Strategies for detecting colon cancer and dysplasia in patients with inflammatory bowel disease.

abstract：BACKGROUND:Host-microbe interactions at the intestinal mucosal-luminal interface (MLI) are critical factors in the biology of inflammatory bowel disease (IBD). METHODS:To address this issue, we performed a series of investigations integrating analysis of the bacteria and metaproteome at the MLI of Crohn's disease, ulc...

journal_title：Inflammatory bowel diseases

authors： Presley LL,Ye J,Li X,Leblanc J,Zhang Z,Ruegger PM,Allard J,McGovern D,Ippoliti A,Roth B,Cui X,Jeske DR,Elashoff D,Goodglick L,Braun J,Borneman J

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND:Oral ferrous iron therapy may reinforce intestinal inflammation. One possible mechanism is by catalyzing the production of reactive oxygen species. We studied the effects of low-dose oral ferrous fumarate on intestinal inflammation and plasma redox status in dextran sulfate sodium (DSS)-induced colitis in ra...

journal_title：Inflammatory bowel diseases

authors： Erichsen K,Milde AM,Arslan G,Helgeland L,Gudbrandsen OA,Ulvik RJ,Berge RK,Hausken T,Berstad A

更新日期：2005-08-01 00:00:00

abstract：:As the frontiers of immunological research expand, new insights into the pathogenesis of long poorly understood diseases, such as inflammatory bowel disease (IBD), are opening up new possible avenues for treatment. Myeloid-derived cells (i.e., monocytes, macrophages, neutrophils, and dendritic cells), long believed to...

journal_title：Inflammatory bowel diseases

authors： Leal MC,Däbritz J

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:Portal vein thrombosis (PVT) is a poorly described complication of inflammatory bowel disease (IBD). We sought to better characterize presentations, compare treatments, and assess outcomes in IBD-related PVT. METHODS:We conducted a retrospective investigation of IBD-related PVT at our institution. Multivari...

journal_title：Inflammatory bowel diseases

authors： Naymagon L,Tremblay D,Zubizarreta N,Moshier E,Naymagon S,Mascarenhas J,Schiano T

更新日期：2021-01-19 00:00:00

abstract：BACKGROUND:Mesalamine, 5-aminosalicylic acid (5-ASA), is a potent antioxidant and is known to enhance peroxisome proliferator-activated receptor γ activity in the intestine. Our previous studies suggested reduced Phosphoinositide 3-Kinase (PI3K)/β-catenin signaling as a mechanism for 5-ASA chemoprevention in chronic ul...

journal_title：Inflammatory bowel diseases

authors： Managlia E,Katzman RB,Brown JB,Barrett TA

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:The postpartum period is marked by physiological and psychological stresses that may impact activity in inflammatory bowel disease. The predictors and outcomes of disease activity during this period have not been well characterized. METHODS:We performed a retrospective review of inflammatory bowel disease p...

journal_title：Inflammatory bowel diseases

authors： Yu A,Friedman S,Ananthakrishnan AN

更新日期：2020-11-19 00:00:00

abstract：:The genetic basis of antineutrophil cytoplasmic antibody, an important biomarker of inflammatory bowel disease (IBD), has never been thoroughly examined on a genome-wide scale. In this study, we performed a 2-stage genome-wide association study (GWAS) on antineutrophil cytoplasmic antibody in IBD cases. In the 2959 IB...

journal_title：Inflammatory bowel diseases

authors： Li D,Silverberg MS,Haritunians T,Dubinsky MC,Landers C,Stempak JM,Milgrom R,Guo X,Chen YD,Rotter JI,Taylor KD,McGovern DP,Targan SR

更新日期：2016-06-01 00:00:00

abstract：:A prospective study was conducted to determine the implications of acute pouchitis on the long-term functional results of restorative proctocolectomy with J-pouch ileoanal anastomosis (IPAA). Between July 1988 and June 1996, 137 consecutive patients underwent IPAA for treatment of ulcerative colitis. 127 patients (93%...

journal_title：Inflammatory bowel diseases

authors： Hurst RD,Chung TP,Rubin M,Michelassi F

更新日期：1998-11-01 00:00:00

abstract：BACKGROUND:Extracellular nucleotides released in conditions of cell stress alert the immune system from tissue injury or inflammation. We hypothesized that the P2X7 receptor (P2X7-R) could regulate key elements in inflammatory bowel disease pathogenesis. METHODS:Colonoscopy samples obtained from patients with Crohn's ...

journal_title：Inflammatory bowel diseases

authors： Neves AR,Castelo-Branco MT,Figliuolo VR,Bernardazzi C,Buongusto F,Yoshimoto A,Nanini HF,Coutinho CM,Carneiro AJ,Coutinho-Silva R,de Souza HS

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:TGFβ is a multifunctional cytokine that is critical in regulating mucosal immunity. Murine studies have revealed that disruption of canonical TGFβ signaling leads to systemic inflammation including colitis. Loeys-Dietz syndrome (LDS) results from heterozygous mutations in the genes encoding the subunits of t...

journal_title：Inflammatory bowel diseases

authors： Guerrerio AL,Frischmeyer-Guerrerio PA,Huang C,Wu Y,Haritunians T,McGovern DPB,MacCarrick GL,Brant SR,Dietz HC

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:The proinflammatory effect of high-fat diet has been observed beyond the cardiovascular system, but there is little evidence to support its role in triggering inflammatory bowel disease. GPx1/2-double-knockout (DKO) mice deficient in 2 intracellular glutathione peroxidases, GPx1 and GPx2, on a C57BL/6 (B6) b...

journal_title：Inflammatory bowel diseases

authors： Gao Q,Esworthy RS,Kim BW,Synold TW,Smith DD,Chu FF

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:The risk of corticosteroid-associated adverse events can limit the use of systemic corticosteroids. Oral, topically acting, second-generation corticosteroids that deliver drug to the site of inflammation, and biologic therapies, are effective treatment alternatives. The aim of this review was to evaluate the...

journal_title：Inflammatory bowel diseases

authors： Cross RK

更新日期：2017-10-01 00:00:00

abstract：:Focal infection theory posits that periodontal pathobionts play a causal role in initiating or exacerbating diseases. Periodontal disease is a common inflammatory, multifactorial disease of the periodontal tissues. The main factor for inflammation is mature dental plaque with the presence of pathogens in the microbial...

journal_title：Inflammatory bowel diseases

authors： Barta Z

更新日期：2020-01-06 00:00:00

abstract：Background:Both muscle-related complaints and elevated serum creatine kinase (CK) levels have been reported in patients with inflammatory bowel disease (IBD) treated with infliximab (IFX), mainly as case reports. The aim of this study was to investigate the effect of IFX therapy on serum CK levels in a cohort of Greek ...

journal_title：Inflammatory bowel diseases

authors： Theodoraki E,Orfanoudaki E,Foteinogiannopoulou K,Koutroubakis IE

更新日期：2018-05-18 00:00:00

abstract：BACKGROUND:Multi-matrix (MMx), a new delivery system for mesalazine, seems to release 5-aminosalicyclic acid (5-ASA) preferentially in the sigmoid colon. This study had 2 objectives: (1) to evaluate the therapeutic response to MMx in patients with active left-sided disease and (2) to gain additional insights as to how ...

journal_title：Inflammatory bowel diseases

authors： Prantera C,Viscido A,Biancone L,Francavilla A,Giglio L,Campieri M

更新日期：2005-05-01 00:00:00

abstract：BACKGROUND:The majority of studies concerning the clinical course and prognosis in ulcerative colitis (UC) are old, retrospective in design, or hospital based. We aimed to identify clinical course and prognosis in a prospective, population-based follow-up study MATERIALS AND METHODS:Patients diagnosed with inflammator...

journal_title：Inflammatory bowel diseases

authors： Henriksen M,Jahnsen J,Lygren I,Sauar J,Kjellevold Ø,Schulz T,Vatn MH,Moum B,IBSEN Study Group.

更新日期：2006-07-01 00:00:00

abstract：BACKGROUND:There has been a dramatic increase in investigations on the potential mechanistic role of the intestinal microbiota in various diseases and factors modulating intestinal microbial composition. We recently reported on intestinal microbial shifts after smoking cessation in humans. In this study, we aimed to co...

journal_title：Inflammatory bowel diseases

authors： Biedermann L,Brülisauer K,Zeitz J,Frei P,Scharl M,Vavricka SR,Fried M,Loessner MJ,Rogler G,Schuppler M

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND AND AIMS:The risk, fate, and ideal management of colorectal dysplasia in inflammatory bowel disease (IBD) remain debated. We estimated the incidence, long-term outcome, and risk factors for progression of colorectal dysplasia (adenomas [adenoma-associated lesions or masses (ALMs)], flat dysplasia, and dyspla...

journal_title：Inflammatory bowel diseases

authors： Jess T,Loftus EV Jr,Velayos FS,Harmsen WS,Zinsmeister AR,Smyrk TC,Tremaine WJ,Melton LJ 3rd,Munkholm P,Sandborn WJ

更新日期：2006-08-01 00:00:00

abstract：BACKGROUND:Improved treatment approaches for ulcerative colitis (UC), including novel medications, might reduce the need for colectomy. We performed a retrospective cohort study of adult patients (age 18-64) with UC in the United States to examine time trends for colectomy and biologic use from 2007 to 2016. METHODS:W...

journal_title：Inflammatory bowel diseases

authors： Barnes EL,Jiang Y,Kappelman MD,Long MD,Sandler RS,Kinlaw AC,Herfarth HH

更新日期：2020-07-17 00:00:00

abstract：BACKGROUND & AIMS:Malnutrition with the accumulation of fat tissue and nonalcoholic fatty liver disease (NAFLD) are conditions associated with inflammatory bowel disease (IBD). Visceral fat and NAFLD-related liver dysfunction can both worsen intestinal inflammation. Because the Mediterranean diet (Md) has been shown to...

journal_title：Inflammatory bowel diseases

authors： Chicco F,Magrì S,Cingolani A,Paduano D,Pesenti M,Zara F,Tumbarello F,Urru E,Melis A,Casula L,Fantini MC,Usai P

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:Crohn's disease is a heterogeneous disease, and several classification systems have been developed to classify the patients in more homogeneous groups. Our aim was to assess the intra- and interobserver variation when classifying patients according to the widely used Vifenna classification. METHODS:Ten rand...

journal_title：Inflammatory bowel diseases

authors： Riis L,Munkholm P,Binder V,Skovgaard LT,Langholz E

更新日期：2005-07-01 00:00:00

abstract：:Citrullination is a posttranslational modification of proteins mediated by a specific family of enzymes called peptidylarginine deiminases (PAD). Dysregulation of these enzymes is involved in the etiology of various diseases, from cancer to autoimmune disorders. In inflammatory bowel disease (IBD), data for a role of ...

journal_title：Inflammatory bowel diseases

authors： Dragoni G,De Hertogh G,Vermeire S

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:Traditional techniques analyzing mouse colitis are invasive, laborious, or indirect. Development of in vivo imaging techniques for specific colitis processes would be useful for monitoring disease progression and/or treatment effectiveness. The aim was to evaluate the applicability of the chemiluminescent pr...

journal_title：Inflammatory bowel diseases

authors： Asghar MN,Emani R,Alam C,Helenius TO,Grönroos TJ,Sareila O,Din MU,Holmdahl R,Hänninen A,Toivola DM

更新日期：2014-08-01 00:00:00

abstract：Background:Kidney disease has been reported in adults with inflammatory bowel disease (IBD) and is regarded an extraintestinal manifestation or more rarely a side effect of the medical treatment. Methods:In this cross-sectional study we describe the extent of kidney pathology in a cohort of 56 children with IBD. Blood...

journal_title：Inflammatory bowel diseases

authors： Lauritzen D,Andreassen BU,Heegaard NHH,Klinge LG,Walsted AM,Neland M,Nielsen RG,Wittenhagen P

更新日期：2018-11-29 00:00:00

abstract：BACKGROUND:Malignant transformation in ulcerative colitis (UC) is associated with pronounced chromosomal instability, reflected by aneuploidy. Although aneuploidy can precede primary cancer diagnosis in UC for more than a decade, little is known of its cellular consequences. METHODS:Whole-genome gene expression analys...

journal_title：Inflammatory bowel diseases

authors： Gerling M,Nousiainen K,Hautaniemi S,Krüger S,Fritzsche B,Homann N,Bruch HP,Auer G,Roblick UJ,Ried T,Habermann JK

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND AND AIMS:Ulcerative colitis (UC) is a form of inflammatory bowel disease, and antibodies against tumor necrosis factor (anti-TNF) are used for treatment. Many patients are refractory or lose response to anti-TNF, and predicting response would be an extremely valuable clinical tool. Unlike most biomarkers, cy...

journal_title：Inflammatory bowel diseases

authors： Obraztsov IV,Shirokikh KE,Obraztsova OI,Shapina MV,Wang MH,Khalif IL

更新日期：2019-02-21 00:00:00

abstract：BACKGROUND:To investigate the contribution of multidrug resistance 1 (MDR1) gene pharmacogenetics (G2677T/A and C3435T) to the efficacy of azathioprine in inducing remission in patients with Crohn's disease (CD). METHODS:A cohort of 327 unrelated Spanish patients with CD recruited from a single center was studied. All...

journal_title：Inflammatory bowel diseases

authors： Mendoza JL,Urcelay E,Lana R,Martín MC,López N,Guijarro LG,Mayol JA,Taxonera C,de la Concha EG,Peña AS,Díaz-Rubio M

更新日期：2007-05-01 00:00:00

abstract：BACKGROUND:Blood translocation of bacterial-DNA has been described in patients with Crohn's disease (CD). The host's immune cell types cooperate to respond against bacterial insults. Some antimicrobial peptides are inducible after culture with bacterial products and a linkage has been established between them and NOD2/...

journal_title：Inflammatory bowel diseases

authors： Gutiérrez A,Holler E,Zapater P,Sempere L,Jover R,Pérez-Mateo M,Schoelmerich J,Such J,Wiest R,Francés R

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:Children with Crohn's disease (CD) suffer from malnutrition. Understanding substrate utilization during exercise may help patients with CD sustain a healthy active lifestyle without compromising nutrition. The aim of this study was to determine whether substrate utilization and bioavailability during exercis...

journal_title：Inflammatory bowel diseases

authors： Nguyen T,Ploeger HE,Obeid J,Issenman RM,Baker JM,Takken T,Parise G,Timmons BW

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Evaluating structural damage using imaging is essential for the evaluation of small intestinal Crohn's disease (CD), but it is limited by potential interobserver variation. We compared the agreement of enterography-based bowel damage measurements collected by experienced radiologists and a semi-automated ima...

journal_title：Inflammatory bowel diseases

authors： Stidham RW,Enchakalody B,Waljee AK,Higgins PDR,Wang SC,Su GL,Wasnik AP,Al-Hawary M

更新日期：2020-04-11 00:00:00