Bacterial Mucosa-associated Microbiome in Inflamed and Proximal Noninflamed Ileum of Patients With Crohn's Disease.

abstract：BACKGROUND:Inflammatory bowel diseases (IBD) are believed to be driven by dysregulated interactions between the host and the gut microbiota. Our goal is to characterize and infer relationships between mucosal T cells, the host tissue environment, and microbial communities in patients with IBD who will serve as basis fo...

journal_title：Inflammatory bowel diseases

authors： Tang MS,Bowcutt R,Leung JM,Wolff MJ,Gundra UM,Hudesman D,Malter LB,Poles MA,Chen LA,Pei Z,Neto AG,Abidi WM,Ullman T,Mayer L,Bonneau RA,Cho I,Loke P

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND:Minimally invasive surgery for Crohn's ileocolitis is well established but few data exist regarding laparoscopic techniques for Crohn's colitis. We aimed to describe outcomes associated with minimally invasive surgery for Crohn's colitis, including predictors of conversion to laparotomy and postoperative com...

journal_title：Inflammatory bowel diseases

authors： Holubar SD,Dozois EJ,Privitera A,Pemberton JH,Cima RR,Larson DW

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND:Fecal biomarkers are used increasingly to monitor Crohn's disease (CD). However, the relative accuracy of different markers in identifying inflammation has been poorly evaluated. We evaluated fecal calprotectin (FC), lactoferrin (FL), and S100A12 (FS) using endoscopic validation in a prospective study of the...

journal_title：Inflammatory bowel diseases

authors： Wright EK,Kamm MA,De Cruz P,Hamilton AL,Ritchie KJ,Keenan JI,Leach S,Burgess L,Aitchison A,Gorelik A,Liew D,Day AS,Gearry RB

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:Evidence supports the role of adherent invasive Escherichia coli (AIEC) in the pathogenesis of inflammatory bowel disease (IBD). However, little is known about the phylogenetic structure and origin of this group of bacteria. Multi-locus sequence typing (MLST), and fimH sequence analysis were performed to elu...

journal_title：Inflammatory bowel diseases

authors： Sepehri S,Kotlowski R,Bernstein CN,Krause DO

更新日期：2009-11-01 00:00:00

abstract：BACKGROUND:Inflammatory bowel disease (IBD) has a remitting and relapsing disease course; however, relatively little is understood regarding how inflammatory damage in acute colitis influences the microbiota, epithelial barrier, and immune function in subsequent colitis. METHODS:Mice were administered trinitrobenzene ...

journal_title：Inflammatory bowel diseases

authors： Wardill HR,Choo JM,Dmochowska N,Mavrangelos C,Campaniello MA,Bowen JM,Rogers GB,Hughes PA

更新日期：2019-06-18 00:00:00

abstract：BACKGROUND:The aim of this study was to develop a shortened Crohn's Disease Activity Index (CDAI). METHODS:A short CDAI was developed retrospectively using patient-level data from four budesonide clinical trials to select variables from the full CDAI which best predicted health-related quality of life as measured by t...

journal_title：Inflammatory bowel diseases

authors： Thia K,Faubion WA Jr,Loftus EV Jr,Persson T,Persson A,Sandborn WJ

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Fatigue is highly prevalent among patients with inflammatory bowel disease (IBD) and may have an unfavorable impact on quality of life (QoL). The IBD-Fatigue scale (with components SCORE1 and SCORE2) is a recently developed disease-specific questionnaire. We sought to validate a Greek version of IBD-F and us...

journal_title：Inflammatory bowel diseases

authors： Varbobitis I,Kokkotis G,Gizis M,Perlepe N,Laoudi E,Bletsa M,Bekiari D,Koutsounas I,Kounadis G,Xourafas V,Lagou S,Kolios G,Papakonstantinou I,Bamias G

更新日期：2020-08-07 00:00:00

abstract：:Restorative proctocolectomy with ileal-pouch anal anastomosis (RPC) is the operation of choice for ulcerative colitis (UC) patients requiring surgery. It is also used for patients with familial adenomatous polyposis (FAP). Pouchitis accounts for 10% of pouch failures. It is an idiopathic inflammatory condition that ma...

journal_title：Inflammatory bowel diseases

authors： Landy J,Al-Hassi HO,McLaughlin SD,Knight SC,Ciclitira PJ,Nicholls RJ,Clark SK,Hart AL

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND:Previous systematic cumulative analyses of the placebo arm in ulcerative colitis (UC) were limited by the wide heterogeneity in the scores and definitions of response. We aimed at estimating the placebo rates of remission, response, and mucosal healing (MH) in phase 2 and 3 randomized placebo-controlled tria...

journal_title：Inflammatory bowel diseases

authors： Macaluso FS,Maida M,Ventimiglia M,Renna S,Cottone M,Orlando A

更新日期：2019-05-04 00:00:00

abstract：:Colitis-associated colorectal neoplasia (CRN) is a well-known complication of chronic inflammation of the colon either with ulcerative colitis (UC) or colonic Crohn's disease (CD). Studies have shown that inflammatory bowel disease (IBD) patients have an overall higher risk for colorectal dysplasia and cancer compared...

journal_title：Inflammatory bowel diseases

authors： Gaidos JK,Bickston SJ

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:Under experimental chronic inflammation, tumor necrosis factor (TNF)-alpha plays a role in damaging spleen marginal zone. This latter has a crucial function in mounting B cell-dependent immune responses against infections by encapsulated bacteria. In Crohn's disease (CD), a chronic inflammatory disorder wher...

journal_title：Inflammatory bowel diseases

authors： Di Sabatino A,Rosado MM,Cazzola P,Biancheri P,Tinozzi FP,Laera MR,Cantoro L,Vanoli A,Carsetti R,Corazza GR

更新日期：2008-05-01 00:00:00

abstract：:Nephrotoxicity has been described in some patients with inflammatory bowel disease (IBD) treated with 5-aminosalicylic acid (5-ASA). Studies with 5-ASA treatment in which serum creatinine or creatinine clearance was measured regularly show that nephrotoxicity is exceptional (mean rate of only 0.26% per patient-year). ...

journal_title：Inflammatory bowel diseases

authors： Gisbert JP,González-Lama Y,Maté J

更新日期：2007-05-01 00:00:00

abstract：BACKGROUND:Oral ferrous iron therapy may reinforce intestinal inflammation. One possible mechanism is by catalyzing the production of reactive oxygen species. We studied the effects of low-dose oral ferrous fumarate on intestinal inflammation and plasma redox status in dextran sulfate sodium (DSS)-induced colitis in ra...

journal_title：Inflammatory bowel diseases

authors： Erichsen K,Milde AM,Arslan G,Helgeland L,Gudbrandsen OA,Ulvik RJ,Berge RK,Hausken T,Berstad A

更新日期：2005-08-01 00:00:00

abstract：BACKGROUND:The incorporation of abstracts from scientific meetings into systematic reviews and practice guidelines may reduce publication bias and delays in implementing therapeutic interventions. METHODS:All abstracts of Phase III randomized controlled trials in inflammatory bowel disease accepted at Digestive Diseas...

journal_title：Inflammatory bowel diseases

authors： Kottachchi D,Nguyen GC

更新日期：2010-06-01 00:00:00

abstract：:Recent reports suggest that unfractionated heparin may be a useful adjunct in the treatment of inflammatory bowel disease (IBD). We report the successful use of subcutaneous unfractionated heparin to treat a moderate-to-severe flare of Crohn's disease during pregnancy, which was refractory to standard therapy. The pat...

journal_title：Inflammatory bowel diseases

authors： Prajapati DN,Newcomer JR,Emmons J,Abu-Hajir M,Binion DG

更新日期：2002-05-01 00:00:00

abstract：BACKGROUND AND AIMS:Poor sleep quality in Crohn's disease (CD) is associated with histologic activity and clinical relapse. We sought to characterize sleep dysfunction and determine the effect of poor sleep quality on risk for hospitalization and surgery. METHODS:Clinical data were collected for CD subjects including ...

journal_title：Inflammatory bowel diseases

authors： Sofia MA,Lipowska AM,Zmeter N,Perez E,Kavitt R,Rubin DT

更新日期：2020-07-17 00:00:00

abstract：Background:Sarcopenia is associated with increased morbidity and mortality in oncologic and transplant surgery. It has a high incidence in chronic inflammatory states including inflammatory bowel disease (IBD). The validity of existing data in IBD and of sarcopenia's correlation with surgical outcomes is limited. Meth...

journal_title：Inflammatory bowel diseases

authors： Ryan E,McNicholas D,Creavin B,Kelly ME,Walsh T,Beddy D

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Children with Crohn's disease (CD) suffer from malnutrition. Understanding substrate utilization during exercise may help patients with CD sustain a healthy active lifestyle without compromising nutrition. The aim of this study was to determine whether substrate utilization and bioavailability during exercis...

journal_title：Inflammatory bowel diseases

authors： Nguyen T,Ploeger HE,Obeid J,Issenman RM,Baker JM,Takken T,Parise G,Timmons BW

更新日期：2013-11-01 00:00:00

abstract：:Mesalamine has a well-established role in the management of ulcerative colitis. However, its role in the management of Crohn's disease (CD) is less clear. Studies evaluating its therapeutic value in CD have produced both positive and negative results. Meta-analyses have not clarified the situation, possibly because th...

journal_title：Inflammatory bowel diseases

authors： Hanauer SB

更新日期：2005-06-01 00:00:00

abstract：Background:The diagnostic work-up of pediatric irritable bowel syndrome (IBS) and functional abdominal pain-not otherwise specified (FAP-NOS) commonly includes invasive tests for discrimination from inflammatory bowel disease (IBD). As this carries a high burden on patients, an ongoing need exists for development of no...

journal_title：Inflammatory bowel diseases

authors： Bosch S,van Gaal N,Zuurbier RP,Covington JA,Wicaksono AN,Biezeveld MH,Benninga MA,Mulder CJ,de Boer NKH,de Meij TGJ

更新日期：2018-10-12 00:00:00

abstract：BACKGROUND:Many patients with Crohn's disease (CD) are treated with medications, including steroids, immunomodulators, and anti-tumor necrosis factor alpha (anti-TNF-α) agents, at the time of surgery. This study evaluated the effects of these medications on postoperative complications in CD patients. METHODS:This retr...

journal_title：Inflammatory bowel diseases

authors： Yu CS,Jung SW,Lee JL,Lim SB,Park IJ,Yoon YS,Kim CW,Yang SK,Ye BD,Park SH,Han M,Kim JC

更新日期：2019-08-20 00:00:00

abstract：BACKGROUND:Optimal levels of adalimumab (ADA) have not been defined according to the ultimate goal of inflammatory bowel disease treatment--histologic and/or endoscopic healing. The aim of this study was to assess the relationship between random serum ADA levels and histologic and endoscopic healing in patients with in...

journal_title：Inflammatory bowel diseases

authors： Yarur AJ,Jain A,Hauenstein SI,Quintero MA,Barkin JS,Deshpande AR,Sussman DA,Singh S,Abreu MT

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND:The pregnane X receptor (PXR/NR1I2) is an important regulator of xenobiotic metabolism and intestinal integrity. However, there are controversial studies on the role of PXR/NR1I2 in inflammatory bowel disease (IBD). We therefore initiated the largest analysis to date on PXR/NR1I2 gene variants in IBD patient...

journal_title：Inflammatory bowel diseases

authors： Glas J,Seiderer J,Fischer D,Tengler B,Pfennig S,Wetzke M,Beigel F,Olszak T,Weidinger M,Göke B,Ochsenkühn T,Folwaczny M,Müller-Myhsok B,Diegelmann J,Czamara D,Brand S

更新日期：2011-09-01 00:00:00

abstract：:Inflammatory bowel disease is associated with industrialization, and its incidence has increased markedly over time. The prospect of reversing these trends motivates the search for the agent(s) involved. Modernity entails several physical and behavioral modifications that compromise both the photosynthesis of cholecal...

journal_title：Inflammatory bowel diseases

authors： Palmer MT,Weaver CT

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:Several studies suggest an increased risk of venous and arterial thromboembolism (TE) in adults with inflammatory bowel disease (IBD) compared to the general population. We performed a systematic review of studies on incidence and characteristic of TE in children with IBD. METHODS:We searched Medline, LILAC...

journal_title：Inflammatory bowel diseases

authors： Lazzerini M,Bramuzzo M,Maschio M,Martelossi S,Ventura A

更新日期：2011-10-01 00:00:00

abstract：:MicroRNAs (miRNAs) are single-stranded RNA molecules, which influence the translation of messenger RNA and hence protein synthesis. The altered expression of miRNAs in disease states in cancer and autoimmune diseases including inflammatory bowel disease is providing new insights into disease pathogenesis. This underst...

journal_title：Inflammatory bowel diseases

authors： Whiteoak SR,Felwick R,Sanchez-Elsner T,Fraser Cummings JR

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND:Inflammatory bowel disease (IBD) affects people during their prime reproductive years. The thiopurines (6-mercaptopurine and azathioprine), commonly used for induction and maintenance of remission, are U.S. Food and Drug Administration (FDA) pregnancy category D, raising concern for fetal risk. We performed ...

journal_title：Inflammatory bowel diseases

authors： Akbari M,Shah S,Velayos FS,Mahadevan U,Cheifetz AS

更新日期：2013-01-01 00:00:00

abstract：Backgrounds:We sought to describe the outcomes of endoscopic therapy of luminal strictures in patients with Crohn's disease (CD) at a large tertiary referral center. Methods:All patients who had undergone endoscopic dilation of CD strictures between January 1, 1990 and November 30, 2013 were identified. Demographics, ...

journal_title：Inflammatory bowel diseases

authors： Shivashankar R,Edakkanambeth Varayil J,Scott Harmsen W,Faubion WA,Wong Kee Song LM,Bruining DH,Schroeder KW,Kisiel J,Loftus EV Jr,Coelho Prabhu N

更新日期：2018-06-08 00:00:00

abstract：BACKGROUND:Helicobacter pylori infection is associated with a lower risk of chronic autoimmune diseases including inflammatory bowel disease (IBD). H.pylori modulates the gastric immune response, decreasing the local inflammatory response to itself. In mice, chronic Salmonellatyphimurium infection induces colitis simil...

journal_title：Inflammatory bowel diseases

authors： Higgins PD,Johnson LA,Luther J,Zhang M,Sauder KL,Blanco LP,Kao JY

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:Improved treatment approaches for ulcerative colitis (UC), including novel medications, might reduce the need for colectomy. We performed a retrospective cohort study of adult patients (age 18-64) with UC in the United States to examine time trends for colectomy and biologic use from 2007 to 2016. METHODS:W...

journal_title：Inflammatory bowel diseases

authors： Barnes EL,Jiang Y,Kappelman MD,Long MD,Sandler RS,Kinlaw AC,Herfarth HH

更新日期：2020-07-17 00:00:00