Impacts of long-term enteral nutrition on clinical and endoscopic disease activities and mucosal cytokines during remission in patients with Crohn's disease: a prospective study.

abstract：BACKGROUND:It is unclear if traditional histopathology and noninvasive blood-based tests are sufficiently accurate to detect cytomegalovirus (CMV) reactivation in inflammatory bowel disease. Therefore, we assessed the diagnostic accuracy of these tests compared with immunohistochemistry (IHC) and tissue polymerase chai...

journal_title：Inflammatory bowel diseases

authors： Tandon P,James P,Cordeiro E,Mallick R,Shukla T,McCurdy JD

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:The efficacy of anti-tumor necrosis factor monoclonal antibody (anti-TNF mAb) for Crohn's disease (CD) is well established, and anti-interleukin-6 receptor (anti-IL-6R) mAb has also been reported to be effective in CD. It is, however, unclear if the efficacy and mechanisms of both agents are different in CD ...

journal_title：Inflammatory bowel diseases

authors： Terabe F,Fujimoto M,Serada S,Shinzaki S,Iijima H,Tsujii M,Hayashi N,Nomura S,Kawahata H,Jang MH,Miyasaka M,Mihara M,Ohsugi Y,Kishimoto T,Naka T

更新日期：2011-02-01 00:00:00

abstract：:Induction and maintenance of remission, mucosal healing, the avoidance of surgical intervention, and decreasing the likelihood of cancer developing are the primary therapeutic goals in ulcerative colitis (UC). For the traditional therapies, 5-aminosalicylic acid (including mesalamine), corticosteroids, and thiopurines...

journal_title：Inflammatory bowel diseases

authors： Ng SC,Kamm MA

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND:Interleukin-13 (IL-13) is a multifunctional cytokine whose net principle action is to diminish inflammatory responses. Dysregulation of IL-13 production has been proposed to contribute to intestinal inflammation in inflammatory bowel disease (IBD) patients. Previous studies implicate IL-13 in IBD pathogenesi...

journal_title：Inflammatory bowel diseases

authors： Kadivar K,Ruchelli ED,Markowitz JE,Defelice ML,Strogatz ML,Kanzaria MM,Reddy KP,Baldassano RN,von Allmen D,Brown KA

更新日期：2004-09-01 00:00:00

abstract：:After 20 years of successful targeting of pro-inflammatory cytokines for the treatment of IBD, an alternative therapeutic strategy has emerged, based on several decades of advances in understanding the pathogenesis of IBD. The targeting of molecules involved in leukocyte traffic has recently become a safe and effectiv...

journal_title：Inflammatory bowel diseases

authors： Pérez-Jeldres T,Tyler CJ,Boyer JD,Karuppuchamy T,Bamias G,Dulai PS,Boland BS,Sandborn WJ,Patel DR,Rivera-Nieves J

更新日期：2019-01-10 00:00:00

abstract：BACKGROUND:Chronic granulomatous disease (CGD) is a rare inherited immunodeficiency disorder characterized by inability of phagocytes to kill certain bacteria and fungi. Histology from colon biopsies of CGD patients have shown the presence of inflammation and granulomas, almost indistinguishable from the findings seen ...

journal_title：Inflammatory bowel diseases

authors： Liu S,Russo PA,Baldassano RN,Sullivan KE

更新日期：2009-08-01 00:00:00

abstract：BACKGROUND:Inflammatory bowel diseases (IBDs) are characterized by various degrees of mucosal surface damage and subsequent impairment of the intestinal barrier function. Resealing of the epithelial barrier requires intestinal cell migration and proliferation. Galectins are increasingly recognized as novel regulators o...

journal_title：Inflammatory bowel diseases

authors： Paclik D,Lohse K,Wiedenmann B,Dignass AU,Sturm A

更新日期：2008-10-01 00:00:00

abstract：BACKGROUND:The aim of the study was to assess perianal fistulas by magnetic resonance imaging (MRI) in patients with severe fistulizing Crohn's disease (CD) using maintenance antitumor necrosis factor alpha (TNF-α) therapy and to correlate MRI changes with clinical outcome. METHODS:Perineal MRI before and after a 1-ye...

journal_title：Inflammatory bowel diseases

authors： Savoye-Collet C,Savoye G,Koning E,Dacher JN,Lerebours E

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:Apolipoprotein E (ApoE) mediates potent antiinflammatory and immunomodulatory properties in addition to its roles in regulating cholesterol transport and metabolism. However, its role in the intestine, specifically during inflammation, is largely unknown. METHODS:Mice (C57BL/6 or ApoE-deficient [ApoE-KO] mi...

journal_title：Inflammatory bowel diseases

authors： Singh V,Kumar M,San Yeoh B,Xiao X,Saha P,Kennett MJ,Vijay-Kumar M

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:Mucosal expression of immunological mediators is modified in inflammatory bowel disease (IBD). Quantification of target gene messenger RNA (mRNA) transcripts depends on the normalization to a housekeeping or reference gene. Stability of housekeeping gene expression is critical for the accurate measurement of...

journal_title：Inflammatory bowel diseases

authors： Bamias G,Goukos D,Laoudi E,Balla IG,Siakavellas SI,Daikos GL,Ladas SD

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:A common feature of preclinical models of colitis is that the time-course, magnitude, and persistence of inflammation vary considerably within the experimental animal group. Accordingly, noninvasive, serial quantification of colonic inflammation could advantageously guide dosing regimens and assess drug effi...

journal_title：Inflammatory bowel diseases

authors： Pohlmann A,Tilling LC,Robinson A,Woolmer O,McCleary S,Kruidenier L,Warnock LC,Lewis HD,Hobson AR,James MF

更新日期：2009-04-01 00:00:00

abstract：:Diagnostics of inflammatory bowel diseases (IBDs) currently relies on a combination of biological and morphological tests. The current method of diagnostic remains a critical challenge for physicians in part due to their invasiveness and also for their limitations in term of diagnosis, prognosis, disease activity and ...

journal_title：Inflammatory bowel diseases

authors： Viennois E,Zhao Y,Merlin D

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:Activation of cannabinoid (CB)(1) receptors results in attenuation of experimental colitis. Our aim was to examine the role of CB(2) receptors in experimental colitis using agonists (JWH133, AM1241) and an antagonist (AM630) in trinitrobenzene sulfonic acid (TNBS)-induced colitis in wildtype and CB(2) recept...

journal_title：Inflammatory bowel diseases

authors： Storr MA,Keenan CM,Zhang H,Patel KD,Makriyannis A,Sharkey KA

更新日期：2009-11-01 00:00:00

abstract：BACKGROUND:Differentiating between enteric infection and relapse of inflammatory bowel disease (IBD) is a common clinical challenge. Few studies have evaluated the impact of multiplex gastrointestinal polymerase chain reaction (GI PCR) pathogen panels on clinical practice compared to stool culture. Our aim was to compa...

journal_title：Inflammatory bowel diseases

authors： Hong S,Zaki TA,Main M,Hine AM,Chang S,Hudesman D,Axelrad JE

更新日期：2021-01-02 00:00:00

abstract：BACKGROUND:Previous systematic cumulative analyses of the placebo arm in ulcerative colitis (UC) were limited by the wide heterogeneity in the scores and definitions of response. We aimed at estimating the placebo rates of remission, response, and mucosal healing (MH) in phase 2 and 3 randomized placebo-controlled tria...

journal_title：Inflammatory bowel diseases

authors： Macaluso FS,Maida M,Ventimiglia M,Renna S,Cottone M,Orlando A

更新日期：2019-05-04 00:00:00

abstract：BACKGROUND:The clinical implication of Clostridium difficile infection (CDI) in patients with ileal pouch-anal anastomosis (IPAA) for underlying inflammatory bowel disease (IBD) has not been well studied. This study was designed to investigate the cumulative incidence, risk factors, and outcome of CDI in patients with ...

journal_title：Inflammatory bowel diseases

authors： Li Y,Qian J,Queener E,Shen B

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND:Microbiota is most likely essential in the pathogenesis of Crohn's disease (CD). Fecal diversion after ileocecal resection (ICR) protects against CD recurrence, whereas infusion of fecal content triggers inflammation. After ICR, the majority of patients experience endoscopic recurrence in the neoterminal ile...

journal_title：Inflammatory bowel diseases

authors： Olaisen M,Flatberg A,Granlund AVB,Røyset ES,Martinsen TC,Sandvik AK,Fossmark R

更新日期：2021-01-01 00:00:00

abstract：Background:Clinical trials investigating the use of cannabinoid drugs for the treatment of intestinal inflammation are anticipated secondary to preclinical literature demonstrating efficacy in reducing inflammation. Methods:We systematically reviewed publications on the benefit of drugs targeting the endo-cannabinoid ...

journal_title：Inflammatory bowel diseases

authors： Couch DG,Maudslay H,Doleman B,Lund JN,O'Sullivan SE

更新日期：2018-03-19 00:00:00

abstract：BACKGROUND:Vitamin D (25(OH)D) deficiency occurs in active Crohn's disease (CD) and may be secondary to reduced sunlight exposure and oral intake. Vitamin D-binding protein (VDBP) levels, however, fluctuate less with season and sunlight. The aim, therefore, was to examine patients with CD in remission and determine any...

journal_title：Inflammatory bowel diseases

authors： Ghaly S,Murray K,Baird A,Martin K,Prosser R,Mill J,Simms LA,Hart PH,Radford-Smith G,Bampton PA,Lawrance IC

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:Adipose tissue is recognized as a compartment secreting highly active molecules. Creeping fat represents a characteristic feature of Crohn's disease (CD). Proinflammatory or anti-inflammatory adipose-derived secretory products, now generally called adipocytokines, may play a role in the pathogenesis of CD. ...

journal_title：Inflammatory bowel diseases

authors： Paul G,Schäffler A,Neumeier M,Fürst A,Bataillle F,Buechler C,Müller-Ladner U,Schölmerich J,Rogler G,Herfarth H

更新日期：2006-06-01 00:00:00

abstract：BACKGROUND:The objectives of this study were to determine the prevalence and incidence of inflammatory bowel disease (IBD) in a representative Lebanese cohort and to describe practice prevalence trends, disease characteristics, and impact on quality of life (QoL) of IBD patients in Lebanon. METHODS:All of a university...

journal_title：Inflammatory bowel diseases

authors： Abdul-Baki H,ElHajj I,El-Zahabi LM,Azar C,Aoun E,Zantout H,Nasreddine W,Ayyach B,Mourad FH,Soweid A,Barada KA,Sharara AI

更新日期：2007-04-01 00:00:00

abstract：:: Inflammatory bowel disease is associated with a reduction in serum and red blood cell folate levels that may contribute to colonic carcinogenesis. Sulfasalazine may exacerbate such deficiencies. Indirect evidence suggests that folate supplements reduce the risk of colonic neoplasia in those using this agent, althoug...

journal_title：Inflammatory bowel diseases

authors： Meenan J,Oʼhallinan E,Scott J,Weir DG

更新日期：1996-10-01 00:00:00

abstract：BACKGROUND:Host-microbe interactions at the intestinal mucosal-luminal interface (MLI) are critical factors in the biology of inflammatory bowel disease (IBD). METHODS:To address this issue, we performed a series of investigations integrating analysis of the bacteria and metaproteome at the MLI of Crohn's disease, ulc...

journal_title：Inflammatory bowel diseases

authors： Presley LL,Ye J,Li X,Leblanc J,Zhang Z,Ruegger PM,Allard J,McGovern D,Ippoliti A,Roth B,Cui X,Jeske DR,Elashoff D,Goodglick L,Braun J,Borneman J

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND:This study compared the efficacy of an elemental formula (EF) to a polymeric formula (PF) in inducing remission for pediatric Crohn's disease (CD). METHODS:Newly diagnosed CD children were randomized to EF or PF for 6 weeks. Change in the Pediatric Crohn's Disease Activity Index (PCDAI), fecal calprotectin,...

journal_title：Inflammatory bowel diseases

authors： Grogan JL,Casson DH,Terry A,Burdge GC,El-Matary W,Dalzell AM

更新日期：2012-02-01 00:00:00

abstract：:There is no standard practice in the induction of colitis by 2,4,6-trinitrobenzene sulfonic acid. In this review the current practice in 2,4,6-trinitrobenzene sulfonic acid colitis is studied using 20 recently published articles. We compare the different protocols, discuss the mechanism of disease and give recommendat...

journal_title：Inflammatory bowel diseases

authors： te Velde AA,Verstege MI,Hommes DW

更新日期：2006-10-01 00:00:00

abstract：BACKGROUND:The PAILOT trial was a randomized controlled trial aimed to evaluate proactive vs reactive therapeutic drug monitoring in children with Crohn's disease (CD) treated with adalimumab. Our aim in this post hoc analysis of the PAILOT trial was to assess the efficacy and safety of adalimumab combination treatment...

journal_title：Inflammatory bowel diseases

authors： Matar M,Shamir R,Turner D,Broide E,Weiss B,Ledder O,Guz-Mark A,Rinawi F,Cohen S,Topf-Olivestone C,Shaoul R,Yerushalmi B,Ben-Horin S,Assa A

更新日期：2020-10-23 00:00:00

abstract：BACKGROUND:The aim of this study was to assess the clinical benefit and tolerability of adalimumab, a fully human monoclonal antibody to tumor necrosis factor (TNF), in patients with ulcerative colitis (UC). METHODS:Patients with active UC, including those who had lost response or developed intolerance to the chimeric...

journal_title：Inflammatory bowel diseases

authors： Afif W,Leighton JA,Hanauer SB,Loftus EV Jr,Faubion WA,Pardi DS,Tremaine WJ,Kane SV,Bruining DH,Cohen RD,Rubin DT,Hanson KA,Sandborn WJ

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND:Increased strength of red blood cell (RBC) aggregates are present during the acute inflammatory response and contribute to erythrocyte aggregation and may lead to microvascular dysfunction. Inflammatory bowel diseases (IBDs) are characterized by damage to the bowel wall. This damage may be at least partially...

journal_title：Inflammatory bowel diseases

authors： Maharshak N,Arbel Y,Shapira I,Berliner S,Ben-Ami R,Yedgar S,Barshtein G,Dotan I

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND:High levels of patient activation (having the knowledge, skills, and confidence to effectively manage one's care), have been associated with improved outcomes in many chronic conditions. There have been few studies of the effects of activation in patients with inflammatory bowel disease (IBD). We performed a...

journal_title：Inflammatory bowel diseases

authors： Barnes EL,Long MD,Kappelman MD,Martin CF,Sandler RS

更新日期：2019-06-18 00:00:00

abstract：BACKGROUND:The era of genome-wide association studies (GWAS) has led to the identification of many inflammatory bowel disease (IBD)-associated single-nucleotide polymorphisms (SNPs) with unknown function. The next step would be to identify the functional consequences of these polymorphisms in order to target them effic...

journal_title：Inflammatory bowel diseases

authors： Huebner C,Petermann I,Lam WJ,Shelling AN,Ferguson LR

更新日期：2010-02-01 00:00:00