CD68 expression is markedly different in Crohn's disease and the colitis associated with chronic granulomatous disease.

abstract：BACKGROUND:The inflammatory bowel diseases (IBDs) are chronic inflammatory disorders, associated with genetic, immunologic, and environmental factors. Although hundreds of genes are implicated in IBD etiology, it is likely that additional genes play a role in the disease process. We developed a machine learning-based g...

journal_title：Inflammatory bowel diseases

authors： Isakov O,Dotan I,Ben-Shachar S

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND:Inflammatory bowel disease (IBD)-associated dysbiosis is characterized by a loss of Faecalibacterium prausnitzii, whose supernatant exerts an anti-inflammatory effect. However, the anti-inflammatory substances in F. prausnitzii supernatant and the mechanism in ameliorating colitis in IBD have not yet been fu...

journal_title：Inflammatory bowel diseases

authors： Zhou L,Zhang M,Wang Y,Dorfman RG,Liu H,Yu T,Chen X,Tang D,Xu L,Yin Y,Pan Y,Zhou Q,Zhou Y,Yu C

更新日期：2018-08-16 00:00:00

abstract：BACKGROUND:Intestinal inflammation produces an induction of alkaline phosphatase (AP) activity that is attributable in part to augmented expression, accompanied by a change in isoform, in epithelial cells. METHODS:This study focuses on induction of AP in intestinal epithelial cells in vitro. RESULTS:Treatment with th...

journal_title：Inflammatory bowel diseases

authors： López-Posadas R,González R,Ballester I,Martínez-Moya P,Romero-Calvo I,Suárez MD,Zarzuelo A,Martínez-Augustin O,Sánchez de Medina F

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND:The clinical utility of cellular therapies is being investigated in a broad range of therapeutic areas. This phase 1 study represents the first exploration of PDA001, a preparation of cells cultured from human placental tissue, in subjects with Crohn's disease. METHODS:Twelve subjects with active, moderate-...

journal_title：Inflammatory bowel diseases

authors： Mayer L,Pandak WM,Melmed GY,Hanauer SB,Johnson K,Payne D,Faleck H,Hariri RJ,Fischkoff SA

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:The purpose of the study was to determine the role of fecal calprotectin and lactoferrin in the prediction of inflammatory bowel disease relapses, both in patients with ulcerative colitis (UC) and Crohn's disease (CD), in a large, long-term, follow-up study. METHODS:The prospective multicenter study include...

journal_title：Inflammatory bowel diseases

authors： Gisbert JP,Bermejo F,Pérez-Calle JL,Taxonera C,Vera I,McNicholl AG,Algaba A,López P,López-Palacios N,Calvo M,González-Lama Y,Carneros JA,Velasco M,Maté J

更新日期：2009-08-01 00:00:00

abstract：BACKGROUND:There is a recognized association between pediatric inflammatory bowel disease (IBD) and cerebral thromboembolic events (CTEs). Historical reporting had described the association as strongest between ulcerative colitis (UC), rather than Crohn's disease (CD). We describe the incidence and outcome of CTE in pe...

journal_title：Inflammatory bowel diseases

authors： Barclay AR,Keightley JM,Horrocks I,Garrick V,McGrogan P,Russell RK

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND:Patients suffering from Crohn's disease (CD) show increased incidence of low bone mineral density. Investigating this complication is difficult because the exact etiology of CD remains elusive. Mice carrying a deletion in the tumor necrosis factor (TNF) AU-rich elements (ARE) are reported as a model for huma...

journal_title：Inflammatory bowel diseases

authors： Huybers S,Apostolaki M,van der Eerden BC,Kollias G,Naber TH,Bindels RJ,Hoenderop JG

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND:The incidence of pediatric inflammatory bowel disease (IBD) around the world is increasing. However, there is a scarcity of data on the epidemiology of pediatric IBD in the Southern Hemisphere. This study aimed to document the point prevalence of pediatric IBD in New Zealand on June 30, 2015. METHODS:All pa...

journal_title：Inflammatory bowel diseases

authors： Lopez RN,Evans HM,Appleton L,Bishop J,Chin S,Mouat S,Gearry RB,Day AS

更新日期：2017-08-01 00:00:00

abstract：:Lymphocyte migration is at the heart of chronic inflammatory ailments, including inflammatory bowel disease (IBD). Whereas naïve lymphocytes migrate to all secondary lymphoid organs, they are mostly excluded from nonlymphoid peripheral tissues. Upon activation, lymphocytes change their pattern of adhesion receptors an...

journal_title：Inflammatory bowel diseases

authors： Mora JR

更新日期：2008-02-01 00:00:00

abstract：BACKGROUND:VSL#3 is a probiotic compound that has been used in the treatment of inflammatory bowel disease. T-cell protein tyrosine phosphatase (TCPTP) is the protein product of the inflammatory bowel disease candidate gene, PTPN2, and we have previously shown that it protects epithelial barrier function. The aim of th...

journal_title：Inflammatory bowel diseases

authors： Krishnan M,Penrose HM,Shah NN,Marchelletta RR,McCole DF

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:The genetic influence on disease course in inflammatory bowel disease (IBD) remains unknown. We therefore aimed to study longitudinal concordance for clinical characteristics and longitudinal stability using the Montreal Classification in an IBD twin population. METHODS:A total of 158 twins with ulcerative ...

journal_title：Inflammatory bowel diseases

authors： Halfvarson J,Jess T,Bodin L,Järnerot G,Munkholm P,Binder V,Tysk C

更新日期：2007-12-01 00:00:00

abstract：BACKGROUND:Substance use disorders (SUDs) impose a substantial individual and societal burden; however, the prevalence and associated factors in persons with inflammatory bowel disease (IBD) are largely unknown. We evaluated the prevalence and risk factors of SUD in an IBD cohort. METHODS:Inflammatory bowel disease pa...

journal_title：Inflammatory bowel diseases

authors： Carney H,Marrie RA,Bolton JM,Patten SB,Graff LA,Bernstein CN,Kowalec K

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:Surgery is the preferred option for patients with symptomatic localized fibrostenotic ileocecal Crohn's disease (CD) but not for those with predominantly active inflammation without obstruction. The benefit of early surgery in patients with a limited nonstricturing ileocecal CD over biologic treatment is sti...

journal_title：Inflammatory bowel diseases

authors： Broide E,Eindor-Abarbanel A,Naftali T,Shirin H,Shalem T,Richter V,Matalon S,Leshno M

更新日期：2020-10-23 00:00:00

abstract：BACKGROUND:Chronic ulcerative colitis (UC) is associated with an increased colorectal cancer risk which may be secondary to repetitive mucosal injury. Both epigenetic methylation and the classic adenoma-to-carcinoma sequence have been implicated in this malignant transformation, but the underlying molecular mechanisms ...

journal_title：Inflammatory bowel diseases

authors： Sanchez JA,Dejulius KL,Bronner M,Church JM,Kalady MF

更新日期：2011-09-01 00:00:00

abstract：:As the frontiers of immunological research expand, new insights into the pathogenesis of long poorly understood diseases, such as inflammatory bowel disease (IBD), are opening up new possible avenues for treatment. Myeloid-derived cells (i.e., monocytes, macrophages, neutrophils, and dendritic cells), long believed to...

journal_title：Inflammatory bowel diseases

authors： Leal MC,Däbritz J

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:The widespread use of the Internet allows for unique research opportunities. We aimed to develop and follow an Internet-based cohort (e-cohort) of patients with self-reported inflammatory bowel diseases (IBD) over time. METHODS:We established an e-cohort of adults with IBD (CCFA Partners) by recruiting thro...

journal_title：Inflammatory bowel diseases

authors： Long MD,Kappelman MD,Martin CF,Lewis JD,Mayer L,Kinneer PM,Sandler RS

更新日期：2012-11-01 00:00:00

abstract：:After 20 years of successful targeting of pro-inflammatory cytokines for the treatment of IBD, an alternative therapeutic strategy has emerged, based on several decades of advances in understanding the pathogenesis of IBD. The targeting of molecules involved in leukocyte traffic has recently become a safe and effectiv...

journal_title：Inflammatory bowel diseases

authors： Pérez-Jeldres T,Tyler CJ,Boyer JD,Karuppuchamy T,Bamias G,Dulai PS,Boland BS,Sandborn WJ,Patel DR,Rivera-Nieves J

更新日期：2019-01-10 00:00:00

abstract：BACKGROUND:Our objectives were to assess the differences in perforating disease behavior, disease severity, and extraintestinal manifestations (EIM) in patients with Crohn's disease (CD) by race. MATERIALS AND METHODS:We identified outpatients with CD evaluated at the University of Maryland Gastroenterology Faculty Pr...

journal_title：Inflammatory bowel diseases

authors： Cross RK,Jung C,Wasan S,Joshi G,Sawyer R,Roghmann MC

更新日期：2006-03-01 00:00:00

abstract：BACKGROUND:Inflammatory bowel diseases (IBDs) are characterized by various degrees of mucosal surface damage and subsequent impairment of the intestinal barrier function. Resealing of the epithelial barrier requires intestinal cell migration and proliferation. Galectins are increasingly recognized as novel regulators o...

journal_title：Inflammatory bowel diseases

authors： Paclik D,Lohse K,Wiedenmann B,Dignass AU,Sturm A

更新日期：2008-10-01 00:00:00

abstract：BACKGROUND:Infliximab levels have been reported to be associated with mucosal healing (MH) in Crohn's disease (CD). However, whether the association differs between postinduction (week 14) and maintenance (week 30) has seldom been investigated. We aimed to analyze the association between serum infliximab trough levels ...

journal_title：Inflammatory bowel diseases

authors： Feng T,Chen B,Ungar B,Qiu Y,Zhang S,He J,Lin S,He Y,Zeng Z,Ben-Horin S,Chen M,Mao R

更新日期：2019-10-18 00:00:00

abstract：BACKGROUND:Fatigue is highly prevalent among patients with inflammatory bowel disease (IBD) and may have an unfavorable impact on quality of life (QoL). The IBD-Fatigue scale (with components SCORE1 and SCORE2) is a recently developed disease-specific questionnaire. We sought to validate a Greek version of IBD-F and us...

journal_title：Inflammatory bowel diseases

authors： Varbobitis I,Kokkotis G,Gizis M,Perlepe N,Laoudi E,Bletsa M,Bekiari D,Koutsounas I,Kounadis G,Xourafas V,Lagou S,Kolios G,Papakonstantinou I,Bamias G

更新日期：2020-08-07 00:00:00

abstract：Background:Clinical trials investigating the use of cannabinoid drugs for the treatment of intestinal inflammation are anticipated secondary to preclinical literature demonstrating efficacy in reducing inflammation. Methods:We systematically reviewed publications on the benefit of drugs targeting the endo-cannabinoid ...

journal_title：Inflammatory bowel diseases

authors： Couch DG,Maudslay H,Doleman B,Lund JN,O'Sullivan SE

更新日期：2018-03-19 00:00:00

abstract：:: We evaluated retrospective smoking data reported by 221 patients with ulcerative colitis in 1984 and repeated in an identical questionnaire in 1989. Reported years of smoking initiation or smoking cessation agreed to a high extent; the difference between the two questionnaires was in mean (± SD) -0.1 ± 1.5 (median, ...

journal_title：Inflammatory bowel diseases

authors： Tysk C,Järnerot G

更新日期：1995-07-01 00:00:00

abstract：Background:Suicide is a leading cause of death worldwide. Transition from suicidal ideation (SI) to suicide attempt is high within a year of SI onset. The risk of suicide and SI is elevated in persons with inflammatory bowel disease (IBD) versus the general population. We aimed to validate the Patient Heath Questionnai...

journal_title：Inflammatory bowel diseases

authors： Litster B,Bernstein CN,Graff LA,Walker JR,Fisk JD,Patten SB,Bolton JM,Sareen J,El-Gabalawy R,Marrie RA

更新日期：2018-07-12 00:00:00

abstract：OBJECTIVES:Studies aimed at establishing which characteristics of patients with ulcerative proctitis could be predictive of the extension of inflammation have failed to provide conclusive results. The aim of the study was to evaluate the prognostic role of clinical and therapeutic parameters in patients with proctitis....

journal_title：Inflammatory bowel diseases

authors： Pica R,Paoluzi OA,Iacopini F,Marcheggiano A,Crispino P,Rivera M,Bella A,Consolazio A,Paoluzi P

更新日期：2004-11-01 00:00:00

abstract：BACKGROUND:Multi-matrix (MMx), a new delivery system for mesalazine, seems to release 5-aminosalicyclic acid (5-ASA) preferentially in the sigmoid colon. This study had 2 objectives: (1) to evaluate the therapeutic response to MMx in patients with active left-sided disease and (2) to gain additional insights as to how ...

journal_title：Inflammatory bowel diseases

authors： Prantera C,Viscido A,Biancone L,Francavilla A,Giglio L,Campieri M

更新日期：2005-05-01 00:00:00

abstract：BACKGROUND:As the American population is aging, the number of older people with inflammatory bowel disease is increasing. We used clinical data from the Sinai-Helmsley Alliance for Research Excellence (SHARE), a prospective cohort, to examine disease and treatment differences in older adults. METHODS:We performed a cr...

journal_title：Inflammatory bowel diseases

authors： Kochar B,Long MD,Galanko J,Raffals LE,Ananthakrishnan A,Sandler RS

更新日期：2017-07-01 00:00:00

abstract：:Focal infection theory posits that periodontal pathobionts play a causal role in initiating or exacerbating diseases. Periodontal disease is a common inflammatory, multifactorial disease of the periodontal tissues. The main factor for inflammation is mature dental plaque with the presence of pathogens in the microbial...

journal_title：Inflammatory bowel diseases

authors： Barta Z

更新日期：2020-01-06 00:00:00

abstract：:: Pericarditis occurs rarely in association with inflammatory bowel disease. Because life-threatening complications may occur, pericarditis should be suspected in patients who present with chest symptoms. We report the case of a 28-year-old patient with ulcerative colitis who presented with pericarditis during an acti...

journal_title：Inflammatory bowel diseases

authors： Hinterreiter M,Allinger S,Punzengruber C,Knoflach P

更新日期：1995-10-01 00:00:00

abstract：:Induction and maintenance of remission, mucosal healing, the avoidance of surgical intervention, and decreasing the likelihood of cancer developing are the primary therapeutic goals in ulcerative colitis (UC). For the traditional therapies, 5-aminosalicylic acid (including mesalamine), corticosteroids, and thiopurines...

journal_title：Inflammatory bowel diseases

authors： Ng SC,Kamm MA

更新日期：2009-06-01 00:00:00