Adherence to anti-TNF therapy in inflammatory bowel diseases: a systematic review.


BACKGROUND:Nonadherence to medications may affect disease outcomes. The aim of this article was to review methods of assessment, prevalence, and predictors of nonadherence to anti-tumor necrosis factor therapy in inflammatory bowel diseases (IBD). METHODS:Studies were identified through the electronic database of MEDLINE (up to January 2012) and the annual meetings of Digestive Disease Week, the American College of Gastroenterology, the United European Gastroenterology Week, and the European Crohn's and Colitis Organization. RESULTS:Among 1783 citations identified, 13 studies evaluated adherence to biologics in IBD. Several methods were used to assess adherence to anti-tumor necrosis factor, including the medication possession ratio, the medication refill adherence, and the Morisky Medication Adherence Scale 8. Pooled adherence to anti-tumor necrosis factor therapy was 82.6%. Pooled adherence was 83.1% in adalimumab and 70.7% in infliximab-treated patients. Female gender, smoking, constraints related to treatment, anxiety, and moodiness were associated with nonadherence to both infliximab and adalimumab. Concomitant immunomodulator use and time since first infusion more than 18 weeks were predictors for nonadherence to infliximab . Regimen of 40 mg every other week, syringe use (versus pen), internal medicine center prescription (versus gastroenterology center prescription), retail pharmacy (versus speciality pharmacy) and new user (versus previous user) were predictors for adalimumab nonadherence. CONCLUSIONS:More than three-quarters of patients with IBD adhere to biologics. Predictors of nonadherence include female gender, smoking, constraints related to treatment, anxiety, and moodiness. These data could be used to develop intervention studies aimed at improving adherence to biologics in IBD.


Inflamm Bowel Dis


Lopez A,Billioud V,Peyrin-Biroulet C,Peyrin-Biroulet L




Has Abstract


2013-06-01 00:00:00












  • Inhibition of Interleukin-10 Signaling Induces Microbiota-dependent Chronic Colitis in Apolipoprotein E Deficient Mice.

    abstract:BACKGROUND:Apolipoprotein E (ApoE) mediates potent antiinflammatory and immunomodulatory properties in addition to its roles in regulating cholesterol transport and metabolism. However, its role in the intestine, specifically during inflammation, is largely unknown. METHODS:Mice (C57BL/6 or ApoE-deficient [ApoE-KO] mi...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Singh V,Kumar M,San Yeoh B,Xiao X,Saha P,Kennett MJ,Vijay-Kumar M

    更新日期:2016-04-01 00:00:00

  • A genome-wide search identifies potential new susceptibility loci for Crohn's disease.

    abstract::Chronic inflammatory bowel disease (IBD) presents as two major clinical forms, Crohn's disease (CD) and ulcerative colitis (UC). Genetic epidemiological studies and animal models suggest that inherited factors play significant roles in the susceptibility to both forms of IBD. From four genome-wide scans, putative susc...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Ma Y,Ohmen JD,Li Z,Bentley LG,McElree C,Pressman S,Targan SR,Fischel-Ghodsian N,Rotter JI,Yang H

    更新日期:1999-11-01 00:00:00

  • CD68 expression is markedly different in Crohn's disease and the colitis associated with chronic granulomatous disease.

    abstract:BACKGROUND:Chronic granulomatous disease (CGD) is a rare inherited immunodeficiency disorder characterized by inability of phagocytes to kill certain bacteria and fungi. Histology from colon biopsies of CGD patients have shown the presence of inflammation and granulomas, almost indistinguishable from the findings seen ...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Liu S,Russo PA,Baldassano RN,Sullivan KE

    更新日期:2009-08-01 00:00:00

  • Use of thiopurine testing in the management of inflammatory bowel diseases in clinical practice: a worldwide survey of experts.

    abstract:BACKGROUND:We performed a worldwide survey to evaluate the extent to which gastroenterologists who are experts in the field of inflammatory bowel diseases (IBDs) are utilizing thiopurine metabolism in practice. METHODS:This was a Web-based cross-sectional survey consisting of 12 multiple-choice and open-ended question...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Roblin X,Oussalah A,Chevaux JB,Sparrow M,Peyrin-Biroulet L

    更新日期:2011-12-01 00:00:00

  • Healing of intestinal inflammation by IL-22.

    abstract::An interleukin (IL)-10 family cytokine, IL-22 is characterized by several unique biological properties, including 1) the target restricted to innate cells; 2) the distinct expression pattern between large and small intestines; 3) alteration of the cellular source depending on several factors; 4) the dual abilities to ...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章,评审


    authors: Mizoguchi A

    更新日期:2012-09-01 00:00:00

  • Thiazolidinedione use and ulcerative colitis-related flares: an exploratory analysis of administrative data.

    abstract:BACKGROUND:Recent animal studies and clinical trials suggest that thiazolidinediones, a class of oral antidiabetic agents, are efficacious in reducing inflammation, yet no studies have evaluated their effectiveness in preventing flares. We examined the association between thiazolidinedione use and ulcerative colitis (U...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Lund JL,Stürmer T,Porter CQ,Sandler RS,Kappelman MD

    更新日期:2011-03-01 00:00:00

  • Accelerated Infliximab Dosing Increases 30-Day Colectomy in Hospitalized Ulcerative Colitis Patients: A Propensity Score Analysis.

    abstract:Background:Standard outpatient induction dosing of infliximab (IFX) may not be effective in hospitalized ulcerative colitis (UC) patients with higher inflammatory burden and colectomy risk. Our aim was to determine whether initial IFX induction dose affects 30-day colectomy rate and other disease-related outcomes. Met...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Shah SC,Naymagon S,Panchal HJ,Sands BE,Cohen BL,Dubinsky MC

    更新日期:2018-02-15 00:00:00

  • Human β-defensin 3 peptide is increased and redistributed in Crohn's ileitis.

    abstract:BACKGROUND:Antimicrobial peptides (AMPs) maintain a sterile environment in intestinal crypts, limiting microbial colonization and invasion. Decreased AMP expression is proposed to increase the risk for inflammatory bowel disease. Expression and function of inducible AMPs, human β-defensin 2 and 3 (hBD-2 and hBD-3), rem...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Meisch JP,Nishimura M,Vogel RM,Sung HC,Bednarchik BA,Ghosh SK,Fu P,McCormick T,Weinberg A,Levine AD

    更新日期:2013-04-01 00:00:00

  • Clinical epidemiology of inflammatory bowel disease in Lebanon.

    abstract:BACKGROUND:The objectives of this study were to determine the prevalence and incidence of inflammatory bowel disease (IBD) in a representative Lebanese cohort and to describe practice prevalence trends, disease characteristics, and impact on quality of life (QoL) of IBD patients in Lebanon. METHODS:All of a university...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Abdul-Baki H,ElHajj I,El-Zahabi LM,Azar C,Aoun E,Zantout H,Nasreddine W,Ayyach B,Mourad FH,Soweid A,Barada KA,Sharara AI

    更新日期:2007-04-01 00:00:00

  • Proteomic profiling of mucosal and submucosal colonic tissues yields protein signatures that differentiate the inflammatory colitides.

    abstract:BACKGROUND:Differentiating ulcerative colitis (UC) from Crohn's colitis (CC) can be difficult and may lead to inaccurate diagnoses in up to 30% of inflammatory bowel disease (IBD) patients. Much of the diagnostic uncertainty arises from the overlap of clinical and histologic features. Matrix-assisted laser desorption/i...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: M'Koma AE,Seeley EH,Washington MK,Schwartz DA,Muldoon RL,Herline AJ,Wise PE,Caprioli RM

    更新日期:2011-04-01 00:00:00

  • Impact of prior irregular infliximab dosing on performance of long-term infliximab maintenance therapy in Crohn's disease.

    abstract:BACKGROUND:Infliximab is efficacious in the management of moderate to severe Crohn's disease (CD). There are limited data regarding performance of infliximab in patients who require reinitiation of maintenance dosing following previous irregular exposure. METHODS:This was a retrospective, observational study of CD pat...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Stein DJ,Ananthakrishnan AN,Issa M,Williams JB,Beaulieu DB,Zadvornova Y,Ward A,Johnson K,Knox JF,Skaros S,Binion DG

    更新日期:2010-07-01 00:00:00

  • Risk Factors and Clinical Outcomes Associated with Cytomegalovirus Colitis in Patients with Acute Severe Ulcerative Colitis.

    abstract:BACKGROUND:Cytomegalovirus (CMV) colitis can contribute to an unfavorable outcome of acute severe ulcerative colitis (ASUC). The purpose of this study was to evaluate the clinical outcomes of ASUC according to the CMV status and identify risk factors for CMV colitis in patients with ASUC. METHODS:We retrospectively an...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Lee HS,Park SH,Kim SH,Kim J,Choi J,Lee HJ,Kim WS,Lee JM,Kwak MS,Hwang SW,Yang DH,Kim KJ,Ye BD,Byeon JS,Myung SJ,Yoon YS,Yu CS,Kim JH,Yang SK

    更新日期:2016-04-01 00:00:00

  • IBD Systems Biology Is Here to Stay.

    abstract:BACKGROUND:Systems biology is a rapidly advancing field of science that allows us to look into disease mechanisms, patient diagnosis and stratification, and drug development in a completely new light. It is based on the utilization of unbiased computational systems free of the traditional experimental approaches based ...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Fiocchi C,Iliopoulos D

    更新日期:2021-01-13 00:00:00

  • Quantitative phenotyping of inflammatory bowel disease in the IL-10-deficient mouse by use of noninvasive magnetic resonance imaging.

    abstract:BACKGROUND:Although magnetic resonance imaging (MRI) is an increasingly used diagnostic tool in the assessment of inflammatory bowel disease (IBD) in humans, diagnosis and quantitation of intestinal inflammation in animal models of IBD still depends on ex vivo techniques. The aim of this study was to evaluate whether h...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Michael S,Keubler LM,Smoczek A,Meier M,Gunzer F,Pöhlmann C,Krause-Buchholz U,Hedrich HJ,Bleich A

    更新日期:2013-01-01 00:00:00

  • Impacts of long-term enteral nutrition on clinical and endoscopic disease activities and mucosal cytokines during remission in patients with Crohn's disease: a prospective study.

    abstract:BACKGROUND:Long-term enteral nutrition may maintain clinical and endoscopic remission in patients with Crohn's disease (CD). The aim of this prospective study was to investigate the impacts of long-term enteral nutrition on clinical and endoscopic disease activities and mucosal tissue cytokines in patients with quiesce...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Yamamoto T,Nakahigashi M,Saniabadi AR,Iwata T,Maruyama Y,Umegae S,Matsumoto K

    更新日期:2007-12-01 00:00:00

  • Severe Legionella pneumophila pneumonia following infliximab therapy in a patient with Crohn's disease.

    abstract:BACKGROUND:Immunosuppressive therapy with anti-TNF-alpha antibodies is effective in patients with inflammatory bowel disease (IBD). However, there is an increased risk for infections associated with this therapy. METHODS:Here, we report the case of a 58-year-old patient with Crohn's disease (CD) treated with steroids ...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Beigel F,Jürgens M,Filik L,Bader L,Lück C,Göke B,Ochsenkühn T,Brand S,Seiderer J

    更新日期:2009-08-01 00:00:00

  • When should ulcerative colitis patients undergo colectomy for dysplasia? Mismatch between patient preferences and physician recommendations.

    abstract:BACKGROUND:If dysplasia is found on biopsies during surveillance colonoscopy for ulcerative colitis (UC), many experts recommend colectomy given the substantial risk of synchronous colon cancer. The objective was to learn if UC patients' perceptions of their colon cancer risk and if their preferences for elective colec...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章,多中心研究


    authors: Siegel CA,Schwartz LM,Woloshin S,Cole EB,Rubin DT,Vay T,Baars J,Sands BE

    更新日期:2010-10-01 00:00:00

  • Escalation of Immunosuppressive Therapy for Inflammatory Bowel Disease Is Not Associated With Adverse Outcomes After Infection With Clostridium difficile.

    abstract:BACKGROUND:Clostridium difficile infection (CDI) is common in patients with inflammatory bowel disease (IBD), often leading to diagnostic confusion and delays in IBD therapy escalation. This study sought to assess outcomes after CDI in IBD patients exposed to new or escalated immunosuppressive therapy. METHODS:This mu...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章,多中心研究


    authors: Lukin DJ,Lawlor G,Hudesman DP,Durbin L,Axelrad JE,Passi M,Cavaliere K,Coburn E,Loftus M,Jen H,Feathers A,Rosen MH,Malter LB,Swaminath A,IBD-ReMEdY Study (Research, Mentoring, Education New York).

    更新日期:2019-03-14 00:00:00

  • Crohn's disease is associated with restless legs syndrome.

    abstract:BACKGROUND:Extraintestinal manifestations of Crohn's disease (CD) have not previously included the central nervous system (CNS). Restless legs syndrome (RLS) is a CNS disorder that is either idiopathic or secondary to a number of diseases. The aim of this study was to determine if RLS was associated with CD because bot...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Weinstock LB,Bosworth BP,Scherl EJ,Li E,Iroku U,Munsell MA,Mullin GE,Walters AS

    更新日期:2010-02-01 00:00:00

  • Enterotoxigenic bacteroides fragilis: a potential instigator of colitis.

    abstract:BACKGROUND:Inflammatory bowel disease (IBD) is proposed to result from a dysregulated mucosal immune response to the colonic flora in genetically susceptible individuals. Enterotoxigenic Bacteroides fragilis (ETBF), a molecular subclass of the common human commensal, B. fragilis, has been associated with IBD. This stud...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Rabizadeh S,Rhee KJ,Wu S,Huso D,Gan CM,Golub JE,Wu X,Zhang M,Sears CL

    更新日期:2007-12-01 00:00:00

  • Using optical markers of nondysplastic rectal epithelial cells to identify patients with ulcerative colitis-associated neoplasia.

    abstract:BACKGROUND:Current surveillance guidelines for patients with long-standing ulcerative colitis (UC) recommend repeated colonoscopy with random biopsies, which is time-consuming, discomforting, and expensive. A less invasive strategy is to identify neoplasia by analyzing biomarkers from the more accessible rectum to pred...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Bista RK,Brentnall TA,Bronner MP,Langmead CJ,Brand RE,Liu Y

    更新日期:2011-12-01 00:00:00

  • A Critical Role for Monocytes/Macrophages During Intestinal Inflammation-associated Lymphangiogenesis.

    abstract:BACKGROUND:Inflammation-associated lymphangiogenesis (IAL) is frequently observed in inflammatory bowel diseases. IAL is believed to limit inflammation by enhancing fluid and immune cell clearance. Although monocytes/macrophages (MΦ) are known to contribute to intestinal pathology in inflammatory bowel disease, their r...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Becker F,Kurmaeva E,Gavins FN,Stevenson EV,Navratil AR,Jin L,Tsunoda I,Orr AW,Alexander JS,Ostanin DV

    更新日期:2016-06-01 00:00:00

  • Providing disease-related information worsens health-related quality of life in inflammatory bowel disease.

    abstract:BACKGROUND:Patients with inflammatory bowel disease (IBD) have identified a need for more information about their disease. PURPOSE:To assess the effect of an educational intervention on health-related quality of life (HRQOL) in patients with IBD. METHODS:Consecutive ambulatory IBD patients were randomized to receive ...

    journal_title:Inflammatory bowel diseases

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Borgaonkar MR,Townson G,Donnelly M,Irvine EJ

    更新日期:2002-07-01 00:00:00

  • Site organization and management.

    abstract::The principal investigator is responsible for everything involved in the conduct of a clinical research study. Prior to the initiation of any clinical trial, an investigator must become acquainted with the material requirements, personnel needs, and best practices involved in the conduct of the trial. Commitment to a ...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Wolf DC,Katz S,Safdi MA,Sandler RS,Lewis JD

    更新日期:2005-11-01 00:00:00

  • Sarcopenia and Inflammatory Bowel Disease: A Systematic Review.

    abstract:Background:Sarcopenia is associated with increased morbidity and mortality in oncologic and transplant surgery. It has a high incidence in chronic inflammatory states including inflammatory bowel disease (IBD). The validity of existing data in IBD and of sarcopenia's correlation with surgical outcomes is limited. Meth...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Ryan E,McNicholas D,Creavin B,Kelly ME,Walsh T,Beddy D

    更新日期:2019-01-01 00:00:00

  • Fecal excretion of deoxyribonucleic acid in long-term follow-up of patients with inactive ulcerative colitis.

    abstract:BACKGROUND:We have developed a technique for measuring fecal excretion of human DNA by assuming that luminal desquamation of epithelial and inflammatory cells increases in damaged colonic mucosa. However, the clinical usefulness of this technique in the follow-up of patients with ulcerative colitis has not been establi...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Casellas F,Borruel N,Antolín M,Varela E,Torrejón A,Armadans L,Guarner F,Malagelada JR

    更新日期:2007-04-01 00:00:00

  • Guide to endoscopy of the ileo-anal pouch following restorative proctocolectomy with ileal pouch-anal anastomosis; indications, technique, and management of common findings.

    abstract::Restorative proctocolectomy (RPC) with ileal pouch-anal anastomosis is the surgical procedure of choice for patients with ulcerative colitis (UC). It is also performed in selected patients with familial adenomatous polyposis (FAP). A significant proportion of patients will develop pouch dysfunction. Flexible pouchosco...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章,实务指引,评审


    authors: McLaughlin SD,Clark SK,Thomas-Gibson S,Tekkis PP,Ciclitira PJ,Nicholls RJ

    更新日期:2009-08-01 00:00:00

  • Outcomes of Perianal Fistulising Crohn's Disease Following Anti-TNFα Treatment Discontinuation.

    abstract:Background:Discontinuation of antitumour necrosis factor (TNF)α therapy with perianal fistulising Crohn's disease remains controversial due to the risk of severe relapse without any clear evidence. Aim:The aim of this study was to assess the rate and type of perianal and luminal relapses following anti-TNFα discontinu...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Legué C,Brochard C,Bessi G,Wallenhorst T,Dewitte M,Siproudhis L,Bouguen G

    更新日期:2018-05-18 00:00:00

  • Chromoendoscopy versus narrow band imaging for colonic surveillance in inflammatory bowel disease.

    abstract:BACKGROUND:Mucosal dye spraying (chromoendoscopy [CE]) has been shown in controlled studies to enhance lesion detection in colitis surveillance. Narrow band imaging (NBI) potentially offers a more convenient mode of highlighting mucosal lesions. The primary objectives of this study were to compare CE and NBI in colitis...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Efthymiou M,Allen PB,Taylor AC,Desmond PV,Jayasakera C,De Cruz P,Kamm MA

    更新日期:2013-09-01 00:00:00

  • Metronidazole or Rifaximin for Treatment of Clostridium difficile in Pediatric Patients with Inflammatory Bowel Disease: A Randomized Clinical Trial.

    abstract:BACKGROUND:Interestingly, Clostridium difficile infection (CDI) worsens the course of inflammatory bowel disease (IBD); however, there is a paucity of data regarding the treatment of CDI in this group of patients. METHODS:This was a prospective, single-blind trial. Children with flare of IBD and CDI were randomly assi...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章,随机对照试验


    authors: Gawronska A,Banasiuk M,Lachowicz D,Pituch H,Albrecht P,Banaszkiewicz A

    更新日期:2017-12-01 00:00:00