MDR1 polymorphisms and response to azathioprine therapy in patients with Crohn's disease.

abstract：:Crohn's disease and ulcerative colitis are quite often complicated with manifestations in extraintestinal organs like joints, eye, and skin. Although the etiopathogenesis of these nonmucosal complications remains unsettled, they all share the characteristic feature of inappropriate leukocyte recruitment in nonlymphati...

journal_title：Inflammatory bowel diseases

authors： Salmi M,Jalkanen S

更新日期：1998-05-01 00:00:00

abstract：BACKGROUND:Although many genetic variants are identified in association with Crohn's disease (CD), CARD15, IL23R, and ATG16L1 association with CD have been firmly confirmed in Caucasians of European ancestry. The prevalence of CD is rapidly rising in Brazil, where European ancestry is firmly admixed with natives and Af...

journal_title：Inflammatory bowel diseases

authors： Baptista ML,Amarante H,Picheth G,Sdepanian VL,Peterson N,Babasukumar U,Lima HC,Kugathasan S

更新日期：2008-05-01 00:00:00

abstract：Background:We quantified loss of response (LOR) to vedolizumab (VDZ) in clinical practice and assessed the effectiveness of VDZ dose intensification for managing LOR. Methods:Retrospective review (May 2014-December 2016) of a prospectively maintained inflammatory bowel disease (IBD) registry. Kaplan-Meier estimates we...

journal_title：Inflammatory bowel diseases

authors： Shmidt E,Kochhar G,Hartke J,Chilukuri P,Meserve J,Chaudrey K,Koliani-Pace JL,Hirten R,Faleck D,Barocas M,Luo M,Lasch K,Boland BS,Singh S,Vande Casteele N,Sagi SV,Fischer M,Chang S,Bohm M,Lukin D,Sultan K,Swamina

更新日期：2018-10-12 00:00:00

abstract：INTRODUCTION:No study to date has evaluated perinuclear antineutrophil cytoplasmic antibody (pANCA) and anti-Saccharomyces cerevisiae antibody (ASCA) in pediatric inflammatory bowel disease-unclassified (IBDU) as compared with Crohn's colitis (CC) and ulcerative colitis (UC), which represent the diagnostic challenge. W...

journal_title：Inflammatory bowel diseases

authors： Birimberg-Schwartz L,Wilson DC,Kolho KL,Karolewska-Bochenek K,Afzal NA,Spray C,Romano C,Lionetti P,Hauer AC,Martinez-Vinson C,Veres G,Escher JC,Turner D,paediatric IBD Porto group of ESPGHAN.

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND:The risk of suicide is increased among people with inflammatory bowel disease (IBD); however, most of the evidence regarding this association comes from studies of all-cause mortality, with small numbers of people who have committed suicide, or from clinical case reports. The current study examined the assoc...

journal_title：Inflammatory bowel diseases

authors： Gradus JL,Qin P,Lincoln AK,Miller M,Lawler E,Sørensen HT,Lash TL

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:Recently, granulocyte and monocyte adsorption apheresis (GCAP) has been shown to be safe and effective for active ulcerative colitis (UC). We analyzed the safety and efficacy of GCAP (G-1 Adacolumn) in patients with steroid-refractory and -dependent UC. G-1 Adacolumn is filled with cellulose acetate carriers...

journal_title：Inflammatory bowel diseases

authors： Naganuma M,Funakoshi S,Sakuraba A,Takagi H,Inoue N,Ogata H,Iwao Y,Ishi H,Hibi T

更新日期：2004-05-01 00:00:00

abstract：BACKGROUND:Caspase activation and recruitment domain 3 (CARD3) is a 61-kDa protein kinase. Recent evidence shows the importance of CARD3 in the immune response and inflammatory diseases. To elucidate its impact on inflammatory bowel disease, we studied the effects of the loss of CARD3 in the acute dextran sodium sulfat...

journal_title：Inflammatory bowel diseases

authors： Yu SJ,Liu Y,Deng Y,Zhu XY,Zhan N,Dong WG

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:Activation of cannabinoid (CB)(1) receptors results in attenuation of experimental colitis. Our aim was to examine the role of CB(2) receptors in experimental colitis using agonists (JWH133, AM1241) and an antagonist (AM630) in trinitrobenzene sulfonic acid (TNBS)-induced colitis in wildtype and CB(2) recept...

journal_title：Inflammatory bowel diseases

authors： Storr MA,Keenan CM,Zhang H,Patel KD,Makriyannis A,Sharkey KA

更新日期：2009-11-01 00:00:00

abstract：BACKGROUND:Drug concentration monitoring may be useful to guide therapeutic adjustments for anti-tumor necrosis factor agents in Crohn's disease. The relationship between serum adalimumab concentrations and clinical outcomes was assessed using data from CLinical Assessment of Adalimumab Safety and Efficacy Studied as I...

journal_title：Inflammatory bowel diseases

authors： Chiu YL,Rubin DT,Vermeire S,Louis E,Robinson AM,Lomax KG,Pollack PF,Paulson SK

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:Crohn's disease (CD)-associated dysbiosis could predispose patients to relapse. Gut microbiota composition of patients from the prospective cohort study designed to identify predictive factors of clinical relapse after infliximab discontinuation (STORI Study) was investigated to determine the impact of dysbi...

journal_title：Inflammatory bowel diseases

authors： Rajca S,Grondin V,Louis E,Vernier-Massouille G,Grimaud JC,Bouhnik Y,Laharie D,Dupas JL,Pillant H,Picon L,Veyrac M,Flamant M,Savoye G,Jian R,Devos M,Paintaud G,Piver E,Allez M,Mary JY,Sokol H,Colombel JF,Seksik P

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:Consensus on what constitutes a quality colonoscopy report for patients with inflammatory bowel disease (IBD) is lacking. We developed a template for quality colonoscopy reporting that can be used broadly by endoscopists. METHODS:After a literature review of topics relevant to colonoscopy reporting, members...

journal_title：Inflammatory bowel diseases

authors： Devlin SM,Melmed GY,Irving PM,Rubin DT,Kornbluth A,Kozuch PL,Raffals LE,Velayos FS,Sparrow MP,Baidoo L,Bressler B,Cheifetz AS,Jones J,Kaplan GG,Siegel CA

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:Vitamin D (25(OH)D) deficiency occurs in active Crohn's disease (CD) and may be secondary to reduced sunlight exposure and oral intake. Vitamin D-binding protein (VDBP) levels, however, fluctuate less with season and sunlight. The aim, therefore, was to examine patients with CD in remission and determine any...

journal_title：Inflammatory bowel diseases

authors： Ghaly S,Murray K,Baird A,Martin K,Prosser R,Mill J,Simms LA,Hart PH,Radford-Smith G,Bampton PA,Lawrance IC

更新日期：2016-10-01 00:00:00

abstract：Background:Anastomotic recurrence is frequent in patients with Crohn's disease (CD) following ileocecal resection. The degree of endoscopic recurrence, quantified by the Rutgeerts score (RS), is correlated with the risk of clinical and surgical recurrence. Noninvasive modalities such as capsule endoscopy (CE), magnetic...

journal_title：Inflammatory bowel diseases

authors： Yung DE,Har-Noy O,Tham YS,Ben-Horin S,Eliakim R,Koulaouzidis A,Kopylov U

更新日期：2017-12-19 00:00:00

abstract：BACKGROUND:A notable proportion of patients with inflammatory bowel disease (IBD) are switched from infliximab (IFX) to adalimumab (ADL). We investigated if immunogenicity of IFX influenced immunogenicity and clinical outcomes of later ADL therapy. METHODS:Single-center cohort study including all patients with IBD ass...

journal_title：Inflammatory bowel diseases

authors： Frederiksen MT,Ainsworth MA,Brynskov J,Thomsen OO,Bendtzen K,Steenholdt C

更新日期：2014-10-01 00:00:00

abstract：:The aim of this study was to describe the clinical course of Crohn's disease (CD) in a well-defined, homogeneous groups of patients. A total of 480 patients with CD were followed up from diagnosis up to 20 years. Definitions of patient subgroups were made according to the Vienna Classification. Markov chain analysis w...

journal_title：Inflammatory bowel diseases

authors： Veloso FT,Ferreira JT,Barros L,Almeida S

更新日期：2001-11-01 00:00:00

abstract：:Corticosteroids, and more recently biologics, have been the mainstay of therapy for patients with inflammatory bowel disease. Unfortunately, both are fraught with side effects and limited by lack of efficacy or loss of response. Many patients ultimately succumb to medically refractory disease and require an operation....

journal_title：Inflammatory bowel diseases

authors： Lightner AL

更新日期：2018-07-12 00:00:00

abstract：:: We evaluated retrospective smoking data reported by 221 patients with ulcerative colitis in 1984 and repeated in an identical questionnaire in 1989. Reported years of smoking initiation or smoking cessation agreed to a high extent; the difference between the two questionnaires was in mean (± SD) -0.1 ± 1.5 (median, ...

journal_title：Inflammatory bowel diseases

authors： Tysk C,Järnerot G

更新日期：1995-07-01 00:00:00

abstract：BACKGROUND:We assessed whether selective granulocyte and monocyte/macrophage adsorption apheresis maintained clinical remission in asymptomatic inflammatory bowel disease (IBD) patients at significant risk of clinical relapse. METHODS:Sixty asymptomatic patients (age 18-70 years) with IBD (in clinical remission) with ...

journal_title：Inflammatory bowel diseases

authors： Maiden L,Takeuchi K,Baur R,Bjarnason I,O'Donohue J,Forgacs I,Chung-Faye G,Sanderson J,Bjarnason I

更新日期：2008-10-01 00:00:00

abstract：:Intestinal fibrosis is a common and serious complication of Crohn's disease (CD) and as it can occur at any time during the disease course, it is crucial to identify patients at risk. The aim is not only to understand the pathophysiology of fibrogenesis but to be able to accurately inform subjects about their disease ...

journal_title：Inflammatory bowel diseases

authors： Rieder F,Lawrance IC,Leite A,Sans M

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND:Inflammatory bowel disease (IBD) patients have a high incidence of wound and overall postoperative complications. A totally laparoscopic approach could potentially reduce these risks. We adopted totally laparoscopic total proctocolectomy (TL-TPC) using the perineal wound for extraction as the procedure of ch...

journal_title：Inflammatory bowel diseases

authors： Holder-Murray J,Zoccali M,Hurst RD,Umanskiy K,Rubin M,Fichera A

更新日期：2012-05-01 00:00:00

abstract：:The risk of colorectal cancer in patients with long-standing ulcerative colitis or colonic Crohn's disease is increased. Patients with long-standing ulcerative colitis are offered enrollment into programs of endoscopic surveillance. Although direct evidence for a protective effect of surveillance against death from co...

journal_title：Inflammatory bowel diseases

authors： Collins PD

更新日期：2013-03-01 00:00:00

abstract：:Inflammatory bowel diseases (IBD), Crohn's disease and ulcerative colitis, are poorly understood disorders affecting the intestinal tract. The current model for disease suggests that genetically susceptible patients develop intolerance to gut microflora, and chronic inflammation develops as a result of environmental i...

journal_title：Inflammatory bowel diseases

authors： Wang W,Jovel J,Halloran B,Wine E,Patterson J,Ford G,OʼKeefe S,Meng B,Song D,Zhang Y,Tian Z,Wasilenko ST,Rahbari M,Reza S,Mitchell T,Jordan T,Carpenter E,Madsen K,Fedorak R,Dielemann LA,Ka-Shu Wong G,Mason AL

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:The effect of the inflammatory bowel diseases (IBD) on menstrual function is largely unknown. The aims of this study were to determine whether changes in menstrual function occur in the year before IBD diagnosis or in the initial years after diagnosis. METHODS:Women aged 18 years and older in the Ocean Stat...

journal_title：Inflammatory bowel diseases

authors： Saha S,Zhao YQ,Shah SA,Esposti SD,Lidofsky S,Salih S,Bright R,Law M,Moniz H,Flowers N,Merrick M,Sands BE

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:Inflammatory bowel diseases (IBD) are believed to be driven by dysregulated interactions between the host and the gut microbiota. Our goal is to characterize and infer relationships between mucosal T cells, the host tissue environment, and microbial communities in patients with IBD who will serve as basis fo...

journal_title：Inflammatory bowel diseases

authors： Tang MS,Bowcutt R,Leung JM,Wolff MJ,Gundra UM,Hudesman D,Malter LB,Poles MA,Chen LA,Pei Z,Neto AG,Abidi WM,Ullman T,Mayer L,Bonneau RA,Cho I,Loke P

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND:CALM was a randomized phase 3 trial in patients with Crohn's disease (CD) that demonstrated improved endoscopic outcomes when treatment was escalated based on cutoffs for inflammatory biomarkers, fecal calprotectin (FC), C-reactive protein (CRP), and CD Activity Index (CDAI) remission vs CDAI response alone....

journal_title：Inflammatory bowel diseases

authors： Reinisch W,Panaccione R,Bossuyt P,Baert F,Armuzzi A,Hébuterne X,Travis S,Danese S,Sandborn WJ,Schreiber S,Berg S,Zhou Q,Kligys K,Neimark E,Suleiman AA,D'Haens G,Colombel JF

更新日期：2020-09-18 00:00:00

abstract：BACKGROUND:Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract, which is currently treated with injected monoclonal antibodies specific for tumor necrosis factor (TNF). We developed and characterized AVX-470, a novel polyclonal antibody specific for human TNF. We evaluated t...

journal_title：Inflammatory bowel diseases

authors： Bhol KC,Tracey DE,Lemos BR,Lyng GD,Erlich EC,Keane DM,Quesenberry MS,Holdorf AD,Schlehuber LD,Clark SA,Fox BS

更新日期：2013-10-01 00:00:00

abstract：:: Crohn's disease (CD) is a lifelong inflammatory condition with underlying environmental and genetic components. CD affects multiple parts of the gastrointestinal tract, and it has a growing incidence in Western societies. IL-23 receptor variants have been identified as susceptibility or resistance factors for CD in ...

journal_title：Inflammatory bowel diseases

authors： Eken A,Singh AK,Oukka M

更新日期：2014-03-01 00:00:00

abstract：:Most conventional forms of drug therapy suppress or modify the host immunoinflammatory response and neglect the other contributor to disease pathogenesis-the environmental microflora. Probiotics are live microbial food ingredients that alter the enteric microflora and have a beneficial effect on health. The rationale ...

journal_title：Inflammatory bowel diseases

authors： Shanahan F

更新日期：2000-05-01 00:00:00

abstract：BACKGROUND:There is often dissociation between inflammatory activity and abdominal pain in children with inflammatory bowel disease (IBD), suggesting other factors may play a role in the pain experience. METHODS:Patients (8 to 17 years) newly diagnosed with IBD were enrolled in the ALLAY Study: Assessing Risk Factors ...

journal_title：Inflammatory bowel diseases

authors： Grossi V,Hyams JS,Glidden NC,Knight BE,Young EE

更新日期：2020-07-17 00:00:00

abstract：:Gastrointestinal disorders, although clinically heterogeneous, share pathogenic mechanisms, including genetic susceptibility, impaired gut barrier function, altered microbiota, and environmental triggers (infections, social and behavioral factors, epigenetic control, and diet). Gut microbiota has been studied for infl...

journal_title：Inflammatory bowel diseases

authors： Putignani L,Del Chierico F,Vernocchi P,Cicala M,Cucchiara S,Dallapiccola B,Dysbiotrack Study Group.

更新日期：2016-02-01 00:00:00