title：Inflammatory bowel diseases

authors： Stocco G,Martelossi S,Barabino A,Decorti G,Bartoli F,Montico M,Gotti A,Ventura A

更新日期：2007-01-01 00:00:00

abstract：:Crohn's disease is complicated by the development of fibrosis and stricture in approximately 30% to 50% of patients over time. The pathogenesis of fibrostenotic disease is multifactorial involving the activation of mesenchymal cells by cytokines, growth factors, and other mediators released by immune cells, epithelial...

journal_title：Inflammatory bowel diseases

authors： Li C,Kuemmerle JF

更新日期：2014-07-01 00:00:00

abstract：:Gastrointestinal disorders, although clinically heterogeneous, share pathogenic mechanisms, including genetic susceptibility, impaired gut barrier function, altered microbiota, and environmental triggers (infections, social and behavioral factors, epigenetic control, and diet). Gut microbiota has been studied for infl...

journal_title：Inflammatory bowel diseases

authors： Putignani L,Del Chierico F,Vernocchi P,Cicala M,Cucchiara S,Dallapiccola B,Dysbiotrack Study Group.

更新日期：2016-02-01 00:00:00

abstract：:Natural killer T (NKT) cells are a subset of lymphocytes that express cell surface molecules of both conventional T cells and natural killer cells and share the features of both innate and adaptive immune cells. NKT cells have been proposed to make both protective and pathogenic contributions to inflammatory bowel dis...

journal_title：Inflammatory bowel diseases

authors： van Dieren JM,van der Woude CJ,Kuipers EJ,Escher JC,Samsom JN,Blumberg RS,Nieuwenhuis EE

更新日期：2007-09-01 00:00:00

abstract：BACKGROUND:The risk of corticosteroid-associated adverse events can limit the use of systemic corticosteroids. Oral, topically acting, second-generation corticosteroids that deliver drug to the site of inflammation, and biologic therapies, are effective treatment alternatives. The aim of this review was to evaluate the...

journal_title：Inflammatory bowel diseases

authors： Cross RK

更新日期：2017-10-01 00:00:00

abstract：Background:Clinical trials investigating the use of cannabinoid drugs for the treatment of intestinal inflammation are anticipated secondary to preclinical literature demonstrating efficacy in reducing inflammation. Methods:We systematically reviewed publications on the benefit of drugs targeting the endo-cannabinoid ...

journal_title：Inflammatory bowel diseases

authors： Couch DG,Maudslay H,Doleman B,Lund JN,O'Sullivan SE

更新日期：2018-03-19 00:00:00

abstract：BACKGROUND:Chemokines regulate the pathways that restrict homing of specific subsets of immune cells, and thereby fine tune the immune response at specific lymphoid and peripheral tissues. CCL2 is a chemokine that induces migration of monocytes, memory T cells, and dendritic cells. Previously, we demonstrated that pM l...

journal_title：Inflammatory bowel diseases

authors： Maharshak N,Hart G,Ron E,Zelman E,Sagiv A,Arber N,Brazowski E,Margalit R,Elinav E,Shachar I

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:Magnetic resonance enteroclysis (MRE) is a recently introduced imaging technique that assesses the small bowel with similar sensitivity and specificity as the fluoroscopically performed conventional enteroclysis. Magnetic resonance imaging colonography (MRC) seems to be a promising technique for polyp assess...

journal_title：Inflammatory bowel diseases

authors： Schreyer AG,Gölder S,Scheibl K,Völk M,Lenhart M,Timmer A,Schölmerich J,Feuerbach S,Rogler G,Herfarth H,Seitz J

更新日期：2005-04-01 00:00:00

abstract：BACKGROUND:The era of genome-wide association studies (GWAS) has led to the identification of many inflammatory bowel disease (IBD)-associated single-nucleotide polymorphisms (SNPs) with unknown function. The next step would be to identify the functional consequences of these polymorphisms in order to target them effic...

journal_title：Inflammatory bowel diseases

authors： Huebner C,Petermann I,Lam WJ,Shelling AN,Ferguson LR

更新日期：2010-02-01 00:00:00

abstract：:Chemokines, a large family of small chemoattractive cytokines, and their receptors play an integral role in the regulation of the immune response and homeostasis. The ability of chemokines to attract specific populations of immune cells sets them apart from other chemoattractants. Chemokines produced within the gastro...

journal_title：Inflammatory bowel diseases

authors： Zimmerman NP,Vongsa RA,Wendt MK,Dwinell MB

更新日期：2008-07-01 00:00:00

abstract：BACKGROUND:Clostridium difficile infection (CDI) and Cytomegalovirus (CMV) reactivation are associated with disease exacerbations and poor outcomes in inflammatory bowel disease (IBD). Therefore, we assessed the association between these organisms in patients with IBD and the impact on colectomy. METHODS:A retrospecti...

journal_title：Inflammatory bowel diseases

authors： McCurdy JD,Enders FT,Khanna S,Bruining DH,Jones A,Killian JM,Tariq R,Smyrk TC,Loftus EV Jr

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND:Endoscopic balloon dilation (EBD) is widely used to manage Crohn's disease-associated strictures. However, most studies of the safety and efficacy are small and heterogenous. We performed a combined analysis of published studies and evaluated 676 comprehensive individual participant data sets to determine th...

journal_title：Inflammatory bowel diseases

authors： Bettenworth D,Gustavsson A,Atreja A,Lopez R,Tysk C,van Assche G,Rieder F

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Minimally invasive surgery for Crohn's ileocolitis is well established but few data exist regarding laparoscopic techniques for Crohn's colitis. We aimed to describe outcomes associated with minimally invasive surgery for Crohn's colitis, including predictors of conversion to laparotomy and postoperative com...

journal_title：Inflammatory bowel diseases

authors： Holubar SD,Dozois EJ,Privitera A,Pemberton JH,Cima RR,Larson DW

更新日期：2010-11-01 00:00:00

abstract：SUMMARY:: In recent years, heparin has emerged as a possible therapy for inflammatory bowel disease (IBD). Several recent, strongly positive, open-labeled series of heparin in both ulcerative colitis (UC) and Crohn's disease (CD) reinforce the work of Gaffney and co-workers that suggested a benefit of heparin in UC. Al...

journal_title：Inflammatory bowel diseases

authors： Korzenik JR

更新日期：1997-07-01 00:00:00

abstract：:Chronic inflammatory bowel disease (IBD) presents as two major clinical forms, Crohn's disease (CD) and ulcerative colitis (UC). Genetic epidemiological studies and animal models suggest that inherited factors play significant roles in the susceptibility to both forms of IBD. From four genome-wide scans, putative susc...

journal_title：Inflammatory bowel diseases

authors： Ma Y,Ohmen JD,Li Z,Bentley LG,McElree C,Pressman S,Targan SR,Fischel-Ghodsian N,Rotter JI,Yang H

更新日期：1999-11-01 00:00:00

abstract：BACKGROUND:Vitamin A is an important regulator of the human immune system, especially in the gut. Recent studies have revealed that retinoic acid (RA) in gut-associated dendritic cells (DCs) enhances the transforming growth factor (TGF)-beta-dependent conversion of naïve T cells into regulatory T (Treg) cells. Thus, RA...

journal_title：Inflammatory bowel diseases

authors： Wada Y,Hisamatsu T,Kamada N,Okamoto S,Hibi T

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND:There is limited contemporary population-based evidence on adverse birth outcomes and pregnancy-related complications for women with inflammatory bowel disease (IBD). This study provides such estimates of these risks and assesses variation by IBD type and surgical interventions. METHODS:We calculated the pr...

journal_title：Inflammatory bowel diseases

authors： Abdul Sultan A,West J,Ban L,Humes D,Tata LJ,Fleming KM,Nelson-Piercy C,Card T

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:The goal of this study was to determine the rate of work disability, unemployment, and sick leave in an unselected inflammatory bowel disease (IBD) cohort and to measure the effect of working status and disability on the patient's health-related quality of life (HRQOL). MATERIALS AND METHODS:All eligible pa...

journal_title：Inflammatory bowel diseases

authors： Bernklev T,Jahnsen J,Henriksen M,Lygren I,Aadland E,Sauar J,Schulz T,Stray N,Vatn M,Moum B

更新日期：2006-05-01 00:00:00

abstract：:Clinical and epidemiological studies have revealed that the incidence of colorectal cancer associated with ulcerative colitis increases with long-term chronic inflammation. Careful endoscopic observation and histological studies to check for dysplasia in the colon are important in detecting neoplasia. Current surveill...

journal_title：Inflammatory bowel diseases

authors： Matsumoto T,Iwao Y,Igarashi M,Watanabe K,Otsuka K,Watanabe T,Iizuka B,Hida N,Sada M,Chiba T,Kudo SE,Oshitani N,Nagawa H,Ajioka Y,Hibi T

更新日期：2008-02-01 00:00:00

abstract：BACKGROUND:Easily accessible predictors of disease course in inflammatory bowel disease (IBD) are scarce, and it remains largely unknown whether a family history of IBD predicts the course of Crohn's disease (CD) and ulcerative colitis (UC). We aimed to compare the course of disease in familial and sporadic cases of IB...

journal_title：Inflammatory bowel diseases

authors： Trier Moller F,Andersen V,Andersson M,Jess T

更新日期：2015-12-01 00:00:00

abstract：:The risk of colorectal cancer in patients with long-standing ulcerative colitis or colonic Crohn's disease is increased. Patients with long-standing ulcerative colitis are offered enrollment into programs of endoscopic surveillance. Although direct evidence for a protective effect of surveillance against death from co...

journal_title：Inflammatory bowel diseases

authors： Collins PD

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:TGFβ is a multifunctional cytokine that is critical in regulating mucosal immunity. Murine studies have revealed that disruption of canonical TGFβ signaling leads to systemic inflammation including colitis. Loeys-Dietz syndrome (LDS) results from heterozygous mutations in the genes encoding the subunits of t...

journal_title：Inflammatory bowel diseases

authors： Guerrerio AL,Frischmeyer-Guerrerio PA,Huang C,Wu Y,Haritunians T,McGovern DPB,MacCarrick GL,Brant SR,Dietz HC

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:A/JCr mice develop typhlitis in response to Helicobacter hepaticus infection, whereas C57BL/6 mice coexist with this bacterium in a "commensal" relationship and do not develop disease even during prolonged colonization. METHODS:To determine mechanisms that control this balance between responsiveness and non...

journal_title：Inflammatory bowel diseases

authors： Myles MH,Dieckgraefe BK,Criley JM,Franklin CL

更新日期：2007-07-01 00:00:00

abstract：:Corticosteroids are considered a drug of choice for the treatment of patients with moderately to severely active Crohn's disease (CD), an inflammatory bowel disease characterized by chronic recurrent flares of disease activity. However, among patients receiving corticosteroid therapy for induction of remission, 20% ha...

journal_title：Inflammatory bowel diseases

authors： Lichtenstein GR

更新日期：2001-05-01 00:00:00

abstract：BACKGROUND:Previous research suggests a link between childhood adversities and inflammatory bowel disease (IBD); however, study limitations prevent generalization of findings. To address this, the current study uses a Canadian population-based sample to investigate the relationship between 3 childhood adversities and 2...

journal_title：Inflammatory bowel diseases

authors： Fuller-Thomson E,West KJ,Sulman J,Baird SL

更新日期：2015-11-01 00:00:00

abstract：:: Restorative proctocolectomy with ileal pouch-anal anastomosis is the standard surgical treatment modality for patients with ulcerative colitis who require colectomy. There are special issues related to male gender. We performed systemic literature review on the topic, incorporating the experience in our specialized ...

journal_title：Inflammatory bowel diseases

authors： Kani HT,Shen B

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND:Advanced oxidation protein products (AOPPs) are new protein markers of oxidative stress with pro-inflammatory properties, accumulated in many pathological conditions. The issue of their enhanced formation in IBD has not been addressed yet. METHODS:The concentration of relative AOPPs (rAOPP; concentration of...

journal_title：Inflammatory bowel diseases

authors： Krzystek-Korpacka M,Neubauer K,Berdowska I,Boehm D,Zielinski B,Petryszyn P,Terlecki G,Paradowski L,Gamian A

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND:Although magnetic resonance imaging (MRI) is an increasingly used diagnostic tool in the assessment of inflammatory bowel disease (IBD) in humans, diagnosis and quantitation of intestinal inflammation in animal models of IBD still depends on ex vivo techniques. The aim of this study was to evaluate whether h...

journal_title：Inflammatory bowel diseases

authors： Michael S,Keubler LM,Smoczek A,Meier M,Gunzer F,Pöhlmann C,Krause-Buchholz U,Hedrich HJ,Bleich A

更新日期：2013-01-01 00:00:00

abstract：:: Pericarditis occurs rarely in association with inflammatory bowel disease. Because life-threatening complications may occur, pericarditis should be suspected in patients who present with chest symptoms. We report the case of a 28-year-old patient with ulcerative colitis who presented with pericarditis during an acti...

journal_title：Inflammatory bowel diseases

authors： Hinterreiter M,Allinger S,Punzengruber C,Knoflach P

更新日期：1995-10-01 00:00:00

abstract：BACKGROUND:Although dysplasia is thought to be the precursor lesion in the development of colitis-associated colorectal cancer (CRC), a significant proportion of patients with ulcerative colitis (UC) and low-grade (LGD) or indefinite (IND) dysplasia remain cancer-free during endoscopic follow-up. There is a need for bi...

journal_title：Inflammatory bowel diseases

authors： van Schaik FD,Oldenburg B,Offerhaus GJ,Schipper ME,Vleggaar FP,Siersema PD,van Oijen MG,Ten Kate FJ

更新日期：2012-03-01 00:00:00