Abstract:
OBJECTIVES:Studies aimed at establishing which characteristics of patients with ulcerative proctitis could be predictive of the extension of inflammation have failed to provide conclusive results. The aim of the study was to evaluate the prognostic role of clinical and therapeutic parameters in patients with proctitis. PATIENTS AND METHODS:Case records of 138 patients with ulcerative proctitis were retrospectively evaluated. The following parameters were considered: gender; age at onset of disease; smoking habits; histologic severity of disease at onset; mean number of clinical relapses of disease per year; mean duration of oral and topical mesalazine treatment; and number of topical corticosteroid treatments per year. RESULTS:Twenty-eight patients were excluded from the analysis for different reasons. During follow-up, inflammation spread proximally in 33 of 110 patients (30%). Patients with extended proctitis showed a significantly higher number of relapses and a shorter duration of oral mesalazine treatment than patients with nonprogressive proctitis (p < 0.001 for both). The multivariate analysis also found that the mean duration of topical mesalazine treatment was longer in patients with extended proctitis. CONCLUSIONS:Ulcerative proctitis patients with more frequent relapses who need a longer duration of topical therapy are at higher risk of extension of the disease, while a more prolonged oral mesalazine treatment period protects against the proximal spread of rectal inflammation.
journal_name
Inflamm Bowel Disjournal_title
Inflammatory bowel diseasesauthors
Pica R,Paoluzi OA,Iacopini F,Marcheggiano A,Crispino P,Rivera M,Bella A,Consolazio A,Paoluzi Pdoi
10.1097/00054725-200411000-00006keywords:
subject
Has Abstractpub_date
2004-11-01 00:00:00pages
731-6issue
6eissn
1078-0998issn
1536-4844pii
00054725-200411000-00006journal_volume
10pub_type
杂志文章abstract:BACKGROUND:If dysplasia is found on biopsies during surveillance colonoscopy for ulcerative colitis (UC), many experts recommend colectomy given the substantial risk of synchronous colon cancer. The objective was to learn if UC patients' perceptions of their colon cancer risk and if their preferences for elective colec...
journal_title:Inflammatory bowel diseases
pub_type: 杂志文章,多中心研究
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更新日期:2010-10-01 00:00:00
abstract::The last 12 months have seen unprecedented progress in identifying the susceptibility genes that predispose to common disease in general and Crohn's disease in particular. Success has derived from the new technique of genome-wide association scanning in large panels of cases and controls. This has itself been made pos...
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pub_type: 杂志文章,评审
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journal_title:Inflammatory bowel diseases
pub_type: 临床试验,杂志文章,随机对照试验
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abstract:OBJECTIVE:Our goal in this multicentric prospective study was 2-fold: first, to test the diagnostic accuracy of ultrasound, color Doppler imaging (CDI), and contrast-enhanced ultrasound (CEUS) in identifying disease activity in patients with Crohn's disease (CD) compared with endoscopy as the reference standard; and, s...
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journal_title:Inflammatory bowel diseases
pub_type: 杂志文章
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更新日期:1997-01-01 00:00:00
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更新日期:2008-10-01 00:00:00
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journal_title:Inflammatory bowel diseases
pub_type: 杂志文章
doi:10.1097/MIB.0000000000000129
更新日期:2014-09-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2013-03-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2017-12-01 00:00:00
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journal_title:Inflammatory bowel diseases
pub_type: 杂志文章
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更新日期:2014-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/ibd.21254
更新日期:2010-09-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章
doi:10.1093/ibd/izaa064
更新日期:2020-08-20 00:00:00
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journal_title:Inflammatory bowel diseases
pub_type: 杂志文章
doi:10.1002/ibd.21586
更新日期:2011-10-01 00:00:00
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journal_title:Inflammatory bowel diseases
pub_type: 杂志文章
doi:10.1097/00054725-199808000-00003
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pub_type: 杂志文章
doi:10.1002/ibd.20022
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pub_type: 杂志文章,meta分析,评审
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更新日期:2017-02-01 00:00:00
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journal_title:Inflammatory bowel diseases
pub_type: 杂志文章
doi:10.1093/ibd/izaa080
更新日期:2020-05-09 00:00:00
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journal_title:Inflammatory bowel diseases
pub_type: 杂志文章
doi:10.1002/ibd.20992
更新日期:2010-02-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2016-12-01 00:00:00
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journal_title:Inflammatory bowel diseases
pub_type: 杂志文章
doi:10.1097/MIB.0000000000000773
更新日期:2016-06-01 00:00:00
abstract:BACKGROUND:Mesalazine preparations are widely used to treat mild to moderately severe ulcerative colitis (UC). We compared once-daily administration of oral mesalazine in patients with quiescent UC with the established 3-times-daily prescription, assessing the efficacy and safety of each method in maintaining remission...
journal_title:Inflammatory bowel diseases
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1097/MIB.0b013e318286fa3d
更新日期:2013-07-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1002/ibd.22977
更新日期:2013-02-01 00:00:00
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journal_title:Inflammatory bowel diseases
pub_type: 杂志文章
doi:10.1097/00054725-200401000-00001
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND:There has been a remarkable increase in the incidence of Crohn's disease (CD) among Arabs in recent years. We conducted this study to determine the clinical epidemiology of CD in Kuwait. METHODS:Sociodemographic and clinical information was collected for a continuous series of 206 Arab patients with CD and ...
journal_title:Inflammatory bowel diseases
pub_type: 杂志文章
doi:10.1002/ibd.21890
更新日期:2012-09-01 00:00:00