Iron Supplements Modulate Colon Microbiota Composition and Potentiate the Protective Effects of Probiotics in Dextran Sodium Sulfate-induced Colitis.

abstract：:It is estimated that over one million people are living with inflammatory bowel disease (IBD) in the United States and that 20-25% of those are children. Pediatric IBD presents with more severe and extensive disease when compared to adults. As with all pediatric chronic illnesses, the patient as well as their parents ...

journal_title：Inflammatory bowel diseases

authors： Donegan A,Boyle B,Crandall W,Dotson JL,Lemont C,Moon T,Kim SC

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:Inflammatory bowel disease is a chronic inflammatory disorder of the gastrointestinal tract that significantly impacts the health-related quality of life (HR-QOL). A decreased HR-QOL has been demonstrated in patients with active disease compared with patients in remission. In this cross-sectional study, we e...

journal_title：Inflammatory bowel diseases

authors： Zhang CK,Hewett J,Hemming J,Grant T,Zhao H,Abraham C,Oikonomou I,Kanakia M,Cho JH,Proctor DD

更新日期：2013-07-01 00:00:00

abstract：:Natural killer T (NKT) cells are a subset of lymphocytes that express cell surface molecules of both conventional T cells and natural killer cells and share the features of both innate and adaptive immune cells. NKT cells have been proposed to make both protective and pathogenic contributions to inflammatory bowel dis...

journal_title：Inflammatory bowel diseases

authors： van Dieren JM,van der Woude CJ,Kuipers EJ,Escher JC,Samsom JN,Blumberg RS,Nieuwenhuis EE

更新日期：2007-09-01 00:00:00

abstract：BACKGROUND:This study examines the resources utilization in patients with Crohn's disease (CD) during the year before (Y - 1) and after (Y + 1) starting treatment with adalimumab and the drug's efficiency. METHODS:Observational, multicenter, prospective cohort study of patients with CD naive to biological drugs. The p...

journal_title：Inflammatory bowel diseases

authors： Saro C,Ceballos D,Muñoz F,De la Coba C,Aguilar MD,Lázaro P,Iglesias-Flores E,Barreiro-de Acosta M,Hernández-Durán MD,Barrio J,Riestra S,Fernández Salazar L,EFICADEC Researchers Group.

更新日期：2015-07-01 00:00:00

abstract：:The last 12 months have seen unprecedented progress in identifying the susceptibility genes that predispose to common disease in general and Crohn's disease in particular. Success has derived from the new technique of genome-wide association scanning in large panels of cases and controls. This has itself been made pos...

journal_title：Inflammatory bowel diseases

authors： Tremelling M,Parkes M

更新日期：2007-12-01 00:00:00

abstract：:: Primary nonresponse and primary nonremission are important limitations of tumor necrosis factor (TNF) antagonists, occurring in 10% to 40% and 50% to 80% of patients with inflammatory bowel disease, respectively. The magnitude of primary nonresponse differs between phase III clinical trials and cohort studies, indic...

journal_title：Inflammatory bowel diseases

authors： Papamichael K,Gils A,Rutgeerts P,Levesque BG,Vermeire S,Sandborn WJ,Vande Casteele N

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Wiskott-Aldrich syndrome protein-deficient patients and mice are immunodeficient and can develop inflammatory bowel disease. The intestinal microbiome is critical to the development of colitis in most animal models, in which Helicobacter spp. have been implicated in disease pathogenesis. We sought to determi...

journal_title：Inflammatory bowel diseases

authors： Nguyen DD,Muthupalani S,Goettel JA,Eston MA,Mobley M,Taylor NS,McCabe A,Marin R,Snapper SB,Fox JG

更新日期：2013-09-01 00:00:00

abstract：:Stigma in patients suffering from chronic disease is associated with worse clinical outcomes and secondary medical issues such as depression, anxiety, and decreased quality of life. We believe various forms of stigma can have different clinical significance in patients with inflammatory bowel disease (IBD). With furth...

journal_title：Inflammatory bowel diseases

authors： Guo L,Rohde J,Farraye FA

更新日期：2020-06-18 00:00:00

abstract：:MicroRNAs (miRNAs) are single-stranded RNA molecules, which influence the translation of messenger RNA and hence protein synthesis. The altered expression of miRNAs in disease states in cancer and autoimmune diseases including inflammatory bowel disease is providing new insights into disease pathogenesis. This underst...

journal_title：Inflammatory bowel diseases

authors： Whiteoak SR,Felwick R,Sanchez-Elsner T,Fraser Cummings JR

更新日期：2015-05-01 00:00:00

abstract：Background:Tumor necrosis factor alpha (TNF-α) inhibitors are linked with increased risk of reactivation of active tuberculosis. The QuantiFERON-TB Gold In-Tube test is approved for screening latent tuberculosis infection in children and adults. There are limited data on the test performance in children on long-term tr...

journal_title：Inflammatory bowel diseases

authors： Vortia E,Uko VE,Yen-Lieberman B,Frawley J,Worley SE,Danziger-Isakov L,Kaplan B,Mahajan L

更新日期：2018-03-19 00:00:00

abstract：:Restorative proctocolectomy (RPC) with ileal pouch-anal anastomosis is the surgical procedure of choice for patients with ulcerative colitis (UC). It is also performed in selected patients with familial adenomatous polyposis (FAP). A significant proportion of patients will develop pouch dysfunction. Flexible pouchosco...

journal_title：Inflammatory bowel diseases

authors： McLaughlin SD,Clark SK,Thomas-Gibson S,Tekkis PP,Ciclitira PJ,Nicholls RJ

更新日期：2009-08-01 00:00:00

abstract：BACKGROUND:We analyzed inflamed mucosal/submucosal layers of ulcerative colitis (UC = 63) and Crohn's colitis (CC = 50), and unexpectedly, we unveiled a pool of free hemoglobin alpha (Hb-α) chain. Patients with colitides have increased reactive oxidative stress (ROS), DNA oxidation products, free iron in mucosa, in pre...

journal_title：Inflammatory bowel diseases

authors： Myers JN,Schäffer MW,Korolkova OY,Williams AD,Gangula PR,MʼKoma AE

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND:The clinical course of ulcerative colitis (UC) is unpredictable. During recent years, the ability of fecal biomarkers to predict relapse in inflammatory bowel disease has been evaluated. The objective of this study was to assess fecal calprotectin (FC) as a predictor of disease recurrence in patients with ne...

journal_title：Inflammatory bowel diseases

authors： Lasson A,Simrén M,Stotzer PO,Isaksson S,Ohman L,Strid H

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:Various physician- and patient-reported instruments exist for quantification of disease activity in inflammatory bowel diseases (IBD) but none are widely used in routine clinical practice. A simple patient-reported outcome measure might help inform clinical decision making. We evaluated a patient-reported 0 ...

journal_title：Inflammatory bowel diseases

authors： Subramanian S,Asher R,Weston W,Rimmer M,McConville A,Malin A,Jackson R,Collins P,Probert C,Dibb M,Rhodes JM

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND AND AIMS:Poor sleep quality in Crohn's disease (CD) is associated with histologic activity and clinical relapse. We sought to characterize sleep dysfunction and determine the effect of poor sleep quality on risk for hospitalization and surgery. METHODS:Clinical data were collected for CD subjects including ...

journal_title：Inflammatory bowel diseases

authors： Sofia MA,Lipowska AM,Zmeter N,Perez E,Kavitt R,Rubin DT

更新日期：2020-07-17 00:00:00

abstract：BACKGROUND:L-arginine (L-Arg) is the substrate for both inducible nitric oxide (NO) synthase (NOS2) and arginase (ARG) enzymes. L-Arg is actively transported into cells by means of cationic amino acid transporter (SLC7) proteins. We have linked L-Arg and arginase 1 activity to epithelial restitution. Our aim was to det...

journal_title：Inflammatory bowel diseases

authors： Coburn LA,Horst SN,Allaman MM,Brown CT,Williams CS,Hodges ME,Druce JP,Beaulieu DB,Schwartz DA,Wilson KT

更新日期：2016-08-01 00:00:00

abstract：:The aim of this study was to describe the clinical course of Crohn's disease (CD) in a well-defined, homogeneous groups of patients. A total of 480 patients with CD were followed up from diagnosis up to 20 years. Definitions of patient subgroups were made according to the Vienna Classification. Markov chain analysis w...

journal_title：Inflammatory bowel diseases

authors： Veloso FT,Ferreira JT,Barros L,Almeida S

更新日期：2001-11-01 00:00:00

abstract：BACKGROUND:Individuals with ulcerative colitis are at high risk of developing colitis-associated cancer. 5-Aminosalicylate (5-ASA) protects from cancer by its antiinflammatory activity as well as by altering cell growth, inducing apoptosis, and reducing replication errors. So far neither 5-ASA's structural specificity ...

journal_title：Inflammatory bowel diseases

authors： Campregher C,Luciani MG,Biesenbach P,Evstatiev R,Lyakhovich A,Gasche C

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND:Long-term enteral nutrition may maintain clinical and endoscopic remission in patients with Crohn's disease (CD). The aim of this prospective study was to investigate the impacts of long-term enteral nutrition on clinical and endoscopic disease activities and mucosal tissue cytokines in patients with quiesce...

journal_title：Inflammatory bowel diseases

authors： Yamamoto T,Nakahigashi M,Saniabadi AR,Iwata T,Maruyama Y,Umegae S,Matsumoto K

更新日期：2007-12-01 00:00:00

abstract：BACKGROUND:Vitamin D (25(OH)D) deficiency occurs in active Crohn's disease (CD) and may be secondary to reduced sunlight exposure and oral intake. Vitamin D-binding protein (VDBP) levels, however, fluctuate less with season and sunlight. The aim, therefore, was to examine patients with CD in remission and determine any...

journal_title：Inflammatory bowel diseases

authors： Ghaly S,Murray K,Baird A,Martin K,Prosser R,Mill J,Simms LA,Hart PH,Radford-Smith G,Bampton PA,Lawrance IC

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:Advanced oxidation protein products (AOPPs) are new protein markers of oxidative stress with pro-inflammatory properties, accumulated in many pathological conditions. The issue of their enhanced formation in IBD has not been addressed yet. METHODS:The concentration of relative AOPPs (rAOPP; concentration of...

journal_title：Inflammatory bowel diseases

authors： Krzystek-Korpacka M,Neubauer K,Berdowska I,Boehm D,Zielinski B,Petryszyn P,Terlecki G,Paradowski L,Gamian A

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND:Patients with inflammatory bowel disease (IBD) are more susceptible to mental health problems than the general population; however, temporal trends in psychiatric diagnoses' incidence or prevalence in the United States are lacking. We sought to identify these trends among patients with IBD using national Vet...

journal_title：Inflammatory bowel diseases

authors： Thakur ER,Sansgiry S,Kramer JR,Waljee AK,Gaidos JK,Feagins LA,Govani SM,Dindo L,El-Serag HB,Hou JK

更新日期：2020-08-20 00:00:00

abstract：BACKGROUND:Mesenchymal stem cells (MSCs) have demonstrated significant potentials for the treatment of inflammatory bowel disease. Clinical feasible methods to individually document the MSC recruitment to intestinal mucosa is lacking. Here, we proposed that endomicroscopy could noninvasively track MSCs in vivo at cellu...

journal_title：Inflammatory bowel diseases

authors： Li M,Zhang YX,Zhang Z,Zhou XY,Zuo XL,Cong Y,Li YQ

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:Several studies suggest an increased risk of venous and arterial thromboembolism (TE) in adults with inflammatory bowel disease (IBD) compared to the general population. We performed a systematic review of studies on incidence and characteristic of TE in children with IBD. METHODS:We searched Medline, LILAC...

journal_title：Inflammatory bowel diseases

authors： Lazzerini M,Bramuzzo M,Maschio M,Martelossi S,Ventura A

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND:There is a recognized association between pediatric inflammatory bowel disease (IBD) and cerebral thromboembolic events (CTEs). Historical reporting had described the association as strongest between ulcerative colitis (UC), rather than Crohn's disease (CD). We describe the incidence and outcome of CTE in pe...

journal_title：Inflammatory bowel diseases

authors： Barclay AR,Keightley JM,Horrocks I,Garrick V,McGrogan P,Russell RK

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND:Thiopurines are effective drugs in treating ulcerative colitis (UC) and Crohn's disease (CD) even if studies that specifically investigate these drugs' profile of efficacy in UC compared with CD are scarce. Our aim was to compare the profile of efficacy of thiopurines in patients with UC and CD. METHODS:We ...

journal_title：Inflammatory bowel diseases

authors： Rispo A,Testa A,De Palma GD,Donetto S,Diaferia M,Musto D,Nardone O,Maione F,Caporaso N,Castiglione F

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND:There is limited contemporary population-based evidence on adverse birth outcomes and pregnancy-related complications for women with inflammatory bowel disease (IBD). This study provides such estimates of these risks and assesses variation by IBD type and surgical interventions. METHODS:We calculated the pr...

journal_title：Inflammatory bowel diseases

authors： Abdul Sultan A,West J,Ban L,Humes D,Tata LJ,Fleming KM,Nelson-Piercy C,Card T

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:Inflammatory bowel disease (IBD) has a remitting and relapsing disease course; however, relatively little is understood regarding how inflammatory damage in acute colitis influences the microbiota, epithelial barrier, and immune function in subsequent colitis. METHODS:Mice were administered trinitrobenzene ...

journal_title：Inflammatory bowel diseases

authors： Wardill HR,Choo JM,Dmochowska N,Mavrangelos C,Campaniello MA,Bowen JM,Rogers GB,Hughes PA

更新日期：2019-06-18 00:00:00

abstract：BACKGROUND:The optimal management of Clostridium difficile infection (CDI) in flaring inflammatory bowel disease (IBD) patients has not been defined. Limited data suggest that coadministration of immunomodulators (IM) with antibiotics (AB) results in a worse outcome. We investigated the prevalent practice among North A...

journal_title：Inflammatory bowel diseases

authors： Yanai H,Nguyen GC,Yun L,Lebwohl O,Navaneethan U,Stone CD,Ghazi L,Moayyedi P,Brooks J,Bernstein CN,Ben-Horin S

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND:Inflammatory bowel diseases (IBDs) are chronic illnesses that require frequent and regular healthcare contact. Regular maintenance care may reduce complications or the need for hospitalization. Availability of physicians may be an important determinant of IBD hospitalizations. METHODS:Using 2008 inpatient d...

journal_title：Inflammatory bowel diseases

authors： Ananthakrishnan AN,McGinley EL,Binion DG,Saeian K

更新日期：2011-02-01 00:00:00