Open-label study of adalimumab in patients with ulcerative colitis including those with prior loss of response or intolerance to infliximab.


BACKGROUND:The aim of this study was to assess the clinical benefit and tolerability of adalimumab, a fully human monoclonal antibody to tumor necrosis factor (TNF), in patients with ulcerative colitis (UC). METHODS:Patients with active UC, including those who had lost response or developed intolerance to the chimeric anti-TNF antibody infliximab, were enrolled in a 24-week uncontrolled trial. Patients were treated with subcutaneous adalimumab 160 mg at week 0, 80 mg at week 2, and 40 mg every other week starting at week 4. After week 8 the dose could be escalated to 40 mg weekly for incomplete response. Outcome measures included clinical response and remission and mucosal healing. RESULTS:Twenty patients were enrolled, of whom 13 had previously received infliximab. Seven patients had dose escalation of adalimumab between weeks 8 and 16, from 40 mg every other week to 40 mg weekly, due to incomplete response. The rates of clinical response were 25% at week 8 and 50% at week 24. The rates of clinical remission were 5% at week 8 and 20% at week 24. The rate of mucosal healing was 30% at week 8. The rates of clinical response and remission and mucosal healing were similar in infliximab-naïve and previously exposed patients. None of the patients experienced hypersensitivity reactions during treatment with adalimumab. CONCLUSIONS:Adalimumab is well tolerated and appears to be a clinically beneficial option for patients with UC, including those who have previously lost their response to or cannot tolerate infliximab.


Inflamm Bowel Dis


Afif W,Leighton JA,Hanauer SB,Loftus EV Jr,Faubion WA,Pardi DS,Tremaine WJ,Kane SV,Bruining DH,Cohen RD,Rubin DT,Hanson KA,Sandborn WJ




Has Abstract


2009-09-01 00:00:00












  • Physician density and hospitalization for inflammatory bowel disease.

    abstract:BACKGROUND:Inflammatory bowel diseases (IBDs) are chronic illnesses that require frequent and regular healthcare contact. Regular maintenance care may reduce complications or the need for hospitalization. Availability of physicians may be an important determinant of IBD hospitalizations. METHODS:Using 2008 inpatient d...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Ananthakrishnan AN,McGinley EL,Binion DG,Saeian K

    更新日期:2011-02-01 00:00:00

  • Two-stage genome-wide methylation profiling in childhood-onset Crohn's Disease implicates epigenetic alterations at the VMP1/MIR21 and HLA loci.

    abstract:BACKGROUND:As a result of technological and analytical advances, genome-wide characterization of key epigenetic alterations is now feasible in complex diseases. We hypothesized that this may provide important insights into gene-environmental interactions in Crohn's disease (CD) and is especially pertinent to early onse...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Adams AT,Kennedy NA,Hansen R,Ventham NT,OʼLeary KR,Drummond HE,Noble CL,El-Omar E,Russell RK,Wilson DC,Nimmo ER,Hold GL,Satsangi J

    更新日期:2014-10-01 00:00:00

  • The Relationship Between Adverse Childhood Experiences and Health Care Use in the Manitoba IBD Cohort Study.

    abstract:BACKGROUND:We aimed to determine the prevalence of adverse childhood experiences (ACEs) in persons with inflammatory bowel disease (IBD) and whether having ACEs was associated with health care utilization post-IBD diagnosis. METHOD:Three hundred forty-five participants from the population-based Manitoba IBD Cohort Stu...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Witges KM,Bernstein CN,Sexton KA,Afifi T,Walker JR,Nugent Z,Lix LM

    更新日期:2019-09-18 00:00:00

  • Aneuploidy-associated gene expression signatures characterize malignant transformation in ulcerative colitis.

    abstract:BACKGROUND:Malignant transformation in ulcerative colitis (UC) is associated with pronounced chromosomal instability, reflected by aneuploidy. Although aneuploidy can precede primary cancer diagnosis in UC for more than a decade, little is known of its cellular consequences. METHODS:Whole-genome gene expression analys...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Gerling M,Nousiainen K,Hautaniemi S,Krüger S,Fritzsche B,Homann N,Bruch HP,Auer G,Roblick UJ,Ried T,Habermann JK

    更新日期:2013-03-01 00:00:00

  • Population-based case-control study of measles, mumps, and rubella and inflammatory bowel disease.

    abstract:BACKGROUND:Previous controversy was generated over the hypothesis that a paramyxovirus such as measles or vaccination against such viruses might be causally associated with inflammatory bowel disease (IBD). We aimed to determine if Crohn's disease (CD) or ulcerative colitis (UC) subjects are more likely to be seroposit...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Bernstein CN,Rawsthorne P,Blanchard JF

    更新日期:2007-06-01 00:00:00

  • Dark lumen magnetic resonance enteroclysis in combination with MRI colonography for whole bowel assessment in patients with Crohn's disease: first clinical experience.

    abstract:BACKGROUND:Magnetic resonance enteroclysis (MRE) is a recently introduced imaging technique that assesses the small bowel with similar sensitivity and specificity as the fluoroscopically performed conventional enteroclysis. Magnetic resonance imaging colonography (MRC) seems to be a promising technique for polyp assess...

    journal_title:Inflammatory bowel diseases

    pub_type: 临床试验,杂志文章


    authors: Schreyer AG,Gölder S,Scheibl K,Völk M,Lenhart M,Timmer A,Schölmerich J,Feuerbach S,Rogler G,Herfarth H,Seitz J

    更新日期:2005-04-01 00:00:00

  • Characterization of cecal gene expression in a differentially susceptible mouse model of bacterial-induced inflammatory bowel disease.

    abstract:BACKGROUND:A/JCr mice develop typhlitis in response to Helicobacter hepaticus infection, whereas C57BL/6 mice coexist with this bacterium in a "commensal" relationship and do not develop disease even during prolonged colonization. METHODS:To determine mechanisms that control this balance between responsiveness and non...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Myles MH,Dieckgraefe BK,Criley JM,Franklin CL

    更新日期:2007-07-01 00:00:00

  • IBD Systems Biology Is Here to Stay.

    abstract:BACKGROUND:Systems biology is a rapidly advancing field of science that allows us to look into disease mechanisms, patient diagnosis and stratification, and drug development in a completely new light. It is based on the utilization of unbiased computational systems free of the traditional experimental approaches based ...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Fiocchi C,Iliopoulos D

    更新日期:2021-01-13 00:00:00

  • Hospital Admissions, Biological Therapy, and Surgery in Familial and Sporadic Cases of Inflammatory Bowel Disease: A Population-Based Cohort Study 1977-2011.

    abstract:BACKGROUND:Easily accessible predictors of disease course in inflammatory bowel disease (IBD) are scarce, and it remains largely unknown whether a family history of IBD predicts the course of Crohn's disease (CD) and ulcerative colitis (UC). We aimed to compare the course of disease in familial and sporadic cases of IB...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Trier Moller F,Andersen V,Andersson M,Jess T

    更新日期:2015-12-01 00:00:00

  • Serum adalimumab concentration and clinical remission in patients with Crohn's disease.

    abstract:BACKGROUND:Drug concentration monitoring may be useful to guide therapeutic adjustments for anti-tumor necrosis factor agents in Crohn's disease. The relationship between serum adalimumab concentrations and clinical outcomes was assessed using data from CLinical Assessment of Adalimumab Safety and Efficacy Studied as I...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章,随机对照试验


    authors: Chiu YL,Rubin DT,Vermeire S,Louis E,Robinson AM,Lomax KG,Pollack PF,Paulson SK

    更新日期:2013-05-01 00:00:00

  • MicroRNAs in inflammatory bowel diseases: paradoxes and possibilities.

    abstract::MicroRNAs (miRNAs) are single-stranded RNA molecules, which influence the translation of messenger RNA and hence protein synthesis. The altered expression of miRNAs in disease states in cancer and autoimmune diseases including inflammatory bowel disease is providing new insights into disease pathogenesis. This underst...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章,评审


    authors: Whiteoak SR,Felwick R,Sanchez-Elsner T,Fraser Cummings JR

    更新日期:2015-05-01 00:00:00

  • Utilization of influenza immunization in adults with Crohn's disease-a longitudinal, population-based study.

    abstract:BACKGROUND:The incidence of vaccine-preventable disease is increasing. Several guidelines recommend annual influenza vaccination for patients with inflammatory bowel disease. METHODS:Using the Business Objects database of Clalit Health Services in the Tel Aviv district we identified all patients older than 18 years wi...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Boltin D,Gingold-Belfer R,Kimchi NA,Ben-Bassat O,Niv Y,Birkenfeld S

    更新日期:2014-02-01 00:00:00

  • Changes of OPG and RANKL concentrations in Crohn's disease after infliximab therapy.

    abstract:BACKGROUND:Osteoporosis is a well-known complication of Crohn's disease (CD). Osteoprotegerin (OPG) concentration is elevated in patients with CD compared to healthy controls. Long-term infliximab (IFX) maintenance therapy improves the patients' bone mineral density. The effect of IFX on bone metabolism has not yet bee...

    journal_title:Inflammatory bowel diseases

    pub_type: 临床试验,杂志文章


    authors: Miheller P,Muzes G,Rácz K,Blázovits A,Lakatos P,Herszényi L,Tulassay Z

    更新日期:2007-11-01 00:00:00

  • Antimicrobial peptide response to blood translocation of bacterial DNA in Crohn's disease is affected by NOD2/CARD15 genotype.

    abstract:BACKGROUND:Blood translocation of bacterial-DNA has been described in patients with Crohn's disease (CD). The host's immune cell types cooperate to respond against bacterial insults. Some antimicrobial peptides are inducible after culture with bacterial products and a linkage has been established between them and NOD2/...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Gutiérrez A,Holler E,Zapater P,Sempere L,Jover R,Pérez-Mateo M,Schoelmerich J,Such J,Wiest R,Francés R

    更新日期:2011-08-01 00:00:00

  • Toward an Algorithm for the Diagnosis and Management of CMV in Patients with Colitis.

    abstract:INTRODUCTION:Concurrent cytomegalovirus (CMV) in inflammatory bowel disease-related colitis is an important yet complex clinical scenario associated with high rates of colectomy and other morbidity. This review aimed to examine the literature to produce a comprehensive diagnostic and treatment algorithm for the managem...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章,评审


    authors: Beswick L,Ye B,van Langenberg DR

    更新日期:2016-12-01 00:00:00

  • Feasibility of endoscopic assessment and treating to target to achieve mucosal healing in ulcerative colitis.

    abstract:BACKGROUND:Mucosal healing (MH) as a treatment target for ulcerative colitis is of growing interest because it is associated with improved clinical outcomes. However, the feasibility and probability of reaching MH in clinical practice is unknown. We therefore evaluated the feasibility of "treating to target" according ...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Bouguen G,Levesque BG,Pola S,Evans E,Sandborn WJ

    更新日期:2014-02-01 00:00:00

  • Adherence to anti-TNF therapy in inflammatory bowel diseases: a systematic review.

    abstract:BACKGROUND:Nonadherence to medications may affect disease outcomes. The aim of this article was to review methods of assessment, prevalence, and predictors of nonadherence to anti-tumor necrosis factor therapy in inflammatory bowel diseases (IBD). METHODS:Studies were identified through the electronic database of MEDL...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章,评审


    authors: Lopez A,Billioud V,Peyrin-Biroulet C,Peyrin-Biroulet L

    更新日期:2013-06-01 00:00:00

  • Development and Validation of a Confocal Laser Endomicroscopy-Based Score for In Vivo Assessment of Mucosal Healing in Ulcerative Colitis Patients.

    abstract:Background:Endoscopic monitoring is fundamental for evaluating the therapeutic response in IBD, but a validated endomicroscopic mucosal healing (MH) score is not available to date. However, confocal laser endomicroscopy (CLE) might define MH more precisely than conventional endoscopy. The major aim was to establish and...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Hundorfean G,Chiriac MT,Mihai S,Hartmann A,Mudter J,Neurath MF

    更新日期:2017-12-19 00:00:00

  • Colorectal cancer in ulcerative colitis: survival in patients with and without colorectal cancer symptoms.

    abstract::: Patients with ulcerative colitis are at increased risk for colorectal adenocarcinoma compared with the general population. Although surveillance for colorectal malignancy and dysplasia (a premalignant lesion) has been recommended, a benefit in reducing mortality from colorectal cancer via surveillance or prophylacti...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Giardiello FM,Gurbuz AK,Bayless TM,Goodman SN,Yardley JH

    更新日期:1996-04-01 00:00:00

  • Granulocytapheresis is useful as an alternative therapy in patients with steroid-refractory or -dependent ulcerative colitis.

    abstract:BACKGROUND:Recently, granulocyte and monocyte adsorption apheresis (GCAP) has been shown to be safe and effective for active ulcerative colitis (UC). We analyzed the safety and efficacy of GCAP (G-1 Adacolumn) in patients with steroid-refractory and -dependent UC. G-1 Adacolumn is filled with cellulose acetate carriers...

    journal_title:Inflammatory bowel diseases

    pub_type: 临床试验,杂志文章


    authors: Naganuma M,Funakoshi S,Sakuraba A,Takagi H,Inoue N,Ogata H,Iwao Y,Ishi H,Hibi T

    更新日期:2004-05-01 00:00:00

  • Contraception, Venous Thromboembolism, and Inflammatory Bowel Disease: What Clinicians (and Patients) Should Know.

    abstract::The peak incidence of the inflammatory bowel diseases (IBDs) is between the second and fourth decades of life, which coincides with prime reproductive years. Unplanned or mistimed pregnancies may account for nearly half of all pregnancies and are associated with adverse consequences such as a higher risk of delayed pr...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Limdi JK,Farraye J,Cannon R,Woodhams E,Farraye FA

    更新日期:2019-09-18 00:00:00

  • Interrogating the Gut-Brain Axis in the Context of Inflammatory Bowel Disease: A Translational Approach.

    abstract::This review examines preclinical and clinical studies relevant to our understanding of how the bidirectional gut-brain axis influences the natural history of inflammatory bowel disease. Preclinical studies provide proof of concept that preexisting behavioral illness, such as depression, results in increased susceptibi...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Collins SM

    更新日期:2020-03-04 00:00:00

  • Body Mass Index, Genetic Susceptibility, and Risk of Complications Among Individuals with Crohn's Disease.

    abstract:BACKGROUND:Obesity is associated with systemic and intestine-specific inflammation and alterations in gut microbiota, which in turn impact mucosal immunity. Nonetheless, a specific role of obesity and its interaction with genetics in the progression of Crohn's disease (CD) is unclear. METHODS:We conducted a cross-sect...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Pringle PL,Stewart KO,Peloquin JM,Sturgeon HC,Nguyen D,Sauk J,Garber JJ,Yajnik V,Ananthakrishnan AN,Chan AT,Xavier RJ,Khalili H

    更新日期:2015-10-01 00:00:00

  • High residential sun exposure is associated with a low risk of incident Crohn's disease in the prospective E3N cohort.

    abstract:BACKGROUND:Vitamin D insufficiency has been suggested to be associated with high risk of Crohn's disease (CD). In France, where food fortification is limited, the major source of vitamin D is through sun exposure. The aim of this work was to analyze the relationship between residential sun exposure and the risk of inci...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Jantchou P,Clavel-Chapelon F,Racine A,Kvaskoff M,Carbonnel F,Boutron-Ruault MC

    更新日期:2014-01-01 00:00:00

  • The Management of Intestinal Penetrating Crohn's Disease.

    abstract::Crohn's disease (CD) leads to the development of complications through progressive uncontrolled inflammation and the transmural involvement of the bowel wall. Most of the available literature on penetrating CD focuses on the perianal phenotype. The management of nonperianal penetrating complications poses its own set ...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章,评审


    authors: Hirten RP,Shah S,Sachar DB,Colombel JF

    更新日期:2018-03-19 00:00:00

  • Overexpression of ATP-activated P2X7 receptors in the intestinal mucosa is implicated in the pathogenesis of Crohn's disease.

    abstract:BACKGROUND:Extracellular nucleotides released in conditions of cell stress alert the immune system from tissue injury or inflammation. We hypothesized that the P2X7 receptor (P2X7-R) could regulate key elements in inflammatory bowel disease pathogenesis. METHODS:Colonoscopy samples obtained from patients with Crohn's ...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Neves AR,Castelo-Branco MT,Figliuolo VR,Bernardazzi C,Buongusto F,Yoshimoto A,Nanini HF,Coutinho CM,Carneiro AJ,Coutinho-Silva R,de Souza HS

    更新日期:2014-03-01 00:00:00

  • Accelerated Infliximab Dosing Increases 30-Day Colectomy in Hospitalized Ulcerative Colitis Patients: A Propensity Score Analysis.

    abstract:Background:Standard outpatient induction dosing of infliximab (IFX) may not be effective in hospitalized ulcerative colitis (UC) patients with higher inflammatory burden and colectomy risk. Our aim was to determine whether initial IFX induction dose affects 30-day colectomy rate and other disease-related outcomes. Met...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Shah SC,Naymagon S,Panchal HJ,Sands BE,Cohen BL,Dubinsky MC

    更新日期:2018-02-15 00:00:00

  • Incidence and Predictors of Flares in the Postpartum Year Among Women With Inflammatory Bowel Disease.

    abstract:BACKGROUND:The postpartum period is marked by physiological and psychological stresses that may impact activity in inflammatory bowel disease. The predictors and outcomes of disease activity during this period have not been well characterized. METHODS:We performed a retrospective review of inflammatory bowel disease p...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Yu A,Friedman S,Ananthakrishnan AN

    更新日期:2020-11-19 00:00:00

  • Targeted inhibition of heat shock protein 90 suppresses tumor necrosis factor-α and ameliorates murine intestinal inflammation.

    abstract::Inflammatory bowel diseases are chronic intestinal inflammatory diseases thought to reflect a dysregulated immune response. Although antibody-based inhibition of tumor necrosis factor-α (TNF-α) has provided relief to many inflammatory bowel diseases patients, these therapies are either ineffective in a patient subset ...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章


    authors: Collins CB,Strassheim D,Aherne CM,Yeckes AR,Jedlicka P,de Zoeten EF

    更新日期:2014-04-01 00:00:00

  • Liver diseases associated with anti-tumor necrosis factor-alpha (TNF-α) use for inflammatory bowel disease.

    abstract::The conventional treatment of inflammatory bowel disease (IBD) has focused on nonspecifically targeting mucosal inflammation. In the last decade, with the advent of novel biological agents that directly inhibit proinflammatory cytokines, such as tumor necrosis factor alpha (TNF-α), rapid progress has been made in clin...

    journal_title:Inflammatory bowel diseases

    pub_type: 杂志文章,评审


    authors: Coffin CS,Fraser HF,Panaccione R,Ghosh S

    更新日期:2011-01-01 00:00:00